scholarly journals POTENTIAL ROLE OF PUNICA GRANATUM JUICE FOR TREATING DENGUE FEVER ON CYCLOPHOSPHAMIDE INDUCED SWISS ALBINO MICE

2020 ◽  
Vol 8 (11) ◽  
pp. 494-53
Author(s):  
Liny P. ◽  
◽  
Jayarama M. ◽  
Rajeshwari B.C ◽  
Vijay Kumar S ◽  
...  
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Blood Cells ◽  
White Blood Cells ◽  
Punica Granatum ◽  
Pomegranate Juice ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Leaf Juice

The present work aims at analysing the potential of pomegranate juice which is used for the treatment of dengue fever as it is used in increasing the bodys immune power by increasing the platelets count. The phytochemical characteristics of pomegranate juice extract is studied and compared with papaya leaf juice extract. Both the papaya leaves and pomegranate are naturally and easily available, which are non toxic, has no side effects. In our study, the effectiveness of pomegranate juice was studied by introducing the juice into cyclophosphamide induced swiss albino mice. Before the administration, the platelet count, White Blood Cells (WBC) and Red Blood Cells (RBC) was analysed, after the induction of cyclophosphamide platelet count and white blood cells decreased from 9,74,200, 11380 to 8,42,400, 6140 and no significance for RBC. The blood samples were rechecked after introduction of pomegranate juice extract. It was observed that platelet count, WBC increased significantly, but there was no significant increase in RBC. Therefore, it can be concluded that pomegranate juice significantly increases the platelet count and WBC.

scholarly journals Antiplasmodial and haematological effects of Senna occidentalis leaf ethanolic extracts on Swiss albino mice infected with Plasmodium berghei

2021 ◽  
Vol 12 (2) ◽  
pp. 122-128
Author(s):  
S.M. Babangida ◽  
G.J. Sow ◽  
D.M. Shehu
Keyword(s):  
Plasmodium Berghei ◽  
Blood Cells ◽  
Leaf Extract ◽  
White Blood Cells ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Swiss Albino Mice ◽  
Ethanolic Extracts ◽  
Albino Mice

A research was conducted to investigate the haematological effects of ethanolic leaf extracts of Senna occidentalis on Swiss albino mice infected with 0.2 ml of Plasmodium berghei infected blood. Fifteen (15) mice weighing between 140-260g were assigned into five study groups of three mice each. The first group is treated with 0.2 mL of normal saline (drug free control). Group 2, 3, 4 were treated with 100, 200, and 400mg/kg of theethanolic leaf extract respectively while group 5 received 10mg/kg of chloroquine phosphate. All doses were administered orally. The results obtained were analyzed using Analysis of Variance with Duncan’s Multiple Range Test to separate the means. The result of the preliminary phytochemical analysis revealed the presence of alkaloids, saponins, cardiac glycosides, diterpenoids, flavonoids, steroids, tannins, Triterpenoids, carbohydrates and proteins. The level of parasite suppression ranges from 35% to 75% and the activity increased with increase in concentration of the extracts (dose dependent). The extracts were found to increase the level of some haematological parameters such as Red Blood Cells, White Blood Cells and Haemoglobin. The effect is concentration dependent, increases with increase in concentration. Thus, the anti plasmodial efficacy of the leaf extract of S. occidentalis on P. berghei is confirmed. It is recommended that , 400 mg/kg leaf ethanolic extracts of S. occidentalis couldbe use in the treatment of malarial fever.

scholarly journals EVALUATION OF ANTICANCER POTENTIAL OF ETHANOLIC EXTRACT OF ALANGIUM SALVIFOLIUM LEAVES IN ANIMAL MODELS

2019 ◽  
pp. 397-400
Author(s):  
PRATHIMA C ◽  
SHASHIKUMARA SHASHIKUMARA ◽  
THIPPESWAMY T
Keyword(s):  
Body Weight ◽  
Anticancer Activity ◽  
Blood Cells ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Ethanolic Extract ◽  
Phytochemical Analysis ◽  
Swiss Albino Mice ◽  
Soxhlet Apparatus ◽  
Albino Mice

Objective: The present study aims to evaluate the anticancer potential of ethanolic extract of Alangium salvifolium leaves (EASL) against Ehrlich ascites carcinoma (EAC) in animal model. Methods: The ethanolic extract of A. salvifolium was prepared by continuous method using Soxhlet apparatus. Phytochemical analysis of EASL was conducted. Anticancer activity of the extract was evaluated by EAC model in Swiss albino mice. EASL was administered at the doses of 100 and 200 mg/kg body weight once a day orally for 14 days, after 24 h of tumor inoculation. Results: A. salvifolium leaves extract treatment produced significant decrease in tumor volume and body weight, and increase in total and non-viable cell count, along with elevated life span of EAC-bearing mice. The EASL exhibited potent dose-dependent antitumor activity. Further, the altered hematological parameters such as red blood cells, hemoglobin, and white blood cells levels as well as biochemical parameters such as serum glutamic oxaloacetic transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, albumin, and total protein levels in EAC mice were significantly (p<0.05) regained following treatment with EASL. The anticancer potential of EASL can be attributed to the presence of phenols and flavonoids. Conclusion: Results suggest that EASL possesses significant anticancer activity against EAC tumor-bearing Swiss albino mice.

scholarly journals The Enigma of Eosinophil Degranulation

2021 ◽  
Vol 22 (13) ◽  
pp. 7091
Author(s):  
Timothée Fettrelet ◽  
Lea Gigon ◽  
Alexander Karaulov ◽  
Shida Yousefi ◽  
Hans-Uwe Simon
Keyword(s):  
Blood Cells ◽  
Inflammatory Diseases ◽  
White Blood Cells ◽  
Exact Role ◽  
Effector Cells ◽  
Effector Functions ◽  
Cytotoxic Effector ◽  
Eosinophil Degranulation

Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis. The exact role of these granule-containing leukocytes in health and diseases is still a matter of debate. Degranulation is one of the key effector functions of eosinophils in response to diverse stimuli. The different degranulation patterns occurring in eosinophils (piecemeal degranulation, exocytosis and cytolysis) have been extensively studied in the last few years. However, the exact mechanism of the diverse degranulation types remains unknown and is still under investigation. In this review, we focus on recent findings and highlight the diversity of stimulation and methods used to evaluate eosinophil degranulation.

Candida albicans Shunt Infection: Report of Two Cases

Neurosurgery ◽  
1986 ◽  
Vol 19 (1) ◽  
pp. 111-113 ◽  
Author(s):  
David J. Gower ◽  
Kerry Crone ◽  
Eben Alexander ◽  
David L. Kelly
Keyword(s):  
Candida Albicans ◽  
Blood Cells ◽  
White Blood Cells ◽  
Shunt Infection ◽  
Cerebrospinal Fluid Shunts ◽  
Previous Therapy ◽  
Relationship Of ◽  
The Relationship ◽  
Overall Mortality

Abstract Infection of cerebrospinal fluid shunts with Candida albicans is reported in two patients. Scanning electron microscopy in one case demonstrates the relationship of the Candida hyphae to the white blood cells and to silicone plastic. A review of 10 previously reported cases of Candida shunt infection indicates that the infection usually follows a major bacterial infection or direct contamination or occurs spontaneously, Previous therapy has usually involved removal of the shunt, and the role of parenteral antifungal therapy is still unclear. Overall mortality to date is 25%.

Exploring the therapeutic potential of apple extracts against thrombocytopenia in rat experimental models

2018 ◽  
Vol 48 (3) ◽  
pp. 397-405
Author(s):  
Munawar Abbas ◽  
Farhan Saeed ◽  
Muhammad Umair Arshad ◽  
Muhammad Tahir Nadeem ◽  
Huma Bader-Ul-Ain ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cells ◽  
Therapeutic Potential ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Apple Fruit ◽  
Antioxidant Compounds ◽  
Sprague Dawley ◽  
Content Type ◽  
Apple Seed

Purpose This paper aims to evaluate the therapeutic potential of apple extracts against thrombocytopenia, i.e. decrease in platelet count. Design/methodology/approach Male Sprague Dawley rats were used to evaluate therapeutic potential of apple extracts. Diets enriched with apple fruit and seed’s ethanolic extract were provided to normal and KBrO3-induced thrombocytopenic rats for 60 days. KBrO3 was administered at level of 85 mg/Kg of body weight of rats to intentionally decrease the platelet count. Platelet count and other hematological parameters were monitored at monthly intervals to evaluate therapeutic effect of apple extracts against thrombocytopenia. Findings The results of current research portrayed that both apple seed and fruit extracts enriched diets increased the platelet count significantly (p < 0.05) in thrombocytopenic rats. It was observed that apple fruit extract-enriched diet (AFE) raised the platelet count to 14.72 and 33.07 per cent in normal and thrombocytopenic rats, respectively. Apple seed extract-enriched diet (ASE) raised the platelet count to 11.08 and 32.90 per cent in normal and thrombocytopenic rats, respectively. Other hematological parameters including white blood cells, red blood cells and hemoglobin were also significantly increased. Originality/value Thrombocytopenia is uprising problem in developing world including India and Pakistan accompanied by different diseases especially dengue and related complications. Because of questioning on therapies against thrombocytopenia, research on diet-based therapies, as a substitute to synthetic one, is increasing. Diet rich in antioxidant compounds including apple fruit and seeds are the limelight of manuscript.

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