scholarly journals In-Vivo Anthelmenthic Activity of Various Extracts of Eclipta Alba Leaves

2017 ◽  
Vol 2 (02) ◽  
pp. 32-35
Author(s):  
Swetha Naram Reddy ◽  
Azmath Farhana ◽  
Teja Sri. A ◽  
Aliya Anjum ◽  
Vasudha Bakshi
Keyword(s):  
Plant Extracts ◽  
Standard Dose ◽  
Anthelmintic Activity ◽  
Ethanolic Extract ◽  
Reference Standard ◽  
Eclipta Alba ◽  
Dependent Activity ◽  
Dose Dependent

Different extracts of E.alba were taken for anthelmintic activity against Indian earthworm Pheretima posthuma. Two concentrations (100 and 150 mg/ml) of various extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. Albendazole (20 mg/ml) was used as reference standard. Dose dependent activity was observed in the plant extracts but ethanolic extract exhibited more activity as compared to others.

scholarly journals Comparative in vitro anthelmintic activity of three plants from the Amaranthaceae family

2010 ◽  
Vol 62 (1) ◽  
pp. 185-189 ◽  
Author(s):  
Ashok Kumar ◽  
K. Lakshman ◽  
K.N. Jayaveera ◽  
R. Nandeesh ◽  
B. Manoj ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Anthelmintic Activity ◽  
Reference Standard ◽  
Amaranthus Caudatus ◽  
Methanol Extracts ◽  
Amaranthus Spinosus ◽  
Dose Dependent

The three plants presented in this study are Amaranthus spinosus, Amaranthus caudatus and Amaranthus viridis L. They belong to the Amaranthaceae family and are traditionally used as vermicides. Our aim was to investigate the anthelmintic activity of the three plants using earthworms (Pheretima posthuma). Methanol extracts of the three plants at different concentrations (10, 20, 40, 60, 80, 100 mg/ml) showed dose-dependent vermicidal activities. At concentrations of 80 and 100 mg/ml all three plant extracts caused paralysis (8.18, 5, 12.16, 5.75, 10.2, 7.8 min) and death (14.65, 9.12, 18.6, 8.5, 18.6, 12.7 min), respectively. Piperazine was used as a reference standard at a concentration of 10 mg/ml. Our study found that the three plants possess potent anthelmintic activity when compared to Piperazine.

scholarly journals In vitro and in vivo anthelmintic activity of extracts from Artemisia parviflora and A. sieversiana

2017 ◽  
Vol 54 (3) ◽  
pp. 218-224 ◽  
Author(s):  
S. Irum ◽  
H. Ahmed ◽  
B. Mirza ◽  
K. Donskow-Łysoniewska ◽  
A. Muhammad ◽  
...  
Keyword(s):  
Adult Worm ◽  
Plant Extracts ◽  
Small Ruminants ◽  
Anthelmintic Activity ◽  
Gastrointestinal Nematodes ◽  
Economic Losses ◽  
Egg Hatching ◽  
Infective Larvae

SummaryIn the northern areas of Pakistan, the use of Artemisia based therapeutics is a common practice. Plants of genus Artemisia are known to possess anthelmintic and therapeutic effect. Infections caused by gastrointestinal nematodes are major threat to livestock industry across the world resulting in loss of production and indirect economic losses due to high cost of anthelmintic drugs. Present study was carried out to evaluate in vitro and in vivo effect of Artemisia sieversiana and Artemisia parviflora on Haemonchus contortus, a parasitic nematode of small ruminants. Methanolic plant extract was tested against three different developmental stages using an egg hatch assay, infective larvae and adult worm motility assay. Different concentrations were used for the bioassays and post exposure mortality was recorded after 8 hr for adult worms and infective larvae, while egg inhibition percentage was observed after 27 hr. A highly significant ability to inhibit the egg hatching (100 %) was recorded for both plant extracts while, the highest activity for adult worm assay and larvicidal assay was 90 % for A. sieversiana. The highest activity for adult motility and larvicidal assay for A. parviflora was 89 % and 86.6 % respectively. For in vivo trials maximum parentage reduction was 77.0 % for A. sieversiana and 73.6 % for A. parviflora. It is concluded that selected plant extracts were effective in reducing worm burden in animals.

scholarly journals Anthelmintic and Cytotoxic Activities of Two Medicinal Plants: Polygonum viscosum and Aphanamixis polystachya Growing in Bangladesh

2014 ◽  
Vol 6 (2) ◽  
pp. 339-345 ◽  
Author(s):  
M. N. Amin ◽  
M. S. Majumder ◽  
M. M. R. Moghal ◽  
S. Banik ◽  
A. Kar ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Anthelmintic Activity ◽  
Cytotoxic Activities ◽  
Dependent Manner ◽  
Reference Standard ◽  
Cytotoxic Potential ◽  
Lc50 Value ◽  
Vincristine Sulphate ◽  
Dose Dependent

The present study was designed to investigate in vitro anthelmintic and cytotoxic activities of crude methanolic extract of two plants(Polygonum viscosum and Aphanamixis polystachya) grown in Bangladesh. Evaluation of cytotoxic activity was done using the brine shrimp lethality bioassay. The crude methanolic extract of Polygonum viscosum showed significant cytotoxic potential (LC50 value of 6.34 ?g/ml) among all the fractions comparing with that of standard vincristine sulphate (0.825 ?g/ml). Besides, the LC50 values of crude methanolic extract, pet ether and chloroform extracts of Aphanamixis polystachya showed good cytotoxic activities 11, 10.36, and 16.45 µg/ml, respectively. The other study was undertaken to evaluate anthelmintic activity (using Pheretima posthuma model) where piperazine was used as reference standard. The crude methanolic extract of Polygonum viscosum leaves produced a significant anthelmintic activity in dose dependent manner and the activity of crude extract was comparable with that of standard drugs. Besides, the Aphanamixis polystachya extract revealed moderate anthelmintic activity. Here, the anova testing was done with the P < 0.05. Further studies are suggested to determine the active compounds responsible for the anthelmintic and cytotoxic activities of these two plant extracts.   Keywords: Anthelmintic; Cytotoxic; Medicinal plant; Aphanamixis polystachya; Polygonum viscosu.  © 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.   doi: http://dx.doi.org/10.3329/jsr.v6i2.17299 J. Sci. Res. 6 (2), 339-345 (2014) 

scholarly journals In vivo anthelmintic activity of Callistemon rigidus ethanolic extract on Haemonchus contortus in goats

2020 ◽  
Vol 02 (03) ◽  
pp. 103
Author(s):  
Yongwa Gilbert ◽  
Ndjonka Dieudonné ◽  
Belga Francois Ngnodandi Francois Ngnodandi
Keyword(s):  
Haemonchus Contortus ◽  
Anthelmintic Activity ◽  
Ethanolic Extract ◽  
Callistemon Rigidus

scholarly journals Phytopharmacological Evaluation of Alcoholic Extract of Berberis aristata Leaf in the Treatment of Gastric Ulcer

2020 ◽  
Vol 13 (1) ◽  
pp. 1-5
Author(s):  
Ratnaker Singh ◽  
Y. Trilochana
Keyword(s):  
Acute Toxicity ◽  
Crude Extract ◽  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
Total Phenolic ◽  
Antiulcer Activity ◽  
Alcoholic Extract ◽  
Dose Dependent

For over a century, peptic ulcer has been one of the most common gastrointestinal tract (GIT) disorder. There are number of drugs are now available for treatment. Drugs of herbal origin reduce the offensive factors and have proved to be safe, clinically effective, relatively less expensive, globally competitive, and with better patient tolerance.This study was performed to assess the anti-ulcer activity on different parts of B.aristata. Apart from that, acute toxicity, qualitative chemical analysis, total phenolic content (TPC), total flavonoid content(TFC) and in vitro antioxidant activities were evaluated. The potentially active plant part was selected for screening as gastro protective, in vivo antioxidant and antisecretory activities in ulcerated rats.The 50% ethanolic extract of B. aristata were subjected to preliminary phytochemical screening, estimation of TFC and TPC. The crude extract from the leaves of B. aristata gave best antiulcer activity among flower and stem. In acute toxicity studies, the administration of the crude extract of B. aristata leaves did not reveal any adverse effects or toxicity in rats at fourteen days observations.The results of these studies have shown that ethylexract of B.aristata leaf (EEBAL) produced a significant dose dependent ulcerprotective, antioxidant and antisecretory activity by blocking the activity of proton pump, protecting from antioxidants produced during stress induced ulcer and by enhancing glycoprotein levels.

scholarly journals Preclinical Appraisal of Hematinic Potential of Mandura Bhasma for Treating Anemia

2021 ◽  
pp. 207-214
Author(s):  
Deepak S. Khobragade ◽  
Mrunali S. Potbhare ◽  
Awdhut Pimpale ◽  
Sagar B. Wankhede ◽  
Chandrashekhar R. Tempe
Keyword(s):  
Body Weight ◽  
Ferrous Sulphate ◽  
Standard Drug ◽  
Dependent Activity ◽  
Daily Dose ◽  
Study Institute ◽  
Dose Dependent ◽  
Pharmaceutical Education ◽  
Different Doses

Aims: To evaluate hematinic potential of mandura bhasma. Study Design: Experimental study. Place and Duration of Study: Institute of Pharmaceutical Education and Research, Wardha, Maharashtra, India. 6 Months. Methodology: The anti-anaemic potential of Mandura bhasma in Wistar rats was investigated. Anaemia was induced in rats with phenyl hydrazine hydrochloride at a dose of 10        mg kg-1 body weight by oral administration. Anaemia was treated with mandura bhasma administered in three different doses based on body weight. Results: In vivo investigation showed that though the dose of 6mg kg-1 body weight of mandura bhasm produced only a minimal antianaemic (hematinic) effect, oral daily dose of 11 mg kg-1 body weight and 22mg kg-1 body weight a produced a significant (P < 0.05) antianaemic effect when compared to standard drug ferrous sulphate indicating dose dependent activity. Conclusions: The results indicate that Mandura Bhasm have very potential dose dependant hematinic activity and can be a safe and effective drug for treating anemia.

scholarly journals Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum

2011 ◽  
Vol 61 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Soniamol Joseph ◽  
Baby Sabulal ◽  
Varughese George ◽  
Kuttikkadan Antony ◽  
Kainoor Janardhanan
Keyword(s):  
Ganoderma Lucidum ◽  
Tumour Volume ◽  
Carcinoma Cells ◽  
Tumour Mass ◽  
Dependent Activity ◽  
Tumour Implantation ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Potential Antitumor

Antitumor and anti-inflammatory activities of polysaccharides isolated fromGanoderma lucidumIn this study, polysaccharides were isolated fromGanoderma lucidum (Polyporaceae)and their antitumor and anti-inflammatory activities were investigated usingin vivomodels. Potential antitumor activity was shown byG. lucidumpolysaccharides (GLP) against solid tumor induced by Ehrlich's ascites carcinoma cells. GLP at 100 mg kg-1body mass showed 80.8 and 77.6 % reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2 % inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg-1, GLP exhibited 57.6 and 58.2 % inhibition in carrageenean-induced and formalin-induced assays, respectively.

scholarly journals EFFICACY OF AN ACTIVE COMPOUND OF THE HERB, ASHWAGANDHA IN PREVENTION OF STRESS INDUCED HYPERGLYCEMIA

2018 ◽  
Vol 10 (10) ◽  
pp. 44 ◽  
Author(s):  
Sarjan H. N. ◽  
Yajurvedi H. N.
Keyword(s):  
Phosphoenolpyruvate Carboxykinase ◽  
Ethanolic Extract ◽  
Dependent Manner ◽  
Stress Exposure ◽  
In Vitro Experiment ◽  
Isolated Compound ◽  
Dose Dependent ◽  
Different Doses

Objective: To find out whether an isolated compound (IC) from the ethanolic extract of roots of ashwagandha prevents stress-induced hyperglycemia by direct interference with the action of increased concentration of corticosterone on hepatocytes or by preventing hyper-secretion of corticosterone or both.Methods: A group of rats served as controls, and those in another group were subjected to restraint (1 h) and forced swimming exercise (15 min), after a gap of 4 h daily for 4 w. The third group of rats received orally IC (5 mg/kg bw/rat) 1 h prior to exposure to stressors. After the last treatment period, a blood sample was collected and serum was separated for the estimation of corticosterone and glucose. In in vitro experiment, hepatocytes were treated with different concentrations of corticosterone (100, 200, 300, 400 and 500 ng/ml). In another set of experiment, hepatocytes were treated with different doses of IC (1, 10, 100, 1000 and 10 000 μg/ml of medium) along with corticosterone (400ng/ml). The concentration of glucose and activities of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) were determined after the treatment.Results: Stress exposure caused a significant increase in serum concentration of corticosterone and glucose whereas, administration of IC did not result in similar changes. Further, treatment of corticosterone in in vitro significantly increased the activities of PEPCK and G6Pase and concentration of glucose in a dose-dependent manner in hepatocytes. However, treatment with IC did not interfere with the corticosterone-induced an increase in the activities of PEPCK and G6Pase as well as the concentration of glucose in hepatocytes.Conclusion: The in vivo and in vitro results put together reveal that IC does not directly interfere with the action of corticosterone on hepatocytes. However, it prevents stress-induced hyperglycemia by suppressing hyper-secretion of corticosterone. 

scholarly journals In Vivo Antitumor Activity of Ethanolic Extract of Lepidagathis Pungens Nees Whole Plant

2020 ◽  
Vol 11 (4) ◽  
pp. 6763-6770
Author(s):  
Manoharan Dhanalakshmi ◽  
Subramaniam AnandaThangadurai ◽  
Swaminathan Gomathi
Keyword(s):  
Side Effects ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
Synthetic Drugs ◽  
In Vivo Antitumor Activity ◽  
Whole Plant ◽  
Chemotherapy Patients ◽  
Dose Dependent ◽  
Plant Sources

Cancer is the most dreadful of all the diseases and is the major contributors to the mortality in the world. Out of all the population, almost 1.2 million patients die due to cancer and related problems. The rate and spread of cancer are wide and even in both women and men. It is presently as high as 3.5 million people who have cancer in India alone. There are many ways of treatment of cancer like the surgery, radiation therapy, cryosurgery and chemotherapy. A part of chemotherapy is the usage of a lot of chemicals and synthetic drugs. Due to the side effects of chemotherapy, patients often get symptoms due to the usage of drugs, and so the cancer treatment often is toxic. Because of this, herbal drugs are seemed to have no side effects, and non-toxic effects, and so this project deals with identifying the plant sources of the drugs that treat cancers effectively. The present study focusses on the extraction of the chemical constituents from Lepidagathis pungens whole  plant and using the same to estimate the anti-tumour potential in EAC induced tumour induction method. The activity was tested in two doses 200 and 400 mg/kg of the extract. They showed a dose-dependent activity when estimated for the tumour parameters and other haematological measures like RBC, WBC counts. They showed similar activity when estimated for the antioxidant enzymes like SGOT, SGPT, Catalases, LPO and ALP levels.

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