scholarly journals Money laundering risk management tools based on determining the level of co-ordination of financial companies and credit unions

2019 ◽  
Vol 16 (4) ◽  
pp. 40-51 ◽  
Author(s):  
Nataliya Vnukova ◽  
Daria Hontar ◽  
Mykhaylo Vorotyntsev
Keyword(s):  
Money Laundering ◽  
Risk Group ◽  
Credit Unions ◽  
High Risk Group ◽  
Weapons Of Mass Destruction ◽  
Mass Destruction ◽  
Management Tools ◽  
Financial Conglomerates ◽  
Definition Of ◽  
The Impact

The article proposes a tool for managing money laundering risk based on the definition of the level of coherence of financial companies and credit unions, the application of which will contribute to introduction of a risk-based approach to anti-money laundering, terrorist financing and proliferation of weapons of mass destruction. It was revealed that among the investigated during 2010-2017 financial corporations and credit unions there are financial conglomerates. This confirms the existence of close ties between them. Associated financial companies and credit unions may form or join networks that can be used for possible money laundering. It was established that the share of connected credit unions and financial companies corresponds to the principle of Pareto – 20:80. The proposed methodological support allowed selecting a large number of independent credit unions and financial companies. This will help to prevent the impact of the risk of connected individuals on the high ability of the borrower to fulfill their loan obligations and not to be involved in processes for money laundering using networks. Meanwhile, dedicated joint financial institutions belong to a high-risk group for controlling their financial operations to prevent the legalization of proceeds from crime.

scholarly journals Determining the level of bank connectivity for combating money laundering, terrorist financing and proliferation of weapons of mass destruction

2019 ◽  
Vol 14 (4) ◽  
pp. 42-54
Author(s):  
Nataliya Vnukova ◽  
Sergii Kavun ◽  
Oleh Kolodiziev ◽  
Svіtlana Achkasova ◽  
Daria Hontar
Keyword(s):  
Money Laundering ◽  
Financial Institutions ◽  
Banking System ◽  
Weapons Of Mass Destruction ◽  
Mass Destruction ◽  
Terrorist Financing ◽  
Average Proportion ◽  
Binary Matrices ◽  
The Impact ◽  
Oriented Approach

The study aims at developing an approach to determining the bank connectivity level. This will contribute to implementing a risk-oriented approach to counteracting money laundering, terrorist financing and the proliferation of mass destruction weapons. The article proposes to assess the degree of bank connectivity and determine the impact of these circumstances on money laundering risk using banks from foreign banking groups, whose capital share in the Ukrainian banking system amounts to more than 40 percent. Using the resulting correlation dependencies, two-dimensional binary matrices were constructed, which became the basis for creating graphs of links between banks. The institutions under study are found to be predominantly connected in terms of their sets (varieties), since the average proportion of banks with close direct links is over half, and the non-connectivity coefficient for them is about 40%. Each surveyed bank, on average, has direct links with eight other banks and inverse links with four other banks. Considering banks as tops of the graph, one can assume that there is a hidden relationship between some banks. This approach allows calculating all existing relationships between banks to assess risk. Transforming the graph from non-oriented to oriented made it possible to identify and clearly demonstrate possible directions of links between the investigated financial institutions, which should be further verified to determine the risk of money laundering, terrorist financing, etc.

scholarly journals CD133 Expression in the Nucleus Is Associated with Endometrial Carcinoma Staging and Tumor Angioinvasion

2021 ◽  
Vol 10 (10) ◽  
pp. 2144
Author(s):  
Milosz Pietrus ◽  
Kazimierz Pitynski ◽  
Marcin Waligora ◽  
Katarzyna Milian-Ciesielska ◽  
Monika Bialon ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Plasma Membrane ◽  
Tumor Progression ◽  
Endometrial Carcinoma ◽  
Molecular Level ◽  
Risk Group ◽  
High Risk Group ◽  
Cd133 Expression ◽  
Transmembrane Glycoprotein ◽  
The Impact

Background: (1) Endometrial cancer is one of the most common cancers affecting women, with a growing incidence. To better understand the different behaviors associated with endometrial cancer, it is necessary to understand the changes that occur at a molecular level. CD133 is one of the factors that regulate tumor progression, which is primarily known as the transmembrane glycoprotein associated with tumor progression or cancer stem cells. The aim of our study was to assess the impact of subcellular CD133 expression on the clinical course of endometrial cancer. (2) Methods: CD133 expression in the plasma membrane, nucleus, and cytoplasm was assessed by immunohistochemical staining in a group of 64 patients with endometrial cancer representing FIGO I-IV stages, grades 1–3 and accounting for tumor angioinvasion. (3) Results: Nuclear localization of CD133 expression was increased in FIGO IB-IV stages compared to FIGO IA. Furthermore, CD133 expression in the nucleus and plasma membrane is positively and negatively associated with a higher grade of endometrial cancer and angioinvasion, respectively. (4) Conclusions: Our findings suggest that positive nuclear CD133 expression in the tumor may be related to a less favorable prognosis of endometrial carcinoma patients and has emerged as a useful biomarker of a high-risk group.

scholarly journals The Impact of Preoperative Risk on the Association between Hypotension and Mortality after Cardiac Surgery: An Observational Study

2020 ◽  
Vol 9 (7) ◽  
pp. 2057
Author(s):  
Vanja Ristovic ◽  
Sophie de Roock ◽  
Thierry G. Mesana ◽  
Sean van Diepen ◽  
Louise Y. Sun
Keyword(s):  
Cardiac Surgery ◽  
Risk Factor ◽  
High Risk ◽  
Hospital Mortality ◽  
Risk Group ◽  
High Risk Group ◽  
Group Care ◽  
Intermediate Risk ◽  
Intraoperative Hypotension ◽  
The Impact

Background: Despite steady improvements in cardiac surgery-related outcomes, our understanding of the physiologic mechanisms leading to perioperative mortality remains incomplete. Intraoperative hypotension is an important risk factor for mortality after noncardiac surgery but remains relatively unexplored in the context of cardiac surgery. We examined whether the association between intraoperative hypotension and in-hospital mortality varied by patient and procedure characteristics, as defined by the validated Cardiac Anesthesia Risk Evaluation (CARE) mortality risk score. Methods: We conducted a retrospective cohort study of consecutive adult patients who underwent cardiac surgery requiring cardiopulmonary bypass (CPB) from November 2009–March 2015. Those who underwent off-pump, thoracic aorta, transplant and ventricular assist device procedures were excluded. The primary outcome was in-hospital mortality. Hypotension was categorized by mean arterial pressure (MAP) of <55 and between 55–64 mmHg before, during and after CPB. The relationship between hypotension and death was modeled using multivariable logistic regression in the intermediate and high-risk groups. Results: Among 6627 included patients, 131 (2%) died in-hospital. In-hospital mortality in patients with CARE scores of 1, 2, 3, 4 and 5 was 0 (0%), 7 (0.3%), 35 (1.3%), 41 (4.6%) and 48 (13.6%), respectively. In the intermediate-risk group (CARE = 3–4), MAP < 65 mmHg post-CPB was associated with increased odds of death in a dose-dependent fashion (adjusted OR 1.30, 95% CI 1.13–1.49, per 10 min exposure to MAP < 55 mmHg, p = 0.002; adjusted OR 1.18 [1.07–1.30] per 10 min exposure to MAP 55–64 mmHg, p = 0.001). We did not observe an association between hypotension and mortality in the high-risk group (CARE = 5). Conclusions: Post-CPB hypotension is a potentially modifiable risk factor for mortality in intermediate-risk patients. Our findings provide impetus for clinical trials to determine if hemodynamic goal-directed therapies could improve survival in these patients.

scholarly journals Ventricular arrhythmias in syndrome of balloon deformity of mitral valve. Definition of possible high risk group.

Heart ◽  
1976 ◽  
Vol 38 (10) ◽  
pp. 1053-1057 ◽  
Author(s):  
R W Campbell ◽  
M G Godman ◽  
G I Fiddler ◽  
R M Marquis ◽  
D G Julian
Keyword(s):  
High Risk ◽  
Mitral Valve ◽  
Ventricular Arrhythmias ◽  
Risk Group ◽  
High Risk Group ◽  
Definition Of

scholarly journals Pharmacogenetic score predicts overall survival, progression-free survival and platinum sensitivity in ovarian cancer

2020 ◽  
Vol 21 (14) ◽  
pp. 995-1010
Author(s):  
Sara Gagno ◽  
Michele Bartoletti ◽  
Chiara Romualdi ◽  
Elena Poletto ◽  
Simona Scalone ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Germ Line ◽  
Risk Group ◽  
Prognostic Score ◽  
Progression Free Survival ◽  
High Risk Group ◽  
Free Survival ◽  
Estrogen Activity ◽  
The Impact

Aim: To define the impact of polymorphisms in genes involved in platinum-taxane and estrogen activity in the outcome of platinum-based treated ovarian cancer patients (OCP). Patients & Methods: Two hundred and thirty OCP were analyzed for 124 germ-line polymorphisms to generate a prognostic score for overall survival (OS), progression-free survival (PFS) and platinum-free interval (PFI). Results: ABCG2 rs3219191D>I, UGT1A rs10929302G>A and UGT1A rs2741045T>C polymorphisms were significantly associated with all three parameters (OS, PFS and PFI) and were used to generate a score. Patients in high-risk group had a poorer OS (hazard ratio [HR]: 1.8; 95% CI: 1.3–2.7; p = 0.0019), PFS (HR: 2.0; 95% CI: 1.4–2.9; p < 0.0001) and PFI (HR: 1.9; 95% CI: 1.4–2.8; p = 0.0002) compared with those in low-risk group. Conclusion: The prognostic-score including polymorphisms involved in drug and estrogen pathways stratifies OCP according to OS, PFS and PFI.

Screening for local and regional cancer recurrence in patients curatively treated for laryngeal cancer: Definition of a high-risk group and estimation of the lead time

Head & Neck ◽  
2007 ◽  
Vol 29 (5) ◽  
pp. 431-438 ◽  
Author(s):  
Savitri C. Ritoe ◽  
André L. M. Verbeek ◽  
Paul F. M. Krabbe ◽  
Johannes H. A. M. Kaanders ◽  
Frank J. A. van den Hoogen ◽  
...  
Keyword(s):  
High Risk ◽  
Laryngeal Cancer ◽  
Lead Time ◽  
Risk Group ◽  
Cancer Recurrence ◽  
High Risk Group ◽  
Definition Of

Identification of Novel Tumor Microenvironment-Related Long Non-coding RNAs to Predict the Prognosis for Hepatocellular Carcinoma

2021 ◽  
Author(s):  
Shenglan Huang ◽  
Jian Zhang ◽  
Dan Li ◽  
Xiaolan Lai ◽  
Lingling Zhuang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
High Risk ◽  
Tumor Microenvironment ◽  
Cox Regression ◽  
Risk Group ◽  
High Risk Group ◽  
Low Risk ◽  
Clinicopathological Parameters ◽  
Kaplan Meier ◽  
The Impact

Abstract Introduction: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with poor prognosis. Tumor microenvironment (TME) plays a vital role in the tumor progression of HCC. Thus, we aimed to analyze the association of TME with HCC prognosis, and construct an TME-related lncRNAs signature for predicting the prognosis of HCC patients.Methods: We firstly assessed the stromal/immune /Estimate scores within the HCC microenvironment using the ESTIMATE algorithm based on TCGA database, and its associations with survival and clinicopathological parameters were also analyzed. Then, different expression lncRNAs were filtered out according to immune/stromal scores. Cox regression was performed to built an TME-related lncRNAs risk signature. Kaplan–Meier analysis was carried out to explored the prognostic values of the risk signature. Furthermore, we explored the biological functions and immune microenvironment feathers in high- and low risk groups. Lastly, we probed the association of the risk signature with the treatment responses to immune checkpoint inhibitors (ICIs) in HCC by comparing the immunophenoscore (IPS).Results: Stromal/immune /Estimate scores of HCC patients were obtained based on the ESTIMATE algorithm. The Kaplan-Meier curve analysis showed the high stromal/immune/ Estimate scores were significantly associated with better prognosis of the HCC patients. Then, six TME-related lncRNAs were screened for constructing the prognosis model. Kaplan-Meier survival curves suggested that HCC patients in high-risk group had worse prognosis than those with low-risk. ROC curve and Cox regression analyses demonstrated the signature could predict HCC survival exactly and independently. Function enrichment analysis revealed that some tumor- and immune-related pathways associated with HCC tumorigenesis and progression might be activated in high-risk group. We also discovered that some immune cells, which were beneficial to enhance immune responses towards cancer, were remarkably upregulated in low-risk group. Besides, there was closely correlation of immune checkmate inhibitors (ICIs) with the risk signature and the signature can be used to predict treatment response of ICIs.Conclusions: We analyzed the impact of the tumor microenvironment scores on the prognosis of patients with HCC. A novel TME-related prognostic risk signature was established, which may improve prognostic predictive accuracy and guide individualized immunotherapy for HCC patients.

scholarly journals Obesity and menopause modify the epigenomic profile of breast cancer

2017 ◽  
pp. 351-363 ◽  
Author(s):  
Ana B Crujeiras ◽  
Angel Diaz-Lagares ◽  
Olafur A Stefansson ◽  
Manuel Macias-Gonzalez ◽  
Juan Sandoval ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
High Risk ◽  
Risk Group ◽  
Menopausal Status ◽  
Breast Tumors ◽  
Methylation Pattern ◽  
High Risk Group ◽  
Cpg Sites ◽  
The Impact

Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific methylome. The current work was aimed to explore the impact of obesity and menopausal status on variation in breast cancer methylomes. Data from Infinium 450K array-based methylomes of 64 breast tumors were coupled with information on BMI and menopausal status. Additionally, DNA methylation results were validated in 18 non-tumor and 81 tumor breast samples. Breast tumors arising in either pre- or postmenopausal women stratified by BMI or menopausal status alone were not associated with a specific DNA methylation pattern. Intriguingly, the DNA methylation pattern identified in association with the high-risk group (postmenopausal women with high BMI (>25) and premenopausal women with normal or low BMI < 25) exclusively characterized by hypermethylation of 1287 CpG sites as compared with the low-risk group. These CpG sites included the promoter region of fourteen protein-coding genes of which CpG methylation over the ZNF577 promoter region represents the top scoring associated event. In an independent cohort, the ZNF577 promoter methylation remained statistically significant in association with the high-risk group. Additionally, the impact of ZNF577 promoter methylation on mRNA expression levels was demonstrated in breast cancer cell lines after treatment with a demethylating agent (5-azacytidine). In conclusion, the epigenome of breast tumors is affected by a complex interaction between BMI and menopausal status. The ZNF577 methylation quantification is clearly relevant for the development of novel biomarkers of precision therapy in breast cancer.

scholarly journals Unia Europejska wobec problemu proliferacji broni masowego rażenia. Wpływ kryzysu dotyczącego irańskiego programu atomowego na kształtowanie się oraz implementację strategii Wspólnoty

2017 ◽  
pp. 71-87
Author(s):  
Robert Siudak
Keyword(s):  
Security Studies ◽  
Weapons Of Mass Destruction ◽  
Political Crisis ◽  
Successful Implementation ◽  
The European Union ◽  
Mass Destruction ◽  
Energy Agency ◽  
Post Cold War ◽  
The Impact ◽  
The Eu

Proliferation of weapons of mass destruction (WMD) has been one of the most prominent threat discussed in the post-Cold War security studies. The article presents analyses of the European Union policies towards proliferation of WMD and the impact of the political crisis around Iranian nuclear programme on them. Based on documents of the EU and the International Atomic Energy Agency, two processes are identified as the main source of the EU agenda on non-proliferation. Firstly, internal dynamics of the negotiations on the EU strategy against proliferation of weapons of mass destruction in 2003, including performance of a specific agents promoting their ideas and interests. Secondly, the evolution of the EU role in the debate around Iranian nuclear programme between 2003–2015. Negotiations with Iran are identified as the biggest challenge for the EU policy on WMD so far, with positive conclusions about successful implementation of multilateral mechanisms.

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