scholarly journals Topical therapy of dermatoses in children with complex localizations

2021 ◽  
pp. 192-202
Author(s):  
J. S. Kovaleva ◽  
M. V. Orobei ◽  
N. K. Zyablitskaya ◽  
N. K. Bishevskaya
Keyword(s):  
Side Effects ◽  
Skin Diseases ◽  
Topical Therapy ◽  
Age Groups ◽  
Rapid Onset ◽  
Transepidermal Water Loss ◽  
Omega 3 ◽  
Onset Of Action ◽  
Methylprednisolone Aceponate ◽  
Anti Inflammatory

The skin of children has its own anatomical and physiological characteristics, the epidermis is much thinner than in adults, the layers of the dermis and basement membrane are poorly developed and differentiated, the rate of transepidermal water loss is increased and the level of natural moisturizing factor (NMF) is reduced. Such a structure of the skin predisposes to a violation of its barrier function, contributes to the occurrence of skin diseases, provides an increased resorptive capacity of the skin and requires special attention when prescribing external therapy. The use of high-quality emollients is an important part of the basic treatment of chronic dermatoses and has its own characteristics in childhood. The use of emollients prevents the development of exacerbations and reduces the need for anti-inflammatory topical drugs. With the localization of the inflammatory process on the face, neck, genitals and large folds, it is necessary to give preference to short courses of topical glucocorticosteroids (THCS) with sufficient anti-inflammatory activity, rapid onset of action, minimal side effects. Given the high risk of side effects in children in these areas of the skin, strong fluorinated THCS, high-potency THCS, and the use of THCS under occlusive dressings are not recommended. The Russian experience of using 0.1% methylprednisolone aceponate in children of various age groups in the treatment of allergic dermatoses, including those with localization in sensitive areas, has shown good efficacy, tolerance and the absence of side effects. he article presents own clinical observations of the effectiveness of the use of combination therapy: an emollient agent - a special cream with physiological lipids omega 3-6-9 and cream methylprednisolone aceponate (with ceramides in the base) in the treatment of skin diseases in children with an emphasis on complex localizations, such as face, folds, genital area.

scholarly journals Effectiveness of Dermatosis Topical Therapy

2020 ◽  
Vol 16 (27) ◽  
pp. 6-8
Author(s):  
R.M. Zagrtdinova ◽  
◽  
N.V. Lyashenko ◽  
M.V. Bagautdinova ◽  
Keyword(s):  
Fatty Acids ◽  
Side Effects ◽  
High Efficiency ◽  
Skin Diseases ◽  
Topical Therapy ◽  
Calcineurin Inhibitors ◽  
Complex Treatment ◽  
Omega 3 ◽  
Important Place ◽  
Methylprednisolone Aceponate

In the complex treatment of skin diseases, the important place is given to topical therapy, which has high efficiency and minimal side effects. At the same time, the leaders of such therapy are glucocorticosteroids, calcineurin inhibitors and emollients. The article provides examples of effective topical therapy of various dermatoses using methylprednisolone aceponate and calcineurin inhibitors, as well as emollients containing polyunsaturated omega-3-6-9 fatty acids. The latter are important components for basic skin care for patients with dermatoses.

scholarly journals Comparison of Ketamine and Pentazocine with Fentanyl and Propofol combination for anaesthesia during laparoscopic tubal ligation

2019 ◽  
Vol 8 (4) ◽  
pp. 1525
Author(s):  
Ovais Nazir ◽  
Asif Hussain Bhat ◽  
Hamid Yatoo ◽  
Sanjeevni Gupta ◽  
Rajesh Misra
Keyword(s):  
Side Effects ◽  
Recovery Time ◽  
Postoperative Nausea And Vomiting ◽  
Rapid Onset ◽  
Tubal Ligation ◽  
Onset Of Action ◽  
Anaesthetic Agents ◽  
Minimally Invasive Surgical ◽  
Group I ◽  
Group Ii

Background: Laparoscopic tubal ligation have advantages of minimally invasive surgical technique, without risk of major haemorrhage, early postoperative ambulation and alimentation, making it suitable for ambulatory surgery. The choice of aneasthesia for laparoscopic ligation hence should consider the anaesthetic agents with a rapid onset of action and fast recovery time, with minimal problems for intraoperative control of haemodynamic, airway and pain relief as well as take consideration of the safety, quality, efficacy, and utilization of resources available to the given situation.Methods: A total of 100 patients aged from 18 to 45 years who were scheduled to undergo laparoscopic tubal ligation  were divided into Group I-  Ketamine plus pentazocine group (n=50), Group II- Propofol plus fentanyl group (n=50) and studied  for the intraoperative parameters (hemodynamic and respiratory profile), recovery time, postoperative side effects and discharge time.Results: Intraoperatively MAP and HR were consistently higher in group I as compared to group II. Incidence of apnea and need for bag and mask ventilation was significantly more in Group II than in Group I as was the incidence of Bradycardia. Postoperative nausea and vomiting, psychomimetic effects were significantly more in Group I than in Group II. The time to reach modified PADSS ≥9 (discharge time) was significantly longer in group I (140.3±12.82 min than in group II 102.2±9.2 min), P<0.01.Conclusions: Combination of ketamine and pentazocine gives good anaesthetic conditions during procedure with less incidence of airway and haemodynamic complications intraoperatively but more incidence of postoperative side effects like nausea, vomiting, psycomimetic effects, and time to meet discharge criteria, compared to propofol plus fentanyl.

scholarly journals Variation of Biophysical Parameters of the Skin with Age, Gender, and Body Region

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Alireza Firooz ◽  
Bardia Sadr ◽  
Shahab Babakoohi ◽  
Maryam Sarraf-Yazdy ◽  
Ferial Fanian ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Normal Population ◽  
Normal Skin ◽  
Age Groups ◽  
Transepidermal Water Loss ◽  
The Body ◽  
Body Region ◽  
Biophysical Parameters ◽  
Skin Physiology ◽  
Melanin Index

Background. Understanding the physiological, chemical, and biophysical characteristics of the skin helps us to arrange a proper approach to the management of skin diseases.Objective. The aim of this study was to measure 6 biophysical characteristics of normal skin (sebum content, hydration, transepidermal water loss (TEWL), erythema index, melanin index, and elasticity) in a normal population and assess the effect of sex, age, and body location on them.Methods. Fifty healthy volunteers in 5 age groups (5 males and females in each) were enrolled in this study. A multifunctional skin physiology monitor (Courage & Khazaka electronic GmbH, Germany) was used to measure skin sebum content, hydration, TEWL, erythema index, melanin index, and elasticity in 8 different locations of the body.Results. There were significant differences between the hydration, melanin index, and elasticity of different age groups. Regarding the locations, forehead had the highest melanin index, where as palm had the lowest value. The mean values of erythema index and melanin index and TEWL were significantly higher in males and anatomic location was a significant independent factor for all of 6 measured parameters.Conclusion. Several biophysical properties of the skin vary among different gender, age groups, and body locations.

Low-dose Gabapentin for Intractable Hiccups in a Heart Transplant Recipient

2011 ◽  
Vol 21 (4) ◽  
pp. 340-343 ◽  
Author(s):  
Robert L. Page ◽  
Megan Luna ◽  
Andreas Brieke ◽  
JoAnn Lindenfeld
Keyword(s):  
Side Effects ◽  
Transplant Recipient ◽  
Drug Interactions ◽  
Heart Transplant ◽  
Heart Transplant Recipient ◽  
Rapid Onset ◽  
Transplant Recipients ◽  
Onset Of Action ◽  
One Year ◽  
Intractable Hiccups

Intractable hiccups can be a serious complication in transplant recipients. Unfortunately, many of the pharmacotherapies used to stop hiccups are associated with severe side effects as well as drug-drug interactions with immunosuppressants. We report a case of a heart transplant recipient who had had intractable hiccups for 2 months, resulting in severe insomnia, diminished appetite, and weight loss. To treat the hiccups, treatment with oral baclofen (5–10 mg 3 times daily) was started. After 6 weeks of therapy, the baclofen was titrated down and discontinued because it had not stopped the hiccups and was causing severe central nervous system side effects. Gabapentin (100 mg twice daily) was then prescribed and within 24 hours of the start of that treatment, the hiccups had resolved completely. After 3 weeks of therapy, the patient had no side effects and the gabapentin was subsequently discontinued. One year after stopping the gabapentin, the patient remains free of hiccups. Gabapentin appears to be a promising medication for the treatment of intractable hiccups in thoracic transplant recipients because of its lack of serious side effects at low doses, rapid onset of action, and lack of drug-drug interactions with transplant medications.

scholarly journals EFFEKTIFITAS OBAT HERBAL TERHADAP PENYEMBUHAN JERAWAT : A Systematic Review

2021 ◽  
Vol 1 (2) ◽  
pp. 152-162
Author(s):  
Al Ihksan Agus
Keyword(s):  
Side Effects ◽  
Skin Diseases ◽  
Aloe Vera ◽  
Punica Granatum ◽  
Herbal Remedies ◽  
Tea Tree ◽  
Common Skin ◽  
Herbal Plants ◽  
Aloe Ferox ◽  
Anti Inflammatory

Acne is one of the most common skin diseases and usually affects almost everyone. Herbal remedies can be given to treat acne and do not cause side effects. The purpose of writing is to see the effectiveness of herbal remedies for healing acne. Methods: Recent literature reviews were conducted using the electronic databases of Pubmed, Wiley Online and Science Direct. The review method uses keyword terms and phrases of Herbal Medicine, Acne, and Facial Treatment. Results: From the results of 9 studies, it was found that there was anti-acne activity of herbal plants and was relatively safe because there were no severe side effects compared to conventional or synthetic treatments. And there is the effectiveness of herbal remedies for healing acne. Conclusion: Herbal plants have antioxidant, anti-inflammatory, antibacterial and anti-inflammatory effects. Some of the recommended plants based on journal reviews for treating acne include: Nigela Sativa L, Amurense Phellodendron, Tea Tree Oil, Mangosteen Fruit Skin, Aloe Vera, Lavandulla, Paper Murbey, Green Tea, Hops, Aloe Ferox, Punica Granatum (Pomegranate).

scholarly journals Omega 3 Fatty Acid and Skin Diseases

2021 ◽  
Vol 11 ◽  
Author(s):  
Yu Sawada ◽  
Natsuko Saito-Sasaki ◽  
Motonobu Nakamura
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Food Intake ◽  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Influential Factors ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Beneficial Effects ◽  
Anti Inflammatory

Humans are exposed to various external environmental factors. Food intake is one of the most influential factors impacting daily lifestyle. Among nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have various beneficial effects on inflammatory diseases. Furthermore, omega-3 PUFA metabolites, including resolvins, are known to demonstrate strong anti-inflammatory effects during allergic and inflammatory diseases; however, little is known regarding the actual impact of these metabolites on skin diseases. In this review, we focused on metabolites that have strong anti-inflammatory actions in various inflammatory diseases, as well as those that present antitumor actions in malignancies, in addition to the actual effect of omega-3 PUFA metabolites on various cells.

scholarly journals Combined pathogenetic therapy of allergic dermatoses in children

2021 ◽  
pp. 28-38
Author(s):  
J. S. Kovaleva ◽  
N. K. Zyablitskaya ◽  
M. V. Orobei ◽  
N. K. Bishevskaya
Keyword(s):  
Side Effects ◽  
Skin Diseases ◽  
Local Therapy ◽  
Calcineurin Inhibitors ◽  
Skin Barrier ◽  
The Body ◽  
Skin Barrier Function ◽  
Severe Exacerbation ◽  
Omega 3 ◽  
Topical Calcineurin Inhibitors

Allergodermatoses make up the majority of allergic skin diseases in childhood, have a recurrent course and significantly disrupt the quality of life of patients and their families. The constant use of emollients, allowing to lengthen periods of remission and reduce the need for topical drugs, is associated with defects in the skin barrier function. Treatment with topical glucocorticosteroids (TCS) and topical calcineurin inhibitors (TCI), which are the basis of pharmacotherapy, should be carried out differentially, taking into account the localization, stage and activity of the inflammatory process, the area of the lesion, the age of the child and the multifactorial genesis of the disease. The basic principles of rational local therapy include the choice of the degree of activity of the drug, its concentration, dosage form, dosage frequency, duration of use to obtain a therapeutic effect and minimize side effects. In case of severe exacerbation and localization of inflammatory elements on the body and limbs in children, it is necessary to start treatment with class 2–3 THCS. When the process is localized on the face and other sensitive areas of the skin (neck and large folds), it is recommended to use class 7 TCS or give preference to TCI. The duration of a continuous course of TCS therapy in children depends on the severity of the exacerbation and should not exceed 2 weeks. The most effective way to reduce the course steroid load and avoid side effects is the early and correct use of TCS during an exacerbation. The advantages of TCI in comparison with TCS are the low incidence of side effects, the absence of contraindications for use on sensitive skin areas, and the possibility of longer use. The article contains Russian and foreign literature data on the use of THCS and TEC in the treatment of allegodermatosis in children and our own clinical observations of the effectiveness of the use of combination therapy: Comfoderm K cream (methylprednisolone aceponate with ceramides in the base), 0.03% tacrolimus ointment and emollient means - special cream Sensoderm with physiological lipids omega 3–6–9.

scholarly journals Adjunctive use of anti-inflammatory drugs for schizophrenia: A meta-analytic investigation of randomized controlled trials

2019 ◽  
Vol 53 (8) ◽  
pp. 742-759 ◽  
Author(s):  
Myeongju Cho ◽  
Tae Young Lee ◽  
Yoo Bin Kwak ◽  
Youngwoo Brian Yoon ◽  
Minah Kim ◽  
...  
Keyword(s):  
Side Effects ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Omega 3 ◽  
Double Blind ◽  
Receptor Modulator ◽  
Syndrome Scale ◽  
General Functioning ◽  
Anti Inflammatory ◽  
Negative Syndrome

Objective:Recent evidence suggests that adjuvant anti-inflammatory agents could improve the symptoms of patients with schizophrenia. However, the effects of the adjuvant anti-inflammatory agents on cognitive function, general functioning and side effects have not yet been systematically investigated. The present meta-analysis aimed to explore the effects of anti-inflammatory agents in patients with schizophrenia comprehensively.Method:We performed a literature search in online databases, including PubMed, EMBASE and the Cochrane Database of Systematic Reviews. Randomized, placebo-controlled double-blind studies that investigated clinical outcomes including psychopathology, neurocognition, general functioning and extrapyramidal side effects were included. The examined anti-inflammatory agents included aspirin, celecoxib, omega-3 fatty acids, estrogen, selective estrogen receptor modulator, pregnenolone, N-acetylcysteine, minocycline, davunetide and erythropoietin.Results:Sixty-two double-blind randomized clinical trials studying 2914 patients with schizophrenia met the inclusion criteria for quantitative analysis. Significant overall effects were found for anti-inflammatory agents for reducing total, positive and negative symptom scores in the Positive and Negative Syndrome Scale. Cognitive improvements were significant with minocycline and pregnenolone augmentation therapy. General functioning was significantly enhanced by overall anti-inflammatory agents. There were no significant differences in side effects compared with placebo. Baseline total Positive and Negative Syndrome Scale score and illness duration were identified as moderating factors in the effects of anti-inflammatory augmentation on psychiatric symptom improvements.Conclusion:The comparative evaluation of efficacy and safety supported the use of anti-inflammatory adjuvant therapy over the use of antipsychotics alone. However, future studies could focus on patients with homogeneous clinical profile to figure out more detailed effects of anti-inflammatory therapy.

The ideal opioid: Is oliceridine the answer?

2016 ◽  
Vol 12 (6) ◽  
pp. 375
Author(s):  
Abhijit S. Nair, MD
Keyword(s):  
Clinical Practice ◽  
Side Effects ◽  
Urinary Retention ◽  
Respiratory Depression ◽  
Rapid Onset ◽  
Onset Of Action ◽  
Short Acting ◽  
Practice Characteristics ◽  
Chronic Use ◽  
The Ideal

There is no ideal opioid available in present clinical practice. Characteristics of an ideal opioid should be rapid onset of action, short acting, minimal respiratory depression, least peripheral side effects like constipation, urinary retention and devoid of dependence or tolerance with chronic use.

scholarly journals Pain Relief by Analgesic Eardrops: Paradigm Shift in the Treatment of Acute Otitis Media?

Drug Research ◽  
2021 ◽  
Author(s):  
Olaf Michel
Keyword(s):  
Side Effects ◽  
Otitis Media ◽  
Local Anesthetics ◽  
Paradigm Shift ◽  
Acute Otitis Media ◽  
Rapid Onset ◽  
Onset Of Action ◽  
Duration Of Action ◽  
Treatment Protocols ◽  
Ear Drops

AbstractAcute otitis media is a common middle ear infection in children with the predominant symptoms of hearing impairment and pain. If antibiotics are given, they need time to have an effect on the inflammation, so the focus is on pain control. For pain management local anesthetics have the advantage of lesser systemic side effects but are still subject to scrutiny. In this review the literature between 2000 and 2020 was systematically searched for investigating studies and recommendation in guidelines against the background of the mode of action. 11 clinical studies, 2 guidelines and 5 reports resp. reviews could be identified. Contraindications and side effects were not found in these studies. The analgesic ear drops showed in placebo-controlled studies a relatively short duration of action when applied once but rapid onset of action. There is evidence that analgesic ear drops could provide a first-line analgesia in otitis media without systemic adverse effects such as gastrointestinal disturbance and nausea and could support an antibiotic-saving wait-and-see attitude. The review shows a change in attitude towards the recommendation to include local anesthetics ear drops in otitis media but still there is a lack in treatment protocols which go beyond a single administration. The results do not yet show a significant paradigm shift. The reviews revealed indications that a more adapted galenic preparation could give more effectiveness. Pharmaceutical research in this field should be intensified to exploit the analgesic potential of local anesthetic ear drops in acute otitis media.

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