Prospects for the use of bacterial lysates in the complex therapy of chronic adenoiditis

Introduction. Adenotomy is a common surgical procedure in childhood. In children with recurrent infections of the respiratory tract, hypertrophy of the pharyngeal tonsil, a sign of lymphoproliferative syndrome of a secondary immunodeficiency state, is characterized by reduced adaptive abilities of mucosal immunity with impaired biocenosis in chronic inflammation. Pharyngeal tonsil surgery is considered stressful in frequently ill children and therefore requires preoperative preparation. In this context, it is relevant to study the nature of changes in the factors of mucosal immunity in terms of cell destruction in the nasal secretion in the complex treatment of children with hypertrophy of the pharyngeal tonsil and chronic adenoiditis, as prevention of complications in the postoperative period of adenotomy.Aim. To increase the effectiveness of the treatment of chronic adenoiditis in children with recurrent infections of the respiratory tract using the combined effect of low-frequency ultrasonic cavitation with monochromatic unpolarized light and bacterial lysates.Materials and methods. In order to test the hypothesis about the possibility of canceling adenotomy in 77 children aged 3-6 years with hypertrophy of the pharyngeal tonsil, accompanied by chronic inflammation. The effectiveness of the complex treatment was assessed by the functional and metabolic status of nonspecific resistance factors in the nasal lavage.Results and discussion. The combined effect of low-frequency ultrasonic cavitation with photochromotherapy and bacterial lysates leads to the normalization of pathophysiological changes on the surface of the mucous membrane, leading to a balance of the qualitative and quantitative composition of the functional-metabolic status of NG, which makes it possible to postpone adenotomy. The best clinical result is observed when bacterial lysates are used in complex therapy in combination with physiotherapy in children with chronic adenoiditis and, to a certain extent, substantiate the advisability of a combined effect as a non-invasive and effective method.Conclusions. Topical bacteriolysate in a complex treatment regimen for children with recurrent infections of the respiratory tract against a background of chronic inflammation eliminates bacterial antigens and enhances the intrinsic defenses of the mucous membrane of the pharyngeal tonsil.

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Low-frequency ultrasound and photochromotherapy in the complex treatment of patients with chronic bacterial and viral rhinosinusitis

Terapevt (General Physician) ◽

10.33920/med-12-2003-02 ◽

2020 ◽

pp. 13-23

Author(s):

Natalya Kornova ◽

A. Krylov

Keyword(s):

Chronic Rhinosinusitis ◽

Low Frequency ◽

Chronic Tonsillitis ◽

Complex Treatment ◽

Resonance Imaging ◽

X Ray ◽

Low Frequency Ultrasound ◽

Viral Nature ◽

Ig G ◽

Frequency Ultrasound

The article presents results of a study on the effectiveness of using lowfrequency ultrasound and photochromotherapy in the complex treatment of patients with chronic bacterial and viral rhinosinusitis. The study involved 69 people aged 18 to 55 years: 39 (56.83 %) women and 30 (45.11 %) men with chronic rhinosinusitis during the period of clinical exacerbation and concomitant chronic tonsillitis without exacerbation. All patients included in the study underwent X-ray examination or computed tomography and magnetic resonance imaging of the paranasal sinuses. 100 % of the patients were examined for the presence of antibodies to Human gammaherpesvirus 4 (ELISA), had study of blood serum for IgM and IgG and test to determine the avidity of Ig G antibodies to γ-herpesviruses. The obtained data indicate the effectiveness of including low-frequency ultrasound and photochromotherapy in the complex treatment of patients with chronic rhinosinusitis and concomitant chronic tonsillitis of bacterial and viral nature without exacerbation.

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Chemical Ablation in Adenoid Surgery

Revista de Chimie ◽

10.37358/rc.18.10.6610 ◽

2018 ◽

Vol 69 (10) ◽

pp. 2722-2724

Author(s):

Teodora Ioana Ghindea ◽

Alexandru Dumitras Meius ◽

Dragos Cristian Stefanescu ◽

Catalina Pietrosanu ◽

Irina Ionita ◽

...

Keyword(s):

Surgical Treatment ◽

Conservative Treatment ◽

Chronic Inflammation ◽

Lymphatic Tissue ◽

Tissue Mass ◽

Surgical Method ◽

Endoscopic Control ◽

Chemical Ablation ◽

Pharyngeal Tonsil

The pharyngeal tonsil is a lymphatic tissue mass located in the roof of the nasopharynx. The function of the pharyngeal tonsil is to prevent infections with the help of antibodies. Chronic inflammation and allergies lead to hyperplasia of the adenoids that is found almost exclusively in children. The treatment of choice is surgical treatment; conservative treatment is only indicated preoperatively or if surgery is contraindicated. In this paper, we will present a new surgical method for adenoidectomy performed trans-orally with coblation, under endoscopic control.

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Inhalable Nanovaccine with Biomimetic Coronavirus Structure to Trigger Mucosal Immunity of Respiratory Tract against COVID-19

Chemical Engineering Journal ◽

10.1016/j.cej.2021.129392 ◽

2021 ◽

pp. 129392

Author(s):

Bin Zheng ◽

Wenchang Peng ◽

Mingming Guo ◽

Mengqian Huang ◽

Yuxuan Gu ◽

...

Keyword(s):

Respiratory Tract ◽

Mucosal Immunity

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IL-9 signaling as key driver of chronic inflammation in mucosal immunity

Cytokine & Growth Factor Reviews ◽

10.1016/j.cytogfr.2016.02.002 ◽

2016 ◽

Vol 29 ◽

pp. 93-99 ◽

Cited By ~ 18

Author(s):

Markus F. Neurath ◽

Susetta Finotto

Keyword(s):

Chronic Inflammation ◽

Mucosal Immunity ◽

Key Driver

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Dynamics influence bacterial lysates in the treatment of infections lower respiratory tract infections in young patients

Family Medicine ◽

10.30841/2307-5112.5(73).2017.123129 ◽

2017 ◽

Vol 0 (5(73)) ◽

pp. 83-87

Author(s):

Л. Ф. Матюха ◽

О. Б. Тиш ◽

Т. А. Титова

Keyword(s):

Respiratory Tract ◽

Lower Respiratory Tract ◽

Respiratory Tract Infections ◽

Young Patients ◽

Lower Respiratory Tract Infections ◽

Bacterial Lysates ◽

Tract Infections

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IMMUNOLOGIC RISK FACTORS OF DEVELOPMENT OTITIS MEDIA WITH EFFUSION IN CHILDREN SUFFERING FROM CHRONIC ADENOIDITIS

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2013-3-92-96 ◽

2013 ◽

Vol 12 (3) ◽

pp. 92-96

Author(s):

N. V. Scherbik ◽

A. V. Klimov ◽

Ye. N. Kologrivova ◽

O. V. Fyodorova ◽

S. V. Komarova

Keyword(s):

Risk Factors ◽

Otitis Media ◽

Mucosal Immunity ◽

Otitis Media With Effusion ◽

Clinical Group ◽

Ifn Γ ◽

Chronic Adenoiditis

There were 24 patients with chronic adenoiditis in the 1st group, another 24 patients with chronic adenoiditis in association with otitis media effusion (OME) were included in the 2d group. The study of mucosal immunity included assessment of SIgA, IL-6, IFN- and IL-10 levels in nasal washes. Decrease of SIgA content and increase of the number of IFN-γ-positive samples was revealed in children from the 2nd clinical group, which allows to regard these characteristics of the mucosal immunity as the risk factors for the development of otitis media with effusion.

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An oral bacterial lysate for the prevention of recurrent infections of the respiratory tract. Results of a double-blind placebo controlled 6 months study in 342 patients

Advances in Mucosal Immunology ◽

10.1007/978-94-009-1848-1_96 ◽

1990 ◽

pp. 351-352

Author(s):

H Fischer ◽

H-P Eckenberger ◽

A van Aubel

Keyword(s):

Respiratory Tract ◽

Recurrent Infections ◽

Bacterial Lysate ◽

Double Blind ◽

Double Blind Placebo

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Endogenous intoxication in chronic pathology of pharynx in children

Russian otorhinolaryngology ◽

10.18692/1810-4800-2021-3-94-101 ◽

2021 ◽

Vol 20 (3) ◽

pp. 94-101

Author(s):

T. A. Mashkova ◽

◽

I. I. Chirkova ◽

O. N. Yamshchikov ◽

I. Yu. Revyakin ◽

...

Keyword(s):

Biological Fluids ◽

The Body ◽

Chronic Tonsillitis ◽

Palatine Tonsils ◽

Immunological Markers ◽

Decay Products ◽

Endogenous Intoxication ◽

Pathological Hypertrophy ◽

Chronic Adenoiditis ◽

Pharyngeal Tonsil

A review of scientific Russian and foreign articles devoted to the development of endogenous intoxication in chronic inflammatory pathology of the lymphoepithelial pharyngeal ring is carried out. Chronic tonsillitis and adenoiditis in children are one of the unsolved issues in otorhinolaryngology. Chronic tonsillitis is a chronic inflammation of the palatine tonsils characterized by recurrent exacerbations in the form of tonsillitis and a general toxic-allergic reaction. Adenoid vegetation is a pathological hypertrophy of the pharyngeal tonsil. Chronic adenoiditis is a chronic polyetiologic disease, which is based on a violation of the physiological immune processes of the pharyngeal tonsil. In children, one cannot talk about an isolated inflammation of the pharyngeal tonsil, since as a result of exposure to antigens, an immune response arises, which involves all structures of the lymphoepithelial pharyngeal ring in the process, therefore some authors distinguish the term «adenotonsillitis». With pronounced activation of microflora in the nasopharynx and oropharynx, the body’s resistance to pathogenic microorganisms decreases, as a result of which decay products and toxins damage the vascular endothelium, disrupt their permeability and, penetrating through the epithelial barrier, contribute to the development of chronic intoxication and sensitization of the body. Endogenous intoxication is a polyetiologic and polypathogenetic syndrome characterized by the accumulation of endogenous toxins in tissues and biological fluids. Diagnostics of the endogenous intoxication severity includes a number of clinical and laboratory indicators and immunological markers. But, despite the constant improvement of the research methods, the issue of endotoxicosis diagnosis in chronic tonsillitis and adenoiditis remains insufficiently studied. As a result of the inadequate diagnosis, there is often a simultaneous removal of the pharyngeal and palatine tonsils, which in turn can lead to irreversible consequences.

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Potential immunological effects of fermentable fibres in athletes

Proceedings of The Nutrition Society ◽

10.1017/s0029665120006229 ◽

2020 ◽

Vol 79 (OCE2) ◽

Author(s):

Luciana Torquati ◽

Steven Tamburo ◽

Andrea Macusi ◽

Alessandra Brunetti ◽

Chiara Iengo ◽

...

Keyword(s):

Respiratory Tract ◽

Mucosal Immunity ◽

Bowel Function ◽

Performance Outcomes ◽

Upper Respiratory Tract ◽

Gut Health ◽

Long Term Effects ◽

Upper Respiratory ◽

Tract Infections ◽

Rugby Players

AbstractRecent findings point at novel benefits of specific fibres, like inulin, as their fermentation metabolites can improve mucosal immunity and protect against infections (1,2). This outcome is desirable for athletes, who are at increased exposure to oxidative damage and thus risk of upper respiratory tract infections (URTI). However, whether inulin can improve immune function in athletes is unknown. We investigated the effect of supplementation with inulin-enriched foods on salivary immunoglobulin A (sIgA), a marker of immunity associated with URTI, in rugby players. We hypothesised that inulin supplementation would increase sIgA, and such change would be greater than that observed in a group following a diet without inulin supplementation. Ten rugby players volunteered for this pilot study (24.2 ± 5.4 years, 93.2 ± 18.7 kg). Participants were randomly assigned to either control (CON) or intervention diet (IN) for 3-weeks; and provided with 2% inulin-enriched pasta and bread (IN) or the same products without inulin (CON), to be consumed as part of a prescribed diet plan. sIgA was measured before and after each condition by collecting saliva with validated swabs, and was quantified with enzyme-linked immunoassay. Differences within and between groups were assessed with paired-samples t-test and ANOVA, respectively. Relationships between inulin intake and sIgA were explored with Spearman's correlation and regression analysis. There was a significant increase in sIgA following inulin supplementation (p = 0.002), which was significantly different to CON (+ 53.6 ± 44.7 and 5.8 ± 37.2 mg/dL, p = 0.054). Average inulin intake was 10.9 ± 1.6 g/day, and it was positively associated with sIgA (rs = 0.661, p = 0.038) and correlated with sIgA changes (r2 = 0.438, p = 0.037). There were no significant differences in energy intake between and within groups (p > 0.10). There were no reports of upper-respiratory tract or other infections during the study period (winter). Some IN participants reported improved bowel function. Inulin-enriched products could represent a simple approach to promote mucosal immunity and gut health in athletes. Larger controlled trials are warranted to confirm the dose-response and long-term effects of inulin supplementation including metabolic and performance outcomes.

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