scholarly journals Squamous cell carcinoma of an eyelid in a horse: A case report

2021 ◽  
Vol 77 (01) ◽  
pp. 6478-2021
Author(s):  
Górski K. ◽  
Turek B. ◽  
Drewnowska O. ◽  
Kliczkowska-Klarowicz K. ◽  
Śmich J. ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Acute Inflammation ◽  
Histopathological Examination ◽  
Mattress Suture ◽  
Retrobulbar Block ◽  
Squamous Cell Metaplasia ◽  
Anti Inflammatory ◽  
Lateral Corner

The aim of this report is to describe a clinical case of squamous cell carcinoma in an 18-year-old horse. This tumor is one of the most common superficial oncological problems in these animals. A lesion in the lateral corner of the eye was already observed about 10 years earlier, but due to the lack of significant growth or alarming symptoms, no diagnostics or treatment was implemented. A year before surgery, an episode of acute inflammation in the eye and a slight enlargement of the nodule occurred. Initially, an autoimmune origin of the lesion was assumed, but anti-inflammatory and bactericidal treatment did not lead to a significant improvement. As a result of sampling for histopathological examination, the tumor doubled its volume, so, given the inefficacy of the subsequent anti-inflammatory and antibiotic therapy, the horse was sent to the clinic. A convex, painful lesion partially covering the cornea was found on arrival. In view of the rapid growth of the tumor and its infiltration of surrounding tissues, a decision was made to carry out transpalpebral enucleation. The procedure was performed under general anesthesia and with an additional retrobulbar block. Because of significant tissue tensions and the risk of hematoma, an intermittent horizontal mattress suture was used. The area was secured with a compression dressing. The horse returned to sport, and no recurrence of the tumor was observed up to 7 months after surgery. Histopathological examination confirmed squamous cell metaplasia forming keratin pearls, characteristic of squamous cell carcinoma.

scholarly journals Immature Squamous Metaplasia of Esophageal Glands Associated with Squamous Cell Carcinoma: Case Report

2020 ◽  
Author(s):  
Laurine Verset ◽  
Vincent Huberty ◽  
Vincent Bourgeois ◽  
Arnaud Lemmers ◽  
Pieter Demetter
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Squamous Metaplasia ◽  
Invasive Squamous Cell Carcinoma ◽  
Early Esophageal Cancer ◽  
Case Presentation ◽  
Squamous Cell Carcinoma Case ◽  
Squamous Cell Metaplasia

Abstract Background: Esophageal immature squamous metaplasia is poorly reported in the literature. This entity can, however, be misinterpreted as high grade dysplasia or invasive squamous cell carcinoma and hence represent a potential pitfall. Case presentation: Histopathological examination of a superficial esoophageal lesion removed by endoscopic submucosal dissection revealed a squamous cell carcinoma associated with immature squamous cell metaplasia arising from esophageal glands. Immunohistochemical stainings allowed to distinguish malignant from metaplastic cells.Conclusions: Immunohistochemistry for Ber-EP4 is helpful in making the distinction between esophageal squamous cell carcinoma and immature squamous metaplasia. This can avoid overstaging and overtreatment, especially in early esophageal cancer.

scholarly journals Carcinoma of Vagina in Utero-Vaginal Prolapse: A Rare Presentation

2012 ◽  
Vol 52 (186) ◽  
Author(s):  
S Acharya ◽  
DK Uprety
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Large Cell ◽  
Uterovaginal Prolapse ◽  
Rare Entity ◽  
Rare Presentation ◽  
Vaginal Carcinoma ◽  
Keywords Squamous Cell Carcinoma

Primary vaginal carcinoma in uterovaginal prolapse is a rare entity. We report a case of an 84-years-old lady, who presented with long standing vaginal ulcer in association with third degree uterovaginal prolapse. Incisional biopsy was taken from the ulcer. Histopathological examination showed a large cell keratinizing squamous cell carcinoma. Keywords: Squamous cell carcinoma, uterovaginal prolapse, vaginal carcinoma.

scholarly journals A case report of an unusual caecal metastatic location of a primary cervical squamous cell carcinoma

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Obed Rockson ◽  
Christine Kora ◽  
Abdelbassir Ramdani ◽  
Badr Serji ◽  
Tijani El Harroudi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Management Strategies ◽  
Cervical Squamous Cell Carcinoma ◽  
Right Hemicolectomy ◽  
Secondary Lesion ◽  
The Right ◽  
Metastatic Location

Abstract Squamous cell carcinoma (SCC) of the colon is a rare malignant tumor occurring as either a primary or secondary lesion. Few cases of metastatic or secondary colonic SCC have been published. We report an unusual case of a 59-year-old female patient who was treated by Wertheim hysterectomy and adjuvant chemoradiation for stage IIB SCC of the uterine cervix. Two years later, she developed a metastatic location in the caecum causing an acute intestinal obstruction. She underwent an emergency open right hemicolectomy with ileocolic anastomosis and resection of two nodules of the umbilicus and the right parietal peritoneum. Histopathological examination confirmed a triple metastatic location of SCC. She is disease-free 11 months after surgery. We discuss the clinicopathological features, management strategies, and the prognosis of this rare entity.

scholarly journals Two different clinical forms of squamous cell carcinoma (SCC) in the perineum and vulva of two mares

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrzej Raś ◽  
Iwona Otrocka-Domagała ◽  
Małgorzata Raś-Noryńska
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ultrasound Examination ◽  
Histopathological Examination ◽  
Reproductive Organs ◽  
Malignant Neoplasms ◽  
Surgical Removal ◽  
Chemotherapy Treatment ◽  
Case Presentation

Abstract Background Genital malignant neoplasms in mares are relatively rare. The treatment involve surgical removal of the tumour masses, chemotherapy or both. Case presentation Two elderly warmblood mares, aged 16 and 20 were presented in University Clinic with the lumpy lesions at the region of perineum and left labia. Surgical removals of tumour masses were performed on standing animals. Removed tissues were subjected to histopathological examination which confirmed SCC. Conclusions Clinical and ultrasound examination of reproductive organs in both mares showed no inflammatory or neoplastic changes. Both mares healed within 2 weeks after surgery and showed no signs of tumour recurrence for the following year despite no chemotherapy treatment.

The effect of concomitant cannabinoids during immune checkpoint inhibitor treatment of advanced stage malignancy.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15064-e15064
Author(s):  
Adam Biedny ◽  
Susan Szpunar ◽  
Ahmed Abdalla ◽  
Zyad Kafri ◽  
Tarik H. Hadid
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Advanced Stage ◽  
Anti Inflammatory ◽  
Inflammatory Effect

e15064 Background: Immune checkpoint inhibitors are used in treatment of advanced neoplasms. Immunotherapy agents create a potent pro-inflammatory effect in cancer. The efficacy of immunotherapy may negatively be impacted by the use of anti-inflammatory agents. An anti-inflammatory effect of cannabinoids has been described in literature in several models. Recent data suggests a negative impact of cannabis on tumor response to immunotherapy. Methods: We retrospectively reviewed medical records of all patients with metastatic cancer who received at least 2 months of immune checkpoint inhibitors between August 2014 and August 2018. The patients were stratified by use of cannabis (cannabis vs non-cannabis users). Baseline patients’ characteristics were compared. Overall survival was estimated and compared between the two groups. An analysis was performed using analysis of variance, Student's t-test, correlation, chi-squared test, and logrank test. All data were analyzed with SPSS v. 26.0 and a p-value less than 0.05 was set to indicate statistical significance. Results: A total of 104 patients with advanced-stage malignancy met the inclusion criteria. The median age was 63.9±10.5 years, 48.1% males and 81.7% Caucasians. 41.3% of patients has lung adenocarcinoma, 20.3% has squamous cell carcinoma of the lung, 11.5% has squamous cell carcinoma of the head and neck and 26.9% have other tumor types. Twenty patients (19.2%) had brain metastasis and twenty-three patients (22.1%) had bone metastasis. Seventy patients (66.8%) received Nivolumab, and twenty-seven patients (26%) received Pembrolizumab. The mean duration of immunotherapy use was 10.2 months. Characteristics of patients were similar between the groups except for a higher prevalence of tobacco use in the cannabis group. Twenty-eight patients (26.9%) reported concomitant cannabis use during immunotherapy treatment, 23 were prescribed (dronabinol) and 5 used it recreationally (smoking marijuana/cannabis oil). Non-cannabis users had significantly longer overall survival (OS) compared to cannabis users (40 months vs 16 months, p = 0.004). Conclusions: This study shows significant association between the use of cannabis during immunotherapy treatment and worse OS. This can be explained by an anti-inflammatory effect of cannabis, which may decrease response to immune checkpoint inhibitors. This observation should be further investigated in randomized trials. Health care professionals should be aware of the potentially harmful effect of cannabis on cancer care.

Squamous cell carcinoma of the vagina and cervix in sheep — Case report

2011 ◽  
Vol 59 (1) ◽  
pp. 123-127 ◽  
Author(s):  
Luis Ferrer ◽  
Delia Lacasta ◽  
Juan Ramos ◽  
Jose Jalón ◽  
Marta Ruiz De Arcaute ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mononuclear Cells ◽  
Histopathological Examination ◽  
Basal Membrane ◽  
Vaginal Wall ◽  
Isolated Cells ◽  
Gynaecological Malignancy ◽  
The World

This report describes the clinical and histopathological characteristics of a squamous cell carcinoma infiltrating the cervix and the vaginal wall, producing reproductive symptoms and subnormal fertility in an adult ewe. Necropsy showed a large (15-cm-long) neoplastic mass infiltrating the vaginal wall and the cervix. Histopathological examination revealed atypical squamous epithelial cords invading the basal membrane and dermis, round anaplastic cells, focal areas of necrosis, keratinisation of isolated cells, and pronounced infiltration by mononuclear cells around the cords. No squamous cell carcinoma of such localisation has been reported from sheep before. In humans, this tumour is the most common gynaecological malignancy in the world.

scholarly journals Squamous cell carcinoma transformed from the prostatic adenocarcinoma with endocrine therapy: a case report and literature review

2021 ◽  
Author(s):  
Shizhang Song ◽  
Bo Jiang ◽  
Sichuan Hou ◽  
Xingang Huang ◽  
Chunmei Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Endocrine Therapy ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Specific Antigen ◽  
Prostatic Adenocarcinoma ◽  
Gleason Grading ◽  
Adenocarcinoma Of The Prostate ◽  
Multiple Treatments

Abstract BackgroundSquamous cell carcinoma (SCC) of the prostate is a very rare and highly aggressive tumor, which is insensitive to multiple treatments, prone to metastasis, and has a worse prognosis than adenocarcinoma of the prostate. However, a transformation of prostatic adenocarcinoma into squamous cell carcinoma is rarer and may occur after endocrine or radiotherapy. By now, there are few cases in the world about the transformation from adenocarcinoma into squamous cell carcinoma after treatment. To our knowledge, our case is the first reported in China.Case presentationA 67-year-old man with metastatic adenocarcinoma of the prostate for 2 years, was not suitable for radical prostatectomy due to the disease classified T4N1M1. Endocrine therapy using Luteinizing Hormone-Releasing Hormone (LHRH) analog (leuprorelin) and antiandrogen agent (bicalutamide) was started, and serum prostate-specific antigen (PSA) level gradually decreased to a nadir of 0.04ng/ml. 2 years after treatment, he complained of worsening of lower urinary tract symptoms, and then he underwent transurethral resection of the prostate (TURP). Histopathological examination confirmed most of the tissue areas were accompanied by poorly differentiated keratinizing squamous cell carcinoma. Now, the patient started docetaxel treatment. He has received 2 times of systemic chemotherapy. The patient's current general condition is fair.ConclusionsProstatic adenocarcinoma transformed into squamous cell carcinoma after endocrine therapy is very rare. However, the serum PSA of this tumor is probably normal, PSA and the Gleason grading system are of limited value in the diagnosis of SCC, histopathological can help its diagnosis. The transformation is silent and we cannot know it. The question of whether prostatic adenocarcinoma or SCC of the prostate requires more definitive research to answer.

scholarly journals Adenosquamous and squamous cell carcinoma of the pancreas: two histopathological variants of ductal adenocarcinoma

2021 ◽  
Vol 67 (3) ◽  
pp. 173-176
Author(s):  
Tiberiu-Bogdan Szekely ◽  
Cornelia Toganel ◽  
Zoltan Kadar ◽  
Alexandra Daniela Sava ◽  
Tivadar Bara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Histopathological Examination ◽  
Pancreatic Head ◽  
Ductal Adenocarcinoma ◽  
Mesenchymal Transition ◽  
Carcinoma Of The Pancreas ◽  
First Case

Abstract Introduction: Primary squamous cell carcinoma (SCC) and adenosquamous carcinoma of the pancreas are rare malignancies for which diagnostic and treatment strategy are challenging. In this paper we present a literature review of these tumors based on two case reports. Case presentation: In the first case, a 55-year-old male presented with an inoperable pancreatic head/body junction tumor. Endoscopic ultrasound-guided fine needle aspiration was practiced, and histopathological examination revealed a squamous cell carcinoma of the pancreas. After exclusion of any another tumor, the diagnosis of cT4N0M0-staged primary pancreatic SCC was made. The patient is under treatment with gemcitabine and oxaliplatin. The second case is represented by a 73-year-old patient in which imagistic examinations highlighted a cystic mass of the pancreatic body. Following coporeo-caudal splenic-pancreatectomy and histopathological-proved diagnosis of adenosquamous carcinoma, the patient started chemotherapy but died at 11 months after surgery. Both tumor components displayed positivity for markers which prove ductal (cytokeratin19, maspin) and squamous differentiation (p63, cytokeratin5/6) same as vimentin, as indicator of epithelial mesenchymal transition (EMT). Conclusions: SCC and adenosquamous carcinoma of the pancreas are aggressive malignancies which prognosis remains highly reserved. These tumors might be variants of ductal adenocarcinomas which are dedifferentiated through EMT phenomenon.

scholarly journals Rare presentation of gingival squamous cell carcinoma of maxillary posterior region mimicking pyogenic granuloma in a non-smoker – A case report

2021 ◽  
Vol 6 (3) ◽  
pp. 174-178
Author(s):  
R. Reshmaa ◽  
R. Kadhiresan ◽  
U. Arunmozhi ◽  
R. Shanmugapriya
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Malignant Neoplasm ◽  
Pyogenic Granuloma ◽  
Oral Carcinoma ◽  
Rare Presentation ◽  
Gingival Squamous Cell Carcinoma

Gingival Squamous cell carcinoma (GSCC) in maxilla is a rare malignant neoplasm especially when compared with mandible. The most common sites of oral carcinoma are being the lateral border of the tongue and the floor of the mouth which is followed by palate, buccal mucosa and rarely in gingiva. The clinical picture of oral carcinoma can be misguided for gingival overgrowth, desquamative lesions, traumatic ulcers or even pyogenic granuloma. Maxillary oral gingival carcinoma is a rare entity especially in a non-smoker. In this case report, a 70-year-old male patient presented with a gingival lesion in maxilla 24,25 region mimicking pyogenic granuloma without having a tobacco history. A thorough clinical, radiographical and histopathological examination was done and led to the diagnosis of GSCC and the treatment was initiated.Creating awareness among practitioners about gingival squamous cell carcinoma mimicking pyogenic granuloma in dental practice.

scholarly journals Accuracy of cone-beam computed tomography for the evaluation of mandible invasion by oral squamous cell carcinoma

2020 ◽  
Author(s):  
Zezheng Wang ◽  
Shuang Zhang ◽  
Yumei Pu ◽  
Yuxin Wang ◽  
Zitong Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cone Beam Computed Tomography ◽  
Histopathological Examination ◽  
Preoperative Assessment ◽  
Cone Beam ◽  
Nerve Invasion

Abstract Purpose: Surgery for oral cancer with mandibular invasion requires an accurate preoperative assessment. Although cone-beam computed tomography (CBCT), which yields high spatial resolution, is used widely for mandibular examinations, evidence supporting its accuracy for the evaluation of malignant mandibular invasion is insufficient. Therefore, this study aimed to explore the accuracy of CBCT for the preoperative assessment of mandibular invasion. Methods: Thirty mandibular specimens acquired via mandibulectomy for oral squamous cell carcinoma (OSCC) treatment were collected. The excised samples were marked and subjected to CBCT imaging. Hematoxylin–eosin staining was used for histopathological assessment. Mandibular invasion was estimated based on CBCT and pathologic findings. Invasive borders were delineated via histopathological examination and CBCT and merged to compare the extent of invasion. Results: Although CBCT predicted the excised mandible invasion with 100% accuracy, it predicted nerve invasion with only 69.2% accuracy. The bone samples exhibited significant shrinkage (8.9%) due to tissue processing. This bone mass shrinkage led to a tendency of CBCT to underestimate the extent of invasion, with a mean difference of 2.97 mm. Conclusion: CBCT can reliably assess mandibular invasion, but is much less accurate for the estimation of nerve invasion. Given the potential for underestimation of the extent of mandibular invasion, CBCT would be better used to determine the extent of osteotomy.

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