Adverse Effects of Repaglinide Alone and in Combination of Vitamin E

This chapter presents information on neonatal drugs that begin with V, including use, pharmacology, adverse effects, fetal and infant implications of maternal treatment, treatment, and supply of Vancomycin, Varicella-zoster immunoglobulin and vaccine, Vasopressin, desmopressin, and terlipressin, Vigabatrin, Vitamin A (retinol), Vitamin B12 (hydroxocobalamin), Vitamin D (special formulations), Vitamin D (standard formulations), Vitamin E (alpha tocopherol), Vitamin K1 = phytomenadione (rINN), phytonadione (USAP), and Vitamins (multi-vitamins)

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The effect of reduction or removal of dietary vitamin supplement on broiler chickens performance

Proceedings of the British Society of Animal Science ◽

10.1017/s1752756200010784 ◽

2005 ◽

Vol 2005 ◽

pp. 167-167

Author(s):

H. A. Yousefzadeh ◽

I. Yousefian ◽

B. Navidshad ◽

M. Safari

Keyword(s):

Vitamin E ◽

Adverse Effects ◽

Broiler Chickens ◽

Feed Additives ◽

Dietary Vitamin ◽

Vitamin Supplement ◽

Feed Ingredients ◽

Naturally Occurring ◽

Performance Reduction ◽

Reasonable Proportion

While vitamins naturally occurring in plant and animal based feed ingredients can supply a reasonable proportion of the birds daily needs, their contribution is rarely considered during formulation. This situation arises due to variability, especially in cereals and vegetable proteins, for example, the vitamin E content of corn can vary from 10 to 40 IU/kg. Because of this uncertainty in the natural supply of vitamins within a feed, the bird’s vitamin supply is therefore met by the addition of synthetic vitamins, usually in the form of a so called premix, that contains all vitamins and perhaps some other micronutrients and feed additives. This premixes use according to producer suggestions and in some cases their doses can be higher than real requirements. Skinner et al (1992) removed vitamin premixes from 21 day of age and did not report any adverse effects. Gwyther et al (1992) showed sever performance reduction by vitamin premix withdrawal from 21 to 49 day of age. This experiment was conducted to determine the effects of Vitamin supplement levels on broiler chickens from 28 to 49 days of age.

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Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats

British Journal Of Nutrition ◽

10.1017/s000711450819122x ◽

2009 ◽

Vol 102 (3) ◽

pp. 398-406 ◽

Cited By ~ 14

Author(s):

Sonja Gaedicke ◽

Xiangnan Zhang ◽

Patricia Huebbe ◽

Christine Boesch-Saadatmandi ◽

Yijia Lou ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Vitamin E ◽

Adverse Effects ◽

Redox Status ◽

Male Rats ◽

Dietary Vitamin ◽

Beneficial Effects ◽

Positive Effects ◽

Total Superoxide Dismutase

Oxidative stress is one of the major pathological features of Alzheimer's disease (AD). Here, we investigated whether dietary vitamin E (VE) depletion may induce adverse effects and supplementation with α-tocopherol (αT) may result in beneficial effects on redox status and the regulation of genes relevant in the pathogenesis of AD in healthy rats. Three groups of eight male rats each were fed diets with deficient ( < 1 mg αT equivalents/kg diet), marginal (9 mg αT equivalents/kg diet) or sufficient (18 mg αT equivalents/kg diet) concentrations of natural-source VE for 6 months; a fourth group was fed the VE-sufficient diet fortified with αT (total VE, 146 mg αT equivalents/kg diet). Feeding of the experimental diets dose dependently altered αT concentrations in the cortex and plasma. No significant changes in F2-isoprostane concentrations, activities of antioxidative enzymes (total superoxide dismutase, Se-dependent glutathione peroxidase) and concentrations of glutathione or the expression of AD-relevant genes were observed. In this non-AD model, depletion of VE did not induce adverse effects and supplementation of αT did not induce positive effects on the parameters related to the progression of AD.

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Adverse effects of vitamin E by induction of drug metabolism

Genes & Nutrition ◽

10.1007/s12263-007-0055-0 ◽

2007 ◽

Vol 2 (3) ◽

pp. 249-256 ◽

Cited By ~ 41

Author(s):

Regina Brigelius-Flohé

Keyword(s):

Vitamin E ◽

Adverse Effects ◽

Drug Metabolism

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Antioxidant modulation of nevirapine induced hepatotoxicity in rats

Interdisciplinary Toxicology ◽

10.1515/intox-2015-0002 ◽

2015 ◽

Vol 8 (1) ◽

pp. 8-14

Author(s):

Olufunsho Awodele ◽

Temidayo Popoola ◽

Kunle Rotimi ◽

Victor Ikumawoyi ◽

Wahab Okunowo

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Adverse Effects ◽

Vitamin C ◽

Histopathological Examination ◽

Protective Effects ◽

Blood Cell Count ◽

Blood Samples ◽

Cervical Dislocation ◽

Related Mortality

AbstractHIV/AIDS related mortality has been dramatically reduced by the advent of antiretroviral therapy (ART). However, ART presents with associated adverse effects. One of such adverse effects is hepatotoxicity observed with nevirapine (NVP) containing ART. Since previous studies showed that NVP hepatotoxicity may be due to oxidative stress via generation of oxidative radicals, this study sought to evaluate the protective effects of antioxidants in alleviating NVP induced hepatotoxicity. Rats were divided into 6 groups with 8 animals per group and received doses of the antioxidants jobelyn (10.7 mg/kg/day), vitamin C (8 mg/kg/day), vitamin E (5 mg/kg/day) and/or NVP (6 mg/kg/day) for 60 days. The animals were sacrificed on day 61 by cervical dislocation, blood samples were collected for biochemical and hematological examination. The liver of the sacrificed animals was weighed and subjected to histopathological examination. There was a statistically significant (p<0.05) elevation in MDA level observed in the NVP group as compared with control. The results further showed non-significant decreases in the levels of MDA in the NVP plus antioxidant groups, except vitamin C, when compared with the NVP alone group. Vitamin E and Vitamin E plus C treated groups showed significantly (p<0.05) higher levels of SOD, CAT and GSH. The results also showed statistically significantly (p<0.05) lower levels of ALT and AST in the antioxidant treated groups There was an observed significantly (p<0.05) higher level of TP and urea in the antioxidant treated rats. A significantly (p<0.05) higher white blood cell count was observed in the antioxidant groups. Histopathological assessment of the liver extracted from the rats showed no visible pathology across the groups. Observations from this study suggest a potentially positive modulatory effect of antioxidants and may be indicative for the inclusion of antioxidants in nevirapine containing ART.

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Adverse Effects of Cypermethrin on the Chick (Galus domesticus) Development are Reversed by Co-Treatment with Vitamin E and Olive Oil

Pakistan Veterinary Journal ◽

10.29261/pakvetj/2018.009 ◽

2018 ◽

Vol 38 (01) ◽

pp. 46-50 ◽

Cited By ~ 1

Author(s):

Khawaja Raees

Keyword(s):

Vitamin E ◽

Adverse Effects ◽

Olive Oil

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On the Performance of Trimetazidine and Vitamin E as Pharmacoprotection Agents in Cyclosporin A-Induced Toxicity

ISRN Pharmacology ◽

10.1155/2013/605640 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

De la Cruz Rodríguez Lilia Cristina ◽

Rey María del Rosario ◽

Araujo Carmen Rosa ◽

Oldano Ana Veronica

Keyword(s):

Vitamin E ◽

Adverse Effects ◽

Cyclosporin A ◽

Control Group ◽

Ultrastructural Studies ◽

Transplant Patients ◽

Male Wistar Rats ◽

Liver And Kidney ◽

Group A ◽

B Vitamin

The immunosuppressant drug cyclosporin A (CyA) has been used in diseases with immunological basis and in transplant patients. Nephrotoxicity and hepatotoxicity are the main adverse effects of this drug. To find a protective drug against those effects we assayed the cardioprotector Trimetazidine (TMZ) and vitamin E, used as nutritional supplements to alleviate oxidative stress. Six groups of eight male Wistar rats each were prepared (groups A–F): A, control; B, vitamin E (10 mg/Kg/day); C, TMZ (20 mg/Kg/day); D, 25 mg/Kg/day CyA; E, CyA and vitamin E (25 mg/Kg/day CyA + 10 mg/Kg/day Vit E); F, TMZ for 20 days (20 mg/kg/day); and then CyA (25 mg/kg/day) and TMZ (20 mg/Kg/day). The experiment lasted 120 days. The exposure of rats to CyA promoted nephrotoxicity and hepatotoxicity with an increase in serum urea, creatinine, and glutamate dehydrogenase (GLDH). Structural and ultrastructural studies of liver and kidney were performed. Group D showed adverse effects induced by CyA since statistically significant differences were found with respect to the control group (A). Vitamin E (E) showed no protective effect. Pretreatment with TMZ (F) attenuated the adverse effects of CyA. We conclude that CyA-induced nephrotoxicity and hepatotoxicity are attenuated by the cytoprotective effect of TMZ. TMZ inhibits the reabsorption and, consequently, the accumulation of CyA in the cell. The antioxidant capacity of vitamin E did not improve the effect of CyA.

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