Prevalence of Renal Hypertension In Apparently Healthy Term Newborns.

Objective. To document the occurrence of classical kernicterus in full-term, otherwise healthy, breast-fed infants. Methods. We reviewed the files of 22 cases referred to us by attorneys throughout the United States during a period of 18 years, in which neonatal hyperbilirubinemia was alleged to be responsible for brain damage in apparently healthy, nonimmunized, full-term infants. To qualify for inclusion, these infants had to be born at 37 or more weeks' gestation, manifest the classic signs of acute bilirubin encephalopathy, and have the typical neurologic sequelae. Results. Six infants, born between 1979 and 1991, met the criteria for inclusion. Their peak recorded bilirubin levels occurred 4 to 10 days after birth and ranged from 39.0 to 49.7 mg/dL. All had one or more exchange transfusions. One infant had an elevated reticulocyte count (9%) but no other evidence of hemolysis. The other infants had no evidence of hemolysis, and no cause was found for the hyperbilirubinemia (other than breast-feeding). Conclusions. Although very rare, classic kernicterus can occur in apparently healthy, full-term, breast-fed newborns who do not have hemolytic disease or any other discernible cause for their jaundice. Such extreme elevations of bilirubin are rare, and we do not know how often infants with similar serum bilirubin levels escape harm. We also have no reliable method for identifying these infants early in the neonatal period. Closer follow-up after birth and discharge from the hospital might have prevented some of these outcomes, but rare, sporadic cases of kernicterus might not be preventable unless we adopt an approach to follow-up and surveillance of the newborn that is significantly more rigorous than has been practiced. The feasibility, risks, costs, and benefits of this type of intervention need to be determined.

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Comparison of Computer Tomography and Magnetic Resonance Imaging Scans on the Third Day of Life in Term Newborns With Neonatal Encephalopathy

Yearbook of Neonatal and Perinatal Medicine ◽

10.1016/s8756-5005(09)79114-0 ◽

2009 ◽

Vol 2009 ◽

pp. 120-121

Author(s):

W.E. Benitz

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Computer Tomography ◽

Resonance Imaging ◽

Neonatal Encephalopathy ◽

The Third ◽

Term Newborns

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Prevalence of Factor V Leiden Mutation in Non-European Populations

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655963 ◽

1997 ◽

Vol 77 (02) ◽

pp. 329-331 ◽

Cited By ~ 55

Author(s):

Guglielmina Pepe ◽

Olga Rickards ◽

Olga Camacho Vanegas ◽

Tamara Brunelli ◽

Anna Maria Gori ◽

...

Keyword(s):

Factor V Leiden ◽

Indirect Evidence ◽

Factor V ◽

Factor V Leiden Mutation ◽

The World ◽

Fv Leiden ◽

Sub Saharan ◽

Low Prevalence ◽

European Populations ◽

Apparently Healthy

SummaryA difference in the prevalence of venous thromboembolism (TE) in major human groups has been described and an uneven distribution of FV Leiden mutation over the world has recently been reported.We investigated FV Leiden mutation in 584 apparently healthy sub#jects mostly from populations different from those previously investi#gated: 170 Europeans (Spanish, Italians), 101 sub-saharan Africans (Fon, Bariba, Berba, Dendi), 115 Asians (Indonesians, Chinese, Tharus), 57 Amerindians (Cayapa), 84 Afroamericans (Rio Cayapa, Viche), and 57 Ethiopians (Amhara, Oromo).The mutation was detected in only 1/115 Asian (Tharu) and in 5/170 Europeans (4 Italians, 1 Spanish).These data confirm that in non-Europeans the prevalence of FV mutation is at least 7 times lower than in Europeans and provide indirect evidence of a low prevalence not only of the FV Leiden gene but also of other genes leading to more severe thrombophilia. Finally, findings from the literature together with those pertaining to this study clearly show a marked heterogeneity among Europeans.

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EPIDEMIOLOGY, ECOLOGY AND PREVALENCE OF SOIL TRANSMITTED HELMINTHS FROM KOSHI REGION OF NORTH BIHAR.

FLORA AND FAUNA ◽

10.33451/florafauna.v24i1pp155-162 ◽

2018 ◽

Vol 24 (1) ◽

Author(s):

LAKSHMI CHOUDHARY ◽

PRABHAWATI PRABHAWATI

Keyword(s):

Relative Humidity ◽

Ascaris Lumbricoides ◽

Rainy Season ◽

Climatic Factors ◽

Trichuris Trichiura ◽

Hookworm Infection ◽

Soil Transmitted Helminths ◽

High Incidence ◽

Apparently Healthy

Prevalence of soil transmitted helminthes infections in apparently healthy school going children and other 528 people of different districts of Koshi regions of North Bihar were evaluated. Over all incidences of STHs infection was 39.39% during study. High incidence of STH was seen in the rainy season i.e., in the month of July and August, September, significantly higher (P<0.05) .The incidence of Ascaris lumbricoides was highest in the month of August (18.64%). The month of September was 15.25% followed by that of July (14.4%) and October with 10.16%. Also the incidence of hookworm registered the highest incidence in the month of June (19.27%) and lowest in the month of December (4.82%) during the study period. However prevalence of Trichuris trichiura was negligible and it was almost nil in the most of the months but was highest in month of September with 28.57% and lowest in October with 14.00% The climatic factors are responsible for soil transmitted helminthes which are temperature, rainfall and relative humidity. Ascariasis, Trichuriasis and Ancyclostomiasis (Hookworm infection) are found to be endemic in this region.

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Age development of cortical rhythmics in the EEG depending on the formation of the child’s personal psychical characteristics

Medical alphabet ◽

10.33667/2078-5631-2019-1-8(383)-42-48 ◽

2019 ◽

Vol 1 (8) ◽

pp. 42-50

Author(s):

A. V. Budkevich ◽

L. B. Ivanov ◽

G. R. Novikova ◽

G. M. Dzhanumova

Keyword(s):

Alpha Rhythm ◽

Age Groups ◽

Healthy Children ◽

Brain Organization ◽

Age Related ◽

Mathematical Processing ◽

Functional Brain Organization ◽

Child's Brain ◽

Attention Function ◽

Apparently Healthy

According to the authors, rationing the age-related EEG parameters in children should be based on personal psychical characteristics. A comparative analysis of personal psychical characteristics and electroencephalographic data was carried out in 300 apparently healthy children aged 3-15 years. According to this principle, two subgroups of conditionally healthy children in each age group were singled out: 1) with an immature attention function and 2) with an increased anxious background that do not reach the pathological level. Registration and analysis of EEG was performed by the Neurokariograf computer complex (MBN, Moscow) using mathematical processing methods.The EEG interpretation was based on the principle of assessing the functional state of a child's brain using a three-component model according to: 1) wakefulness level and its dissociation, 2) severity of signs of the EEG neurotic pattern, 3) directionality of formation of traits of the system-functional brain organization (severity of signs functional hypofrontality).lt was found the presence of EEG signs was indicative of a lower level of wakefulness in children with an immature function of attention in all age groups, compared with the indicators of the average population of group and children with an increased background of anxiety. Children with an increased background of anxiety have a tendency to prevalence and excessive spatial synchronization of the alpha rhythm. ln healthy children, the fact of a decrease in wakefulness and the presence of signs of anxiety in the clinic and in EEG patterns indicates individual personalities and should not be considered as pathology.

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ROLE OF THE THYROID GLAND IN DEVELOPMENT AND MAINTENANCE OF RENAL HYPERTENSION IN RATS

Acta Endocrinologica ◽

10.1530/acta.0.xxxiv0411 ◽

1960 ◽

Vol XXXIV (III) ◽

pp. 411-429 ◽

Cited By ~ 3

Author(s):

Melvin J. Fregly ◽

Kenneth M. Cook

Keyword(s):

Blood Pressure ◽

Rate Increase ◽

Renal Hypertension ◽

The Other ◽

Elevated Blood Pressure ◽

Unit Weight ◽

Elevated Blood ◽

Inhibition Of Growth ◽

Testicular Size

ABSTRACT The anti-thyroid drugs, thiouracil, propylthiouracil, and methimazole, prevented both development of elevated blood pressure and cardiac hypertrophy usually accompanying kidney encapsulation with latex envelopes. These drugs also reduced elevated blood pressure of rats with hypertension of 13 to 40 weeks' duration prior to drug administration. Addition of desiccated thyroid powder to diet containing an anti-thyroid drug overcame the anti-hypertensive effect of the latter. Withdrawal of thyroid powder only was followed by return of blood pressure to previous low level within 3 weeks. The results suggest that the anti-hypertensive effect of these drugs is related directly to the hypothyroidism produced rather than to extrathyroidal effects of the drugs. Comparison of potencies of the 3 drugs in terms of anti-hypertensive effect, inhibition of growth rate, increase in testicular size, and increase in thyroid size suggests that propylthiouracil and methimazole are equally potent per unit weight of drug. Thiouracil has approximately half the potency of the other two.

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