Ameliorative effect of aqueous extract of rosemary on cadmium-induced kidney injury in albino rats

2015 ◽  
Vol 1 (1) ◽  
pp. 10-19 ◽  
Author(s):  
A. El-Morsy ◽  
S. Sakr ◽  
M. Bayomy
Keyword(s):  
Aqueous Extract ◽  
Kidney Injury ◽  
Albino Rats ◽  
Ameliorative Effect

scholarly journals AMELIORATIVE EFFECT OF CAROB AQUEOUS EXTRACT ON WATER PIPE SMOKE INDUCED-TOXICITY IN ADULT MALE ALBINO RATS

2016 ◽  
Vol 9 (1) ◽  
pp. 246
Author(s):  
Mona Abdel Rahman ◽  
Fatma Elzahraa H. Salem ◽  
Amira A. Bauomy ◽  
Mona Ahmed Khalifa
Keyword(s):  
Aqueous Extract ◽  
Post Treatment ◽  
Tissue Homogenate ◽  
Albino Rats ◽  
Water Pipe ◽  
Treatment Groups ◽  
Ameliorative Effect ◽  
Liver And Kidney ◽  
Lung Tissue Homogenate ◽  
Kidney Functions

<p><strong>Objective: </strong>The aim of the present study was to investigate the daily effect of pre and post treatment of carob aqueous extract (600 mg/kg b. wt.); on rats exposed to were exposed to water pipe smoke (10 mg/kg; 15 minutes) for 2, 4, 6 and 8 w.</p><p><strong>Methods: </strong>Rats were divided into 6 groups; 1<sup>st</sup> group was served as a control. Rats of the 2<sup>nd</sup> group were administered amiodarone (an antiarrhythmic medication used as a model for lung toxicity) at a dose level of 30 mg/kg. The rats of 3<sup>rd</sup> and 4<sup>th</sup> groups were exposed to water pipe smoke and treated with carob extract respectively. However, the two remaining groups (5<sup>th</sup> and 6<sup>th</sup>) were the pre-and post-treatment groups with carob extract respectively.</p><p><strong>Results: </strong>Amiodarone and water pipe smoke induced a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP); on the contrary, induced a significant decrease in serum total protein and albumin. In addition; serum creatinine and urea showed a significant increase; as well as; amiodarone and water pipe smoke increased the oxidative stress (malondialdehyde/glutathione; MDA/GSH) in lung tissue homogenate. While; carob extract gavage showed protective and curative effects in liver and kidney functions; in addition; it decreased MDA level and increased GSH level significantly.</p><p><strong>Conclusion: </strong>Finally, we can conclude that the carob aqueous extract treatment revealed ameliorative effects on rats were exposed to water pipe smoke.</p>

scholarly journals In vivo protective effect of cinnamon aqueous extract in carbon tetrachloride-treated male albino rats

2021 ◽  
Vol 43 ◽  
pp. e52826
Author(s):  
Othman Baothman ◽  
Bhaa Nagaty ◽  
Mazin Zamzami ◽  
Hasan Al-Talhi
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Liver Damage ◽  
Liver Toxicity ◽  
Histopathological Examination ◽  
Intraperitoneal Administration ◽  
Albino Rats ◽  
Ameliorative Effect ◽  
Serum Biochemical

The liver as an organ is important for the metabolism of drugs and toxins. However, it is not immune from environmental insults. Exposure of liver cells to carbon tetrachloride (CCl4) results in the generation of tricholoromethyl radicals, which induce liver toxicity. This study aims at investigating the ameliorative effect of the cinnamon aqueous extract (CAE) against CCl4-induced hepatotoxicity in male albino rats. Hepatotoxicity was induced in rats through the intraperitoneal administration of 0.5 mL kg-1 body weight of CCl4. The analyses of the results obtained showed significant reduction in the levels of serum biochemical markers for 400 and 600 mg kg-1 bw of CAE protected rats as compared with CCl4 group. In addition, CAE administration reversed liver tissue damaged via increased antioxidants markers. Histopathological examination of CAE treatment on rats showed improved changes to the liver damage caused by CCl4 with no evidence of steatosis and inflammation. This result hence suggests that CAE has marked hepatoprotective and healing activities against CCl4-induced liver damage and could serve as a suitable candidate in drug discovery for the treatment of liver toxicity.

scholarly journals Ameliorative Effect of Citrullus lanatus (Water Melon) Seeds on Alloxan Induced Hepato and Nephro Toxicity

2020 ◽  
pp. 1-10
Author(s):  
H. E. Ogbeifun ◽  
D. E. Peters ◽  
M. O. Monanu
Keyword(s):  
Aqueous Extract ◽  
Histopathological Examination ◽  
Citrullus Lanatus ◽  
Kidney Injury ◽  
Diabetic Rats ◽  
Therapeutic Benefits ◽  
Ameliorative Effect ◽  
Biochemical Analyses ◽  
Melon Seeds ◽  
Water Melon

Some data suggested that the seeds of water melon may have therapeutic benefits. We here attempted to determine ameliorative effects of aqueous extract of Citrullus lanatus (water melon) seeds on alloxan-induced hepato- and nephrotoxicity on wistar rats. Rats were divided into 11 groups, with each group consisting of 3 rats. Groups 2-11 received single dose of 120 mg/kg b.wt. of alloxan monohydrate intraperitoneally. Groups 4 and 5 orally received a dose of 100 mg/kg b.w. of metformin for 7 & 21 days. Groups 6, 8 and 10 orally received 200 mg/kg b.w., 400 mg/kg b.w., and 600 mg/kg b.w. of the extract respectively for 7 days while groups 7, 9 and 11 orally received same doses respectively for 21 days. The most abundant phytochemicals present in the seeds sample were flavonoids mainly catechin (70.88 ± 0.21) and anthocyanin (42.11 ± 0.89). Blood samples were collected 24 hours after 7 and 21 days of treatment. Biochemical analyses were conducted on liver-injury, kidney-injury, and oxidative-stress markers. Liver/kidney histopathology were examined. Result revealed significant (p≤0.05) reduction in liver enzyme activities, creatinine and urea and malondialdehyde levels, while the electrolyte concentrations significantly increased in the extract treated groups on day 7 and 21 when measured against group 1. The histopathological examination revealed regeneration of the liver/kidney tissues in the extract treated groups mostly in 10 and 11. Thus, aqueous extract of water melon seeds ameliorated alloxan induced hepato-/nephron-toxicity in diabetic rats.

scholarly journals Ameliorative efficacy of Sepia officinalis ink extract on hepatorenal injury-induced following high-dose folic acid supplementation in rats

2021 ◽  
Vol 17 (3) ◽  
pp. 038-046
Author(s):  
Mariam T Elrouby ◽  
Sara B Ali ◽  
Nagat Saleh Hossuin Moftha ◽  
Abdeljalil Mohamed Al Shawoush ◽  
Ayman S. Mohamed
Keyword(s):  
Kidney Injury ◽  
Folic Acid Supplementation ◽  
Total Serum ◽  
Albino Rats ◽  
High Dose ◽  
Sepia Officinalis ◽  
High Intake ◽  
Stress Markers ◽  
Ameliorative Effect ◽  
Serum Aminotransferases

Sepia ink, a black suspension of melanin granules, is a multifunctional marine bioactive material. The present study aims to evaluate the ameliorative effect of the ink extract (IE) of the cuttlefish (Sepia officinalis) during high dosage administration of the FA in rats. Kidney injury induced by a single oral dose of FA (250 mg /kg). Eighteen male Wistar albino rats were the control, FA group, and FA+ IE group (250mg/kg). The IE showed a significant ameliorative effect against hepatorenal injury induced by high intake of FA as evident by decreasing the levels of serum aminotransferases (AST and ALT), urea, creatinine, uric acid, and significantly increased total serum albumin. Treatment with IE normalized the antioxidant status of the injured animals by reducing the MDA and the significant increase in the levels of GSH and CAT. The present study revealed that IE had an insightful effect against hepatorenal injury-induced following high intake of FA in rats, as it alleviates the alterations in the oxidative stress markers.

scholarly journals Evaluation of nephroprotective activity of Tinospora cordifolia against gentamicin induced nephrotoxicity in albino rats: an experimental study

2019 ◽  
Vol 8 (6) ◽  
pp. 1179
Author(s):  
Monica Sharma ◽  
Jyoti Pundir ◽  
Pinki Vishwakarma ◽  
Raj Kumar Goel ◽  
Manish Saini ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Aqueous Extract ◽  
Normal Saline ◽  
Total Duration ◽  
Kidney Injury ◽  
Tinospora Cordifolia ◽  
Albino Rats ◽  
Dependent Manner ◽  
Group Iii ◽  
Group I

Background: Gentamicin induced nephrotoxicity is a major contributor to Acute Kidney Injury (AKI) resulting from free radicals induced oxidative stress. Tinospora cordifolia is an Indian medicinal plant, widely used because of its antioxidant activity. Due to limited scientific literature exploring its nephroprotective potential, the present study was designed to investigate the nephroprotective effect of aqueous extract of Tinospora cordifolia against gentamicin induced nephrotoxicity in albino rats.Methods: The study was commenced following approval from Institutional Animal Ethical Committee of L.L.R.M. Medical College, Meerut (UP). Twenty four rats were randomised into four groups of six animals each. Total duration of study was 21 days. Group I received normal saline p.o., group II received normal saline along with gentamicin on last 5 days, group III and IV received Tinospora cordifolia in graded doses p.o. along with gentamicin on last 5 days. Injection gentamicin (40mg/kg) i.p. was given once daily for last 5 days to induce nephrotoxicity in rats of groups II, III and IV. The rats were sacrificed under anaesthesia, blood samples analysed for blood urea nitrogen (BUN) and serum creatinine levels and histopathological changes were studied. Statistical analysis was done using ANOVA followed by post hoc test.Results: Tinospora cordifolia pre-treated groups exhibited significant (p<0.001) limitation in rise in levels of BUN and serum creatinine in a dose dependent manner. Histolopathological observations further corroborated the biochemical findings.Conclusions: The present study concluded that aqueous extract of Tinospora cordifolia possesses nephroprotective potential against gentamicin induced nephrotoxicity.

scholarly journals AMELIORATIVE EFFECT OF CYPERUS SQUARROSUS (CYPERACEAE) PLANT EXTRACTS ON DIABETIC CARDIOMYOPATHY AGAINST STREPTOZOTOCININDUCED DIABETES IN WISTAR RATS

2020 ◽  
pp. 160-165
Author(s):  
RAGHAVENDRA HG ◽  
RAVI PRAKASH P ◽  
DEVANNA N
Keyword(s):  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Cardiovascular Complications ◽  
Serum Glucose ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Standard Drug ◽  
Ameliorative Effect

Objective: Cyperus squarrosus, belongs to the family Cyperaceae, has been claimed to possess antidiabetic activity in the ethnomedicinal literature in India. Therefore, the present study was to investigate the effects of aqueous and ethanolic extracts of C. squarrosus (EECS) on diabetes and its cardiovascular complications with streptozotocin-induced diabetes in rats. Methods: Wister albino rats of either sex were made diabetic with streptozotocin (65 mg/kg, i.v.). Glibenclamide (5 mg/kg) was taken as standard drug. Treatment of aqueous and EECS (aqueous extract of C. squarrosus and EECS) was given in the dose of 200 and 400 mg/kg/day, p.o for 8 weeks and biochemical (serum glucose, cholesterol, triglycerides, and high-density lipoprotein [HDL]) parameters were recorded. Results: Streptozotocin-treated group produced significant increased levels of serum glucose, cholesterol, triglycerides, HDL, creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) levels and all these changes were prevented by the treatment with aqueous and EECS in both doses. Conclusion: As compare with ethanolic extract treated group, aqueous extract treated group exhibits significant (p<0.001) effect on CK-MB and LDH levels. Our result suggests that aqueous and EECS prevents the streptozotocin-induced metabolic abnormalities as well as cardiovascular complications.

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