scholarly journals AMELIORATIVE EFFECT OF CAROB AQUEOUS EXTRACT ON WATER PIPE SMOKE INDUCED-TOXICITY IN ADULT MALE ALBINO RATS

2016 ◽  
Vol 9 (1) ◽  
pp. 246
Author(s):  
Mona Abdel Rahman ◽  
Fatma Elzahraa H. Salem ◽  
Amira A. Bauomy ◽  
Mona Ahmed Khalifa
Keyword(s):  
Aqueous Extract ◽  
Post Treatment ◽  
Tissue Homogenate ◽  
Albino Rats ◽  
Water Pipe ◽  
Treatment Groups ◽  
Ameliorative Effect ◽  
Liver And Kidney ◽  
Lung Tissue Homogenate ◽  
Kidney Functions

<p><strong>Objective: </strong>The aim of the present study was to investigate the daily effect of pre and post treatment of carob aqueous extract (600 mg/kg b. wt.); on rats exposed to were exposed to water pipe smoke (10 mg/kg; 15 minutes) for 2, 4, 6 and 8 w.</p><p><strong>Methods: </strong>Rats were divided into 6 groups; 1<sup>st</sup> group was served as a control. Rats of the 2<sup>nd</sup> group were administered amiodarone (an antiarrhythmic medication used as a model for lung toxicity) at a dose level of 30 mg/kg. The rats of 3<sup>rd</sup> and 4<sup>th</sup> groups were exposed to water pipe smoke and treated with carob extract respectively. However, the two remaining groups (5<sup>th</sup> and 6<sup>th</sup>) were the pre-and post-treatment groups with carob extract respectively.</p><p><strong>Results: </strong>Amiodarone and water pipe smoke induced a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP); on the contrary, induced a significant decrease in serum total protein and albumin. In addition; serum creatinine and urea showed a significant increase; as well as; amiodarone and water pipe smoke increased the oxidative stress (malondialdehyde/glutathione; MDA/GSH) in lung tissue homogenate. While; carob extract gavage showed protective and curative effects in liver and kidney functions; in addition; it decreased MDA level and increased GSH level significantly.</p><p><strong>Conclusion: </strong>Finally, we can conclude that the carob aqueous extract treatment revealed ameliorative effects on rats were exposed to water pipe smoke.</p>

scholarly journals HEPATOPROTECTIVE AND NEPHROPROTECTIVE EFFECTS OF THE AQUEOUS EXTRACT OF TURMERIC (CURCUMA LONGA) IN RIFAMPICIN AND ISONIAZID-INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN RATS

2019 ◽  
pp. 293-298
Author(s):  
MAHDI M THUAWAINI ◽  
MAWAHIB B GASIM AL-FARHAAN ◽  
KARIMA F ABBAS
Keyword(s):  
Aqueous Extract ◽  
Total Bilirubin ◽  
Curcuma Longa ◽  
Albino Rats ◽  
Histopathological Study ◽  
Protective Effects ◽  
Significant Elevation ◽  
Liver And Kidney ◽  
Histopathological Studies ◽  
Kidney Functions

Objectives: The present study was designed to estimate the influences of oral administration of aqueous extract of turmeric (Curcuma longa) in hepatotoxicity and nephrotoxicity induced in rats by isoniazid and rifampicin (RIF) for 4 weeks. Influences were determined through the estimation of liver and kidney functions and histopathological changes. Materials and Methods: A total of 48 male albino rats were randomly divided into six groups: Normal control, INH+RIF treated rats, Turmeric aqueous extract 100 mg/kg treated rats, Turmeric aqueous extract 100 mg/kg + INH and RIF treated rats, Turmeric aqueous extract 200 mg/kg treated rats, Turmeric aqueous extract 200 mg/kg+ INH and RIF treated rats. Turmeric aqueous extract and INH + RIF (50 mg/kg bwpo, daily) were given for 4 weeks. Liver and kidney function markers (aspartate transaminase [AST], alanine transaminase [ALT], alanine phosphatase [ALP], bilirubin, blood urea, and creatinine) were determined enzymatically. In addition, tissues of liver and kidney were quickly separated and fixed in 10% formalin and subjected to histopathological studies. Statistical analysis was carried out using t-test. Results: The aqueous extract of turmeric (at a dose of 100 and 200 mg/kg bw, p.o. daily ) showed hepato- and reno-protective effects in hepato- and reno- toxicity induced by RIF and INH in rats. Significant elevation of serum ALT, AST, ALP, total bilirubin, creatinine, urea, and total protein, due to RIF and INH treatment, were significantly decreased. The histopathological study further confirmed the biochemical results. Conclusion: Results of the present study indicated that turmeric has hepatoprotective and renoprotective action against RIF- and INH-induced hepatic and renal injury in rats.

scholarly journals Bougainvillea spectabilisExhibits Antihyperglycemic and Antioxidant Activities in Experimental Diabetes

2015 ◽  
Vol 21 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Pratibha Chauhan ◽  
Sunil Mahajan ◽  
Archana Kulshrestha ◽  
Sadhana Shrivastava ◽  
Bechan Sharma ◽  
...  
Keyword(s):  
Dna Damage ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Glycosylated Hemoglobin ◽  
Histological Changes ◽  
Liver And Kidney ◽  
Bougainvillea Spectabilis ◽  
Streptozotocin Induced Diabetes ◽  
Kidney Functions

The study investigates the effects of aqueous extract of Bougainvillea spectabilis leaves on blood glucose, glycosylated hemoglobin, lipid profile, oxidative stress, and on DNA damage, if any, as well as on liver and kidney functions in streptozotocin-induced diabetes in Wistar rats. Daily administration of the aqueous extract of B spectabilis leaves for 28 days resulted in significant reduction in hyperglycemia and hyperlipidemia as evident from restoration of relevant biochemical markers following extract administration. The extract also exhibited significant antioxidant activity as evidenced from the enzymatic and nonenzymatic responses and DNA damage markers. The extract restored kidney and liver functions to normal and proved to be nontoxic. A marked improvement in the histological changes of tissues was also observed. The present study documented antihyperglycemic, antihyperlipidemic, and antioxidative potentials of the aqueous extract of B spectabilis leaves without any toxicity in streptozotocin-treated Wistar rats.

scholarly journals In vitro Antioxidant and In vivo Hepatocurative and Nephrocurative Activities of Aqueous Leaf Extract of Newbouldia laevis in Albino Rats

2021 ◽  
pp. 114-125
Author(s):  
Mohammed A. Sulaiman ◽  
Mahmoud S. Jada ◽  
Augustine Elizabeth ◽  
Abubakar Umar Modibbo
Keyword(s):  
Oral Administration ◽  
Leaf Extract ◽  
Kidney Diseases ◽  
Albino Rats ◽  
Protein Levels ◽  
Ameliorative Effect ◽  
Liver And Kidney ◽  
Aqueous Leaf Extract

The in vitro antioxidant activity and in vivo hepatocurative and nephrocurative potential of Newbouldia laevis aqueous leaf extract (NLALE) was evaluated. The study used 30 male, albino rats (Rattus norvegicus) weighing 180 ± 20 g, of which 25 were intoxicated by oral administration of a single dose of diclofenac (100 mg/kg b. wt.). Animals were treated by oral administration of silymarin (200 mg/kg b. wt.), furosemide (1.5 mg/kg b. wt.) and NLALE (200 mg/kg and 400 mg/kg b. wt.) for seven consecutive days before animals were sacrificed on the 8th day and serum/plasma was analyzed for biochemical markers of hepatotoxicity and nephrotoxicity. Phytochemical screening of NLALE revealed the presence of alkaloids, flavonoids, glycosides, phenols, saponins, steroids and tannins. The extract scavenged DPPH radical, reduced Fe3+ and inhibited TBARs in comparable manner to ascorbic acid in vitro. NLALE also attenuated diclofenac-induced liver and kidney intoxication as indicated by the significantly (p<0.05) reduced levels of serum biomarkers of hepatotoxicity: ALT, AST, bilirubin, but increased total protein levels and nephrotoxicity: urea, creatinine, Na+ and K+. The observed effects are dose dependent as the 400 mg/kg b. wt. appeared to be more potent than the 200 mg/kg b. wt. dose. It may be concluded from this study that Newbouldia laevis leaf has ameliorative effect against diclofenac-induced hepatotoxicity and nephrotoxicity probably through antioxidative mechanism and the curative claim and the folkloric use of the plant in the treatment of liver and kidney diseases have been scientifically validated

scholarly journals EFFECT OF METHOMYL AND IMIDACLOPRID ON LIVER AND KIDNEY FUNCTIONS IN MALE ALBINO RATS

2007 ◽  
Vol 32 (6) ◽  
pp. 5009-5018
Author(s):  
M .H. Salem ◽  
M. Saad ◽  
Olfat Radwan ◽  
Naglaa Younes
Keyword(s):  
Albino Rats ◽  
Liver And Kidney ◽  
Kidney Functions
Sign in / Sign up

Export Citation Format

Share Document