scholarly journals Radiological and chemical risk assessment from uranium concentrations in groundwater samples collected from Al-Kufa area, Iraq

2020 ◽  
Vol 20 (8) ◽  
pp. 3194-3206
Author(s):  
Ali Abid Abojassim ◽  
Hayder Hussan Neama
Keyword(s):  
Annual Effective Dose ◽  
Hazard Quotient ◽  
Uranium Isotopes ◽  
Average Daily Dose ◽  
Average Value ◽  
Chemical Risk Assessment ◽  
Excess Cancer Risk ◽  
Groundwater Samples ◽  
Toxicity Risk ◽  
Daily Dose

Abstract In nature, uranium is composed of three isotopes, 238U, 235U, and 234U. Emitting alpha particles leads to radionuclides decay. The aim of this work is to set up a database for uranium concentrations in groundwater samples collected from Kufa city, Al-Najaf governorate, Iraq. Twenty four samples have been examined for detecting the presence of uranium levels using a CR-39 detector. The measured uranium concentrations were used to determine uranium isotopes with their ingested radiological toxicity risk (annual effective dose of uranium isotopes and excess cancer risk) and chemical toxicity risk (lifetime average daily dose and hazard quotient) from consumption of the water samples in the present study. The results show that the average value of uranium concentrations, uranium isotopes 238U, 235U, and 234U (1.20 ± 0.04) μg/L, (1.48 ± 0.06) Bq/L, (0.069 ± 0.002) Bq/L and (1.49 ± 0.06) Bq/L respectively. Also, it is concluded that the total average annual effective dose and excess cancer risk in all regions under study were (0.10 ± 0.004) mSv/y and (0.31 ± 0.013) × 10−3 respectively. Moreover, the average value lifetime average daily dose, and hazard quotient was 0.0389 ± 0.0016 μg/kg.day and 0.0649 ± 0.0026 respectively. All results of radiological and chemical risk assessment from uranium concentrations in groundwater samples collected from the Al-Kufa area when used as drinking water were within the global limitations of the organization International Commission on Radiological Protection (1.9 μg/L; 1 mSv/y and 0.18 mSv/y) and World Health Organization recommended (0.6 μg/kg/day). Finally, it can be concluded that uranium concentrations do not affect human health according to radiation contents.

URANIUM QUANTIFICATION IN GROUNDWATER AND HEALTH RISK FROM ITS INGESTION IN AND AROUND TIRUVANNAMALAI, TAMIL NADU, INDIA

2020 ◽  
Vol 189 (2) ◽  
pp. 137-148 ◽  
Author(s):  
Durai Ganesh ◽  
G Senthil Kumar ◽  
Laith Ahmed Najam ◽  
V Raja ◽  
M A Neelakantan ◽  
...  
Keyword(s):  
Drinking Water ◽  
Tamil Nadu ◽  
Hazard Quotient ◽  
Life Time ◽  
Carcinogenic Risk ◽  
Excess Cancer Risk ◽  
Led Fluorimeter ◽  
Daily Dose ◽  
Contaminated Drinking Water ◽  
Drinking Water Samples

Abstract The aim of this study is to assess the degree of contamination in drinking water sources around the holy mountain “Arunachala” in Tiruvannamalai, Tamil Nadu. Drinking water samples from 20 different sites were collected, and their physio-chemical parameters, pH, electrical conductivity and total dissolved solvents were determined. An LED fluorimeter was used to determine the concentration of uranium in these samples. As consumption of contaminated drinking water involves both carcinogenic and non-carcinogenic risk, excess cancer risk; life-time average daily dose; hazard quotient and annual effective dose were calculated for the samples. On comparing these values with their respective maximum permissible limits, it is found that water from the aquifers around the mountain is safe to consume.

scholarly journals AB0474 THE USE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) IN WOMEN WITH ANKYLOSING SPONDYLITIS (AS) DURING PREGNANCY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1264.2-1265
Author(s):  
O. Krichevskaya ◽  
T. Dubinina ◽  
E. Ilinykh ◽  
S. Glukhova ◽  
A. Demina
Keyword(s):  
New York ◽  
Back Pain ◽  
Nsaid Therapy ◽  
International Studies ◽  
Average Daily Dose ◽  
Time Data ◽  
The Third ◽  
Increased Risk ◽  
Daily Dose ◽  
Adherence To Therapy

Background:NSAIDs remain the first-line drugs in treatment of AS. During pregnancy, COX-2 non-selective NSAIDs are allowed for intake up to 32 weeks, but the question of the dose-dependent effect of NSAIDs on fetal organogenesis in the 1st trimester and on fetal kidney function and the increased risk of bleeding in childbirth when taken in the second half of pregnancy continues to be discussed. At the same time, data on the effectiveness of NSAIDs, including their low and medium doses, during pregnancy are extremely small.Objectives:to describe the frequency of using NSAIDs during pregnancy, to determine relationship between the dose of NSAIDs, adherence to therapy with the activity of AS.Methods:50 pregnancies were followed in 49 pregnant women with confirmed AS (modified New York criteria, 1984). The average age of the pts was 31.6 ± 4.9 years, the duration of the disease was 134.4 ± 85.8 months. The visits were conducted at 10-11, 20-21, and 31-32 weeks of pregnancy. The BASDAI in the month of conception and in the trimesters (trim.) of pregnancy was: 1,4[0,6; 3,3]; 2,3[1,2; 4,4]; 2,8[1,4; 4,2] and 2,2[1,6; 4,0], respectively. The level of nocturnal back pain according to the NRS in the first, second and third trim. was: 3.2±2.0; 5.4±2.5 and 5.2±2.6, respectively. The drug of choice was ibuprofen at a maximum daily dose of 1200 mg, its withdrawal - no later than 32 weeks of pregnancy.Adherence to NSAID therapy was defined as the ratio of the actual dose taken to the prescribed dose; an indicator of less than 80% was regarded as non-adherence to therapy. The total dose of NSAIDs was determined by the NSAID intake index (M. Dougados, 2001). The” actual daily dose” of ibuprofen was the sum of the doses of ibuprofen taken, divided by the number of actual days of taking the drug. The “average daily dose” was defined as the sum of the ibuprofen doses taken, divided by the number of days in the trimester.Results:At the time of conception and in the first, second and third trim. of pregnancy, NSAIDs were taken 23 (46%), 20 (40%), 30 (60%) and 21 (43.8%) women, respectively. The NSAID intake index, the actual and average daily dose of ibuprofen are shown in the Table 1.month of conceptiontrim. 1trim. 2trim. 3the actual daily dose, mg-700[425; 800]800[400; 1000]750[400; 1200]the average daily dose, mg-158[87,9; 307,7]355,1[138,5; 685,7]580[320; 1200]NSAIDs intake index28,6 [16,7; 50]5,8 [2,9; 11,8]15,5 [4,7; 30,9]24,4 [9,5; 50]The index of NSAID intake in the first trim. was lower than before pregnancy and in the second half of gestation (p<0.05 compared to the month of conception, II and III trim.). The average daily dose of ibuprofen was also lower in the first trim. than in the second and third trim. (p<0.05), while the actual daily dose in the second trim. was higher than in the first and third trim. (p<0.05 in all cases).There was no correlation between BASDAI AS activity, the level of nocturnal pain and the ibuprofen intake index, likewise the fact of NSAID withdrawal throughout pregnancy. In addition, there were no differences in BASDAI levels and back pain in women with a subjective need for NSAIDs, who did and did’t take ibuprofen.50% of women were committed to NSAID therapy in the first trim., 43.5% in the second trim., and 67.4% in the third trim. In pts with non-adherence to NSAID therapy, the BASDAI level was higher than in those who followed the recommendations of the rheumatologist throughout pregnancy: in the first trim. – 3.8[3.4; 4.7] and 1.7[0.8; 2.2]; in the second trim. - 3[2.3; 4.6] and 1.4[0.8; 2.7]; in the third trim. - 3.1[2.1; 4.0] and 1.7[1.1; 4.0], p<0.05 in all cases. However, women with adherence > 80% were initially less active and NSAIDs were prescribed “on demand”, which increased their compliance.Conclusion:intake of ibuprofen in low doses does not affect the activity of AS. Due to the ongoing discussion about the effect of NSAIDs on neonatal outcomes, further international studies are required for development an optimal treatment regimen during pregnancy with a possible extension of the indications for the appointment of TNF inhibitors (BASDAI<4).Disclosure of Interests:None declared.

Letters to the Editor

PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 469-469
Author(s):  
Daniel Safer ◽  
Richard P. Allen
Keyword(s):  
Significant Relationship ◽  
Dose Range ◽  
Growth Suppression ◽  
Average Daily Dose ◽  
Letters To The Editor ◽  
Daily Dose

You are quite correct; the dose of dextroamphetamine was not included in the paper.1 The daily dose range for dextroamphetamine was 5 to 40 mg. The average daily dose was 12.4 mg. Fifty-four percent of the children received this medication during the summer, and 10% received the medication three times daily. There was no significant relationship between the dose of dextroamphetamine and growth suppression, a finding presented in Table IV of the paper. We do not know if doses less than 5 mg daily are nonsuppressive of growth.

Abstract 187: Loop Diuretic Therapy in Acute Decompensated Heart Failure among Premier Hospitals

2012 ◽  
Vol 5 (suppl_1) ◽  
Author(s):  
Behnood Bikdeli ◽  
Kelly Strait ◽  
Kumar Dharmarajan ◽  
Chohreh Partovian ◽  
Nancy Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Loop Diuretic ◽  
Acute Decompensated Heart Failure ◽  
Diuretic Therapy ◽  
Loop Diuretics ◽  
High Rate ◽  
Average Daily Dose ◽  
Duration Of Therapy ◽  
Daily Dose ◽  
Hospital Use

Background: Although loop diuretics are frequently used for patients with heart failure (HF), little is known about the variation in patterns of diuretic therapy in US hospitals. We sought to describe such treatment patterns among a diverse group of hospitals. Methods: We studied HF hospitalizations occurring during 2009-10 in Premier Inc. hospitals participating in a collaborative project to pool administrative and charge data, which includes information about drug types, average daily dose, and duration of therapy. We excluded hospitals with less than 25 HF hospitalizations. For ease of comparison, all diuretic doses were converted to bioequivalent doses of intravenous (IV) furosemide: 40mg IV furosemide ∼ 80mg oral furosemide ∼ 20mg (oral or IV) torsemide ∼ 1mg (oral or IV) bumetanide. Summary statistics were calculated. Results: Among 366 studied hospitals (264,675 HF hospitalizations), use of any loop diuretic had an interquartile range (IQR) from 92% to 96% (median: 94%). At the hospital level, the average daily dose IQR varied from 45mg to 64 mg (median: 55 mg) and the median duration of therapy was 4 days (IQR: 4 to 4; median: 4), as was the median length of stay. The IQR for use of furosemide varied from 89% to 94% (median: 92%), and its median average daily dose had an IQR from 40mg to 60 mg (median: 53 mg). Hospital use of bumetanide had an IQR from 2% to 11%, and hospital use of torsemide had an IQR from 0% to 4% (medians of 5% and 1%, respectively). The variation in median average daily dose for bumetanide and torsemide was greater than for furosemide (bumetanide IQR: 79mg to 127 mg, with median of 89 mg; torsemide IQR: 53mg to 120 mg, with median of 80 mg). Use of IV diuretics on the last day before home discharge had an IQR from 16% to 33% (median: 24%) across hospitals. Conclusion: US hospitals administer loop diuretics, particularly furosemide, to the vast majority of HF inpatients. The duration and daily dosage of therapy was similar across most hospitals. In contrast, a minority of hospitals used bumetanide and torsemide for several patients. The daily dosage of these agents showed more marked variation. We observed a high rate of intravenous diuretic use on the last day of hospitalization, with considerable variation across hospitals.

scholarly journals Radiation Risk Assessment on Public in Motijheel Thana, Dhaka, Bangladesh

2021 ◽  
Vol 9 (1) ◽  
pp. 23-31
Author(s):  
Mohammed Belayet Hossain ◽  
Dr. Mohammad Sohelur Rahman ◽  
Dr. Mohammad Amir Hossain Bhuiyan ◽  
Selina Yeasmin
Keyword(s):  
Cancer Risk ◽  
Effective Dose ◽  
Real Time ◽  
Annual Effective Dose ◽  
Life Time ◽  
Radiation Monitoring ◽  
Radiation Hazard ◽  
Monitoring Device ◽  
The Real ◽  
Average Value

Objective: The pollution free environment is required for healthy life. The real-time radiation monitoring is very important for radiation hazard detection in the environment. The excess life-time cancer risk (ELCR) on public is to assess based on the real-time radiation monitoring data in the area. Methods: The real-time radiation monitoring was performed using portable digital radiation monitoring device. This real-time digital portable radiation monitoring device meets all European CE standards as well as the American “FCC 15 standard”. The real-time digital portable radiation monitoring device was placed at 1 meter above the ground on tripod and data collection time for each monitoring point (MP) was 1 hour. 27 MPs were chosen for collection of real-time radiation data at various outdoor environment in Motijheel Thana, Dhaka from May-August 2018.Results: The real-time radiation dose rates at Motijheel Thana due to natural radionuclides were ranged from 0.095 ± 0.041 µSv.h-1 to 0.185 ± 0.042 µSv.h-1 with an average of 0.147 ± 0.047 µSv.h-1. The annual effective dose to public from outdoor environmental radiation at Motijheel Thana were found to be 0.166 ± 0.066 mSv to 0.324 ± 0.061 mSv with an average of 0.257 ± 0.039 mSv. Excess Life-time Cancer Risk (ELCR) on public are also estimated based on annual effective dose that is ranged from 0.662 ×10-3 to 1.289 ×10-3 with an average value of 1.025 ×10-3, which is higher than world average value of 0.29×10-3. Conclusion: This type of study is required for detection of the radiation hazard arising from the natu-ral as well as man-made sources and also for generation of the baseline database. From this study, it is observed that there is no pose any radiation hazard in the study area due to man-made sources.

scholarly journals Measurement of Indoor Radon Gas Concentration in same Region of Baghdad Governorate Using CR-39 Nuclear Track Detector

2017 ◽  
Vol 14 (4) ◽  
pp. 688-691 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Effective Dose ◽  
Radon Concentration ◽  
Annual Effective Dose ◽  
Indoor Radon ◽  
Track Detector ◽  
Nuclear Track Detector ◽  
Gas Concentration ◽  
Alpha Emitters ◽  
Average Value ◽  
Radon Gas

In this research the activity of radon gas in air in Baghad governorate,Iraq, using “alpha-emitters track registration (CR-39) track detector were measured. This measurement was done for selected areas from Baghdad Governorate, The results obtained shows that the highest average concentrations for Rn-222 is (179.077 Bq/m^3) which was recorded within Al-Shaaib city and less average concentrations was (15.79 Bq/m^3) in the nearby residential area of Baghdad International Airport and the overall average concentrations is (86.508 Bq/m^3) for these regions. Then the radon concentration was measured annual effective dose calculated from radon concentration and found in range from 0.4031 mSv/y to 4.5179 mSv /y with an average value of 2.1824 mSv/y. The annual effective dose of radon was within the allowed international limits.

Indoor Radon and Thoron Concentration and the Associated Effective Dose Rate Determination in Dwellings of Suq Alshouk, Thiqar (Iraq)

2021 ◽  
Vol 19 (12) ◽  
pp. 06-10
Author(s):  
Hussam Najem Abood ◽  
Ahmed Abbas Mohamed
Keyword(s):  
Effective Dose ◽  
Dose Rate ◽  
Annual Effective Dose ◽  
Indoor Radon ◽  
Type Ii ◽  
Average Value ◽  
Effective Dose Rate

Indoor radon/thoron concentration has been determined in some dwellings of Suq Alshouk district in Thiqar Governorate southern of Iraq, using LR-115 type II and CR-39 (SSNTDs). In this work the indoor radon/thoron concentration varies from (8-73) Bq m-3 for radon with an average 35±2Bq m-3, and ranges (1- 47) Bq m-3 for thoron with an average16±2Bq m-3. The average annual effective dose due to radon and thoron varies from 0.43-3.38m Sv y-1 with average value 1.43±0.11 mSv y-1.

scholarly journals Assessment of the Nutrients in the Leachate and the Groundwater Quality for Drinking and Farming around the Nkolfoulou Landfill in Yaoundé, Cameroon

2019 ◽  
Vol 2019 ◽  
pp. 1-16
Author(s):  
Gilbert Feuyit ◽  
John Ngolui Lambi ◽  
Estella Njoyim-Tamungang ◽  
Samuel Laminsi
Keyword(s):  
Groundwater Quality ◽  
Major Ions ◽  
Hazard Quotient ◽  
Hazard Index ◽  
Wet Season ◽  
Cancer Risks ◽  
Groundwater Samples ◽  
Standard Set ◽  
Effluent Discharge ◽  
Pollute Groundwater

This study focuses on the assessment of the nutrients in the leachate and the groundwater quality around the Nkolfoulou landfill in Yaoundé known in French as “Centre de Traitement de Déchets (CTD).” Landfilling generates leachate that can pollute groundwater. Leachate along with groundwater samples (n=1+13) was collected in January (long dry season) and May (long wet season) 2014 and explored for various parameters including pH, temperature, EC, turbidity, TDS, TA, TSS, TH, BOD5, COD, Na+, K+, Mg2+, Ca2+, NH4+, NO3−, Cl−, F−, SO42−, PO43−, HCO3−, and colour using standard methods. In the leachate samples, values of TSS (700.2 and 130.2 mg/L), BOD5 (140 mg/L), COD (1350 and 1750 mg/L), NH4+ (82.50 and 39.51 mg/L), NO3− (159.32 and 74.82 mg/L), and Cl− (702.69 and 345.50 mg/L) exceeded the Cameroonian standards for effluent discharge. All the values of pH and some values of turbidity (4.55 and 4.50 NTU) and NH4+ (0.51 and 0.73 mg/L) in the groundwater samples violated the Cameroonian standards for drinking water. Based on the water quality index (WQI), an average of 11.53% of groundwater samples was improper for drinking in both seasons. Based on the parameters assessed, all the samples complied with the standard set for irrigation, poultry, and livestock. The hazard quotient (HQ) and the hazard index (HI) of NO3− and F− for children and adults were <1, and hence, the increased non-cancer risks due to these ions through the drinking of groundwater was low. From the statistical analysis, the Nkolfoulou landfill may not be the main source of major ions to the nearby groundwater.

scholarly journals THE COMPARATIVE EFFECTS OF NEUTRONS AND X-RAYS ON THE WHOLE BODY

1937 ◽  
Vol 66 (6) ◽  
pp. 667-688 ◽  
Author(s):  
John H. Lawrence ◽  
Robert Tennant
Keyword(s):  
Normal Tissue ◽  
Whole Body ◽  
X Rays ◽  
Average Daily Dose ◽  
Tissue Destruction ◽  
Delayed Effects ◽  
Long Period ◽  
Tolerance Dose ◽  
Daily Dose ◽  
Small Doses

Irradiation of the whole bodies of mice with neutron rays in sufficient quantities, leads to a clinical, bacteriological and anatomical picture similar to that following Roentgen irradiation. The mucosa of the small intestine and the lymphoid and hemapoietic tissues are the most radiosensitive. The mechanism of death after both forms of radiation seems to be a combination of tissue destruction and enterogenous infection, the former predominating in the acute deaths after large doses. Aside from any possible delayed effects from exposure to small doses over a long period of time, concerning which we have no information, these changes after relatively large doses make it imperative that workers in laboratories generating neutrons protect themselves from exposure by screening. For the same amount of ionization measured by a small bakelite-walled thimble chamber, neutrons are more biologically destructive than x-rays. The average daily dose to those working with neutrons should not exceed one-fourth of the tolerance dose accepted for x-rays. Whether daily doses of this magnitude, over a long period of time, will result in damage is not known. Also, if neutrons are tried therapeutically normal tissue must be protected from undue irradiation.

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