Efeitos adversos no tratamento da tuberculose

Objetivo: Analisar ocorrências de efeitos adversos relacionados a medicamentos no tratamento de tuberculose e sua associação com variáveis clínicas e desfecho. Método: Estudo transversal com 63 casos de tuberculose tratados no Ambulatório de Tuberculose e Hanseníase de São José do Rio Preto, São Paulo, no período de 2010 a 2015. Utilizou-se análise de frequência e teste qui-quadrado com correção de Monte Carlo. Resultados: Os efeitos adversos iniciaram-se antes do terceiro mês de tratamento; efeitos menores foram mais frequentes, com predomínio de irritação gástrica. Houve associação entre conduta médica e efeitos adversos (p = 0,009). Conclusão: Efeitos adversos causados pelos medicamentos podem prejudicar o desfecho clínico devido ao risco de abandono do tratamento. Profissionais de saúde devem estar atentos aos sinais e sintomas relacionados aos efeitos adversos, implementando condutas necessárias para neutralizar ou diminuir as queixas, visando adesão ao tratamento e cura da doença.Descritores: Tuberculose; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos; Terapia Combinada; Tuberculose Resistente a Múltiplos Medicamentos; Tuberculose Pulmonar. ADVERSE EFFECTS IN THE TREATMENT OF TUBERCULOSIS Objective: To analyze occurrences of drug-related adverse effects in treatment of tuberculosis and its association with clinical variables and outcome. Method: Cross-sectional study with 63 cases of tuberculosis treated at Tuberculosis and Leprosy Outpatient Clinic of São José do Rio Preto, São Paulo, from 2010 to 2015. We used frequency analysis and chi-square test with Monte Carlo correction. Results: Adverse effects started before the third month of treatment; effects were more frequent, with predominance of gastric irritation. There was association between medical conduct and adverse effects (p=0.009). Conclusion: Adverse effects caused by medications may impair the clinical outcome due to risk of treatment withdrawal. Health professionals should be alert to signs and symptoms related to adverse effects, implementing the necessary behaviors to neutralize or reduce complaints, aiming adherence to treatment and cure of the disease.Descriptors: Tuberculosis; Drug-Related Side Effects and Adverse Reactions; Combined Modality Therapy; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary.EFECTOS ADVERSOS EN EL TRATAMIENTO DE TUBERCULOSISObjetivo: Analizar los efectos adversos relacionados con medicamentos en tratamiento de la tuberculosis y su asociación con variables clínicas y desenlace. Método: Estudio transversal con 63 casos de tuberculosis tratados en Ambulatorio de Tuberculosis y Hanseniasis de São José Rio Preto, São Paulo, en período de 2010 a 2015. Se utilizó análisis de frecuencia y prueba chi-cuadrado con corrección de Monte Carlo. Los efectos adversos se iniciaron antes del tercer mes de tratamiento; los efectos menores fueron más frecuentes, con predominio de irritación gástrica. Se observó asociación entre conducta médica y efectos adversos (p=0,009). Resultados: Los efectos adversos causados por medicamentos pueden perjudicar el resultado clínico debido al riesgo de abandono del tratamiento. Conclusiones: Los profesionales de salud deben estar atentos a los signos y síntomas relacionados con efectos adversos, implementando conductas necesarias para neutralizar o disminuir las quejas, visando adhesión al tratamiento y cura de la enfermedad.Descriptores: Tuberculosis; Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos; Terapia Combinada; Tuberculosis Resistente a Múltiples Medicamentos; Tuberculosis Pulmonar.

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Mix of destinations and sedentary behavior among Brazilian adults: a cross-sectional study

BMC Public Health ◽

10.1186/s12889-020-10123-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Alex Antonio Florindo ◽

Gavin Turrell ◽

Leandro Martin Totaro Garcia ◽

João Paulo dos Anjos Souza Barbosa ◽

Michele Santos Cruz ◽

...

Keyword(s):

Built Environment ◽

Sedentary Behavior ◽

Latin American ◽

Cross Sectional Study ◽

Sao Paulo ◽

Sitting Time ◽

São Paulo ◽

Related Factors ◽

Cross Sectional ◽

Economies In Transition

Abstract Background Sedentary behavior is influenced by contextual, social, and individual factors, including the built environment. However, associations between the built environment and sitting time have not been extensively investigated in countries with economies in transition such as Brazil. The objective of this study is to examine the relationship between sitting-time and access to a mix of destinations for adults from Sao Paulo city, Brazil. Methods This study uses data from the Health Survey of Sao Paulo. Sedentary behavior was assessed by a questionnaire using two questions: total sitting time in minutes on a usual weekday; and on a usual weekend day. The mix of destinations was measured by summing the number of facilities (comprising bus stops, train/subway stations, parks, squares, public recreation centres, bike paths, primary health care units, supermarkets, food stores, bakeries, and coffee-shops) within 500 m of each participant’s residence. Minutes of sitting time in a typical weekday and weekend day were the outcomes and the mix of destinations score in 500 m buffers was the exposure variable. Associations between the mix of destinations and sitting time were examined using multilevel linear regression: these models accounted for clustering within census tracts and households and adjusted for environmental, sociodemographic, and health-related factors. Results After adjustment for covariates, the mix of destinations was inversely associated with minutes of sitting time on a weekday (β=− 8.8, p=0.001) and weekend day (β=− 6.1, p=0.022). People who lived in areas with a greater mix of destinations had shorter average sitting times. Conclusion Greater mix of destinations within 500 m of peoples’ residences was inversely associated with sitting time on a typical weekday and weekend day. In Latin American cities like Sao Paulo built environments more favorable for walking may contribute to reducing sedentary behavior and prevent associated chronic disease.

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ORTHOPEDIC INJURIES IN MEN'S PROFESSIONAL SOCCER IN BRAZIL: PROSPECTIVE COMPARISON OF TWO CONSECUTIVE SEASONS 2017/2016

Acta Ortopédica Brasileira ◽

10.1590/1413-785220182605194940 ◽

2018 ◽

Vol 26 (5) ◽

pp. 338-341 ◽

Cited By ~ 1

Author(s):

Eduardo Ramalho de Moraes ◽

Gustavo Gonçalves Arliani ◽

Paulo Henrique Schmidt Lara ◽

Eli Henrique Rodrigues da Silva ◽

Jorge Roberto Pagura ◽

...

Keyword(s):

Cross Sectional Study ◽

Sao Paulo ◽

Lower Limbs ◽

São Paulo ◽

Level Of Evidence ◽

Cross Sectional ◽

Paulo State ◽

Professional Soccer ◽

Prospective Comparison ◽

São Paulo State

ABSTRACT Purpose: The purpose is to compare the incidence and characteristics of injuries sustained in two consecutive seasons of the São Paulo State Football Championship. Methods: Prospective study performed using an electronic form previously developed by the Medical Committee of the São Paulo State Football Federation, sent to the physicians responsible for the tournament's series A1 and A2 teams, after each round. Results: 17.63 injuries sustained per 1000 hours of matches in the A1 series and 14.91 injuries sustained per 1000 hours of matches in the A2 series. Incidence of injuries per 1000 hours of matches decreased from 24.16 to 17.63 in the A1 series (p<0.037) and from 19.10 to 14.01 in the A2 series (p<0.064). External defenders suffered most injuries, while muscular injuries were most common and lower limbs, the most affected areas. Most injuries occurred between 30 and 45 minutes of the match and only 11.9% of the injuries required surgery. Conclusions: Prevalence and frequency of injuries decreased between seasons. Most injuries were sustained in the lower limbs; strains were the most common injuries, followed by strains and contusions; MRIs were the most frequently requested exams and most injuries were classified as moderate (8-28 days). Level of evidence III, Cross-Sectional Study.

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Cerebrovascular diseases mortality in the elderly in the state of São Paulo

10.5327/1516-3180.417 ◽

2021 ◽

Author(s):

Isaac Rêgo Purificação ◽

Allêh Kauãn Santos Nogueira ◽

Matheus Araújo de Souza ◽

Camila de Almeida Costa Alencar ◽

Sancha Mohana Brito Goes Rios

Keyword(s):

Age Groups ◽

The Elderly ◽

Cross Sectional Study ◽

Cerebrovascular Diseases ◽

Sao Paulo ◽

Primary Objective ◽

The State ◽

São Paulo ◽

Cross Sectional ◽

Lack Of Information

Background: Cerebrovascular disease (CVD) is the world 2nd death cause and the main cause of disability. Nevertheless, there is a lack of information regarding the mortality profile for this etiology in the last decade. Objective and Methods: Using prospectively collected data available in TabNet (DataSUS) platform, a descriptive and cross-sectional study was conducted. The primary objective is to access the demographic information most associated with DCV mortality in individuals older than 50 years-old, in São Paulo (SP), from 2010 to 2019. Results: The highest mortality in the state of SP was in 2019 (16,945 deaths), according to the growing trend; in the 2010-2019 period, the annual mean by city of deaths (± standard deviation [SD]) was 14,885 (± 1,341). During these years, the number of deaths was higher in the municipality of São Paulo (57,013; 31%). The annual mean deaths (± SD) in the capital and in the interior cities were, respectively: 4,684 (± 269) and 31 (± 58). The age groups from 70 to 79 years and over 80 years were the most affected. Caucasian race represents 71% of deaths. Individuals with 1 to 3 years of school were more affected (38%). The ratio of male deaths to female deaths was 1.02. Conclusion: In the last decade, there was an increasing mortality by CVD among the elderly population, and the city of São Paulo leads the number of cases.

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The relationship between ultra-processed food consumption and Internalizing Symptoms among adolescents from São Paulo city, Southeast Brazil

Public Health Nutrition ◽

10.1017/s1368980021004195 ◽

2021 ◽

pp. 1-25

Author(s):

Alexandre Faisal-Cury ◽

Maria Alvim Leite ◽

Maria Mercedes Loureiro Escuder ◽

Renata Bertazzi Levy ◽

Maria Fernanda Tourinho Peres

Keyword(s):

Internalizing Symptoms ◽

Structural Equation ◽

School Health ◽

Structural Equation Models ◽

Positive Association ◽

Cross Sectional Study ◽

Sao Paulo ◽

São Paulo ◽

Processed Food ◽

Cross Sectional

Abstract Objective: To investigate the association between ultra-processed food (UPF) consumption and Internalizing Symptoms (IS) among adolescents. Design: It is a cross-sectional study. Paper-pencil survey was completed in classroom with information on UPF consumption, IS and selected covariates. IS were assessed with the Internalizing Symptoms sub-scale from the Social Behaviour Questionnaire (ISs-SBQ). UPF was evaluated with a food frequency questionnaire extracted from the Brazilian National School Health Survey. Crude and adjusted association between UPF and IS was investigated with Structural Equation Models. Setting: São Paulo, SP, Brazil. Participants: n= 2,680 students, Mage= 14.85; CI95% 14.81-14.88. Results: UPF consumption was associated with higher scores in IS in the crude (ß=0.14; p<0.001) and adjusted (ß=0.12; p<0.001) models. The higher the consumption of UPF, the higher the IS score. The following variables were associated with a lower risk of UPF consumption: male gender, public school and having more meals with parents. The change in the magnitude of the standardized score was almost negligible, but the model was significantly improved with the inclusion of covariates. Conclusions: Our results provide evidence about the positive association between UPF consumption and IS among adolescents. The association, despite its low magnitude, remained significant after adjusting for potential confounders. These results are relevant considering the increase in UPF consumption worldwide and in low- and middle-income countries. Also, our study emphasizes the importance of a healthy diet with a reduction in UPF consumption among adolescents.

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Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000400002 ◽

2010 ◽

Vol 128 (4) ◽

pp. 187-191 ◽

Cited By ~ 13

Author(s):

Aurea Cristina Portorreal Miranda ◽

Rodrigo Strehl Machado ◽

Edina Mariko Koga da Silva ◽

Elisabete Kawakami

Keyword(s):

Helicobacter Pylori ◽

Cross Sectional Study ◽

Sao Paulo ◽

Helicobacter Pylori Infection ◽

Socioeconomic Level ◽

São Paulo ◽

Sectional Study ◽

Cross Sectional ◽

Low Socioeconomic ◽

H Pylori

CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study, among patients attended at an outpatient clinic. METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age. CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence.

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The Prevalence of Headache Among Elderly in a Low-Income Area of São Paulo, Brazil

Cephalalgia ◽

10.1111/j.1468-2982.2007.01507.x ◽

2008 ◽

Vol 28 (4) ◽

pp. 329-333 ◽

Cited By ~ 20

Author(s):

IM Benseñor ◽

PA Lotufo ◽

AC Goulart ◽

PR Menezes ◽

M Scazufca

Keyword(s):

Low Income ◽

International Headache Society ◽

The Elderly ◽

Cross Sectional Study ◽

Sao Paulo ◽

Tension Type Headache ◽

São Paulo ◽

Cross Sectional ◽

Migraine Headaches ◽

Type Headache

There are scarce data about headache prevalence and its characteristics among elderly people. The aim was to carry out a cross-sectional study to determine the 1-year prevalence of tension-type and migraine headaches in people >65 years old in the city of São Paulo, Brazil. All 1615 people living in the study catchment area who agreed to participate in the study answered a questionnaire based in the International Headache Society criteria. Prevalence (mean and 95% confidence interval) of any type of headache in the last year was 45.6% (43.2, 48.0). Prevalence of tension-type headache in the last year was 33.1% (30.8, 35.4): 28.1% (24.6, 31.6) for men and 36.4% (33.4, 39.4) for women; for migraine headaches, prevalence in the last year was 10.6% (9.1, 12.1): 5.1% (3.4, 6.8) for men and 14.1% (11.9, 16.3) for women. One-year prevalence rates of headaches, and especially of migraine headaches, are very high among the elderly in Brazil.

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Musculoskeletal Disorders among Brazilian Dentists in São Paulo

Revista Odonto Ciência ◽

10.15448/1980-6523.2018.1.29699 ◽

2018 ◽

Vol 33 (1) ◽

pp. 33

Author(s):

Gabriella Barreto Soares ◽

Carlos Eduardo Gomes Siqueira ◽

Lorena Estrada-Martinez ◽

Cléa Adas Saliba Garbin ◽

Artênio José Ísper Garbin

Keyword(s):

Musculoskeletal Disorders ◽

Cross Sectional Study ◽

Health Problems ◽

Sao Paulo ◽

São Paulo ◽

Related Factors ◽

Cross Sectional ◽

Work Related ◽

And Gender ◽

Public Clinics

OBJECTIVE: This study aimed at investigating the relationships between health and work-related musculoskeletal disorders (WMSDs) in dentists, and the relationship with socio-demographic, work and health variables.METHODS: We conducted a cross-sectional study of 204 dentists who work in public clinics in the state of São Paulo, Brazil. We used a self-administered survey that included questions on sociodemographic and health aspects, work-related factors, and the Nordic questionnaire.RESULTS: WMSDs were often reported in the neck, shoulder, lower back, and hand/wrists. Logistic regression analysis revealed that there was a correlation between reports of WMSD in the neck and age (OR = 9.48) and health problems (OR = 6.71). Moreover, strong associations were found between MSDs in the shoulders, gender (OR = 5.88) and breaks between appointments (OR = 4.17).CONCLUSION: We concluded that the health problems diagnosed, work-related activities and gender contributed to musculoskeletal disorders in dentists in this clinic.

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