Effects of Diets on Adipose Tissue

2019 ◽  
Vol 26 (19) ◽  
pp. 3593-3612
Author(s):  
Silvia Ezquerro ◽  
Amaia Rodríguez ◽  
Piero Portincasa ◽  
Gema Frühbeck
Keyword(s):  
Adipose Tissue ◽  
Food Preferences ◽  
Overweight And Obesity ◽  
Economic Consequences ◽  
Present Review ◽  
Calorie Intake ◽  
Dietary Interventions ◽  
Major Health Problem ◽  
Global Epidemic ◽  
Excess Adiposity

Background: Obesity is a major health problem that has become a global epidemic. Overweight and obesity are commonly associated with the development of several pathologies, such as insulin resistance, cardiovascular diseases, sleep apnea and several types of cancer, which can lead to further morbidity and mortality. An increased abdominal adiposity renders overweight and obese individuals more prone to metabolic and cardiovascular problems. Objective: This Review aims to describe the dietary strategies to deal with excess adiposity given the medical, social and economic consequences of obesity. Methods: One hundred and eighty-five papers were included in the present Review. Results: Excess adiposity leads to several changes in the biology, morphology and function of the adipose tissue, such as adipocyte hypertrophy and hyperplasia, adipose tissue inflammation and fibrosis and an impaired secretion of adipokines, contributing to the onset of obesity- related comorbidities. The first approach for obesity management and prevention is the implementation of a diet combined with physical activity. The present review summarizes the compelling evidence showing body composition changes, impact on cardiometabolism and potential adverse effects of very-low calorie, low- and high-carbohydrate, high-protein or low-fat diets. The use of macronutrients during the preprandial and postprandial state has been also reviewed to better understand the metabolic changes induced by different dietary interventions. Conclusion: Dietary changes should be individualised, tailored to food preferences and allow for flexible approaches to reducing calorie intake in order to increase the motivation and compliance of overweight and obese patients.

scholarly journals Contemporary pharmacological obesity treatments

2016 ◽  
Vol 29 (2) ◽  
pp. 57-60 ◽  
Author(s):  
Katarzyna Kaszubska ◽  
Barbara Budzynska ◽  
Grazyna Biala
Keyword(s):  
Clinical Trials ◽  
Overweight And Obesity ◽  
Present Review ◽  
Proper Treatment ◽  
Short Term ◽  
Global Epidemic ◽  
Obesity Drugs ◽  
Obesity Treatments

AbstractIn the last few years, obesity has become a global epidemic. Consequently, worldwide costs associated with managing obesity and obesity-related comorbidities are huge. Numerous studies have focused on discerning the appropriate proper treatment of weight related problems such as overweight and obesity. Moreover, many clinical trials have been conducted for many years in order to introduce effective anti-obesity drugs. The aim of the present review is to provide an overview of current and future pharmacotherapy for obesity, and to provide the reader with a determination of the concentration and composition of long and short term anti-obesity drugs, doing so by placing emphasis on pharmacotherapy and up-to-day solutions. It should be noted that, currently, the worldwide pharmacotherapy is represented by phendimetrazine, benzphetamine and diethylpropion, as well as by orlistat, lorcaserin, phentermine/topiramate, naltrexone/bupropion and liraglutide. In our paper, individual cases of patients’ needs are thoroughly illustrated by way of examples. Medical prescriptions and contraindications are also described.

scholarly journals The Potential Role of Exosomes in Child and Adolescent Obesity

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 196
Author(s):  
Ioanna Maligianni ◽  
Christos Yapijakis ◽  
Flora Bacopoulou ◽  
George Chrousos
Keyword(s):  
Child And Adolescent ◽  
Cardiovascular Complications ◽  
Adolescent Obesity ◽  
Overweight And Obesity ◽  
Calorie Intake ◽  
Target Cells ◽  
Special Role ◽  
Exosomal Mirnas ◽  
Risk Biomarkers

Child and adolescent obesity constitute one of the greatest contemporary public health menaces. The enduring disproportion between calorie intake and energy consumption, determined by a complex interaction of genetic, epigenetic, and environmental factors, finally leads to the development of overweight and obesity. Child and adolescent overweight/obesity promotes smoldering systemic inflammation (“para-inflammation”) and increases the likelihood of later metabolic and cardiovascular complications, including metabolic syndrome and its components, which progressively deteriorate during adulthood. Exosomes are endosome-derived extracellular vesicles that are secreted by a variety of cells, are naturally taken-up by target cells, and may be involved in many physiological and pathological processes. Over the last decade, intensive research has been conducted regarding the special role of exosomes and the non-coding (nc) RNAs they contain (primarily micro (mi) RNAs, long (l) non-coding RNAs, messenger (m) RNAs and other molecules) in inter-cellular communications. Through their action as communication mediators, exosomes may contribute to the pathogenesis of obesity and associated disorders. There is increasing evidence that exosomal miRNAs and lncRNAs are involved in pivotal processes of adipocyte biology and that, possibly, play important roles in gene regulation linked to human obesity. This review aims to improve our understanding of the roles of exosomes and their cargo in the development of obesity and related metabolic and inflammatory disorders. We examined their potential roles in adipose tissue physiology and reviewed the scarce data regarding the altered patterns of circulating miRNAs and lncRNAs observed in obese children and adolescents, compared them to the equivalent, more abundant existing findings of adult studies, and speculated on their proposed mechanisms of action. Exosomal miRNAs and lncRNAs could be applied as cardiometabolic risk biomarkers, useful in the early diagnosis and prevention of obesity. Furthermore, the targeting of crucial circulating exosomal cargo to tissues involved in the pathogenesis and maintenance of obesity could provide a novel therapeutic approach to this devastating and management-resistant pandemic.

scholarly journals Bone Marrow Adipocytes—Role in Physiology and Various Nutritional Conditions in Human and Animal Models

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1412
Author(s):  
Katarzyna Piotrowska ◽  
Maciej Tarnowski
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Anorexia Nervosa ◽  
Animal Models ◽  
Diabetes Mellitus Type 1 ◽  
Medullary Canal ◽  
Dietary Interventions ◽  
Nutritional Conditions ◽  
Heterogeneous Tissue

In recent years, adipose tissue has attracted a lot of attention. It is not only an energy reservoir but also plays important immune, paracrine and endocrine roles. BMAT (bone marrow adipose tissue) is a heterogeneous tissue, found mostly in the medullary canal of the long bones (tibia, femur and humerus), in the vertebrae and iliac crest. Adipogenesis in bone marrow cavities is a consequence of ageing or may accompany pathologies like diabetes mellitus type 1 (T1DM), T2DM, anorexia nervosa, oestrogen and growth hormone deficiencies or impaired haematopoiesis and osteoporosis. This paper focuses on studies concerning BMAT and its physiology in dietary interventions, like obesity in humans and high fat diet in rodent studies; and opposite: anorexia nervosa and calorie restriction in animal models.

scholarly journals Promoting healthy foods among urban school children in Bangladesh: a qualitative inquiry of the challenges and opportunities

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. M. Rumayan Hasan ◽  
George Smith ◽  
Md Harunor Rashid ◽  
Mohammad Abdus Selim ◽  
Sabrina Rasheed
Keyword(s):  
School Children ◽  
Food System ◽  
Vegetable Consumption ◽  
Food Preferences ◽  
Urban School ◽  
Qualitative Inquiry ◽  
Overweight And Obesity ◽  
Food Culture ◽  
Healthy Foods ◽  
Raw Foods

Abstract Background In Bangladesh overweight and obesity among urban school children are on the rise. Urban school children tend to consume foods dense in calories and few fruits and vegetables which is associated with overweight and obesity. The current study explored the barriers and opportunities for promoting healthy diets among school children from the perspective of teachers and parents in Dhaka, Bangladesh. Methods We conducted 14 key informant interviews with teachers and principals, six focus group discussions with 31 mothers of school children (5 to 15 year old) and 14 structured observations of the school food environment. Inductive thematic analysis was performed manually. Results Schools were important for development of food preferences of children, however, most school cafeterias provided foods based on profit rather than health considerations. A shift in food culture resulted in making eating out acquire many meanings beyond convenience. Mothers, especially those who were employed, struggled to prepare healthy foods due to time pressure. Mothers were generally concerned about chemicals added to raw foods in markets which led to limited fruit and vegetable consumption. Conclusions There were many challenges to promoting healthy foods to school children within and outside the school. It is important to formulate policies and guidance to create a supportive environment for healthy foods in and in the proximity of schools. It is also important to educate consumers about identifying and choosing healthy foods. Laws related to food safety should be adequately implemented to boost the population’s confidence in safety of available healthy foods in the food system.

Obesity and inflammatory bowel disease

2021 ◽  
Vol 75 (1) ◽  
pp. 20-28
Author(s):  
Vladimír Teplan ◽  
Milan Lukáš
Keyword(s):  
Inflammatory Bowel Disease ◽  
Adipose Tissue ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Perioperative Complications ◽  
Overweight And Obesity ◽  
Special Role ◽  
Low Concentrations ◽  
Inflammatory Bowel

The incidence and prevalence of overweight and obesity has dramatically increased in the last decades and is generally considered to be global pandemics. The incidence of inflammatory bowel disease (IBD) is rising parallel with overweight and obesity. Contrary to a conventional believe, about 15–40% patients with IBD are obese, which can contribute to the development and course of IBD, especially in Crohn’s disease. Although the findings of some cohort studies are still conflicting, recent results indicate a special role of visceral adipose tissue and particularly mesenteric adipose tissue known as creeping fat, leading to intestinal inflammation. The involvement of altered adipocyte function and deregulated production of adipokines such as leptin and adiponectin has been suggested in the pathogenesis of IBD. The emerging role of Western diet and microbiota can also open new possibilities in IBD management. The effect of obesity on the IBD-related therapy remains to be studied. The finding that obesity results in suboptimal response to the therapy, potentially promoting rapid clearance of biologic agents and thus leading to their low concentrations, has a great importance. Obesity also makes IBD colorectal surgery technically challenging and might increase a risk of perioperative complications.

Abstract P303: Association of Overweight/Obesity and Self Reported Health Status in Hispanics: A Comparison with Non Hispanic Whites

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Connie Ingram ◽  
Maria Canossa-Terris ◽  
Mary Comerford ◽  
Paul Kurlansky
Keyword(s):  
Logistic Regression ◽  
Health Status ◽  
Good Health ◽  
Overweight And Obesity ◽  
Poor Health ◽  
Self Perception ◽  
Heart Research ◽  
Major Health Problem ◽  
Perception Of Health ◽  
The Impact

Introduction The growing global prevalence of obesity is recognized as an important risk for cardiovascular disease. Understanding self perception of weight as it pertains to health is critical to the success of weight reduction programs. The impact of ethnicity on this association has not been examined. Methods The sample included 927 Hispanic (H) and 72 Non-Hispanics white (NHW) adults who received free cardiovascular screening from Florida Heart Research Institute. Overweight and obesity were measured by Body Mass Index. Self-perceived health status was characterized as excellent, very good, good, fair or poor health. Logistic regression was used to determine independent risk factors for perceived fair-poor health, as well as for excellent, very good health. Odds ratios and 95% Confidence Intervals were calculated. Results Both H and NHW overweight/obese subjects tended to view their health as good, very good or excellent: H (overweight 81.1%/obese 73%) and NHW (89.3%/66.7%). Logistic regression revealed the following independent correlates of self-perceived very good or excellent health: NHW (OR 3.618, CI 2.126, 6.157, p<0.001) and exercise (OR 1.640;CI 1.186, 2.268; p=0.003). Hypertension (OR 0.392; CI 0.246, 0.625; p<0.001), overweight (OR 0.551, CI0.386, 0.785, p=0.001) and obesity (OR 0.431, CI 0.288, 0.644; p<0.001) were all negatively associated with very good/excellent status. Conclusions Although it is not surprising that participation in regular exercise is associated with a better self-perception of health status, or that hypertension and obesity is correlated with a worse self-assessed health status, there are two striking findings that emerge from this data: 1. The vast majority of both H and NHW subjects do not perceive either overweight or obesity to be a major health problem. 2. Hispanics have a significantly worse self-perception of health status even after controlling for associated factors.This information provides a critical foundation for overcoming fundamental barriers to effective patient education_a critical first step in addressing the current epidemic of obesity in ethnically diverse populations.

Neuroendocrine regulation of energy balance: Implications on the development and surgical treatment of obesity

2017 ◽  
Vol 23 (3) ◽  
pp. 131-146 ◽  
Author(s):  
Gisele Farias ◽  
Bárbara Dal Molin Netto ◽  
Solange Cravo Bettini ◽  
Ana Raimunda Dâmaso ◽  
Alexandre Coutinho Teixeira de Freitas
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Gastrointestinal Tract ◽  
Energy Balance ◽  
Public Health Problem ◽  
Neuroendocrine Regulation ◽  
Calorie Intake ◽  
Hormone Signaling ◽  
Sustained Weight Loss

Introduction: Obesity, a serious public health problem, occurs mainly when food consumption exceeds energy expenditure. Therefore, energy balance depends on the regulation of the hunger–satiety mechanism, which involves interconnection of the central nervous system and peripheral signals from the adipose tissue, pancreas and gastrointestinal tract, generating responses in short-term food intake and long-term energy balance. Increased body fat alters the gut- and adipose-tissue-derived hormone signaling, which promotes modifications in appetite-regulating hormones, decreasing satiety and increasing hunger senses. With the failure of conventional weight loss interventions (dietary treatment, exercise, drugs and lifestyle modifications), bariatric surgeries are well-accepted tools for the treatment of severe obesity, with long-term and sustained weight loss. Bariatric surgeries may cause weight loss due to restriction/malabsorption of nutrients from the anatomical alteration of the gastrointestinal tract that decreases energy intake, but also by other physiological factors associated with better results of the surgical procedure. Objective: This review discusses the neuroendocrine regulation of energy balance, with description of the predominant hormones and peptides involved in the control of energy balance in obesity and all currently available bariatric surgeries. Conclusions: According to the findings of our review, bariatric surgeries promote effective and sustained weight loss not only by reducing calorie intake, but also by precipitating changes in appetite control, satiation and satiety, and physiological changes in gut-, neuro- and adipose-tissue-derived hormone signaling.

scholarly journals Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity

2019 ◽  
Author(s):  
Grzegorz Józef Nowicki ◽  
Barbara Ślusarska ◽  
Andrzej Prystupa ◽  
Maciej Polak ◽  
Maria Czubaj-Kowal ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Adipose Tissue ◽  
Cardiovascular Event ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Overweight And Obesity ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Antioxidative Status ◽  
Total Antioxidative Status

Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress level. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). OxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the studied groups. Significant positive correlation between PerOx and percentage of adipose tissue (FM [%]) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with VAI in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAI of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.

Economic consequences of overweight and obesity in Asia-Pacific

2011 ◽  
Vol 3 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Thomas Reinhold ◽  
Adrian von Schultzendorff ◽  
Falk Müller-Riemenschneider
Keyword(s):  
Overweight And Obesity ◽  
Economic Consequences ◽  
Asia Pacific

Evaluation of subcutaneous drainage system versus tissue re-approximation alone using Pfannenstiel incision in obese females undergoing caesarean section.

2021 ◽  
Author(s):  
Safaa A. Ibrahim ◽  
Mena M. Abdalla ◽  
Rofida M. Elshafei
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Caesarean Section ◽  
Drainage System ◽  
Negative Effects ◽  
Major Health Problem ◽  
Major Health ◽  
Pfannenstiel Incision ◽  
System Versus ◽  
Minor Ailments

Abstract Obesity is a growing problem and a major health problem. In 1919, Dr. Kelly described obesity by saying that "to be a storehouse for useless adipose tissue and to carry this handicap around, openly displayed wherever one goes, is one of most distressing of life's minor ailments." It has complex negative effects on the functions and procedures of various organs, and includes problems relating to wound healing .

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