Male Urogenital Disorders and Metabolic Syndrome: Possible Links, Characteristics and Potential Treatment Strategies

2018 ◽  
Vol 24 (9) ◽  
pp. 1019-1033 ◽  
Author(s):  
Cetin Volkan Oztekin ◽  
Ecem Kaya-Sezginer ◽  
Didem Yilmaz-Oral ◽  
Serap Gur
Keyword(s):  
Metabolic Syndrome ◽  
Basic Science ◽  
Scientific Evidence ◽  
Therapeutic Targets ◽  
Treatment Strategies ◽  
Holistic Approach ◽  
Urogenital System ◽  
Science Literature ◽  
Definition Of

Background: Metabolic syndrome (MetS), as a cluster of metabolic derangements which are major risk factors for vascular disease is one of the most important threats to public health. Although the epidemiological and limited amount of basic science and clinical evidence link MetS to several male urogenital disorders, a holistic approach aiming to define common mechanistic pathways and new possible therapeutic targets are lacking. Objective: The current review has focused on providing scientific evidence on the role of MetS and its components on male urogenital disorders and the definition of new therapeutic targets. Method: In this review, current clinical and basic science literature were assessed examining the role of MetS in etiology and pathogenesis of male urogenital disorders and performed through PubMed from 2000 to May 2017. Results and Conclusion: MetS shows an important association with common male urogenital disorders such as benign prostatic enlargement, lower urinary tract symptoms, erectile dysfunction, infertility and renal disease. MetS affects male urogenital system mainly through endocrine and vascular mechanisms. Obesity, hypogonadism, obesity-induced androgen deficiency, hyperinsulinemia and inflammation are the mechanisms commonly involved and may act as potential targets for MetS-male urogenital system interrelations. Future studies are needed to evaluate the therapeutic approaches for intervention in MetS-male urogenital disease relations.

scholarly journals Drug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2878
Author(s):  
Claudia Maria Hattinger ◽  
Maria Pia Patrizio ◽  
Leonardo Fantoni ◽  
Chiara Casotti ◽  
Chiara Riganti ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Therapeutic Targets ◽  
Treatment Strategies ◽  
Cure Rate ◽  
Acquired Drug Resistance ◽  
Unselected Patient ◽  
Dismal Prognosis ◽  
Non Coding Rnas ◽  
High Grade Osteosarcoma

High-grade osteosarcoma (HGOS), the most common primary malignant tumor of bone, is a highly aggressive neoplasm with a cure rate of approximately 40–50% in unselected patient populations. The major clinical problems opposing the cure of HGOS are the presence of inherent or acquired drug resistance and the development of metastasis. Since the drugs used in first-line chemotherapy protocols for HGOS and clinical outcome have not significantly evolved in the past three decades, there is an urgent need for new therapeutic biomarkers and targeted treatment strategies, which may increase the currently available spectrum of cure modalities. Unresponsive or chemoresistant (refractory) HGOS patients usually encounter a dismal prognosis, mostly because therapeutic options and drugs effective for rescue treatments are scarce. Tailored treatments for different subgroups of HGOS patients stratified according to drug resistance-related biomarkers thus appear as an option that may improve this situation. This review explores drug resistance-related biomarkers, therapeutic targets and new candidate treatment strategies, which have emerged in HGOS. In addition to consolidated biomarkers, specific attention has been paid to the role of non-coding RNAs, tumor-derived extracellular vesicles, and cancer stem cells as contributors to drug resistance in HGOS, in order to highlight new candidate markers and therapeutic targets. The possible use of new non-conventional drugs to overcome the main mechanisms of drug resistance in HGOS are finally discussed.

scholarly journals KARAKALPAK STORIES CHRONICLES IN THE PERIOD OF INDEPENDENCE

2020 ◽  
Vol 3 (11) ◽  
pp. 61-63
Author(s):  
Ktaibekova Zulfiya Kengesbaevna
Keyword(s):  
Scientific Evidence ◽  
Definition Of ◽  
Scientific Ideas

The article examines the plot features of the Karakalpak stories. The role of the chronic plot in the construction of the story is discussed and a review of scientific opinions on the definition of the plot is made. Examples of stories entering into a chronic plot, scientific evidence are given. The author notes that the study of Karakalpak stories is of great practical and theoretical importance. The article explores the plot features of Karakalpak stories. He spoke about the role of the chronic plot in the construction of the story and analyzed the scientific ideas on the definition of the plot. Examples of the occurrence of stories in a chronic plot, scientific evidence are given. The author emphasizes the great practical and theoretical importance of researching Karakalpak stories.

scholarly journals ESG Indicators as Organizational Performance Goals: Do Rating Agencies Encourage a Holistic Approach?

2020 ◽  
Vol 12 (24) ◽  
pp. 10228
Author(s):  
Esmee M. Veenstra ◽  
Naomi Ellemers
Keyword(s):  
Organizational Performance ◽  
Holistic Approach ◽  
Performance Assessments ◽  
Organizational Sustainability ◽  
Social Domain ◽  
Rating Agencies ◽  
Sustainability Performance ◽  
Different Dimensions ◽  
Definition Of

Offering environmental, social, and governance (ESG) assessment and certification can invite organizations to adapt their activities to accommodate environmental, social, and governance concerns. Prior research points to shortcomings in accurately monitoring and assessing organizational sustainability performance. This contribution aims to highlight the role of ESG indicators as motivating organizations to prioritize sustainability goals. Theory and research elucidate that the definition of specific goals guides the degree of effort organizations invest, the priorities they set, and the persistence they display in pursuing targeted outcomes. The extent to which performance assessments of rating agencies specify and integrate ESG concerns thus impacts the likelihood that organizations will address each of these sustainability targets. The likely impact of ESG indicators was examined by consulting ratings, rankings, and indexes from 130 rating agencies included in the Reporting Exchange Platform. We identified and categorized 237 unique indicators in over 600 corporate ESG indicators. Results reveal that themes covered are less well specified in the governance domain than in the environmental and social domain. Further, different dimensions are emphasized depending on which stakeholder is addressed (investors, consumers, companies). Taken together, we conclude that this makes it more difficult for organizations to adopt a holistic approach to the achievement of sustainability goals.

scholarly journals The Pathogenic Role of Very Low Density Lipoprotein on Atrial Remodeling in the Metabolic Syndrome

2020 ◽  
Vol 21 (3) ◽  
pp. 891 ◽  
Author(s):  
Hsiang-Chun Lee ◽  
Yi-Hsiung Lin
Keyword(s):  
Metabolic Syndrome ◽  
Structural Changes ◽  
Scientific Evidence ◽  
Lipid Lowering ◽  
Atrial Remodeling ◽  
Lipid Lowering Therapy ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
The Metabolic Syndrome

Atrial fibrillation (AF) is the most common persistent arrhythmia, and can lead to systemic thromboembolism and heart failure. Aging and metabolic syndrome (MetS) are major risks for AF. One of the most important manifestations of MetS is dyslipidemia, but its correlation with AF is ambiguous in clinical observational studies. Although there is a paradoxical relationship between fasting cholesterol and AF incidence, the beneficial benefit from lipid lowering therapy in reduction of AF is significant. Here, we reviewed the health burden from AF and MetS, the association between two disease entities, and the metabolism of triglyceride, which is elevated in MetS. We also reviewed scientific evidence for the mechanistic links between very low density lipoproteins (VLDL), which primarily carry circulatory triglyceride, to atrial cardiomyopathy and development of AF. The effects of VLDL to atria suggesting pathogenic to atrial cardiomyopathy and AF include excess lipid accumulation, direct cytotoxicity, abbreviated action potentials, disturbed calcium regulation, delayed conduction velocities, modulated gap junctions, and sarcomere protein derangements. The electrical remodeling and structural changes in concert promote development of atrial cardiomyopathy in MetS and ultimately lead to vulnerability to AF. As VLDL plays a major role in lipid metabolism after meals (rather than fasting state), further human studies that focus on the effects/correlation of postprandial lipids to atrial remodeling are required to determine whether VLDL-targeted therapy can reduce MetS-related AF. On the basis of our scientific evidence, we propose a pivotal role of VLDL in MetS-related atrial cardiomyopathy and vulnerability to AF.

scholarly journals The Role of the Sociocultural Environment of Inclusion in the Modern Educational Institution

2021 ◽  
Vol 10 (3) ◽  
pp. 211
Author(s):  
Nadiia Chernukha ◽  
Mariana Mateeva Petrova ◽  
Maryna Vasylieva-Khalatnykova ◽  
Zoriana Krupnyk ◽  
Yuliia Krasilova
Keyword(s):  
Social Order ◽  
Educational Institution ◽  
Modern Society ◽  
Holistic Approach ◽  
Cultural Environment ◽  
Internal Factors ◽  
Sociocultural Environment ◽  
Definition Of ◽  
Conceptual Foundations

The article presents a consideration of the peculiarities of the organization of the socio-cultural environment of inclusion in a modern educational institution. The new conceptual foundations of social order, as stated in the UN Declaration on Social Development, are the ability of modern society to develop on the basis of tolerance, tolerance, condemnation of discrimination, respect for human diversity, equality of opportunity, solidarity and security. It is noted that the basis of such integration is the concept of a holistic approach, which opens the way to the realization of rights and opportunities for everyone and, above all, provides equal access to quality education. It is emphasized that the principle of accessibility, which is leading in the holistic approach of modern social policy and is formulated on the basis of respect for human rights. The aim of the article is to reveal the content of the socio-cultural environment of inclusion in a modern educational institution. The socio-cultural environment of inclusion in a modern educational institution is analyzed. Analysis of the definitions of socio-cultural environment allowed to form our own definition of the phenomenon for people with disabilities: socio-cultural environment - is the environment of people in the educational institution, including social groups, information flows, the influence of various public organizations, cultural and educational activities; jointly influence the change and formation of internal attitudes and external characteristics of the object and its socialization. The peculiarities of the socio-cultural environment of inclusion in a modern educational institution are determined. A model of the socio-cultural environment of an educational institution for a person with a disability has been developed and represented, which includes external and internal factors influencing its components, contribution flows and products.

scholarly journals Food for life, love and hope: an exemplar of the philosophy of palliative care in action

2004 ◽  
Vol 63 (3) ◽  
pp. 427-429 ◽  
Author(s):  
Katherine Hopkins
Keyword(s):  
Palliative Care ◽  
Health Care Professionals ◽  
Multidisciplinary Approach ◽  
Malignant Disease ◽  
Holistic Approach ◽  
World Health ◽  
Philosophical Approach ◽  
Philosophy Of Palliative Care ◽  
Definition Of

The World Health Organization's (1990) definition of palliative care describes an holistic approach to care for patients with advanced progressive illness. Issues relating to nutrition, lack of appetite and the subsequent weight loss the individuals may experience present a challenge to all concerned with providing both formal and informal care to this patient group. The philosophy of palliative care requires a multidisciplinary approach to the constellation of issues and problems related to food that are faced by both patients and carers in receipt of palliative care. The literature in this area is mainly related to those patients with a cancer diagnosis. The developing role of palliative care in patients with non-malignant disease provides further challenges for health care professionals. The present paper aims to reflect an entire philosophical approach to care through an examination of one area of practice.

scholarly journals Metabolic Syndrome or Insulin Resistance: Evolution, Controversies and Association With Cardiovascular Disease Risk

2020 ◽  
Vol 1 (2) ◽  
pp. 77-85
Author(s):  
Arun K. Chopra
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Atherogenic Dyslipidemia ◽  
Unique Role ◽  
Resistance Evolution ◽  
Definition Of

Metabolic syndrome is a clinical entity characterized by abdominal obesity, atherogenic dyslipidemia, impaired glucose tolerance, and hypertension (HT). Despite various attempts at definition, the syndrome has remained mired in controversy over its components and utility. Insulin resistance and its association with risk of cardiovascular disease are discussed at length in this article. This review also discusses the controversies in the definition of this syndrome, the unique role of insulin resistance in its development, and the causes and implications of this clustering of risk factors characteristic to it, along with suggestions for a more comprehensive approach to this common problem.

scholarly journals Case Based Approach in Pharmacology: A Novel Approach

2014 ◽  
Vol 4 (1) ◽  
pp. 301-305 ◽  
Author(s):  
Indrajit Banerjee
Keyword(s):  
Basic Science ◽  
Teaching And Learning ◽  
Medical Curriculum ◽  
Holistic Approach ◽  
Clinical Approach ◽  
Novel Approach ◽  
Approach To Teaching ◽  
In The Beginning ◽  
Oriented Approach

Case Oriented approach in Pharmacology will be helpful to know/study all the basic science in an integrated manner. This approach is a better approach so that the medical student will get the clinical scenario in the beginning of the topic. It will be also be effective tool for the students to solve the problem based questions and also they will learn the role of the clinical pharmacology too. Thus case oriented approach in teaching pharmacology will make Pharmacology more interesting subject.  Recently based on certain evidences it was found out that basic science medical curriculum is based   on clinical approach in which pharmacology is one integrated component in a holistic approach to teaching and learning methodology. One major problem of teaching pharmacology is that a student doesn’t see patients in basic science teaching and learning method. This problem can be solved to some extent by this novel case oriented approach in Pharmacology.DOI: http://dx.doi.org/10.3126/nje.v4i1.10125 Nepal Journal of Epidemiology 2014;4 (1): 301-305

scholarly journals Understanding the complex pathophysiology of idiopathic intracranial hypertension and the evolving role of venous sinus stenting: a comprehensive review of the literature

2018 ◽  
Vol 45 (1) ◽  
pp. E10 ◽  
Author(s):  
Nisha Giridharan ◽  
Smruti K. Patel ◽  
Amanda Ojugbeli ◽  
Aria Nouri ◽  
Peyman Shirani ◽  
...  
Keyword(s):  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Clinical Symptoms ◽  
Treatment Strategies ◽  
Venous Sinus ◽  
Review Of The Literature ◽  
Optic Nerve Sheath Fenestration ◽  
Standard Management ◽  
Definition Of

Idiopathic intracranial hypertension (IIH) is a disease defined by elevated intracranial pressure without established etiology. Although there is now consensus on the definition of the disorder, its complex pathophysiology remains elusive. The most common clinical symptoms of IIH include headache and visual complaints. Many current theories regarding the etiology of IIH focus on increased secretion or decreased absorption of cerebrospinal fluid (CSF) and on cerebral venous outflow obstruction due to venous sinus stenosis. In addition, it has been postulated that obesity plays a role, given its prevalence in this population of patients. Several treatments, including optic nerve sheath fenestration, CSF diversion with ventriculoperitoneal or lumboperitoneal shunts, and more recently venous sinus stenting, have been described for medically refractory IIH. Despite the availability of these treatments, no guidelines or standard management algorithms exist for the treatment of this disorder. In this paper, the authors provide a review of the literature on IIH, its clinical presentation, pathophysiology, and evidence supporting treatment strategies, with a specific focus on the role of venous sinus stenting.

Medical and Legal Issues Raised by the Protz Decision Issued by the Pennsylvania Supreme Court

2017 ◽  
Vol 22 (4) ◽  
pp. 12-13
Author(s):  
LuAnn Haley ◽  
Marjorie Eskay-Auerbach
Keyword(s):  
Supreme Court ◽  
Scientific Evidence ◽  
Workers Compensation ◽  
Sixth Edition ◽  
Complex Concept ◽  
The Supreme Court ◽  
Compensation Claims ◽  
Recent Edition ◽  
Impairment Ratings ◽  
Definition Of

Abstract Pennsylvania adopted the impairment rating provisions described in the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) in 1996 as an exposure cap for employers seeking predictability and cost control in workers’ compensation claims. In 2017, the Supreme Court of Pennsylvania handed down the Protz decision, which held that requiring physicians to apply the methodology set forth in the most recent edition of the AMA Guides reflected an unconstitutional delegation of legislative power to the American Medical Association. The decision eliminates the impairment-rating evaluation (IRE) mechanism under which claimants were assigned an impairment rating under the most recent edition of the AMA Guides. The AMA Guides periodically are revised to include the most recent scientific evidence regarding impairment ratings, and the AMA Guides, Sixth Edition, acknowledges that impairment is a complex concept that is not yet defined in a way that readily permits an evidence-based definition of assessment. The AMA Guides should not be considered standards frozen in time simply to withstand future scrutiny by the courts; instead, workers’ compensation acts could state that when a new edition of the AMA Guides is published, the legislature shall review and consider adopting the new edition. It appears unlikely that the Protz decision will be followed in other jurisdictions: Challenges to using the AMA Guides in assessing workers’ compensation claims have been attempted in three states, and all attempts failed.

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