Pattern of calculated inflammation ratios as prognostic values in patients with colorectal cancer

2020 ◽  
Vol 23 ◽  
Author(s):  
Andra Cioca ◽  
Sorana D. Bolboac ◽  
Cristina Druga ◽  
Răzvan A. Cioca ◽  
Florin Grau ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Cirrhosis ◽  
Postoperative Complications ◽  
Ischemic Cardiomyopathy ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Age And Gender ◽  
Lymphocyte Ratio ◽  
And Gender ◽  
Regional Institute

Aim: In our study, we evaluated the prognostic value of four calculated inflammatory ratios in patients with colorectal cancer. Material and methods: A six years retrospective study was conducted on subjects admitted for colorectal cancer at "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology Cluj-Napoca, Romania, from January 2014 until September 2019. The medical charts of patients diagnosed with colorectal cancer were used as the source of raw data and for the calculation of four ratios (neutrophil-to-lymphocyte ratio-NLR, derived neutrophil-to-lymphocyte ratio-dNLR, platelet-to-lymphocyte ratio-PLR, and systemic immune-inflammation index-SII), considered as prognostic markers related to mortality in colorectal cancer. Results: One thousand six hundred and eighty-eight patients, with ages ranging from 17 to 98 years, were evaluated. NLR and dNLR displayed significantly higher values among patients who died (NLR: 4.2 for deceased vs. 3.4 for alive, Pvalue=0.0224; dNLR: 2.7 for deceased vs. 2.3 for alive, P-value=0.0566). Ischemic cardiomyopathy (odds ratio (OR)=2.70), liver cirrhosis (OR=7.84), postoperative complications (OR=2.39), and neutrophil-to-lymphocyte ratio (OR=1.08) proved to be significant prognostic factors for the primary outcome, independent of age and gender. Conclusions: Patients with high NLR, postoperative complications, ischemic cardiomyopathy an d/or liver cirrhosis are the candidates to a less favorable outcome among subjects with colorectal cancer regardless the age and gender.

scholarly journals Is there a relationship between renal scarring and neutrophil-to-lymphocyte ratio in patients with vesicoureteral reflux?

2021 ◽  
Vol 93 (4) ◽  
pp. 436-440
Author(s):  
Mehmet Demir ◽  
İsmail Yağmur ◽  
Eyyup Sabri Pelit ◽  
Bülent Katı ◽  
Eser Ördek ◽  
...  
Keyword(s):  
Vesicoureteral Reflux ◽  
Lymphocyte Count ◽  
Renal Scarring ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet Volume ◽  
Age And Gender ◽  
Lymphocyte Ratio ◽  
Direct Damage ◽  
And Gender ◽  
The Relationship

Objectives: Vesicoureteral reflux (VUR) exacerbates the risk of renal scarring by establishing a ground for pyelonephritis. It is known that the inflammatory process is more influential than the direct damage caused by bacterial infection in the development of renal scars after pyelonephritis. Therefore, the present study aims to investigate the relationship between renal scarring and systemic inflammatory markers in patients with VUR.Material and methods: Hundred and ninety-two patients (116 females, 76 males) diagnosed with VUR were divided into two groups based on the presence or absence of renal scarring and into three groups according to the grade of VUR (low, moderate and high). Neutrophil count, lymphocyte count, mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) were compared among the groups.Results: Of the 192 patients, 102 had renal scarring. The age and gender distribution did not differ significantly between the groups with and without renal scarring (p > 0.05). However, the grade of reflux and lymphocyte count were significantly higher in the group with renal scarring (p < 0.05), and the NLR was significantly lower in the group with renal scarring (p < 0.05). The lymphocyte count was significantly higher (p < 0.05) and NLR was significantly lower in the high-grade VUR group (p < 0.05). However, MPV values did not differ significantly (p > 0.05) between the groups. Conclusions: NLR can be used to predict renal scarring in patients with VUR, especially in the period of 3-6 months after the first attack of infection, and may even serve as a candidate marker for treatment selection. However, larger series and prospective studies are needed.

scholarly journals The Relationships between Neutrophil/Lymphocyte Ratio and Child-Turcotte-Pugh Classification in Assessing Severity of Liver Cirrhosis

2019 ◽  
Vol 3 (1) ◽  
pp. 14-27
Author(s):  
Griselda Griselda ◽  
Kemas Ya'Kub Rahadiyanto ◽  
Rachmat Hidayat
Keyword(s):  
Liver Cirrhosis ◽  
Medical Records ◽  
High Morbidity ◽  
Substantial Agreement ◽  
Age And Gender ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Moderate Agreement ◽  
And Gender ◽  
Kappa Agreement

Background Liver cirrhosis is a disease with high morbidity and mortality in Indonesia. The Child-Turcotte-Pugh classification is a noninvasive parameter to assess severity of liver cirrhosis. Meanwhile, the neutrophil/lymphocyte ratio can reflect person's immunity to liver cirrhosis. This study was conducted to determine the agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in assessing severity of liver cirrhosis. Methods Analytical observational study with Cohen’s Kappa agreement test was conducted in 86 liver cirrhosis patients. Data was retrieved by observing the medical records. Neutrophil count, lymphocyte count, hepatic encephalopathy, ascites, albumin, bilirubin, and INR were all recorded. Documented variables were analyzed by the Cohen’s Kappa agreement test. Results In Cohen’s Kappa agreement test, there was moderate agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in all samples (κ = 0.591 and p <0.001). Agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification based on age and gender was found to be κ = 0.777 at age ≤45 years, κ = 0.532 at age >45 years, κ = 0.682 in male, and κ = 0.445 in female (p <0.001). The highest agreement is the substantial agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification obtained at age ≤45 years (κ = 0.777 and p <0.001) and male (κ = 0.682 and p <0.001). Conclusion There is moderate agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in assessing severity of liver cirrhosis. Substantial agreement obtained at age ≤45 years and male gender.   Keywords: Neutrophil/Lymphocyte Ratio, Child-Turcotte-Pugh, Liver Cirrhosis

scholarly journals Is there a relationship between renal scarring and neutrophil-to-lymphocyte ratio in patients with vesicoureteral reflux?

2021 ◽  
Author(s):  
Mehmet Demir ◽  
ismail yağmur ◽  
Bulent Kati ◽  
Eyyup Sabri Pelit ◽  
Eser Ördek ◽  
...  
Keyword(s):  
Vesicoureteral Reflux ◽  
Lymphocyte Count ◽  
Renal Scarring ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet Volume ◽  
Age And Gender ◽  
Lymphocyte Ratio ◽  
Direct Damage ◽  
And Gender ◽  
The Relationship

Aim: Vesicoureteral reflux (VUR) exacerbates the risk of renal scarring by establishing a ground for pyelonephritis. It is known that the inflammatory process is more influential than the direct damage caused by bacterial infection in the development of renal scars after pyelonephritis. Therefore, the present study aims to investigate the relationship between renal scarring and systemic inflammatory markers in patients with VUR. Methods: Hundred and ninety-two patients (116 girls, 76 boys) diagnosed with VUR were divided into two groups based on the presence or absence of renal scarring and into three groups according to the grade of VUR (low, moderate and high). Neutrophil count, lymphocyte count, mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) were compared among the groups. Results: Of the 192 patients, 102 had renal scarring. The age and gender distribution did not differ significantly between the groups with and without renal scarring (p > 0.05). However, the grade of reflux and lymphocyte count were significantly higher in the group with renal scarring (p < 0.05), and the NLR was significantly lower in the group with renal scarring (p < 0.05). The lymphocyte count was significantly higher (p <0.05) and NLR was significantly lower in the high-grade VUR group (p < 0.05). However, MPV values did not differ significantly (p > 0.05) between the groups. Conclusion: NLR can be used to predict renal scarring in patients with VUR and may even serve as a candidate marker for treatment selection. However, larger series and prospective studies are needed. Keywords: vesicoureteral reflux, neutrophil-to-lymphocyte ratio, pyelonephritis, renal scarring

Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively?

2012 ◽  
Vol 27 (10) ◽  
pp. 1347-1357 ◽  
Author(s):  
Sum-Fu Chiang ◽  
Hsin-Yuan Hung ◽  
Reiping Tang ◽  
Chung Rong Changchien ◽  
Jinn-Shiun Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Neutrophil To Lymphocyte Ratio ◽  
Curative Surgery ◽  
Lymphocyte Ratio ◽  
Colorectal Cancer Patients

Immature granulocyte and other hematological inflammatory parameters in patients with migraine headache

2021 ◽  
pp. 101-104
Keyword(s):  
Complete Blood Count ◽  
Control Group ◽  
Age And Gender ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Inflammatory Parameters ◽  
Group Data ◽  
Healthy Control ◽  
Immature Granulocyte ◽  
And Gender

Background: Today, many hypotheses have been proposed in the pathogenesis of migraine. The inflammatory hypothesis is one of them. The immature granulocyte count (IGC) is also an inflammatory parameter which importance has been understood recently. There are no studies evaluating IGC in migraine. The aim of the study to investigate the levels of IGC and other hematological inflammatory parameters in migraine. Material and Method: Materials and Methods: Forty-eight patients diagnosed with migraine who applied to Kastamonu Training and Research Hospital Neurology outpatient clinic between 07.01.2020 and 10.01.2021 were included in the study. 42 people with similar age and gender distribution were included for the control group. Data on laboratory tests, age and gender of patients were obtained from the hospital Laboratory Information System (LIS). CBC parameters of the patients at the first admission and before any treatment, calculated with an automated hematological analyzer (XN-1000-Hematology-analyzer-Sysmex Corporation, Japan) were analyzed. Using Complete Blood Count (CBC) data, neutrophil count (NEUT#), neutrophil percentage (NEUT%), lymphocyte percentage (LYMPH%), and IGC were recorded. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune inflammation index (SII) values were calculated with the formula. Results: In our study, NLR and IGC was significantly higher than the healthy control group (p=0.002, p=0.025). PLR was also found to be high, but it was not statistically significant (p=0.063). Conclusion: The significantly higher NLR and IGC levels in migraine patients compared to the healthy controls support the role of inflammation in etiopathogenesis.

Pengaruh Ekstrak Daun Moringa Oleifera terhadap Mean Platelet Volume dan Neutrophil-To-Lymphocyte Ratio pada Pasien Autoimun

2021 ◽  
Vol 6 (1) ◽  
pp. 355
Author(s):  
Nurhasan Agung Prabowo ◽  
Arief Nurudhin
Keyword(s):  
Rheumatoid Arthritis ◽  
Mean Platelet Volume ◽  
Moringa Oleifera ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Platelet Volume ◽  
Lymphocyte Ratio

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak MO terhadap MVP dan NLR pada pasien autoimun. Metode penelitian yang digunakan adalah eksperimental yang dilakukan pada 30 pasien autoimun yang terdiri dari 28 pasien lupus dan 2 pasien rheumatoid arthritis di Poliklinik Reumatologi RSUD Moewardi pada Januari-Juli 2020. Pasien dikelompokkan menjadi dua, yaitu kelompok perlakuan dan kontrol. Pasien kelompok perlakuan mendapat 2gram ekstrak MO per hari, sedangkan pada kelompok kontrol mendapat plasebo. Perlakuan dilakukan selama 4 minggu, Pemeriksaan MPV dan NLR menggunakan haemositometer. Analisis statistik dilakukan dengan menggunakan uji-T berpasangan dan uji-T independen. Nilai p dianggap signifikan ketika p <0,05. Hasil penelitian menunjukkan bahwa MO menurunkan MPV (delta MPV = 4.141; r = 0.656; p = 0.02) dan NLR (delta NLR = 4.1391; r 0.489; p-value = 0.04). dapat disimpulkan MO menurunkan MPV dan NLR pada pasien autoimun.

scholarly journals Profile of Colorectal Tumor in Gastroentero-Hepatology Center, Department of Internal Medicine, Dr Soetomo Hospital, Surabaya

2020 ◽  
Vol 56 (1) ◽  
pp. 15
Author(s):  
Husin Thamrin ◽  
Khafidhotul Ilmiah ◽  
Ni Wajan Tirthaningsih
Keyword(s):  
Colorectal Cancer ◽  
Medical Records ◽  
Colorectal Tumor ◽  
Age And Gender ◽  
Male And Female ◽  
The Third ◽  
Common Cancer ◽  
Significant Difference ◽  
And Gender ◽  
Ethical Clearance

Colorectal cancer has became burden in the world.The latest study shows that colorectal cancer is the third most common cancer in men and second most common cancer in women globally. There are difference characteristic of epidemiology in every countries. Moreover, there is no study that represents epidemiology of colorectal cancer in Indonesia yet, especially in East Java. The aim of this study was to describe colorectal tumor profile by age and gender in Gastroentero-Hepatology Center, Dr Soetomo Hospital. This study has received a certificate of Ethical Clearance No.273/Panke.KKE/IV/2015, a descriptive retrospective study. We collected data using medical records, and patients who have been colonoscopy examination and suspected colorectal tumor were included. There were 201 patients, divided to 100 males and 101 females. The peak of incidence was on 51-60 years old group, but on the 31-40 years old incidence of colorectal tumor was increased. The youngest patient was 17 years old. And tumors are more likely develop in distal area, especially in rectum. This study shows a different characteristic profile of colorectal tumor, where tumor is developed at young people and there is no significant difference between male and female for the incidence.

scholarly journals Escherichia coli as uropathogen: antibiotic susceptibility profiling

2018 ◽  
Vol 7 (3) ◽  
pp. 433
Author(s):  
Anuja Jha ◽  
Manju Agrawal ◽  
Arvind Neral ◽  
Rajesh Hishikar ◽  
Basant Maheshwari
Keyword(s):  
Empirical Therapy ◽  
Resistance Pattern ◽  
P Value ◽  
Age And Gender ◽  
Exact Test ◽  
Significant Difference ◽  
Gender Based ◽  
And Gender ◽  
Tract Infections ◽  
Uncomplicated Cystitis

Background: Empirically chosen antibiotics based on the local resistance pattern of uropathogens remain the principle treatment of urinary tract infections (UTI).Methods: Antibiogram of most frequent uropathogen was determined. Based on the antibiogram result, authors compared effectiveness of drugs recommended for UTI by National centre for disease control (NCDC), India, and assessed age and gender based variability in the effectiveness of these drugs.Results: 1278 urine samples were accounted, of which 405 samples showed significant growth. E. coli was the most common uropathogen (n=146, 36%) followed by enterococcus species (31%) and Klebsiella pneumoniae (10%). Using McNemar’s test authors found that nitrofurantoin (90% sensitivity) was statistically the most effective drug among drugs recommended by NCDC for uncomplicated cystitis. Furthermore, authors used Fisher’s exact test on adults and paediatrics and found that significant difference in effectiveness was observed for nitrofurantoin (p-value <0.001) and cotrimoxazole (p-value 0.034). Using logistic regression, authors found that with age, effectiveness of ciprofloxacin and cotrimoxazole deteriorate significantly (p-value 0.021 and 0.002 respectively). Additionally, authors observed that cotrimoxazole has significantly better efficacy in males compared to females (p-value 0.022).Conclusions: In accordance with present study, nitrofurantoin can be used as first line treatment for uncomplicated cystitis. Age and gender should be considered while prescribing empirical treatment for UTI. Periodic surveillance should be carried out to identify the on-going pattern of antibiogram to update the guideline for empirical therapy.

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