Melatonin Modulates Lactation by Regulating Prolactin Secretion Via Tuberoinfundibular Dopaminergic Neurons in the Hypothalamus- Pituitary System

2020 ◽  
Vol 21 (8) ◽  
pp. 744-750 ◽  
Author(s):  
Hongyang Li ◽  
JingyaWei ◽  
Fengtao Ma ◽  
Qiang Shan ◽  
Duo Gao ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Pituitary Gland ◽  
Antioxidant Capacity ◽  
Dopaminergic Neurons ◽  
Growth And Development ◽  
Endocrine System ◽  
Mammary Glands ◽  
Prolactin Secretion ◽  
The Body ◽  
Stimulation Of

In-depth studies have identified many hormones important for controlling mammary growth and maintaining lactation. One of these is melatonin, which is synthesized and secreted by the pineal gland to regulate circadian rhythms, improve antioxidant capacity, and enhance immunity. Prolactin is secreted by the pituitary gland and is associated with the growth and development of mammary glands as well as initiation and maintenance of lactation. The hypothalamus-pituitary system, the most important endocrine system in the body, regulates prolactin secretion mainly through dopamine released from tuberoinfundibular dopaminergic neurons. This review provides a reference for further study and describes the regulation of lactation and prolactin secretion by melatonin, primarily via the protection and stimulation of tuberoinfundibular dopaminergic neurons.

2. How hormones work

2014 ◽  
pp. 16-23
Author(s):  
Martin Luck
Keyword(s):  
Nervous System ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Endocrine System ◽  
The Body ◽  
The Other ◽  
Chemical Signal ◽  
Physiological Control ◽  
Working Together ◽  
External Events

What is a hormone? ‘How hormones work’ defines a hormone as a chemical signal which enables an event in one part of the body to have an effect somewhere else. Hormones make up one of the two great physiological control systems—the other being the nervous system—which keep the functions of the body working together. There are strong, multifunctional connections between the nervous and endocrine systems. As well as only operating inside the body, hormones are affected by internal stimuli and by external events detected by the senses. The endocrine system comprises several interlinked sub-systems, including five main axes centred on the hypothalamic and anterior pituitary gland. The processes of hormone transport and action through these systems are described.

SENSITIVITY OF ANTERIOR HYPOTHALAMIC AREAS TO GONADAL STEROID IMPLANTATION IN ANDROGENIZED FEMALE RATS

1977 ◽  
Vol 74 (2) ◽  
pp. 315-NP ◽  
Author(s):  
A. DANGUY ◽  
J. L. PASTEELS ◽  
F. ECTORS
Keyword(s):  
Single Injection ◽  
Mammary Glands ◽  
Prolactin Secretion ◽  
Female Rats ◽  
Male Rats ◽  
Control Synthesis ◽  
Normal Female ◽  
Immunofluorescence Studies ◽  
Oestradiol Benzoate ◽  
Stimulation Of

A single injection of 1 mg of a complex of testosterone esters on day 5 of life was used to prepare constantly oestrous rats. Such androgenized female rats were then ovariectomized and submitted to stereotaxical implantation of 1 μg oestradiol benzoate, 5 μg testosterone isobutyrate or, as a control, 10 μg cholesterol in the anterior hypothalamic areas. The effects of the steroids on plasma and pituitary FSH and LH were assessed by radioimmunoassay. As reported previously by us in normal female and male rats, the preoptic–suprachiasmatic area (POA) was able to control synthesis and secretion of both gonadotrophins and did not lose its sensitivity to oestradiol and testosterone in androgenized rats. Evidence for enhanced prolactin secretion in androgenized rats was derived from immunofluorescence studies of the pituitary gland and from histology of the mammary glands. In this respect the condition of the androgenized females was opposite to that of the males. The present work demonstrated that stimulation of prolactin secretion in androgenized female rats resulted from oestrogen action due to permanent oestrus rather than from impairment of hypothalamo-hypophysial relationships. Indeed, prolactin stimulation was suppressed when the androgenized rats were ovariectomized and restored when they were subsequently implanted with oestradiol in the POA.

scholarly journals Anatomical identification of the neuroendocrine system in the Nothobranchius furzeri brain

2020 ◽  
Author(s):  
Eunjeong Do ◽  
Yumi Kim
Keyword(s):  
Pineal Gland ◽  
Pituitary Gland ◽  
Three Dimensional ◽  
Endocrine System ◽  
Neuroendocrine System ◽  
Main Body ◽  
Nothobranchius Furzeri ◽  
Pituitary Glands ◽  
Basic Features ◽  
The Brain

AbstractThe hypophysis functions as a central gland of the neuroendocrine system for regulating fundamental body physiology. Upon aging, several hormones produced by the endocrine system are dramatically altered. Recently, Nothobranchius furzeri (the turquoise killifish) has become a popular model for aging studies because of its short lifespan and highly conserved aging phenotypes. However, the anatomical details of the major neuroendocrine system of the killifish have not been investigated so far. In this study, we have identified the pituitary and pineal glands of the turquoise killifish, which are critical components of the brain endocrine system. These two neuroendocrine glands were weakly attached to the main body of the killifish brain. The pineal gland was located on the dorsal part of the brain, while the pituitary gland was located on the ventral part. Brain sections containing pineal and pituitary glands were performed and revealed that cells in both the pituitary and pineal glands are densely placed than any other regions of brain. Further, three-dimensional images both in pineal and pituitary glands were uncovered their distinctive cellular arrangements. Vasopressin intestinal peptide (VIP) was strongly expressed in the neurohypophysis of the pituitary gland. Glial cells were found inside the pineal gland, while astrocytes covered the outside. These findings illustrate basic features of the neuroendocrine system of Nothobranchius furzeri.

Patterns of progesterone, melatonin and prolactin secretion in ewes maintained in four different photoperiods

1983 ◽  
Vol 97 (2) ◽  
pp. 229-242 ◽  
Author(s):  
D. J. Kennaway ◽  
L. M. Sanford ◽  
B. Godfrey ◽  
H. G. Friesen
Keyword(s):  
Pineal Gland ◽  
Endocrine System ◽  
Prolactin Secretion ◽  
Constant Light ◽  
Ovarian Activity ◽  
Dark Phase ◽  
Melatonin Secretion ◽  
Night Time ◽  
Serum Progesterone ◽  
Natural Photoperiod

Twenty-four-hour patterns of serum melatonin and prolactin levels were determined in ewes on nine occasions during a year. The sheep were maintained in four different photoperiods: room 1, simulated natural photoperiod; room 2, normal daylength extremes twice in 12 months, changes occurring in a regular fashion; room 3, alternating long (16 h) and short (8 h) days for 90 days; room 4, constant light. Cyclic ovarian activity, determined by twice-weekly determinations of serum progesterone, commenced in rooms 1, 2 and 3 after a transition from long to short daylength and terminated during long daylength. Thus in rooms 2 and 3 there were two periods of ovarian activity. In room 4 (constant light) ovarian activity began earlier than in room 1 and was of greater duration (240 days v. 190 days). Basal prolactin levels were highest (50–134 μg/l) during periods of long daylength and lowest (< 10 μ/l) in short daylength. Ewes maintained in constant light had an intermediate level (21–62 μg/l) throughout the study. Melatonin secretion was lowest during daylight (< 78 pmol/l) and highest during darkness. Night-time melatonin levels varied markedly from hour to hour and between individuals in rooms 1, 2 and 3. There was, however, no consistent seasonal change in the absolute levels of melatonin, although the duration of melatonin secretion did closely follow the length of the dark phase. There were no significant changes in melatonin levels during the oestrous cycle. Ewes kept in constant light had < 78 pmol melatonin/l throughout the period of study. If the pineal gland is involved in transmitting photoperiodic information to the endocrine system, then it is most likely to be by means of an interaction between duration of melatonin secretion and an underlying change in sensitivity of end organs to melatonin.

scholarly journals Transcriptomic changes throughout post-hatch development in Gallus gallus pituitary

2017 ◽  
Vol 58 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Elizabeth M Pritchett ◽  
Susan J Lamont ◽  
Carl J Schmidt
Keyword(s):  
Nervous System ◽  
Pituitary Gland ◽  
Nervous Tissue ◽  
System Development ◽  
Endocrine System ◽  
Tissue Expression ◽  
Nervous System Development ◽  
The Body ◽  
Tissue Development ◽  
Time Points

The pituitary gland is a neuroendocrine organ that works closely with the hypothalamus to affect multiple processes within the body including the stress response, metabolism, growth and immune function. Relative tissue expression (rEx) is a transcriptome analysis method that compares the genes expressed in a particular tissue to the genes expressed in all other tissues with available data. Using rEx, the aim of this study was to identify genes that are uniquely or more abundantly expressed in the pituitary when compared to all other collected chicken tissues. We applied rEx to define genes enriched in the chicken pituitaries at days 21, 22 and 42 post-hatch. rEx analysis identified 25 genes shared between all time points, 295 genes shared between days 21 and 22 and 407 genes unique to day 42. The 25 genes shared by all time points are involved in morphogenesis and general nervous tissue development. The 295 shared genes between days 21 and 22 are involved in neurogenesis and nervous system development and differentiation. The 407 unique day 42 genes are involved in pituitary development, endocrine system development and other hormonally related gene ontology terms. Overall, rEx analysis indicates a focus on nervous system/tissue development at days 21 and 22. By day 42, in addition to nervous tissue development, there is expression of genes involved in the endocrine system, possibly for maturation and preparation for reproduction. This study defines the transcriptome of the chicken pituitary gland and aids in understanding the expressed genes critical to its function and maturation.

scholarly journals Features of pubertas of young egg chickens when grown under monochromatic and white lighting

2020 ◽  
pp. 144-150
Author(s):  
I. V. Siianova ◽  
T. V. Kruchinkina
Keyword(s):  
Pineal Gland ◽  
Pituitary Gland ◽  
Spectral Composition ◽  
Live Weight ◽  
The Body ◽  
Light Sources ◽  
Fluorescent Lamps ◽  
Absolute Mass ◽  
The Absolute ◽  
Different Color

The work was carried out in the Amur region at the Belogorsk poultry farm. In the period from 2015 to 2019, five experiments were carried out taking into account the seasonality. The aim of the study was to identify the influence of the spectral composition of light sources on the pubertation of replacement young egg chickens at the age of 15 weeks: the development of the pineal gland, pituitary gland and genital organs of the youngs. The study on replacement young egg crosses of Hisex White and Decalb White chickens was carried out. In the breeding workshop, four groups of day-old chickens were formed, 200 heads each. From one day of age to 15 weeks, young birds were kept under light of different colors in conditions of gradually decreasing daylight hours from 24 to 12 hours a day and an illumination level from 50-30 to 7-6 lux. White, yellow, green and blue compact fluorescent lamps were used as light sources. In young birds at the age of 30, 60 and 90 days, the live weight was determined by weighing 100 heads from each group. A 15-week-old bird was bled for β-estradiol content at a random selection of 30 birds from each group. For anatomical examination, 5 pullets from each group were sacrificed at the age of 15 weeks, taking into account the body weight required by the norm. The absolute mass of the pineal gland, pituitary gland, ovary, oviduct was determined in the bird, the length of the oviduct was measured. Regardless of the season of the year, the live weight of 90-day-old young in groups under white and yellow illumination had the upper values of the norm, with green and blue it could be at its lower border. Under white and yellow illumination, pullets at 15 weeks of age have higher serum β-estradiol levels. At anatomical examination in 15-week-old chickens under white and yellow lamps, the absolute mass of the pineal gland is less by 10.5 - 41.7% than under green and blue ones, and the mass of the pituitary gland, on the contrary, is more by 4.8 - 8.3%. Pullets with different color illumination did not have significant differences in the mass of the ovary and oviduct, as well as the length of the oviduct, the level of development of which corresponded to a given age. Under white and yellow lighting, the first signs of the onset of puberty at 15 weeks of age are slightly more pronounced than under green and blue light sources.

Endocrine and Metabolic Systems

2020 ◽  
Author(s):  
Suwarna Anand
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Growth And Development ◽  
Endocrine System ◽  
Keywords Diabetes Mellitus ◽  
The Body ◽  
Keywords Diabetes ◽  
Metabolic Systems ◽  
Other Substances ◽  
Growth Development

The endocrine system and the nervous system work in synchrony to maintain homeostasis in the body. Growth, development, reproduction, blood pressure, concentrations of ions and other substances in blood, and even behavior are all regulated by the endocrine system. Endocrine physiology involves the secretion of hormones and their subsequent actions on target tissues. The present overview focuses on the endocrine physiology and the pathophysiologic states that influence the growth and development of an individual. This review contains 11 tables, and 27 references. Keywords: diabetes mellitus, thyroid, parathyroid hormone, hypoparathyroid, hypothalamus, pituitary, adrenal gland, carbohydrate metabolism, protein, lipids

The Role of Polyphenols in the Modulation of Plasma Non-Enzymatic Antioxidant Capacity (NEAC)

2012 ◽  
Vol 82 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Mauro Serafini ◽  
Giuseppa Morabito
Keyword(s):  
Antioxidant Capacity ◽  
Dietary Intervention ◽  
Ex Vivo ◽  
The Body ◽  
Dietary Polyphenols ◽  
Enzymatic Antioxidant ◽  
Endogenous Antioxidant

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist

2019 ◽  
Vol 1 (9) ◽  
pp. 38-46
Author(s):  
A. P. Babkin ◽  
A. A. Zuikova ◽  
O. N. Krasnorutskaya ◽  
Yu. A. Kotova ◽  
D. Yu. Bugrimov ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Pharmacological Action ◽  
The Body ◽  
Natural Resistance ◽  
Acute Respiratory Diseases ◽  
T Helpers ◽  
T Killers ◽  
Stimulation Of

The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in the epithelial component of antiviral protection of the body. Based on the above, the study of the clinical efficacy of Derinat® in the form of spray in the treatment of acute respiratory viral infections is relevant.

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