Bone Degeneration, Inflammation and Secondary Complications of Arthritis: Potential Targets and their Natural Inhibitors

SummaryThe risk of thromboembolic events (TE) is increased by acquired or inherited thrombo -philias (IT). We know that some hormonal contraceptives also increase the risk of thrombosis, thus, the use of such contraceptives are discussed as contraindications in women with IT. TEs are infrequent events in children and adolescents and in the majority of cases are associated with secondary complications from underlying chronic illness. Although adolescents are not typically considered to be at high-risk for TE, this cohort is frequently using hormonal contraception, leading to an increased risk in cases with unknown IT. The risk of TE with pregnancy alone is higher than associated with combined hormonal contra -ception. Progestin-only methods have not been found to increase the risk of TE with only moderate changes of coagulation proteins compared to normal reference values. Conclusion: Thrombophilic women are good candidates for progestin-only contraceptive methods.

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Successful in silico discovery of natural inhibitors for human rhinovirus coat protein

Planta Medica ◽

10.1055/s-2007-986891 ◽

2007 ◽

Vol 73 (09) ◽

Author(s):

JM Rollinger ◽

TM Steindl ◽

K Anrain ◽

EP Ellmerer ◽

M Schmidtke ◽

...

Keyword(s):

Coat Protein ◽

In Silico ◽

Human Rhinovirus ◽

Natural Inhibitors

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Aerobic Exercise Training in Stroke Rehabilitation: Any Gap in Knowledge

Nigerian Journal of Medical Rehabilitation ◽

10.34058/njmr.v18i1.111 ◽

2015 ◽

Author(s):

Tal-hatu Kolapo Hamzat ◽

Nelson Echezona Ekechukwu

Keyword(s):

Aerobic Exercise ◽

Methodological Quality ◽

Interval Training ◽

Aerobic Exercise Training ◽

Stroke Survivors ◽

Secondary Complications ◽

Stroke Outcomes ◽

Haematological Profile ◽

Cardio Respiratory Fitness

Background: Most stroke survivors live with residual physical impairments that may promote a sedentary lifestyle and resultant secondary complications, especially poor cardio-respiratory fitness. This systematic review was conceived to examine the extent of research on the effect of aerobic exercise on health outcomes of stroke survivors as a prelude to a clinical trial.Method: Electronic databases were searched with the last search performed in May, 2014. The methodological quality of studies was assessed using the PEDro scale. High-quality randomized controlled trials (RCTs) were considered level 1 evidence while lower-quality RCTs were considered level 2 evidence. Result: A total of 642 articles were generated from the search strategy; 10 articles fulfilled all criteria and were selected for this review. 50% of these studies recruited stroke survivors with ischaemic type of stroke while 30% had individuals with either ischaemic or haemorrhagic types. 70% of the studies had good scores while 30% had fair scores in methodological quality. The majority of the studies used VO2max as the outcome for assessing aerobic fitness; a few studies (10% each) assessed anthropometric outcomes and biochemical profile. No study assessed a haematological profile nor compared the effects of continuous and interval aerobic exercise on stroke outcomes. Conclusion: A gap in clinical trials on the effects of aerobic exercise on biochemical, haematological and anthropometric profiles of stroke survivors exists as well as in the comparative effects of continuous and interval training on stroke outcomes.

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Flavonoids as Potential Therapeutic Agents for the Management of Diabetic Neuropathy

Current Pharmaceutical Design ◽

10.2174/1381612826666200826164322 ◽

2020 ◽

Vol 26 (42) ◽

pp. 5468-5487 ◽

Cited By ~ 1

Author(s):

Ankita Sood ◽

Bimlesh Kumar ◽

Sachin Kumar Singh ◽

Pankaj Prashar ◽

Anamika Gautam ◽

...

Keyword(s):

Neuropathic Pain ◽

Diabetic Neuropathy ◽

Glucose Utilization ◽

Antioxidant Properties ◽

Therapeutic Agents ◽

Secondary Complications ◽

Naturally Occurring ◽

Glycation End Products ◽

Treatment Of Diabetes ◽

Pharmaceutical Industries

Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones, and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathways and leads to secondary complications such as neuropathy, retinopathy, nephropathy, and cardiomyopathy. Among them, the management of diabetic neuropathy is one of the major challenges for physicians as well as the pharmaceutical industries. Naturally occurring flavonoids are extensively used for the treatment of diabetes and its related complications due to their antioxidant properties. Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like the reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products, and inhibition of the α-glucosidase enzyme. This review entails current updates on the therapeutic perspectives of flavonoids in the treatment of neuropathic pain. This manuscript explains the pathological aspects of neuropathic pain, the chemistry of flavonoids, and their application in amelioration of neuropathic pain through preclinical studies either alone or in combination with other therapeutic agents.

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A case of milker’s nodules in Saskatchewan, Canada

SAGE Open Medical Case Reports ◽

10.1177/2050313x20984118 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2098411

Author(s):

Zoë C Phillips ◽

Karen I Holfeld ◽

Amanda LS Lang ◽

Lindsay D Richels

Keyword(s):

Secondary Complications

We present a case of milker’s nodules in a 41-year-old rancher from Saskatchewan, Canada, with secondary complications consisting of papular erythema and lymphadenopathy.

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A Comparative Analysis of Outcomes of Conventional Cold Dissection Versus Laser Tonsillectomy in Pediatric Cases in a Tertiary Care Hospital in Haryana

Indian Journal of Otolaryngology and Head & Neck Surgery ◽

10.1007/s12070-020-02301-1 ◽

2021 ◽

Author(s):

Amit Kumar ◽

Surender Kumar ◽

Anand Krishnan ◽

Manish Verma ◽

Uma Garg ◽

...

Keyword(s):

Operative Time ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Paediatric Population ◽

Care Hospital ◽

Secondary Complications ◽

Post Operative Pain ◽

Secondary Bleeding ◽

Paediatric Age ◽

Cold Dissection

AbstractTonsillectomy is one of the commonest ENT procedures done in paediatric population, the technique of which has evolved over years to decrease the morbidity associated with the surgery. This prospective randomized comparative study is done to evaluate the efficacy of two different techniques of this surgery, conventional cold dissection and laser tonsillectomy based on operative time, blood loss, post-operative pain and occurrence of secondary complications. The study was done in 68 patients of paediatric age group, 34 in each group underwent cold dissection and laser tonsillectomy. Operative time and bleeding were significantly low for laser group. Pain score was comparable in early post-operatives days, but was high towards the end of first week. Our study reported only one incidence of complication in the form of a secondary bleeding.

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Proposal of novel natural inhibitors of severe acute respiratory syndrome coronavirus 2 main protease: Molecular docking and ab initio fragment molecular orbital calculations

Biophysical Chemistry ◽

10.1016/j.bpc.2021.106608 ◽

2021 ◽

Vol 275 ◽

pp. 106608

Author(s):

Divya Shaji ◽

Shohei Yamamoto ◽

Ryosuke Saito ◽

Ryo Suzuki ◽

Shunya Nakamura ◽

...

Keyword(s):

Molecular Docking ◽

Severe Acute Respiratory Syndrome ◽

Ab Initio ◽

Molecular Orbital ◽

Molecular Orbital Calculations ◽

Fragment Molecular Orbital ◽

Main Protease ◽

Natural Inhibitors

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Natürliche Hemmstoffe von Keimung und Wachstum, I Ausarbeitung eines quantitativen Biotests und Anwendung auf Extrakte aus Spelzen von Avena sativa L. / Natural Inhibitors of Germination and Growth, I. Development of a Quantitative Biotest and Application upon Extracts from Husks of Avena sativa L.

Zeitschrift für Naturforschung C ◽

10.1515/znc-1982-0911 ◽

1982 ◽

Vol 37 (9) ◽

pp. 793-801 ◽

Cited By ~ 4

Author(s):

Rudolf Karl ◽

Wolfhart Rüdiger

Keyword(s):

Abscisic Acid ◽

Root Growth ◽

Organic Acids ◽

Avena Sativa ◽

Inhibitory Activity ◽

Lepidium Sativum ◽

Carbonic Acids ◽

Germination And Growth ◽

Natural Inhibitors ◽

Lepidium Sativum L

Extracts from oat husks inhibit germination of a variety of seeds including Avena sativa L., Sorghum spec., Phalleris spec., Raphanus spec., Amaranthus caudatus, Lepidium sativum L. A quantitative assay for this inhibition was developed on the basis of percentage of root growth of Avena in the presence of extracted material compared with root growth of water controls. Fractionation of the extracts revealed that about half of the total inhibitory activity was found in the fraction of free organic acids. The inhibition was not due to known inhibitors. Abscisic acid. was not found in this extract. Phenole carbonic acids were determined in the extract. Their concentration was too low to significantly contribute to the observed inhibitory activity.

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