scholarly journals Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis

2019 ◽  
Vol 16 (5) ◽  
pp. 386-399 ◽  
Author(s):  
Mert Ilhan ◽  
Fatma Tuğçe Gürağaç Dereli ◽  
Esra Küpeli Akkol
Keyword(s):  
Medicinal Plants ◽  
Drug Targets ◽  
Herbal Medicines ◽  
New Drugs ◽  
Medical Treatments ◽  
Traditional Medicines ◽  
Drug Molecules ◽  
Gynecological Disorders ◽  
Rational Therapy ◽  
Novel Drug

Endometriosis is a disease in which the lining of the endometrium is found outside of the uterus. Recent medical treatments for endometriosis have adverse effects, limiting their long-term use. Furthermore, the recurrence of the disease after the cessation of therapy is quite common, and most patients need to continue treatment to maintain a hypoestrogenic environment till conception. Notwithstanding recent advances in computational and chemical practices, traditional medicines are considered the most consistent sources for the discovery of new drugs. Numerous medicinal plants and plantderived compounds have been tested against gynecological disorders, mainly endometriosis. This review aimed to describe the pharmacological activity profile of the medicinal plants and their active ingredients and draw attention to the discovery of multitargeted drug molecules for rational therapy.

Traditional Herbs With Potential Wound Healing Properties

2022 ◽  
pp. 214-232
Author(s):  
Neelesh Babu ◽  
Ajeet Singh ◽  
Navneet
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Human Health ◽  
Healing Process ◽  
Herbal Medicines ◽  
Wound Healing Process ◽  
Traditional Medicines ◽  
Natural Remedies ◽  
Wide Zone

Medicinal plants have been necessary to conventional and non-customary types of prescriptions dating back to somewhere around 5000 years ago. Researchers progressively depend on current logical techniques and proof-based medication to demonstrate the viability of herbal medicines and spotlight on a better comprehension of the systems of their activity. Notwithstanding, data concerning quantitative human health advantages on natural remedies is yet uncommon, constraining their legitimate valuation. Traditional medicines are regularly utilized for the wound-healing process covering a wide zone of various skin-related infections. This chapter will give information about the wound-healing capability of plants that are useful for the advancement of new wound-healing formulations.

scholarly journals Antimycobacterial Potential of Indian Spices: A Review

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
Neha Chaudhary ◽  
Varsha Mehra ◽  
Payal Mago ◽  
Manisha Khatri
Keyword(s):  
Herbal Medicines ◽  
Antimycobacterial Activity ◽  
Review Article ◽  
Plant Part ◽  
New Drugs ◽  
Major Health Problem ◽  
Major Health ◽  
Traditional Medicines ◽  
Ancient Times ◽  
Considerable Morbidity

Natural products and their plant-derived analogs are often a source of drugs or drug templates with limited toxicity, which has the potential to mitigate compliance issues during protracted administration.Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) infection, represents a major health problem globally. Despite the introduction of inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen 40 years ago, TB continues to cause considerable morbidity and mortality worldwide. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. Since ancient times, different plant part extracts have been used as traditional medicines against diseases including tuberculosis. This knowledge may be useful in developing future powerful drugs. In this regard this review article is an attempt to investigate the antimycobacterial activity of the spices as an alternative and highlight them for further investigation as leads for drug development. The choice of spice as an alternative is based on two basic reasons: firstly, plants have been the model source of medicine since ancient times and secondly, the increasing acceptance of herbal medicines by general population.

Traditional Herbs With Potential Wound Healing Properties

2020 ◽  
pp. 177-199
Author(s):  
Neelesh Babu ◽  
Ajeet Singh ◽  
Navneet
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Human Health ◽  
Healing Process ◽  
Herbal Medicines ◽  
Wound Healing Process ◽  
Traditional Medicines ◽  
Natural Remedies ◽  
Wide Zone

Medicinal plants have been necessary to conventional and non-customary types of prescriptions dating back to somewhere around 5000 years ago. Researchers progressively depend on current logical techniques and proof-based medication to demonstrate the viability of herbal medicines and spotlight on a better comprehension of the systems of their activity. Notwithstanding, data concerning quantitative human health advantages on natural remedies is yet uncommon, constraining their legitimate valuation. Traditional medicines are regularly utilized for the wound-healing process covering a wide zone of various skin-related infections. This chapter will give information about the wound-healing capability of plants that are useful for the advancement of new wound-healing formulations.

scholarly journals An Ethnobotanical and Ethnomedicinal Investigation of Phytomedical Knowledge and Practice of Medicinal Plants in Lingchuan County, Shanxi, China

2021 ◽  
Author(s):  
Shan Jin ◽  
Shanshan Zhang ◽  
Nasir Shad ◽  
Abid Naeem ◽  
Yandeng Yang ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Herbal Medicines ◽  
New Drugs ◽  
Shanxi Province ◽  
Plant Resources ◽  
Plant Parts ◽  
Forsythia Suspensa ◽  
Use Values ◽  
Human Disorders ◽  
One Year

Abstract BackgroundLingchuan County is the main producing area of Chinese medicinal materials in Shanxi Province, rich in medicinal plant resources. The aboriginal residents of Lingchuan County have certain traditional knowledge and experience in the use of medicinal plants and can effectively use medicinal plants to treat common diseases. MethodologyA field survey in 53 villages was carried out over one year, i.e., November 2017—August 2018. Ethnomedicinal data was collected through designed questionaries/interviews by involving 180 informants familiar with medicinal plants utilization. Documented data were evaluated using the quantitative indices. ResultsA total of 138 traditional medicinal plants were investigated, belonging to 123 genera of 60 families. Among them, Asteraceae was the dominant plant family with 19 species. Roots were the most commonly used plant parts, and the dominant life form was herbs. Quantitative analysis revealed that Forsythia suspensa was with higher (0.33) RFC value, and Scutellaria baicalensis was recorded with higher (0.91) UV. Treated diseases were categorized in 12 groups and evaluated by their FIC value, in which gynecological diseases having higher (0.93) FIC value followed by urinary system diseases. The most medicinal plants are used to clear away heat and relieve the surface. At the same time, people use boiled water to use medicinal plants. Most of the plants investigated are non-toxic. ConclusionThis study reported traditional herbal medicines for the first time to be used against various disorders in Lingchuan County, China and are still practiced by the local communities. Some of the new ethnobotanical claims documented in this investigation should need to be further explored clinically. The medicinal plants with the highest use values recorded in this study may signpost the probable existence of valuable phytochemical compounds that requires a search for prospective new drugs to cure many human disorders.

scholarly journals Investigation of the Anti-TB Potential of Selected Phytochemicals of Nigella Sativa using Molecular Docking Approach

2021 ◽  
pp. 278-286
Author(s):  
Shabir Ahmad Mir
Keyword(s):  
Molecular Docking ◽  
Drug Targets ◽  
Nigella Sativa ◽  
New Drugs ◽  
Docking Score ◽  
Discovery Studio ◽  
Biological Studies ◽  
Docking Approach ◽  
Novel Drug

Background: Tuberculosis (TB) is one of the foremost causes of human mortality across the world. In general, it is a curable disease and several drugs are available in market for its treatment, however, because of the drug resistance to the currently available anti-TB drugs, the development and/or discovery of new drugs with better efficacy against TB cannot be overlooked. In the present study, we performed virtual screening of the major phytochemicals of the plant Nigella sativa for investigating their potential to inhibit some novel drug targets of Mycobacterium tuberculosis, which included- pantothenate kinase, type 1 (MtPanK), β-ketoacyl ACP synthase I (MtKasA), and decaprenylphosphoryl-β-D-ribose 2′-epimerase 1 (MtDprE1). Methods: The screening of the phytochemicals was investigated through a molecular docking approach using Auto dock vina and the molecular interactions in the protein-ligand complexes were visualized and analysed through PyMol and BioVia Discovery Studio Visualizer. Results: Our in silico observations reveal that, out of the nine selected phytochemicals screened, five compounds, namely α-hederin, dithymoquinone, nigellidine, thymoquinone and thymol binded to one or more of the selected target enzymes with significant docking scores. α-hederin binded to MtDprE1 and MtKasA with a docking score of −8.5kcal/mol and −7.9kcal/mol, respectively, dithymoquinone binded to MtKasA, MtDprE1 and MtPanK with a docking score of −6.5kcal/mol, −8.2kcal/mol and −9.2kcal/mol, respectively and nigellidine binded to MtDprE1 and MtPanK with a docking score of −8.1kcal/mol and −8.2kcal/mol, respectively. Further, thymol as well as thymoquinone were observed to bind MtKasA with a docking score of −6.6kcal/mol. Conclusions: The results of our study indicate that the five phytochemicals of N. sativa, including α-hederin, dithymoquinone, nigellidine, thymoquinone and thymol, are worth studying further for their anti-TB activity, however, additional biological studies are warranted to validate these findings.

A Brief Review on Herbal Medicines

2021 ◽  
pp. 101-102
Author(s):  
Vinod Matole ◽  
Yogesh Thorat ◽  
Shrishail Ghurghure ◽  
Suyash Ingle ◽  
Avinash Birajdar ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Traditional Medicine ◽  
Herbal Medicines ◽  
Herbal Remedies ◽  
Human History ◽  
Archaeological Evidence ◽  
Medical Treatments

Herbal medicine (also Herbalism) is the study of pharmacognosy and the use of medicinal plants. Plants have been the basis for medical treatments through most of human history, and such traditional medicine is still widely practiced today. Archaeological evidence indicates that the use of medicinal plants dates back to the Paleolithic age, approximately 60,000 years ago. Written evidence of herbal remedies dates back over 5,000 years to the Sumerians, who compiled lists of plants.

A Nanoinformatics Approach to Evaluate the Pharmacological Properties of Nanoparticles for the treatment of Alzheimer’s Disease

2021 ◽  
Vol 24 ◽  
Author(s):  
Muhammad Zohaib Nawaz ◽  
Syed Awais Attique ◽  
Qurat-ul-Ain ◽  
Fahdah Ayed Alshammari ◽  
Heba Waheeb Alhamdi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Carbon Nanotubes ◽  
Alzheimer's Disease ◽  
Nervous System ◽  
Drug Targets ◽  
Kinase Domain ◽  
New Drugs ◽  
Drug Candidates ◽  
Experimental Approaches ◽  
Novel Drug

Background: Alzheimer’s disease is a nervous system destructive disease which causes structural, biochemical and electrical abnormalities inside the human brain and results due to genetic and various environmental factors. Traditional therapeutic agents of Alzheimer’s disease such as tacrine and physostigmine has been found causing adverse effects to the nervous system and gastrointestinal tract. Nanomaterials like graphene, metals, carbon-nanotubes and metal-oxides are gaining attention as potential drugs against Alzheimer’s disease due to their properties such as large surface area which provides clinical efficiency, targeted drug designing and delivery. Objectives: Designing new drugs by using experimental approaches are time-consuming, tedious and laborious processes which also require advanced technologies. This study aims to identify the novel drug candidates against Alzheimer’s disease with no or less associated side effects using molecular docking approaches. Methods: In this study, we utilized nanoinformatics based approaches for evaluating the interaction properties of various nanomaterials and metal nanoparticles with the drug targets including TRKB kinase domain, EphA4 and histone deacetylase. Furthermore, drug-likeness of carbon nanotubes was confirmed through ADME analysis. Results: Carbon nanotubes, either single or double-walled in all the three-configuration including zigzag, chiral, and armchair forms are found to interact with the target receptors with varying affinities. Conclusion: This study provides a novel and clearer insights into the interaction properties and drug suitability of known putative nanoparticles as potential agents for the treatment of Alzheimer’s disease.

A Mini Review Medicinal plants with Antiviral properties against SARS-CoV-2

2021 ◽  
pp. 158-160
Author(s):  
Nagavamsidhar Muthyala
Keyword(s):  
Medicinal Plants ◽  
Drug Targets ◽  
Complementary Therapies ◽  
Basic Knowledge ◽  
Diverse Range ◽  
Important Target ◽  
Main Protease ◽  
Vaccine Treatment ◽  
Therapeutic Properties ◽  
Novel Drug

Background: The aim of the present project is to provide basic knowledge about the treatment of Coronavirus via medicinal plants. Coronavirus (COVID-19, SARS-CoV, and MERS-CoV) as a viral pneumonia causative agent, infects thousands of people worldwide. There is currently no specific medicine or vaccine available and it is considered a threat to develop effective novel drug or anti-coronavirus vaccine treatment. However, natural compounds to treat coronaviruses are the most alternative and complementary therapies due to their diverse range of biological and therapeutic properties. Coronaviruses have large viral RNA Genomes and are single-stranded positive-sense RNA viruses. The nsp10/nsp16 protein is an important target because it is essential for the virus to replicate, the papain-like protease (Nsp3), the main protease (Nsp5), the primary RNA-dependent RNA polymerase (Nsp12) are also attractive drug targets for this disease. The main aim of this review is gathering information about medicinal plants with antiviral properties from plant database.

scholarly journals Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Luara de Sousa Monteiro ◽  
Katherine Xavier Bastos ◽  
José Maria Barbosa-Filho ◽  
Petrônio Filgueiras de Athayde-Filho ◽  
Margareth de Fátima Formiga Melo Diniz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Medicinal Plants ◽  
Antitumor Activity ◽  
New Technologies ◽  
Herbal Medicines ◽  
Biologically Active ◽  
New Drugs ◽  
High Morbidity ◽  
Antitumor Potential ◽  
Living Organisms

Lung cancer is a disease with high morbidity and mortality rates. As a result, it is often associated with a significant amount of suffering and a general decrease in the quality of life. Herbal medicines are recognized as an attractive approach to lung cancer therapy with little side effects and are a major source of new drugs. The aim of this work was to review the medicinal plants and other living organisms with antitumor potential against lung cancer. The assays were conducted with animals and humans, and Lewis lung carcinoma was the most used experimental model. China, Japan, South Korea, and Ethiopia were the countries that most published studies of species with antitumor activity. Of the 38 plants evaluated, 27 demonstrated antitumor activity. In addition, six other living organisms were cited for antitumor activity against lung cancer. Mechanisms of action, combination with chemotherapeutic drugs, and new technologies to increase activity and reduce the toxicity of the treatment are discussed. This review was based on the NAPRALERT databank, Web of Science, and Chemical Abstracts. This work shows that natural products from plants continue to be a rich source of herbal medicines or biologically active compounds against cancer.

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