7,9,12b-Triazabenzo[a]aceanthrylen-8-one, the First Representative of a Novel Pentacyclic Ring System and its Biological Activities

2013 ◽  
Vol 10 (8) ◽  
pp. 568-572 ◽  
Author(s):  
Andreas Puzik ◽  
Franz Bracher
Keyword(s):  
Biological Activities ◽  
Ring System

Resolving the Mystery of Ring Opening in the Synthesis of Benzo[d][1, 3]oxazin-4-one and Quinazolin-4(3H)-one

2019 ◽  
Vol 16 (11) ◽  
pp. 898-905
Author(s):  
Harun Patel ◽  
Rahul Pawara ◽  
Sanjay Surana
Keyword(s):  
Characteristic Feature ◽  
Ring Opening ◽  
Biological Activities ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Time Saving ◽  
Fusion Strategy ◽  
Good Template ◽  
Lead Generation

Quinazoline is the six-membered heterocyclic ring system reported for its versatile biological activities. This characteristic feature of quinazoline makes it a good template for a lead generation library. Ring opening is one of the major concerns in the synthesis of quinazolin-4(3H)-one that results in diamide formation. Here, alternative fusion strategy is reported, which is a time-saving and costeffective method to overcome the ring opening problem associated with the synthesis of benzo[ d][1,3]oxazin-4-one and quinazolin-4(3H)-one.

Diversity-Oriented Synthetic Approaches for Furoindoline: A Review

2019 ◽  
Vol 16 (3) ◽  
pp. 342-368 ◽  
Author(s):  
Ramandeep Kaur ◽  
Yagyesh Kapoor ◽  
Sundeep K. Manjal ◽  
Ravindra K. Rawal ◽  
Kapil Kumar
Keyword(s):  
Rheumatoid Arthritis ◽  
Cancer Cachexia ◽  
Biological Activities ◽  
Ring System ◽  
Synthetic Methods ◽  
Structural Units ◽  
Current Article ◽  
Tetrahydropyranyl Ether ◽  
Synthetic Approaches ◽  
Synthetic Target

The furo [2,3-b] indoline ring system is one of the most important structural units in various natural products. It has been known to have inherent biological activities and is utilized as a synthetic target for a number of natural compounds; therefore, this has contributed to a great demand for the growth of synthetic methods for this ring system. Most important compounds with furoindoline ring system are physovenine, madindoline A and B and makomotindoline etc. These compounds are well known to exhibit biological activity against different diseases such as glaucoma, cancer, cachexia, Castleman’s disease, rheumatoid arthritis, etc. The current article focuses on various synthetic approaches for furoindoline containing compounds and essential furoindoline moiety, such as oxindole-5-O-tetrahydropyranyl ether route etc., and various other diastereoand enantio- controlled approach in a very concise way.

Triazole As Potent Anti-Cancer Agent- A Pharmacophoric Scaffold

2021 ◽  
Vol 17 ◽  
Author(s):  
Nidhi Kala ◽  
Kalpana Praveen Rahate
Keyword(s):  
Characteristic Feature ◽  
Biological Activities ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Review Article ◽  
Current Review ◽  
Anti Cancer ◽  
Good Template ◽  
Cancer Agent

: Triazole is the main five-membered Nitrogen-containing basic heterocyclic ring system reported for their biological activities and compounds with multiple pharmacophores, which fetch together acquaintance of a target with sympathetic types of the molecule that might interact with the target. In addition, healthy, adaptable, and scalable chemistry must be employed to achieve the task. This characteristic feature of triazole would make a good template for a lead cohort library. The current review article focuses on recent advancements in triazole moiety as an anti-cancer agent with their mechanism pathways of synthesized analogues.

scholarly journals Synthesis and Biological Activities of Some Pyrimidine Derivatives: A Review

2020 ◽  
Vol 36 (6) ◽  
pp. 1001-1015
Author(s):  
Nadia Ali Ahmed Elkanzi
Keyword(s):  
Nitrogen Atom ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Pyrimidine Derivatives ◽  
Pharmacological Activities ◽  
Cardiovascular Agents ◽  
Anti Hiv ◽  
Biological And Pharmacological Activities

Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine possess both biological and pharmacological activities, and defend as aromatic six heterocyclic with 1and 3 nitrogen atom in ring. Preparation of pyrimidine via different methods offer its importance in fields of medicinal chemistry and Chemistry. Pyrimidines and their derivatives act as anti-inflammatory, anti-malaria, anti-tumor, cardiovascular agents, anti-neoplastic, anti-tubercular, anti- HIV, diuretic ,anti-viral, anti-microbial, ,analgesic .This review give light up on biological and pharmacological activities of pyrimidine nucleus.

scholarly journals Which are major players, canonical or non-canonical strigolactones?

2017 ◽  
Author(s):  
Koichi Yoneyama ◽  
Xiaonan Xie ◽  
Kaori Yoneyama ◽  
Takaya Kisugi ◽  
Takahito Nomura ◽  
...  
Keyword(s):  
Zea Mays ◽  
Plant Species ◽  
Root Exudates ◽  
Biological Activities ◽  
Ring System ◽  
Host Recognition ◽  
Shoot Branching ◽  
Enol Ether ◽  
Avena Strigosa ◽  
Populus Spp

Strigolactones (SLs) can be classified into two structurally distinct groups: canonical and non-canonical SLs. Canonical SLs contain the ABCD ring system, and non-canonical SLs lack the A, B, or C ring but have the enol ether–D ring moiety which is essential for biological activities. The simplest non-canonical SL is the SL biosynthetic intermediate carlactone (CL). In plants, CL and its oxidized metabolites such as carlactonoic acid and methyl carlactonoate, are present in root and shoot tissues. In some plant species including black oat (Avena strigosa), sunflower (Helianthus annuus), and maize (Zea mays), non-canonical SLs are major germination stimulants in the root exudates. Various plant species such as tomato (Solanum lycopersicum) release carlactonoic acid, and poplar (Populus spp.) was found to exude methyl carlactonoate into the rhizosphere. These results suggest that both canonical and non-canonical SLs are active as host recognition signals in the rhizosphere. In contrast, limited distribution of canonical SLs in the plant kingdom and structure- and stereo-specific transportation of canonical SLs from roots to shoots suggest that plant hormones inhibiting shoot branching are not canonical SLs but are rather non-canonical SLs.

Synthesis of novel chromenones linked to 1,2,3-triazole ring system: Investigation of biological activities against Alzheimer’s disease

2017 ◽  
Vol 70 ◽  
pp. 86-93 ◽  
Author(s):  
Mina Saeedi ◽  
Maliheh Safavi ◽  
Elahe Karimpour-Razkenari ◽  
Mohammad Mahdavi ◽  
Najmeh Edraki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activities ◽  
Triazole Ring ◽  
Ring System

scholarly journals Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents

2009 ◽  
Vol 6 (4) ◽  
pp. 1133-1138 ◽  
Author(s):  
Niti Bhardwaj ◽  
S. K. Saraf ◽  
Pankaj Sharma ◽  
Pradeep Kumar
Keyword(s):  
Heterocyclic Compounds ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Reaction Scheme ◽  
Ring System ◽  
Indole Ring ◽  
Different Strains ◽  
Derivatives Of

1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activitiesetc. It is well known that the synthesis of heterocyclic compounds tend to contain multi-structure in a molecule. The ring formation involves the condensation reaction. The challenge is to develop the ring system by incorporating the indole nucleus into it through the proposed reaction scheme. There are two free positions for the substitution in the oxadiazole ring system. In this study, it was planned to incorporate the oxadiazole ring system into indole ring. Synthesis of derivatives of 1,3,4-oxadiazoles from different benzaldehydes Characterization of the synthesized compounds along with their antimicrobial activity on different strains.

scholarly journals Crystal structure of 1,1′-{(1E,1′E)-[4,4′-(9H-fluorene-9,9-diyl)bis(4,1-phenylene)]bis(azanylylidene)bis(methanylylidene)}bis(naphthalen-2-ol) dichlorobenzene monosolvate

2020 ◽  
Vol 76 (10) ◽  
pp. 1579-1581
Author(s):  
Ayalew Wodajo ◽  
Alexander G. Tskhovrebov ◽  
Tuan Anh Le ◽  
Alexey S. Kubasov ◽  
Maria M. Grishina ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Dihedral Angle ◽  
Biological Activities ◽  
Ring System ◽  
Enol Form ◽  
Class Iii ◽  
One Dimensional ◽  
Compound C ◽  
Centroid Distance ◽  
Π Stacking Interaction

The bis(anil) molecule of the title compound, C47H32N2O2·C6H4Cl2, contains two anil fragments in the enol–enol form, exhibiting intramolecular O—H...N hydrogen bonds. The two hydroxynaphthalene ring systems are approximately parallel to each other with a dihedral angle of 4.67 (8)° between them, and each ring system makes a large dihedral angle [55.11 (11) and 48.50 (10)°] with the adjacent benzene ring. In the crystal, the bis(anil) molecules form an inversion dimer by a pair of weak C—H...O interactions. The dimers arrange in a one-dimensional column along the b axis via another C—H...O interaction and a π–π stacking interaction between the hydroxynaphthalene ring system with a centroid–centroid distance of 3.6562 (16) Å. The solvent 1,2-dichlorobenzene molecules are located between the dimers and bind neighbouring columns by weak C—H...Cl interactions. Theoretical prediction of potential biological activities was performed, which suggested that the title anil compound can exhibit histone deacetylase SIRT2, histone deacetylase class III and histone deacetylase SIRT1 activities, and will act as inhibitor to aspulvinone dimethylallyltransferase, dehydro-L-gulonate decarboxylase and glutathione thiolesterase.

The effect of carbonyl on the isomerization of a galanthan ring system and total synthesis of (±)-β-lycorane

2021 ◽  
Vol 19 (12) ◽  
pp. 2767-2772
Author(s):  
Leilei Liang ◽  
Ji Li ◽  
Baochun Shen ◽  
Yili Zhang ◽  
Jianping Liu ◽  
...  
Keyword(s):  
Drug Development ◽  
Total Synthesis ◽  
Biological Activities ◽  
Ring System ◽  
Privileged Structures

Lycorine-type alkaloids are privileged structures in drug development due to their attractive biological activities.

Syntheses and biological activities of chemically stable prostacyclin mimics with cis-bicyclo[4.3.0]nonene ring system: The novel homoisocarbacyclin analogues

1993 ◽  
Vol 1 (2) ◽  
pp. 77-118 ◽  
Author(s):  
Sen-ichi Narita ◽  
Atsuo Takahashi ◽  
Tsuyoshi Aoki ◽  
Hiroyasu Sato ◽  
Shoji Satoh ◽  
...  
Keyword(s):  
Biological Activities ◽  
Ring System ◽  
The Novel
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