Synthesis and Biological Properties of Coumarin Analogue: A Brief Review

2021 ◽  
Vol 18 ◽  
Author(s):  
Diksha Chaudhary ◽  
Pooja Bedi ◽  
Soumava Santra ◽  
Tanay Pramanik
Keyword(s):  
Chemical Compound ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Drug Industry ◽  
Crystalline Solid ◽  
Organic Chemical ◽  
Laser Dyes ◽  
Physical Identity ◽  
Pechmann Condensation

: One of the most prominent aromatic organic chemical compound is Coumarin having formula C9H6O2 which is widely known for its benefits in drug industry. Colourless crystalline solid having sweet scent is coumarin’s physical identity. It serves various purposes such as in synthesis of medicines, laser dyes, perfumes and many more. Having enormous usages it becomes important to synthesize such compound so various reactions were performed in order to obtain coumarins. This review explicates the preparation of coumarin by Pechmann Condensation and its biological characteristics.

scholarly journals The influence of seasonal influenza viruses biological features on the effectiveness of development strains for live influenza vaccine

2019 ◽  
pp. 24-34
Author(s):  
N. V. Larionova ◽  
I. V. Kiseleva ◽  
E. A. Bazhenova ◽  
E. P. Grigorieva ◽  
L. G. Rudenko
Keyword(s):  
Influenza Vaccine ◽  
Vaccine Development ◽  
Molecular Genetic ◽  
Biological Properties ◽  
Influenza Viruses ◽  
Biological Characteristics ◽  
Phenotypic Properties ◽  
Hyperimmune Serum ◽  
Genetic Characteristics ◽  
Effective Development

Aim. Evaluation of the efficiency of the method of reassortant strains for live influenza vaccine development and ways to optimize it, taking into account the differences in the current epidemic influenza viruses by key biological characteristics.Materials and methods. Influenza viruses — candidates for seasonal LAIVs, MDVs for Russian LAIVs A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69. The vaccine strains development in developing chicken embryos included reassortment, selective passages at low temperature in the presence of hyperimmune serum to the MDV, several stages of reassortants cloning, their virological and molecular genetic characteristics. Epidemic influenza viruses and LAIVs strains were evaluated by their ability to reproduction at temperatures beyond optimal values, by sensitivity to serum inhibitors.Results. The assessment of phenotypic properties used in reassortment epidemic viruses is carried out. Presented the data on the efficiency of development reassortant strains for LAIV depending on the biological properties of circulating epidemic influenza viruses: their temperature-resistant, cold-sensitive phenotype, inhibitor resistance, and receptor specificity.Conclusion. Based on the assessment of the influence of the biological characteristics of the epidemic viruses, the rational methodological techniques for the most effective development of reassortants for LAIV are selected.

scholarly journals Features of the Biological Properties of Vibrio cholerae Isolated during the Monitoring of Water Bodies in Rostov-on-Don from 1989 to 2018

2021 ◽  
pp. 148-151
Author(s):  
M. I. Ezhova ◽  
D. А. Levchenkо ◽  
I. V. Arkhangelskaya ◽  
V. D. Kruglikov ◽  
N. B. Nepomnyashchaya
Keyword(s):  
Environmental Protection ◽  
Vibrio Cholerae ◽  
Statistical Methods ◽  
Direct Relationship ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Water Bodies ◽  
Environmental Objects ◽  
Toxigenic Strains ◽  
El Tor

The goal is to study the features of the biological properties of Vibrio cholerae strains found in environmental objects (EO) on the territory of Rostov-on-Don from 1989 to 2018.Materials and methods. Bacteriological, molecular biological and statistical methods were used to study 73 strains of cholera vibrios O1, O139 and 1702 strains of nonO1/nonO139 serogroups isolated over a 30-year period.Results and discussion. It was found that in Rostovon-Don, 78.0 % of toxigenic strains were isolated from all isolated from environmental protection in Russia, among which 2 were genetically unchanged. The V. cholerae O1 classical strain and 72 V. cholerae El Tor strains were found, of which 70 % belonged to the Ogawa serovar, and 3 % of the nontoxigenic strains were susceptible to the classical phage. A “very weak direct relationship” was statistically revealed between the isolation of V. cholerae O1, O139 and V. cholerae nonO1/nonO139 strains, in which the dominant serogroups (O67, O76, O75, O53, O16) were identified, and 18 % of the strains showed atypical agglutinability. Revealing the biological characteristics of V. cholerae strains contributes to the optimization of monitoring studies.

scholarly journals Bone Marrow Progenitor Cells Isolated from Young Rabbit Trochlea Are More Numerous and Exhibit Greater Clonogenic, Chondrogenic, and Osteogenic Potential than Cells Isolated from Condyles

Cartilage ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 378-390 ◽  
Author(s):  
Garima Dwivedi ◽  
Anik Chevrier ◽  
Caroline D. Hoemann ◽  
Michael D. Buschmann
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Cell Yield ◽  
Young Rabbit ◽  
Bone Marrow Progenitor

Objective. Bone marrow stimulation procedures initiate repair by fracturing or drilling subchondral bone at base of cartilaginous defect. Earlier studies have shown that defect location and animal age affect cartilage repair outcome, suggesting a strong influence of structural and biological characteristics of subchondral bone. Here, we analyzed comprehensive biological characteristics of bone marrow progenitor cells (BMPCs) in subchondral bone of young and old rabbit condyle and trochlea. We tested the hypothesis that in vitro biological properties of BMPCs are influenced by location, age of donor and method of their isolation. Design. In vitro biological properties, including cell yield, colony-forming unit fibroblasts (CFU-f), surface marker expression, and differentiation potential were determined. Comparisons were carried out between trochlea versus condyle and epiphyseal versus metaphyseal bone using old ( N = 5) and young animal knees ( N = 8) to generate collagenase and explant-derived BMPC cultures. Results. CFU-f, cell yield, expression of stem cell markers, and osteogenic differentiation were significantly superior for younger animals. Trochlear subchondral bone yielded the most progenitors with the highest clonogenic potential and cartilaginous matrix expression. Trochlear collagenase-derived BMPCs had higher clonogenic capacity than explant-derived ones. Epiphyseal cells generated a larger chondrogenic pellet mass than metaphyseal-derived BMPCs. All older pellet cultures and one non-responder young rabbit failed to accumulate glycosaminoglycans (GAGs). Conclusion. Taken together, these results suggest that properties intrinsic to subchondral progenitors could significantly influence cartilage repair potential, and could partly explain variability in cartilage repair outcomes using same cartilage repair approach.

Enhanced mechanical and biological characteristics of PLLA composites through surface grafting of oligolactide on magnesium hydroxide nanoparticles

2020 ◽  
Vol 8 (7) ◽  
pp. 2018-2030 ◽  
Author(s):  
Eun Young Kang ◽  
Sung-Bin Park ◽  
Bogyu Choi ◽  
Seung-Woon Baek ◽  
Kyoung-Won Ko ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Magnesium Hydroxide ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Surface Grafting ◽  
Surface Modified ◽  
Magnesium Hydroxide Nanoparticles

Surface-modified magnesium hydroxide (MH) was incorporated to not only improve physico-mechanical properties but also enhance biological properties of Poly(l-lactic acid) (PLLA) more effectively.

scholarly journals Decellularized Skin Extracellular Matrix (dsECM) Improves the Physical and Biological Properties of Fibrinogen Hydrogel for Skin Bioprinting Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1484 ◽  
Author(s):  
Adam M Jorgensen ◽  
Zishuai Chou ◽  
Gregory Gillispie ◽  
Sang Jin Lee ◽  
James J Yoo ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Human Skin ◽  
Structural Integrity ◽  
The United States ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Full Thickness ◽  
Healthy Human ◽  
Hybrid Hydrogel

Full-thickness skin wounds are a significant clinical burden in the United States. Skin bioprinting is a relatively new technology that is under investigation as a new treatment for full-thickness injuries, and development of hydrogels with strong physical and biological characteristics are required to improve both structural integrity of the printed constructs while allowing for a more normal extracellular matrix milieu. This project aims to evaluate the physical and biological characteristics of fibrinogen hydrogel supplemented with decellularized human skin-derived extracellular matrix (dsECM). The hybrid hydrogel improves the cell viability and structural strength of bioprinted skin constructs. Scanning electron microscopy demonstrates that the hybrid hydrogel is composed of both swelling bundles interlocked in a fibrin network, similar to healthy human skin. This hybrid hydrogel has improved rheological properties and shear thinning properties. Extrusion-based printing of the fibrinogen hydrogel + dsECM demonstrates significant improvement in crosshatch pore size. These findings suggest that incorporating the properties of dsECM and fibrinogen hydrogels will improve in vivo integration of the bioprinted skin constructs and support of healthy skin wound regeneration.

scholarly journals The study of the biological properties of structural analogues of sex steroids in order to create drugs

1997 ◽  
Vol 43 (4) ◽  
pp. 38-42 ◽  
Author(s):  
V. P. Fedotov
Keyword(s):  
Oral Contraceptive ◽  
Replacement Therapy ◽  
Sex Steroids ◽  
Chemical Structure ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Two Component ◽  
Structural Analogues ◽  
Pharmaceutical Institute

Biological properties of structural analogs of sex steroids are studied. Alteration of the chemical structure of sex steroids helped single out a number of potential drugs possessing anabolic, antitumor, and contraceptive effects. Some potent estrogens may be used for replacement therapy. The biological characteristics of nitroxy derivative of ethynylestradiol nistranol are described in detail. This agent is characterized by an extremely high contraception index (4.6 times higher than ethynylestradiol). A new Russian two-component oral contraceptive Nitrogest has been developed, with the gestagenic component acetomepregnol synthesized at the Research Chemical Pharmaceutical Institute and the estrogen nistranol replacing the traditional ethynylestradiol.

scholarly journals Synthesis and Antibacterial Activity of Novel 3-Hydroxy Benzoic Acid Hybrid Derivative [Part I]

2018 ◽  
pp. 369-374
Author(s):  
Maruti S. Satpute ◽  
Vijay D. Gangan ◽  
Indu Shastri
Keyword(s):  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Direct Action ◽  
Biological Properties ◽  
Chemotherapeutic Agents ◽  
Organic Chemical ◽  
Cell Disease ◽  
Drug Candidates ◽  
Derivatives Of ◽  
Hybrid Derivative

3-hydroxy benzoic acid is an organic chemical which can be obtained naturally as well as synthetically. The literature survey reveals its various biological properties viz. antimicrobial, antialgal, antimutagenic, antiestrogenic, hypoglycemic, anti-inflammatory, anti-platelet aggregating, nematicidal, antiviral, antioxidant etc. It is also reported to be used as preservative in many drugs, cosmetic products, pharmaceuticals, food and beverages. Some derivatives of 3-hydroxybenzoic acid are found to possess direct action on Hbs molecules, inhibit acetic acid induced oedema and used in management of sickle cell disease. It is also has wide applications in perfumery industries. In this paper, novel ester / hybrid derivative of 3- Hydroxy benzoic acid was synthesized and tested for its potential antibacterial activity. This combinatorial synthesis of novel 3-Hydroxy benzoic ester / hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

scholarly journals Ecotoxicological assessment of Zn, Cu and Ni based NPs contamination in Arenosols

2021 ◽  
Vol 18 (2) ◽  
pp. 143
Author(s):  
Sergey Kolesnikov ◽  
Аlena Timoshenko ◽  
Tatiana Minnikova ◽  
Tatiana Minkina ◽  
Vishnu D Rajput ◽  
...  
Keyword(s):  
Sandy Loam ◽  
Soil Condition ◽  
Inhibitory Effect ◽  
Biological Properties ◽  
Ecological Condition ◽  
Biological Characteristics ◽  
Biological Parameters ◽  
Negative Consequences ◽  
Ecotoxicological Assessment ◽  
Microbiological Characteristics

Nanoparticles are increasingly used in many industrial fields because of their special properties. In this context, several questions arise related to possible negative consequences associated with nanoparticle (NPs) entrance into the ecosystem.  The adsorption of NPs by soil can adversely influence its biological properties. In the present article, the influence of Cu, Zn, and Ni NPs on the biological characteristics of Arenosol is considered. Research aimed to study the effect of Cu, Zn, Ni NPs on the biological characteristics of sandy loam chernozem. Copper, Zn, and Ni NPs were added to the soil in concentrations of 100, 1,000, and 10,000 mg kg<sup>-1</sup>. The effect of NPs on the biological properties of Arenosol was evaluated after 10-day incubation. The biological indices of the ecological condition of the soil, including the germination of radish, the length of the roots, the bacteria population, <em>Azotobacter</em> sp. count, the catalase activity, and dehydrogenases were studied. As a result of this study, it was revealed that the degree of indices changes depending on the concentration of Cu, Zn, and Ni NPs in the Arenosols. Microbiological characteristics (bacteria population, and <em>Azotobacter</em> sp. count) and phytotoxic feature (length of roots and radish germination) properties were most sensitive to contamination compared to the enzyme activity of Arenosol. Based on the soil integral index of a biological state, the strongest inhibitory effect on biological parameters of Arenosols relative to the control was exerted by Cu NPs (lower than control by 48-72%), while the greatest stability in Arenosol was found for Ni NPs (lower than control by 30-55%). The studied biological parameters allow characterizing the severity of nanoparticle exposure on Arenosols. Early diagnostics of the severity of soil contamination by NPs can be successfully used to quickly assess their impact on the soil condition and prevent possible adverse consequences.

scholarly journals INTERMICROBIAL «SELF-NON-SELF» DISCRIMINATION IN «DOMINANT-ASSO-CIANT» PAIR OF PROBIOTIC STRAINS OF ESCHERICHIA COLI M-17 AND E.COLI LEGM-18

2016 ◽  
pp. 3-9
Author(s):  
O. V. Bukharin ◽  
N. B. Perunova ◽  
E. V. Ivanova ◽  
S. V. Andryuschenko
Keyword(s):  
Escherichia Coli ◽  
Pathogenicity Island ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Coliform Bacteria ◽  
E Coli ◽  
Growth Properties ◽  
Probiotic Strains ◽  
Antilysozyme Activity ◽  
Special Growth

Aim. To use earlier developed method of intermicrobial «self-non-self» discrimination in «dominant-associant» pair for the assessment of foreignness of probiotic cultures of Escherichia coli M-17 (with pathogenicity island) and E. coli LEGM-18 (without pathogenicity island). Materials and methods. As dominants reference and clinical strains of bifidobacteria were used in the work, cultures of E. coli M-17 and E. coli LEGM-18 were taken as associants, differing in the presence of genes which code colibactin. Detection of the phenomenon of microbial discrimination was conducted according to the developed algorithm (Bukharin O.V., Perunova N.B., 2011) based on the principle of metabolite induction as a result of preliminary coincubation of dominants (bifidobacteria) with supernatant of associants and the formation of feed back in «dominant-as-sociant» pair. Special growth properties, biofilm formation, and antilysozyme activity served as biological characteristics of investigated coliform bacteria. Results. Testing of E. coli M -17 culture revealed depression of biological properties under investigation and it was estimated as «non-self» possibly due to the presence of pathogenicity island whereas E. coli LEGM-18 (without this fragment) sharply strengthened its biological characteristics and was subjected to assessment as «self». Conclusion. Use of intermicrobial «self-non-self» discrimination in «dominant-associant» pair is promising as basic method when selecting probiotic strains and cultures for creation of new symbiotic compositions and is suitable for quality control of probiotic products.

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