Bioactive Flavonoids from Verbenaceae

2020 ◽  
Vol 17 (6) ◽  
pp. 754-766
Author(s):  
Kui-Wu Wang ◽  
Ting-Ting Zhang
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Structural Diversity ◽  
Plant Kingdom ◽  
Anti Oxidant ◽  
Anti Inflammatory

Flavonoids are widely distributed in the plant kingdom and possess a variety of biological activities, such as anti-oxidant, anti-inflammatory, and anti-viral activities. Due to the structural diversity and biological activity, flavonoid derivatives isolated from Verbenaceae family have received a lot of attention by the research scholars. In this paper, a total of 150 natural flavonoids isolated from Verbenaceae and their bioactivities were summarized.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

2020 ◽  
Vol 17 (9) ◽  
pp. 1102-1116
Author(s):  
Sudip Kumar Mandal ◽  
Utsab Debnath ◽  
Amresh Kumar ◽  
Sabu Thomas ◽  
Subhash Chandra Mandal ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Structural Diversity ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Anti Cancer ◽  
Drug Discovery Program ◽  
Anti Inflammatory ◽  
Family Based

Background and Introduction: Sesquiterpene lactones are a class of secondary metabolite that contains sesquiterpenoids and lactone ring as pharmacophore moiety. A large group of bioactive secondary metabolites such as phytopharmaceuticals belong to this category. From the Asteraceae family-based medicinal plants, more than 5,000 sesquiterpene lactones have been reported so far. Sesquiterpene lactone-based pharmacophore moieties hold promise for broad-spectrum biological activities against cancer, inflammation, parasitic, bacterial, fungal, viral infection and other functional disorders. Moreover, these moiety based phytocompounds have been highlighted with a new dimension in the natural drug discovery program worldwide after the 2015 Medicine Nobel Prize achieved by the Artemisinin researchers. Objective: These bitter substances often contain an α, β-unsaturated-γ-lactone as a major structural backbone, which in recent studies has been explored to be associated with anti-tumor, cytotoxic, and anti-inflammatory action. Recently, the use of sesquiterpene lactones as phytomedicine has been increased. This study will review the prospect of sesquiterpene lactones against inflammation and cancer. Methods: Hence, we emphasized on the different features of this moiety by incorporating its structural diversity on biological activities to explore structure-activity relationships (SAR) against inflammation and cancer. Results: How the dual mode of action such as anti-inflammatory and anti-cancer has been exhibitedby these phytopharmaceuticals will be forecasted in this study. Furthermore, the correlation of anti-inflammatory and anti-cancer activity executed by the sesquiterpene lactones for fruitful phytotherapy will also be revealed in the present review in the milieu of pharmacophore activity relation and pharmacodynamics study as well. Conclusion: So, these metabolites are paramount in phytopharmacological aspects. The present discussion on the future prospect of this moiety based on the reported literature could be a guide for anti-inflammatory and anti-cancer drug discovery programs for the upcoming researchers.

AN UPDATE ON THE SYNTHESIS OF BENZOXAZOLES

2017 ◽  
Vol 10 (10) ◽  
pp. 48 ◽  
Author(s):  
Jyothi M ◽  
Ramchander Merugu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Activity ◽  
Biological Activities ◽  
Starting Material ◽  
Bioactive Molecules ◽  
Living Systems ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Benzoxazoles being structurally similar to bases adenine and guanine interact with biomolecules present in living systems. These compounds possess antimicrobial, central nervous system activities, antihyperglycemic potentiating activity, analgesic, and anti-inflammatory activity. It can also be used as starting material for other bioactive molecules. Modifications in structure and the biological profiles of new generations of benzoxazoles were found to be more potent with enhanced biological activity. Considering all these, we have prepared this review and discussed the synthesis and biological activities of benzoxazoles.

scholarly journals Dittrichia Viscosa L. Greuter: Phytochemistry and Biological Activity

2008 ◽  
Vol 3 (11) ◽  
pp. 1934578X0800301
Author(s):  
Alejandro F. Barrero ◽  
M. Mar Herrador ◽  
Pilar Arteaga ◽  
Julieta V. Catalán
Keyword(s):  
Biological Activity ◽  
Mediterranean Region ◽  
Biological Activities ◽  
Dittrichia Viscosa ◽  
The Mediterranean ◽  
Anti Inflammatory

Dittrichia viscosa is a plant widely distributed in the Mediterranean region. This species and its components present a broad range of biological activities (for example, anti-inflammatory, antifungal, antiulcer, antiviral, antiparasitic), which are reviewed. Extracts of the species are particularly rich in terpenoids, in particular eudesmane acids, notably ilicic acid (45) and α-costic acid (44). Flavonoids are also abundant, especially during flowering.

scholarly journals Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5430
Author(s):  
Maria Elaine Araruna ◽  
Catarina Serafim ◽  
Edvaldo Alves Júnior ◽  
Clelia Hiruma-Lima ◽  
Margareth Diniz ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Biological Activities ◽  
Structural Diversity ◽  
Experimental Models ◽  
New Drugs ◽  
Inflammatory Activity ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Anti Inflammatory

Inflammatory bowel diseases (IBDs) refer to a group of disorders characterized by inflammation in the mucosa of the gastrointestinal tract, which mainly comprises Crohn’s disease (CD) and ulcerative colitis (UC). IBDs are characterized by inflammation of the intestinal mucosa, are highly debilitating, and are without a definitive cure. Their pathogenesis has not yet been fully elucidated; however, it is assumed that genetic, immunological, and environmental factors are involved. People affected by IBDs have relapses, and therapeutic regimens are not always able to keep symptoms in remission over the long term. Natural products emerge as an alternative for the development of new drugs; bioactive compounds are promising in the treatment of several disorders, among them those that affect the gastrointestinal tract, due to their wide structural diversity and biological activities. This review compiles 12 terpenes with intestinal anti-inflammatory activity evaluated in animal models and in vitro studies. The therapeutic approach to IBDs using terpenes acts basically to prevent oxidative stress, combat dysbiosis, restore intestinal permeability, and improve the inflammation process in different signaling pathways.

A Review: Therapeutic and Biological Activity of Benzothiazole Derivatives

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Suresh Choudhary ◽  
G Jeyabalan ◽  
Naresh Kalra
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
New Products ◽  
Therapeutic Agents ◽  
Present Review ◽  
Benzothiazole Derivatives ◽  
Anti Inflammatory

The Benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess interesting biological activities, such as antitumor, antimicrobial, anthelmintic, antileishmanial, anticonvulsant and anti-inflammatory. The present review focuses on the benzothiazoles with potential activities that are now in development. The synthesized benzothiazole derivatives could be considered as lead molecule for the development of therapeutic agents.

Overview of Coumarins and its Derivatives: Synthesis and Biological Activity

2020 ◽  
Vol 17 ◽  
Author(s):  
Tanvi Sahni ◽  
Sunita Sharma ◽  
Diksha Verma ◽  
Pardeep Kaur
Keyword(s):  
Biological Activity ◽  
Pharmaceutical Industry ◽  
Schiff Bases ◽  
Enzyme Inhibitors ◽  
Biological Activities ◽  
Anti Inflammatory

Abstract: Coumarin is a heterocyclic scaffold and its derivatives namely Schiff bases, esters, and hydrazides, etc, play an important role in the field of agrochemical and pharmaceutical industry due to its structure. Over the years, various biological activities like antifungal, antimicrobial, anti-viral, anti-cancerous, anti-tumor, anti-inflammatory, anti-filarial, enzyme inhibitors, anti-aflatoxigenic, analgesics, antioxidant and Oestrogenic, etc had been analyzed. This review covers the latest literature and knowledge on the synthetic procedures for various coumarin and its derivatives, biological and pharmacological applications.

Recent progress in andrographolide derivatization: structural modification and biological activity

2021 ◽  
Vol 21 ◽  
Author(s):  
Wang Wang ◽  
Yueying Yang ◽  
Yang Liu ◽  
Dejuan Sun ◽  
Hua Li ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Modification ◽  
Structural Modification ◽  
Recent Progress ◽  
Biological Activities ◽  
Structural Diversity ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Novel Drugs ◽  
Labdane Diterpenoid

: Natural products have remarkable structural diversity and biological characteristics, providing researchers with more possibilities to develop novel drugs for disease therapeutics. Andrographolide, an ent-labdane diterpenoid from traditional Chinese medicines, Andrographis paniculata, exhibits a broad range of biological activities, which has been a hot area of research for several years. Up to now, lots of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes andrographolide derivatives prepared in the last ten years (2006-present), classifies them by different biological activities, and provides some discussion about the design of novel and potent derivatives.

scholarly journals Phytochemical profiling, and anti-oxidant, anti-bacterial, and anti-inflammatory properties of Viburnum coriaceum Blume

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Vijayakumar Vijaytha ◽  
R. V. Anupama ◽  
M. Haridas
Keyword(s):  
Methanol Extract ◽  
Biological Activities ◽  
Zone Of Inhibition ◽  
Agar Gel ◽  
Anti Oxidant ◽  
Medicinal Properties ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Drug Leads ◽  
Diffusion Assay

Abstract Background Viburnums comprise a taxonomic group of plants distributed all over the world and were reported to have many biological activities. Viburnum coriaceum Blume is one of the least explored members of the group. The present study was aimed to explore the phytochemical profile of the plant, Viburnum coriaceum Blume with special emphasis to its anti-oxidant, anti-bacterial, and anti-inflammatory activities. Results Extracts of all parts of plants were found to possess a spectrum of chemicals in considerable amount, including triterpenoids and glycosides. Anti-oxidant property was found in extracts made of any part of the plant. Methanol extract of root expressed a prominent zone of inhibition in agar gel well-diffusion assay involving many microorganisms. Inhibition of enzymes, LOX, and trypsin showed by the hexane extract of root suggested a prominent anti-inflammatory potential of the plant under investigation. Conclusion Phytochemical profiling and the other assays using the plant extracts provide us with a plant having many valuable medicinal properties. Viburnum coriaceum Blume could be noted as a promising material for drug leads.

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