Visualization of Cartilage from Knee Joint Magnetic Resonance Images and Quantitative Assessment to Study the Effect of Age, Gender and Body Mass Index (BMI) in Progressive Osteoarthritis (OA)

2019 ◽  
Vol 15 (6) ◽  
pp. 565-572
Author(s):  
Mallikarjunaswamy Shivagangadharaiah Matada ◽  
Mallikarjun Sayabanna Holi ◽  
Rajesh Raman ◽  
Sujana Theja Jayaramu Suvarna
Keyword(s):  
Body Mass Index ◽  
Magnetic Resonance ◽  
Knee Joint ◽  
Body Mass ◽  
3D Visualization ◽  
Cartilage Degradation ◽  
Magnetic Resonance Images ◽  
Cartilage Thickness ◽  
Knee Joints ◽  
Data Set

Background: Osteoarthritis (OA) is a degenerative disease of joint cartilage affecting the elderly people around the world. Visualization and quantification of cartilage is very much essential for the assessment of OA and rehabilitation of the affected people. Magnetic Resonance Imaging (MRI) is the most widely used imaging modality in the treatment of knee joint diseases. But there are many challenges in proper visualization and quantification of articular cartilage using MRI. Volume rendering and 3D visualization can provide an overview of anatomy and disease condition of knee joint. In this work, cartilage is segmented from knee joint MRI, visualized in 3D using Volume of Interest (VOI) approach. Methods: Visualization of cartilage helps in the assessment of cartilage degradation in diseased knee joints. Cartilage thickness and volume were quantified using image processing techniques in OA affected knee joints. Statistical analysis is carried out on processed data set consisting of 110 of knee joints which include male (56) and female (54) of normal (22) and different stages of OA (88). The differences in thickness and volume of cartilage were observed in cartilage in groups based on age, gender and BMI in normal and progressive OA knee joints. Results: The results show that size and volume of cartilage are found to be significantly low in OA as compared to normal knee joints. The cartilage thickness and volume is significantly low for people with age 50 years and above and Body Mass Index (BMI) equal and greater than 25. Cartilage volume correlates with the progression of the disease and can be used for the evaluation of the response to therapies. Conclusion: The developed methods can be used as helping tool in the assessment of cartilage degradation in OA affected knee joint patients and treatment planning.

Validation of Cartilage Thickness Calculations Using Indentation Analysis

2010 ◽  
Vol 132 (4) ◽  
Author(s):  
Matthew F. Koff ◽  
Le Roy Chong ◽  
Patrick Virtue ◽  
Dan Chen ◽  
Xioanan Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Measurement Techniques ◽  
Magnetic Resonance Images ◽  
Cartilage Thickness ◽  
Mr Images ◽  
Data Set ◽  
Data Points ◽  
Indentation Analysis ◽  
Thickness Measurements

Different methods have been used to cross-validate cartilage thickness measurements from magnetic resonance images (MRIs); however, a majority of these methods rely on interpolated data points, regional mean and/or maximal thickness, or surface mean thickness for data analysis. Furthermore, the accuracy of MRI cartilage thickness measurements from commercially available software packages has not necessarily been validated and may lead to an under- or overestimation of cartilage thickness. The goal of this study was to perform a matching point-to-point validation of indirect cartilage thickness calculations using a magnetic resonance (MR) image data set with direct cartilage thickness measurements using biomechanical indentation testing at the same anatomical locations. Seven bovine distal femoral condyles were prepared and a novel phantom filled with dilute gadolinium solution was rigidly attached to each specimen. High resolution MR images were acquired, and thickness indentation analysis of the cartilage was performed immediately after scanning. Segmentation of the MR data and cartilage thickness calculation was performed using semi-automated software. Registration of MR and indentation data was performed using the fluid filled phantom. The inter- and intra-examiner differences of the measurements were also determined. A total of 105 paired MRI-indentation thickness data points were analyzed, and a significant correlation between them was found (r=0.88, p<0.0001). The mean difference (±std. dev.) between measurement techniques was 0.00±0.23 mm, with Bland–Altman limits of agreement of 0.45 mm and −0.46 mm. The intra- and inter-examiner measurement differences were 0.03±0.22 mm and 0.05±0.24 mm, respectively. This study validated cartilage thickness measurements from MR images with thickness measurements from indentation by using a novel phantom to register the image-based and laboratory-based data sets. The accuracy of the measurements was comparable to previous cartilage thickness validation studies in literature. The results of this study will aid in validating a tool for clinical evaluation of in-vivo cartilage thickness.

scholarly journals Knee Cartilage Thickness Differs Alongside Ages: A 3-T Magnetic Resonance Research Upon 2,481 Subjects via Deep Learning

2021 ◽  
Vol 7 ◽  
Author(s):  
Liping Si ◽  
Kai Xuan ◽  
Jingyu Zhong ◽  
Jiayu Huo ◽  
Yue Xing ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Deep Learning ◽  
Magnetic Resonance ◽  
Knee Joint ◽  
Magnetic Resonance Images ◽  
Cartilage Thickness ◽  
Imaging Data ◽  
Knee Cartilage ◽  
Large Collection ◽  
The Relationship

Background: It was difficult to distinguish the cartilage thinning of an entire knee joint and to track the evolution of cartilage morphology alongside ages in the general population, which was of great significance for studying osteoarthritis until big imaging data and artificial intelligence are fused. The purposes of our study are (1) to explore the cartilage thickness in anatomical regions of the knee joint among a large collection of healthy knees, and (2) to investigate the relationship between the thinning pattern of the cartilages and the increasing ages.Methods: In this retrospective study, 2,481 healthy knees (subjects ranging from 15 to 64 years old, mean age: 35 ± 10 years) were recruited. With magnetic resonance images of knees acquired on a 3-T superconducting scanner, we automatically and precisely segmented the cartilage via deep learning and calculated the cartilage thickness in 14 anatomical regions. The thickness readings were compared using ANOVA by considering the factors of age, sex, and side. We further tracked the relationship between the thinning pattern of the cartilage thickness and the increasing ages by regression analysis.Results: The cartilage thickness was always thicker in the femur than corresponding regions in the tibia (p &lt; 0.05). Regression analysis suggested cartilage thinning alongside ages in all regions (p &lt; 0.05) except for medial and lateral anterior tibia in both females and males (p &gt; 0.05). The thinning speed of men was faster than women in medial anterior and lateral anterior femur, yet slower in the medial patella (p &lt; 0.05).Conclusion: We established the calculation method of cartilage thickness using big data and deep learning. We demonstrated that cartilage thickness differed across individual regions in the knee joint. Cartilage thinning alongside ages was identified, and the thinning pattern was consistent in the tibia while inconsistent in patellar and femoral between sexes. These findings provide a potential reference to detect cartilage anomaly.

scholarly journals Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation

2017 ◽  
Vol 42 (7) ◽  
pp. 773-779 ◽  
Author(s):  
Joanna L. Bowtell ◽  
Zainie Aboo-Bakkar ◽  
Myra E. Conway ◽  
Anna-Lynne R. Adlam ◽  
Jonathan Fulford
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Cognitive Function ◽  
Magnetic Resonance ◽  
Body Mass ◽  
Brain Perfusion ◽  
Magnetic Resonance Images ◽  
Healthy Older Adults ◽  
Male Age ◽  
Blueberry Supplementation

Blueberries are rich in flavonoids, which possess antioxidant and anti-inflammatory properties. High flavonoid intakes attenuate age-related cognitive decline, but data from human intervention studies are sparse. We investigated whether 12 weeks of blueberry concentrate supplementation improved brain perfusion, task-related activation, and cognitive function in healthy older adults. Participants were randomised to consume either 30 mL blueberry concentrate providing 387 mg anthocyanidins (5 female, 7 male; age 67.5 ± 3.0 y; body mass index, 25.9 ± 3.3 kg·m−2) or isoenergetic placebo (8 female, 6 male; age 69.0 ± 3.3 y; body mass index, 27.1 ± 4.0 kg·m−2). Pre- and postsupplementation, participants undertook a battery of cognitive function tests and a numerical Stroop test within a 1.5T magnetic resonance imaging scanner while functional magnetic resonance images were continuously acquired. Quantitative resting brain perfusion was determined using an arterial spin labelling technique, and blood biomarkers of inflammation and oxidative stress were measured. Significant increases in brain activity were observed in response to blueberry supplementation relative to the placebo group within Brodmann areas 4/6/10/21/40/44/45, precuneus, anterior cingulate, and insula/thalamus (p < 0.001) as well as significant improvements in grey matter perfusion in the parietal (5.0 ± 1.8 vs –2.9 ± 2.4%, p = 0.013) and occipital (8.0 ± 2.6 vs –0.7 ± 3.2%, p = 0.031) lobes. There was also evidence suggesting improvement in working memory (2-back test) after blueberry versus placebo supplementation (p = 0.05). Supplementation with an anthocyanin-rich blueberry concentrate improved brain perfusion and activation in brain areas associated with cognitive function in healthy older adults.

scholarly journals AB0867 INCREASED ADIPONECTIN LEVELS ARE ASSOCIATED WITH HIGHER RADIOGRAPHIC SCORES IN THE KNEE JOINT, BUT NOT IN THE HAND JOINT: THE DONG-GU STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1740.1-1740
Author(s):  
J. H. Kang ◽  
S. E. Choi ◽  
H. Xu ◽  
D. J. Park ◽  
S. S. Lee
Keyword(s):  
Body Mass Index ◽  
Knee Joint ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Joint Space ◽  
Serum Adiponectin ◽  
Hand Osteoarthritis ◽  
X Rays ◽  
Subchondral Cyst ◽  
The Relationship

Background:Several studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA), with mixed results.Objectives:The aim of this study was to investigate the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA.Methods:A total of 2,402 subjects were recruited from the Dong-gu Study. Baseline characteristics were collected via a questionnaire, and X-rays of knee and hand joints were scored by a semi-quantitative grading system. The relationship between serum adiponectin levels and radiographic severity was evaluated by linear regression analysis.Results:Subjects with higher tertiles of serum adiponectin were older and had a lower body mass index than those with lower tertiles. In the knee joint scores, serum adiponectin levels were positively associated with the total score (P<0.001), osteophyte score (P=0.003), and joint space narrowing (JSN) score (P<0.001) among the three tertiles after adjustment for age, sex, body mass index, smoking, alcohol consumption, education, and physical activity. In the hand joint scores, no association was found between serum adiponectin levels and the total score, osteophyte score, JSN score, subchondral cyst score, sclerosis score, erosion score, and malalignment score among the three tertiles after adjustment.Conclusion:In this study, we found that increased adiponectin levels were associated with higher radiographic scores in the knee joint, but not in the hand joint, suggesting different pathophysiologic mechanisms in the development of OA.Disclosure of Interests:None declared

scholarly journals A Case of Bilateral Permanent Subluxation of the Lateral Meniscus

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Jun Suganuma ◽  
Tadashi Sugiki ◽  
Yutaka Inoue
Keyword(s):  
Magnetic Resonance ◽  
Knee Joint ◽  
Lateral Meniscus ◽  
Detailed Examination ◽  
Magnetic Resonance Images ◽  
Posterior Segment ◽  
Anterior Dislocation ◽  
Normal Position ◽  
Straight Position ◽  
History Of

We report a case of bilateral, permanent subluxation of the lateral meniscus. To our knowledge, the present case is the first reported description of bilateral irreducible anterior dislocation of the posterior segment of the lateral meniscus. This disorder is characterized by a flipped meniscus sign of the lateral meniscus on sagittal magnetic resonance images of the knee joint, with no history of trauma or locking symptoms. A detailed examination of serial magnetic resonance images of the lateral meniscus can help differentiate this condition from malformation of the lateral meniscus, that is, a double-layered meniscus. We recommend two-stage treatment for this disorder. First, the knee joint is kept in straight position for 3 weeks after the lateral meniscus is reduced to the normal position. Second, if subluxation of the lateral meniscus recurs, meniscocapsular suture is then performed. Although subluxation of the lateral meniscus without locking symptoms is rare, it is important to be familiar with this condition to diagnose and treat it correctly.

scholarly journals THE ROLE OF MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF DEFORMING ARTHROSIS OF PROFESSIONAL ETIOLOGY IN MINERS

2018 ◽  
Vol 5 ◽  
pp. 3-11
Author(s):  
Angela Basanets ◽  
Maria Bulavko
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Knee Joint ◽  
Joint Damage ◽  
Knee Joints ◽  
Prognostic Models ◽  
Diagnostic Efficiency ◽  
Resonance Imaging ◽  
Physical Loading ◽  
Medial Hypertrophy

The paper analyzes the effectiveness of magnetic resonance imaging with cartilage diagram in diagnosing signs of professional deforming arthrosis of knee joints in miners working in conditions of significant physical loading. Aim of the research – to determine of diagnostic efficiency of indicators of magnetic resonance imaging of the knee joint and cartilage diagram in miners of the main occupations suffering from deforming arthrosis. Methods. The research is conducted in 30 miners of basic occupations: 20 mining workers of breakage face (MWBF) and 10 machinists of shearer mining machines (МSMM) have been treated in the inpatient department of occupational pathology of the Lviv Regional Clinical Hospital in 2015-2017 due to deforming arthrosis. Damages of the main anatomical elements of the knee joint with arthrosis were analyzed, visualized initially with the help of MRI, and then - cartilage diagram. Results. According to the MRI data, in miners of the main occupations with arthrosis of the knee joint the posterior cross-shaped ligament are most commonly affected (in 75.0±9.7 % MWBF and 70.0±14.5 % МSMM), damage to the medial collateral ligament are diagnosed less frequently (in 5.0±4.9 % in the MWBF and in 10.0±9.5 % in the МSMM). On average 3.8±0.4 modified elements of the knee joint are visualized in patients, whereas 4.8±0.1 affected areas are visualized on the cartilage diagram (р<0.05). In 86.7±6.2 % patients, in the analysis of cartilage diagram, changes in all five analyzed areas are diagnosed, indicating a higher efficiency of the diagnosis of changes in the structures of the joint with DA of the professional etiology of the method of cartilage diagram compared with MRI. According to the cartilage diagram the most significant changes are noted in the hypertrophy of the femur: among all miners 62.5±0.3 ms (medial) and 62.6±0.4 ms (lateral), in the MWBF group the average time of Т2-delay is the largest in the area of the medial hypertrophy of the femur is 60.9±2.3 ms, in the МSMM group – in the area of the lateral hypertrophy of the femur: 66.7±3.3 ms, which can be linked to the peculiarities of the forced working position of miners of these professions and the kinetics of joint structures. These results can be used to diagnose the initial lesions of joint structures with DA of professional genesis, as well as the creation of prognostic models for determining the the degree of risk of development of knee joint damage, which will allow to improve the system of personified approach to diagnostic and preventive measures in working persons in conditions of considerable physical activity and forced working position.

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