Past, present and future of electroanalytical sensor for aspirin, ibuprofen and paracetamol detection

2021 ◽  
Vol 17 ◽  
Author(s):  
Xuejiao Li ◽  
Jian Kang ◽  
Hong Ji ◽  
Ping Gong ◽  
Nan Li
Keyword(s):  
Materials Science ◽  
High Sensitivity ◽  
Drug Analysis ◽  
Electrochemical Analysis ◽  
Electrochemical Sensing ◽  
Detection Methods ◽  
Technical Problems ◽  
Sensing Technology ◽  
Electrochemical Technology ◽  
Pain Analgesics

Background: Pain not only affects quality of life but can also lead to people suffering from mental illness due to the lack of effective treatment for long-term pain. Analgesics refer to drugs that can partially or completely relieve pain, including non-steroidal anti-inflammatory drugs and central analgesics. Methods: In recent years, the cross integration of electrochemical analysis technology with biochemistry, materials science, biomedicine and other disciplines has driven the vigorous development of electrochemical sensing technology in the field of life sciences. The electrochemical sensor has many advantages, such as simple equipment, good specificity, high sensitivity, economy and convenience. As a newly emerging technology, electrochemical sensing technology is increasingly widely used in drug analysis. Results: This review introduces the recent advances of the detection of analgesics using electrochemical technology. We deliberately selected three representative drugs for discussion: aspirin, ibuprofen and paracetamol. Conclusion: Electrochemical sensing technology has the advantages of high sensitivity, a low detection limit and simple operation. However, sensors still have some technical problems, such as the existence of many interference factors in actual samples in blood drug concentration monitoring and the need for the further optimization of the method conditions for multi-channel detection. With the continuous advancement of research, the application of new detection methods, nanomaterials, and biomolecules has enabled electrochemical technology to make certain progress in the field of drug analysis. In particular, the emergence of new nanomaterials will greatly promote the development of electrochemical sensing technology in drug analysis. As a cutting-edge technology, electrochemical sensing technology has enormous potential application value.

scholarly journals Application of Electrochemical Sensors Based on Carbon Nanomaterials for Detection of Flavonoids

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2020
Author(s):  
Jinchun Hu ◽  
Zhenguo Zhang
Keyword(s):  
Carbon Nanomaterials ◽  
Electrochemical Sensors ◽  
Graphene Quantum Dots ◽  
High Sensitivity ◽  
Research Field ◽  
Electrochemical Sensing ◽  
Detection Methods ◽  
Health Issues ◽  
Fast Detection ◽  
Anti Cancer

Flavonoids have a variety of physiological activities such as anti-free radicals, regulating hormone levels, antibacterial factors, and anti-cancer factors, which are widely present in edible and medicinal plants. Real-time detection of flavonoids is a key step in the quality control of diverse matrices closely related to social, economic, and health issues. Traditional detection methods are time-consuming and require expensive equipment and complicated working conditions. Therefore, electrochemical sensors with high sensitivity and fast detection speed have aroused extensive research interest. Carbon nanomaterials are preferred material in improving the performance of electrochemical sensing. In this paper, we review the progress of electrochemical sensors based on carbon nanomaterials including carbon nanotubes, graphene, carbon and graphene quantum dots, mesoporous carbon, and carbon black for detecting flavonoids in food and drug homologous substances in the last four years. In addition, we look forward to the prospects and challenges of this research field.

scholarly journals Electrochemical Sensors and Biosensors for the Analysis of Tea Components: A Bibliometric Review

2022 ◽  
Vol 9 ◽  
Author(s):  
Jinhua Shao ◽  
Chao Wang ◽  
Yiling Shen ◽  
Jinlei Shi ◽  
Dongqing Ding
Keyword(s):  
Bibliometric Analysis ◽  
High Performance ◽  
Electrochemical Sensors ◽  
Materials Science ◽  
Low Cost ◽  
Relevant Literature ◽  
Electrochemical Techniques ◽  
High Sensitivity ◽  
Electrochemical Analysis ◽  
Electrochemical Biosensing

Tea is a popular beverage all around the world. Tea composition, quality monitoring, and tea identification have all been the subject of extensive research due to concerns about the nutritional value and safety of tea intake. In the last 2 decades, research into tea employing electrochemical biosensing technologies has received a lot of interest. Despite the fact that electrochemical biosensing is not yet the most widely utilized approach for tea analysis, it has emerged as a promising technology due to its high sensitivity, speed, and low cost. Through bibliometric analysis, we give a systematic survey of the literature on electrochemical analysis of tea from 1994 to 2021 in this study. Electrochemical analysis in the study of tea can be split into three distinct stages, according to the bibliometric analysis. After chromatographic separation of materials, electrochemical techniques were initially used only as a detection tool. Many key components of tea, including as tea polyphenols, gallic acid, caffeic acid, and others, have electrochemical activity, and their electrochemical behavior is being investigated. High-performance electrochemical sensors have steadily become a hot research issue as materials science, particularly nanomaterials, and has progressed. This review not only highlights these processes, but also analyzes and contrasts the relevant literature. This evaluation also provides future views in this area based on the bibliometric findings.

scholarly journals Optical Fiber Sensor for Heavy Chemical Detection: An Overview

2021 ◽  
Vol 2075 (1) ◽  
pp. 012010
Author(s):  
Nurul Athirah Mohamad Abdul Ghafar ◽  
Arni Munira Markom ◽  
Marni Azira Markom ◽  
Ahmad Razif Muhammad
Keyword(s):  
Optical Fiber ◽  
Electromagnetic Interference ◽  
Low Cost ◽  
Optical Fiber Sensor ◽  
High Sensitivity ◽  
Electrochemical Analysis ◽  
Detection Methods ◽  
Fiber Sensor ◽  
Sensor Technology ◽  
Compact Size

Abstract Heavy metal contaminations such as mercury, lead, arsenic, cadmium, and zinc are becoming more serious and have become a hazard to human health. Due to their non-biodegradable nature, they can easily accumulate in the environment and cause toxicity even at low concentrations. Therefore, detecting the presence of these metal ions requires a highly sensitive sensing method. Traditional detection methods, such as electrochemical analysis, require complicated sample preparation, are costly, and typically require a lengthy measurement period. These days, optical fiber sensors have been acknowledged due to their unique characteristics such as compact size, high sensitivity, low cost, high flexibility, and immunity to electromagnetic interference. An overview of an optical fiber sensor technology for heavy chemical measurement is discussed in this paper. The sensing mechanisms are summarized, as well as the chemical water quality parameters and sensitivities.

scholarly journals Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4607
Author(s):  
Dounia Elfadil ◽  
Abderrahman Lamaoui ◽  
Flavio Della Pelle ◽  
Aziz Amine ◽  
Dario Compagnone
Keyword(s):  
Food Safety ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Electrochemical Analysis ◽  
Ease Of Use ◽  
Electrochemical Sensing ◽  
Food Contaminants ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

Graphene: An Insight Into Electrochemical Sensing Technology

Monoelements ◽  
2020 ◽  
pp. 169-233
Author(s):  
Anantharaman Shivakumar ◽  
Honnur Krishna
Keyword(s):  
Electrochemical Sensing ◽  
Sensing Technology ◽  
Insight Into

scholarly journals Nanopore Technology for the Application of Protein Detection

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1942
Author(s):  
Xiaoqing Zeng ◽  
Yang Xiang ◽  
Qianshan Liu ◽  
Liang Wang ◽  
Qianyun Ma ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Detection ◽  
High Sensitivity ◽  
Single Molecule Detection ◽  
Sequence Detection ◽  
Fast Detection ◽  
Material Basis ◽  
Sensing Technology ◽  
Detection Technology ◽  
Structure Recognition

Protein is an important component of all the cells and tissues of the human body and is the material basis of life. Its content, sequence, and spatial structure have a great impact on proteomics and human biology. It can reflect the important information of normal or pathophysiological processes and promote the development of new diagnoses and treatment methods. However, the current techniques of proteomics for protein analysis are limited by chemical modifications, large sample sizes, or cumbersome operations. Solving this problem requires overcoming huge challenges. Nanopore single molecule detection technology overcomes this shortcoming. As a new sensing technology, it has the advantages of no labeling, high sensitivity, fast detection speed, real-time monitoring, and simple operation. It is widely used in gene sequencing, detection of peptides and proteins, markers and microorganisms, and other biomolecules and metal ions. Therefore, based on the advantages of novel nanopore single-molecule detection technology, its application to protein sequence detection and structure recognition has also been proposed and developed. In this paper, the application of nanopore single-molecule detection technology in protein detection in recent years is reviewed, and its development prospect is investigated.

scholarly journals Monitoring of a Highly Flexible Aircraft Model Wing Using Time-Expanded Phase-Sensitive OTDR

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3766
Author(s):  
Miguel Soriano-Amat ◽  
David Fragas-Sánchez ◽  
Hugo F. Martins ◽  
David Vallespín-Fontcuberta ◽  
Javier Preciado-Garbayo ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Fuel Efficiency ◽  
Optical Fiber Sensor ◽  
High Sensitivity ◽  
Time Domain Reflectometry ◽  
Structural Deformation ◽  
Flexible Wings ◽  
Sensing Technology ◽  
Distributed Optical Fiber Sensor ◽  
Phase Sensitive

In recent years, the use of highly flexible wings in aerial vehicles (e.g., aircraft or drones) has been attracting increasing interest, as they are lightweight, which can improve fuel-efficiency and distinct flight performances. Continuous wing monitoring can provide valuable information to prevent fatal failures and optimize aircraft control. In this paper, we demonstrate the capabilities of a distributed optical fiber sensor based on time-expanded phase-sensitive optical time-domain reflectometry (TE-ΦOTDR) technology for structural health monitoring of highly flexible wings, including static (i.e., bend and torsion), and dynamic (e.g., vibration) structural deformation. This distributed sensing technology provides a remarkable spatial resolution of 2 cm, with detection and processing bandwidths well under the MHz, arising as a novel, highly efficient monitoring methodology for this kind of structure. Conventional optical fibers were embedded in two highly flexible specimens that represented an aircraft wing, and different bending and twisting movements were detected and quantified with high sensitivity and minimal intrusiveness.

Recent Developments In Monochromatic Microprobe X-Ray Fluorescence (MMXRF)

1998 ◽  
Vol 4 (S2) ◽  
pp. 378-379
Author(s):  
Z. W. Chen ◽  
D. B. Wittry
Keyword(s):  
Materials Science ◽  
High Vacuum ◽  
Three Dimensional ◽  
High Sensitivity ◽  
X Rays ◽  
Fluorescence Excitation ◽  
X Ray ◽  
Quantitative Microanalysis ◽  
Recent Developments ◽  
Fifth Order

A monochromatic x-ray microprobe based on a laboratory source has recently been developed in our laboratory and used for fluorescence excitation. This technique provides high sensitivity (ppm to ppb), nondestructive, quantitative microanalysis with minimum sample preparation and does not require a high vacuum specimen chamber. It is expected that this technique (MMXRF) will have important applications in materials science, geological sciences and biological science.Three-dimensional focusing of x-rays can be obtained by using diffraction from doubly curved crystals. In our MMXRF setup, a small x-ray source was produced by the bombardment of a selected target with a focused electron beam and a toroidal mica diffractor with Johann pointfocusing geometry was used to focus characteristic x-rays from the source. In the previous work ∼ 108 photons/s were obtained in a Cu Kα probe of 75 μm × 43 μm in the specimen plane using the fifth order reflection of the (002) planes of mica.

Gold Immunochromatography Assay - A Newly Rapid Detection Technique for Aquatic Products

2013 ◽  
Vol 690-693 ◽  
pp. 1449-1454
Author(s):  
Yuan Wang ◽  
Hui Juan Yu ◽  
Bei Lei Qian ◽  
You Qiong Cai ◽  
Dong Mei Huang ◽  
...  
Keyword(s):  
Rapid Detection ◽  
High Sensitivity ◽  
Detection Technique ◽  
Detection Methods ◽  
Future Perspectives ◽  
Auxiliary Equipment ◽  
Basic Principles ◽  
Aquatic Products ◽  
Immunological Detection

Gold immunochromatography assay (GICA) technique has the following characteristics: rapid and simple, high sensitivity, good specificity, no auxiliary equipment, ease of interpreting results, and satisfactory stability. The technique has become one of the most rapid and sensitive immunological detection methods, which is widely used in medical, biological and other fields. The article focuses on the basic principles and technical characteristics of GICA, and briefly describes the applications and future perspectives in the rapid detection of aquatic products.

A rapid and accurate method for screening T-2 toxin in food and feed using competitive AlphaLISA

2021 ◽  
Vol 368 (6) ◽  
Author(s):  
Liwen Zhang ◽  
Qingyu Lv ◽  
Yuling Zheng ◽  
Xuan Chen ◽  
Decong Kong ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Accurate Method ◽  
Detection Methods ◽  
Cereal Crops ◽  
Detection Range ◽  
Highly Sensitive ◽  
Food And Feed ◽  
Good Repeatability ◽  
Feed Samples ◽  
Better Than

ABSTRACT T-2 is a common mycotoxin contaminating cereal crops. Chronic consumption of food contaminated with T-2 toxin can lead to death, so simple and accurate detection methods in food and feed are necessary. In this paper, we establish a highly sensitive and accurate method for detecting T-2 toxin using AlphaLISA. The system consists of acceptor beads labeled with T-2-bovine serum albumin (BSA), streptavidin-labeled donor beads and biotinylated T-2 antibodies. T-2 in the sample matrix competes with T-2-BSA for antibodies. Adding biotinylated antibodies to the test well followed by T-2 and T-2-BSA acceptor beads yielded a detection range of 0.03–500 ng/mL. The half-maximal inhibitory concentration was 2.28 ng/mL and the coefficient of variation was <10%. In addition, this method had no cross-reaction with other related mycotoxins. This optimized method for extracting T-2 from food and feed samples achieved a recovery rate of approximately 90% in T-2 concentrations as low as 1 ng/mL, better than the performance of a commercial ELISA kit. This competitive AlphaLISA method offers high sensitivity, good specificity, good repeatability and simple operation for detecting T-2 toxin in food and feed.

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