Current Insights for the Management of Acne in the Modern Era

2020 ◽  
Vol 15 (1) ◽  
pp. 3-29
Author(s):  
Neha Singh ◽  
Apoorva Singh ◽  
Kalpana Pandey ◽  
Nimisha
Keyword(s):  
Drug Delivery ◽  
Adverse Effects ◽  
Acne Vulgaris ◽  
Research Work ◽  
Aloe Vera ◽  
Pharmaceutical Research ◽  
Topical Delivery ◽  
Research Area ◽  
Self Confidence ◽  
Novel Drug

Background: Acne vulgaris a chronic disease which is caused by blockage of the sebaceous gland is commonly seen in almost every human being at some point in their lives. There are 20-25% chances of progression of acne to severe cases, which leads to permanent scarring that results in psychological problems like depression, social isolation, lowered self-esteem, and lowered self-confidence. Objective: Though several conventional treatments are available in the market but still there are various adverse effects associated with topical anti-acne agents due to which it lacks patient compatibility. The present study is undertaken to find out the major shortcoming; why the current therapies do not give the desired therapeutic results. Conclusion: Novel drug delivery strategies can play a crucial role in the enhancement of topical delivery of anti-acne agents by escalating their dermal localization and reducing their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia etc. have clinical evidence regarding the effective management of acne. The current inclination towards nanotechnology is considerable due to several changes in the pharmaceutical research area. To secure the research work in different pharmaceutical fields, patents are filed against various agents like Galderma Research & Development have filed patents for adapalene and benzoyl peroxide for the management of acne vulgaris. The current review highlights the potential of various novel drug delivery approaches like liposomes, niosomes, ethosomes, transfersomes etc. in enhancing the topical delivery of anti-acne agents.

A Review on Fast Dissolving Tablet

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Sagar T. Malsane ◽  
Smita S. Aher ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Research Area ◽  
Oral Route ◽  
Dosage Forms ◽  
The Novel ◽  
The Past ◽  
Orally Disintegrating Tablets ◽  
Novel Drug ◽  
Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

scholarly journals EMERGING NOVEL NANOPHARMACEUTICALS FOR DRUG DELIVERY

2018 ◽  
Vol 11 (7) ◽  
pp. 35 ◽  
Author(s):  
Abishek Wadhwa ◽  
Vashish Mathura ◽  
Shaila Angela Lewis
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Adverse Effects ◽  
Public Interest ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Preparation Strategy ◽  
Novel Drug

Nanotechnology is an area of growing public interest. Employing nanotechnology in the field of drug delivery has led to the advent of nanopharmaceuticals. Nanopharmaceuticals are bound to surmount various obstacles that the field of pharmacy is currently facing by offering various advantages thereby, a promising potential to formulate advanced medicines with fewer adverse effects. Extensive research is in place, thus instigating the development of novel drug delivery systems, such as carbon nanotubes, nanosponges, nano wafers, and nanofibers, to name a few. Since their inception, these nanopharmaceuticals have advanced significantly regarding their preparation strategy and scope of applications. This article aims to review the merits, limitations, and scope of these aforementioned delivery systems.

scholarly journals Topical Delivery of Aceclofenac: Challenges and Promises of Novel Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Kaisar Raza ◽  
Manish Kumar ◽  
Pramod Kumar ◽  
Ruchi Malik ◽  
Gajanand Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Topical Delivery ◽  
World Population ◽  
The Novel ◽  
Inflammatory Drugs ◽  
The Common ◽  
Novel Drug ◽  
Regulatory Challenges

Osteoarthritis (OA), a common musculoskeletal disorder, is projected to affect about 60 million people of total world population by 2020. The associated pain and disability impair the quality of life and also pose economic burden to the patient. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed in OA, while diclofenac is the most prescribed one. Oral NSAIDs are not very patient friendly, as they cause various gastrointestinal adverse effects like bleeding, ulceration, and perforation. To enhance the tolerability of diclofenac and decrease the common side effects, aceclofenac (ACE) was developed by its chemical modification. As expected, ACE is more well-tolerated than diclofenac and possesses superior efficacy but is not completely devoid of the NSAID-tagged side effects. A series of chemical modifications of already planned drug is unjustified as it consumes quanta of time, efforts, and money, and this approach will also pose stringent regulatory challenges. Therefore, it is justified to deliver ACE employing tools of drug delivery and nanotechnology to refine its safety profile. The present review highlights the constraints related to the topical delivery of ACE and the various attempts made so far for the safe and effective topical delivery employing the novel materials and methods.

scholarly journals Carrier-Based Drug Delivery System for Treatment of Acne

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Amber Vyas ◽  
Avinesh Kumar Sonker ◽  
Bina Gidwani
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Topical Treatment ◽  
Side Effect ◽  
Acne Vulgaris ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
Pharmaceutical Ingredients ◽  
Conventional Systems ◽  
Novel Drug

Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system.

Formulation and Standardization of Anti-Acne Herbal Foaming Face wash using Curcuma longa along with Aloe vera, Rosa centifolia and Citrus sinensis

2021 ◽  
Vol 11 ◽  
Author(s):  
Niharika Lal ◽  
Maharabi Rana ◽  
Bhanu P S Sagar ◽  
Navneet Verma
Keyword(s):  
Citrus Sinensis ◽  
High Performance ◽  
Propionibacterium Acnes ◽  
Curcuma Longa ◽  
Contact Allergy ◽  
Acne Vulgaris ◽  
Skin Irritation ◽  
Research Work ◽  
Aloe Vera ◽  
Soxhlet Apparatus

Objectives: Acne vulgaris is a very common skin disorder peaks at teenage, but many men and women between 20-40 years of age are also affected by the disorder. For the treatment of acne, herbal medication are considered safer than allopathic medicines as allopathic medicines are associated with side effects such as like contact allergy, local irritation, scaling, photosensitivity, itching and redness of the skin etc. The present research work was performed to check effectiveness of foaming face wash formulation containing Curcuma longa along with herbals excipient Aloe vera, Rosa centifolia and Citrus sinensis. Curcuma longa have been reported to contain active phytoconstituents having significant anti-microbial activity and used locally for acne. Method: The plant material Curcuma longa, Aloe vera, Rosa centifolia and Citrus sinensis were authenticated and their extracts has been prepared using Soxhlet Apparatus and the the resulting essential oil was analyzed for its physical properties. The foaming face wash was than prepared by using the herbal extracts with excipients that were free from sulphates, parabens, silicon and petroleum products. Two formulations, A1and A2 has been prepared and their physicochemical studies were perfomed. The presence and efficacy of Curcuma longa in suppression of Propionibacterium acnes was assessed by analytical methods and anti-microbial techniques, respectively. Skin irritation studies were conducted using Wistar rats by scoring method. Accelerated stability studies were also performed for a period of 60 days. Result: The physicochemical properties were evaluated and found to be satisfactory. Analytical techniques like High Performance Liquid Chromatography, High Performance Thin Layer Chromatography and Infra Red spectral analysis confirmed the qualitative presence of Curcuminoid, which is a mixture of curcumin, desmethoxycurcumin [4-hydroxycinnamoyl-(4-hydroxy-3-methoxycinnamoyl) methane] and Bis- demethoxycurcumin [bis-(4-hydroxy cinnamoyl) methane] in the sample. The Antibacterial activity of developed face wash assessed against Propionibacterium acnes was more than that of Clindamycin (10μg/ml). Also, the developed formulation showed a very high activity against Staphylococcus epidermidis with respect to the activity of the standard clindamycin. The prepared formulation showed no sign of localized reactions were confirmed by a skin irritation study indicating the formulation was safe and compatible with the skin. Conclusion: On the basis of our study, it could be stated, that formulation has antimicrobial activity and could be used safely on human skin

Sign in / Sign up

Export Citation Format

Share Document