Is Ocular Toxicity Expected in Chloroquine/Hydroxychloroquine Prescription as a Therapeutic or Prophylactic Option in COVID-19?

2020 ◽  
Vol 15 (2) ◽  
pp. 113-118
Author(s):  
Masood Bagheri ◽  
Zahra Rashe ◽  
Mohammad H. Ahur ◽  
Mojtaba Eidizadeh
Keyword(s):  
Retinal Toxicity ◽  
Public Health Emergency ◽  
Cross Infection ◽  
Evidence Based ◽  
Ocular Toxicity ◽  
First Line ◽  
Therapeutic Protocol ◽  
The One ◽  
Novel Coronavirus ◽  
Short Time

Background: On 11th March 2020, WHO announced novel coronavirus infectious (COVID-19) as a pandemic. New Coronavirus Pneumonia (NCP) that emerge on 31st December 2019 from China and quickly became a Public Health Emergency of International Concern (PHEIC). In the absence of evidence-based proven prophylactic or therapeutic options, chloroquine/hydroxychloroquine (CQ/HCQ) patented as first line choice in COVID- 19 treatment, which raised concerns about drug poisoning, especially ocular toxicity. Objective: This study aims to investigate the possibility of ocular toxicity and the need for ophthalmic counseling to prescribing this therapeutic protocol. Methods: All the articles that were most relevant to the COVID-19 therapeutic or prophylactic options and CQ derivative ocular toxicity, were founded by a literature search and were thoroughly reviewed. Results: Anecdotal recent reports introduce CQ/HCQ as an effective therapeutic or prophylactic choice for COVID-19. Because of the short time prescribe and the insignificant cumulative dose of the drug on the one hand and a higher risk of cross-infection during an ophthalmic examination, on the other hand, an ophthalmologic consult is not recommended except in highrisk patients for retinal toxicity. Conclusion: This study recommended ophthalmic evaluation before CQ/HCQ prescription for treatment or prophylaxis of COVID-19 only in preexisting maculopathy.

scholarly journals Exploring the Rescue Strategy for Cardiac Arrest in Makeshift (FangCang) Hospital Workers during the Pneumonia Outbreak Associated with COVID-19

2020 ◽  
Author(s):  
Ke FENG ◽  
Bin MEI ◽  
Zhongwei CHEN ◽  
Xufeng FU
Keyword(s):  
Cardiac Arrest ◽  
High Strength ◽  
Respiratory Illness ◽  
Cross Infection ◽  
Hospital Workers ◽  
First Line ◽  
The World ◽  
Novel Coronavirus ◽  
Resuscitation Team

Background: Beginning in Dec 2019, a novel coronavirus, designated SARS-CoV-2, has caused an international outbreak of respiratory illness termed COVID-19. The workers in the FangCang hospital have to work for more than 8 h and the work is high strength. Furthermore, to protect health and prevent serious cross-infection, they need to wear isolation equipment when working in FangCang hospital. These characteristics increase the risk of cardiac arrest (CA), which seriously endangers the lives of workers. Methods: We participated in the rescue of the patient and workers at first-line in FangCang hospital, and summarized the rescue strategies for workers rescuing. Results: Workers with CA were rescued in time according our guideline and showed zero dead in FangCang hospital. Conclusion: This study establishes the strategy for the CA of workers including the establishment of an in-FangCang resuscitation team, the establishment of a dedicated rescue room, and the formulation of rescue measures and procedures for CA of workers in the FangCang hospital. Therefore, we aimed to provide a strategy for the rescue of workers with CA in the FangCang hospital and share the success in rescuing with the world.

Der Erzieher als Manager

2019 ◽  
Vol 95 (4) ◽  
pp. 517-530
Author(s):  
Diana Lohwasser
Keyword(s):  
Educational Process ◽  
The Other ◽  
Critical View ◽  
Other Hand ◽  
The One ◽  
Short Time ◽  
Time Diagnosis

Abstract The Educator as a Manager. A Critical View In the following article tasks and motifs of the educator as manager are described. It is clear that there are other educator metaphors and associated behaviors. To some extent, the actions of the different educator metaphors overlap, but they differ in their purpose and perspective on the educational process and the person to be educated. First, a short time diagnosis is made, which describes the context of this metaphor of the educator as manager. Subsequently, on the one hand, the various motifs, tasks and objectives of an educator as manager are discussed. On the other hand, it is asked if it is possible in the current discourse to take a different perspective on the educational process.

Local hospital experience of emergency management in the response to SARS (Preprint)

2020 ◽  
Author(s):  
Ying Yan
Keyword(s):  
Emergency Management ◽  
Infection Prevention ◽  
Public Health Emergency ◽  
The Novel ◽  
Prevention Measures ◽  
Hospital Emergency ◽  
Local Hospital ◽  
Referral Network ◽  
Novel Coronavirus ◽  
Hospital Transmission

UNSTRUCTURED The ongoing outbreak of SARS-CoV-2 infection was first identified in Wuhan, China at the late of 2019. Following the acceleration of the novel coronavirus spreading, person-person transmissions in family residences, hospitals and other public environments have led to a major public hazard in China. Currently, the SARS-CoV-2 outbreak has been further developed into a public health emergency of international concern. In response to an occurring pandemic, hospitals need an emergency strategy and plan to manage their space, staff, and other essential resources, therefore, to provide optimum care to patients involved. In addition, infection prevention measures urgently need to be implemented to reduce in-hospital transmission and avoid the occurrence of virus super-spreading. For hospitals without capacity to manage severe patients, a referral network is often needed. We present our successful field experience regarding hospital emergency management and local hospitals network model in response to SARS-CoV-2 emerging epidemic.

scholarly journals Deep Learning Approach for Vibration Signals Applications

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3929
Author(s):  
Han-Yun Chen ◽  
Ching-Hung Lee
Keyword(s):  
Surface Roughness ◽  
Tool Wear ◽  
Parameters Optimization ◽  
Frequency Spectra ◽  
Vibration Signals ◽  
Bearing Faults ◽  
Time Frequency ◽  
And Performance ◽  
The One ◽  
Short Time

This study discusses convolutional neural networks (CNNs) for vibration signals analysis, including applications in machining surface roughness estimation, bearing faults diagnosis, and tool wear detection. The one-dimensional CNNs (1DCNN) and two-dimensional CNNs (2DCNN) are applied for regression and classification applications using different types of inputs, e.g., raw signals, and time-frequency spectra images by short time Fourier transform. In the application of regression and the estimation of machining surface roughness, the 1DCNN is utilized and the corresponding CNN structure (hyper parameters) optimization is proposed by using uniform experimental design (UED), neural network, multiple regression, and particle swarm optimization. It demonstrates the effectiveness of the proposed approach to obtain a structure with better performance. In applications of classification, bearing faults and tool wear classification are carried out by vibration signals analysis and CNN. Finally, the experimental results are shown to demonstrate the effectiveness and performance of our approach.

scholarly journals A new model for COVID-19 control and its implementation in the city of Honghu, China: a case report

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
He-ran Wang ◽  
Meng-chun Gong ◽  
Jing-Yuan Sun ◽  
Jian Sun ◽  
Yi Guo ◽  
...  
Keyword(s):  
Management Strategy ◽  
Human Infection ◽  
Public Health Emergency ◽  
Medical Resources ◽  
Case Presentation ◽  
Management Measures ◽  
Rapid Spread ◽  
Medical Teams ◽  
Novel Coronavirus ◽  
The City

Abstract Background Novel coronavirus pneumonia has been the most serious worldwide public health emergency since being identified in December 2019. The rapid spread of the pandemic and the strong human to human infection rate of COVID-19 poses a great prevention challenge. There has been an explosion in the number of confirmed cases in several cities near Wuhan, including the highest in Honghu, Jinzhou. Owing to the limited admission capacity and medical resources, increasing numbers of suspected cases of COVID-19 infection were difficult to confirm or treat. Case presentation Following the arrival of the Guangdong medical aid team on 11 February, 2020, COVID-19 care in Honghu saw changes after a series of solutions were implemented based on the ‘Four-Early’ and ‘Four-centralization’ management measures. The ‘Four-Early’ measures are: early detection, early reporting, early quarantine, and early treatment for meeting an urgent need like the COVID-19 pandemic. ‘Four-centralization’ refers to the way in which recruited medical teams can make full use of medical resources to give patients the best treatment. These solutions successfully increased the recovery rate and reduced mortality among patients with COVID-19 in Honghu. Conclusions This management strategy is called the ‘Honghu Model’ which can be generalized to enable the prevention and management of COVID-19 worldwide.

scholarly journals Comprehensive physiotherapy management in covid-19 – a narrative review

2020 ◽  
Vol 30 (1) ◽  
pp. 38030 ◽  
Author(s):  
Deivendran Kalirathinam ◽  
Raj Guruchandran ◽  
Prabhakar Subramani
Keyword(s):  
Narrative Review ◽  
World Health ◽  
Evidence Based ◽  
The United Kingdom ◽  
Global Pandemic ◽  
Related Quality ◽  
Health Related ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Uk

The 2019 novel coronavirus officially named as coronavirus disease 2019 (COVID-19) pandemic by the World Health Organization, has spread to more than 180 countries. The ongoing global pandemic of severe acute respiratory syndrome coronavirus, which causes COVID-19, spread to the United Kingdom (UK) in January 2020. Transmission within the UK was confirmed in February, leading to an epidemic with a rapid increase in cases in March. As on April 25- 2020, there have been 148,377 confirmed cases of COVID-19 in the UK and 20,319 people with confirmed infection have died. Survival of critically ill patients is frequently associated with significant functional impairment and reduced health-related quality of life. Early physiotherapy and community rehabilitation of COVID-19 patients has recently been identified as an essential therapeutic tool and has become a crucial evidence-based component in the management of these patients. This comprehensive narrative review aims to describe recent progress in the application of physiotherapy management in COVID 19 patients. Assessment and evidence- based treatment of these patients should include prevention, reduction of adverse consequences in immobilization, and long-term impairment sequelae. A variety of techniques and modalities of early physiotherapy in intensive care unit are suggested by clinical research. They should be applied according to the stage of the disease, comorbidities, and patient’s level of cooperation.

Experience with an evidence-based protocol using fibrinolysis as first line treatment for empyema in children

2013 ◽  
Vol 48 (6) ◽  
pp. 1312-1315 ◽  
Author(s):  
Alessandra C. Gasior ◽  
E. Marty Knott ◽  
Susan W. Sharp ◽  
Daniel J. Ostlie ◽  
George W. Holcomb ◽  
...  
Keyword(s):  
Evidence Based ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment

Acid Volatile Sulfide (AVS) and Simultaneously Extracted Metals (SEM) in Surface Sediments of Chaohu Lake, Anhui Province, China

2013 ◽  
Vol 779-780 ◽  
pp. 1213-1219
Author(s):  
Shu Qin Chen ◽  
Lei Zhang ◽  
Zhao Sheng Chu ◽  
She Rong Hu
Keyword(s):  
Surface Sediments ◽  
Local Scale ◽  
Acid Volatile Sulfide ◽  
Anthropogenic Factors ◽  
Chaohu Lake ◽  
Lake Surface ◽  
Different Seasons ◽  
The One ◽  
Short Time ◽  
Spot 5

At present there are few studies on the AVS and SEM in sediments of Chaohu Lake. Most of the previous studies on heavy metals based on the one time, the short-time or a local-scale survey. In this paper, [AVS] and [SEM] in Chaohu Lake surface sediments were studied for different seasons in 2007, 2008 and 2009. The results showed that: (a) The three-year average of [AV and [ΣSE in surface sediments of Chaohu Lake is 4.2μmolg-1and 2.31μmolg-1, respectively. The maximum of [AV appears on spot 5 (14.845μmolg-1) in summer while the minimum appears on spot 9 (0.13μmolg-1) in winter. (b) In spot 5 which near the estuary of Yuxi River, three-year average of [SE was the maximum (5.81μmolg-1), and the minimum of [ΣSE (0.07μmolg-1) appears on spot 8 which locates in the middle of Chaohu Lake. In spot 13 the [ΣSEM]-[AVS]=3.2>2 and [ΣSEM]/[AVS]=4.45>2.34 indicate that heavy metal contaminants from Hefei city have threatened the biosafety of Chaohu Lake. (c) The spatial autocorrelation of SEMCdis weak, which indicates that spatial distribution of SEMCdis determined by anthropogenic factors rather than sediments' own attribute. Chaohu Lake has been heavily polluted by Cd from no-point source and electronic electroplating industry.

CLASSICAL DIFFUSION AND QUANTAL LOCALIZATION OF A KICKED PARTICLE IN A WELL

1988 ◽  
Vol 02 (01) ◽  
pp. 103-120 ◽  
Author(s):  
AVRAHAM COHEN ◽  
SHMUEL FISHMAN
Keyword(s):  
Diffusion Coefficient ◽  
Classical Limit ◽  
Approximate Formula ◽  
Quantum Systems ◽  
Potential Well ◽  
Diffusive Growth ◽  
Classical Chaos ◽  
The One ◽  
Short Time ◽  
Infinite Potential Well

The classical and quantal behavior of a particle in an infinite potential well, that is periodically kicked is studied. The kicking potential is K|q|α, where q is the coordinate, while K and α are constants. Classically, it is found that for α > 2 the energy of the particle increases diffusively, for α < 2 it is bounded and for α = 2 the result depends on K. An approximate formula for the diffusion coefficient is presented and compared with numerical results. For quantum systems that are chaotic in the classical limit, diffusive growth of energy takes place for a short time and then it is suppressed by quantal effects. For the systems that are studied in this work the origin of the quantal localization in energy is related to the one of classical chaos.

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