Reviewing Antiviral Research Against Viruses Causing Human Diseases - A Structure Guided Approach

2021 ◽  
Vol 14 ◽  
Author(s):  
Arunima Sikdar ◽  
Rupali Gupta ◽  
Evzen Boura
Keyword(s):  
Viral Infections ◽  
Human Diseases ◽  
The World ◽  
Science Strategies ◽  
Hiv Aids

: The littlest of all the pathogens, viruses have continuously been the foremost strange microorganisms to consider. Viral Infections can cause extreme sicknesses as archived by the HIV/AIDS widespread or the later Ebola or Zika episodes. Apprehensive framework distortions are too regularly watched results of numerous viral contaminations. Besides, numerous infections are oncoviruses, which can trigger different sorts of cancer. Nearly every year a modern infection species rises debilitating the world populace with an annihilating episode. Subsequently, the need of creating antivirals to combat such rising infections. In any case, from the innovation of to begin with antiviral medicate Idoxuridine in 1962 to the revelation of Baloxavir marboxil (Xofluza) that was FDA-approved in 2018, the hone of creating antivirals has changed significantly. In this article, different auxiliary science strategies have been described that can be referral for therapeutics innovation.

scholarly journals Metavirome Survey of Eight Ray-Finned Fishes Revealed Domination of Giant Viral Members of Pandoravirus and Megaviricetes

2021 ◽  
Author(s):  
Fatemeh Sana Askari ◽  
Alireza Mohebbi
Keyword(s):  
Public Health ◽  
Microbial Diversity ◽  
Evolutionary History ◽  
Viral Infections ◽  
Marine Ecosystem ◽  
Marine Ecosystems ◽  
Human Diseases ◽  
Dna Viruses ◽  
The World

Abstract Background Fishes are an essential source of food all around the world. The bulk of the microbial diversity in marine ecosystems is uncharacterized, with viruses accounting for most of the remaining diversity. This may be a major danger to public health, therefore knowing the variety of viruses in the marine ecosystem is critical. The goal was to assess the virome of ray-finned fishes in terms of variety and relation to human diseases. Results It was revealed that the viral kingdom was allocated 2,228,888 sequence reads. The pooled genome assay of the ray-finned fishes indicated a significant abundance of viruses in three clades of the genus Pandoravirus (31%), the order of Herepesvirales (23%), and the kingdom of Bamfordvirae (10%). Furthermore, 432281/2031445 reads (21%) of mapped reads were unassigned viruses. According to the GiantVirusFinder findings, 17931 hits (4.15$) were mapped to the genomes of known giantviruses. Conclusion Humans eat seafood regularly as one of their primary diets. Ray-finned fishes have a long evolutionary history and, as demonstrated here, are hosts to a variety of large DNA viruses. Fish must be screened for viral infections that are linked to human illnesses.

World Bank/USAID co-hosted debate on "funding allocations for HIV/AIDS", webcasted live from the World Bank

2012 ◽  
Author(s):  
Timothy Mah ◽  
Marelize Gorgens ◽  
Elizabeth Ashbourne ◽  
Cristina Romero ◽  
Nejma Cheikh
Keyword(s):  
World Bank ◽  
The World Bank ◽  
The World ◽  
Hiv Aids

scholarly journals COVID-19: Role of Nutrition and Supplementation

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 976
Author(s):  
Fiorenzo Moscatelli ◽  
Francesco Sessa ◽  
Anna Valenzano ◽  
Rita Polito ◽  
Vincenzo Monda ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Viral Infections ◽  
Overweight And Obesity ◽  
Shortness Of Breath ◽  
Nutritional Interventions ◽  
The World ◽  
Diet Regimen ◽  
Specific Diet

At the end of 2019, a new coronavirus (COVID-19) appeared on the world scene, which mainly affects the respiratory system, causing pneumonia and multi-organ failure, and, although it starts with common symptoms such as shortness of breath and fever, in about 2–3% of cases it leads to death. Unfortunately, to date, no specific treatments have been found for the cure of this virus and, therefore, it is advisable to implement all possible strategies in order to prevent infection. In this context, it is important to better define the role of all behaviors, in particular nutrition, in order to establish whether these can both prevent infection and improve the outcome of the disease in patients with COVID-19. In the literature, it is widely shown that states of malnutrition, overweight, and obesity negatively affect the immune system, leading to viral infections, and several studies have shown that nutritional interventions can act as immunostimulators, helping to prevent viral infections. Even if several measures, such as the assumption of a specific diet regimen, the use of dietary supplements, and other similar interventions, are promising for the prevention, management, and recovery of COVID-19 patients, it is important to highlight that strong data from randomized clinical trials are needed to support any such assumption. Considering this particular scenario, we present a literature review addressing several important aspects related to diet and SARS-CoV-2 infection, in order to highlight the importance of diet and supplementation in prevention and management of, as well as recovery from COVID-19.

scholarly journals Informed consent and informed intervention: SARS-CoV-2 vaccinations not just call for disclosure of newly emerging safety data but also for hypothesis generation and testing

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Johannes C. Fischer ◽  
Albrecht G. Schmidt ◽  
Edwin Bölke ◽  
Verena Keitel ◽  
Torsten Feldt ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Providers ◽  
Viral Infections ◽  
Safety Data ◽  
Hypothesis Generation ◽  
Care Providers ◽  
Vaccination Programs ◽  
Major Threat ◽  
The World ◽  
Population Scale

Abstract Background COVID-19 infection is a major threat to patients and health care providers around the world. One solution is the vaccination against SARS-CoV-2. Methods We performed a comprehensive query of the latest publications on the prevention of viral infections including the recent vaccination program and its side effects. Results The situation is evolving rapidly and there is no reasonable alternative to population-scale vaccination programs as currently enrolled. Conclusion Therefore, regulatory authorities should consider supplementing their conventional mandate of post-approval pharmacovigilance, which is based on the collection, assessment, and regulatory response to emerging safety findings.

scholarly journals Epidemiology of African Swine Fever and Its Risk in Nepal

2021 ◽  
Vol 12 (3) ◽  
pp. 580-591
Author(s):  
Deepak Subedi ◽  
Suman Bhandari ◽  
Saurav Pantha ◽  
Uddab Poudel ◽  
Sumit Jyoti ◽  
...  
Keyword(s):  
Viral Infection ◽  
Management Practices ◽  
Viral Infections ◽  
African Swine Fever ◽  
Illegal Trade ◽  
Effective Management ◽  
Pork Industry ◽  
Wild Pigs ◽  
The World ◽  
The Government

African swine fever (ASF) is a highly contagious viral infection of domestic and wild pigs with high mortality. First reported in East Africa in the early 1900s, ASF was largely controlled in domestic pigs in many countries. However, in recent years ASF outbreaks have been reported in several countries in Europe and Asia. The occurrence of ASF in China, the largest pork producer in the world, in 2018 and in India, the country that surrounds and shares open borders with Nepal, has increased the risk of ASF transmission to Nepal. Lately, the pork industry has been growing in Nepal, overcoming traditional religious and cultural biases against it. However, the emergence of viral infections such as ASF could severely affect the industry's growth and sustainability. Because there are no effective vaccines available to prevent ASF, the government should focus on preventing entry of the virus through strict quarantine measures at the borders, controls on illegal trade, and effective management practices, including biosecurity measures.

scholarly journals The social construction of HIV/AIDS

2003 ◽  
Vol 8 (2) ◽  
Author(s):  
Natalie Goldstein ◽  
H G Pretorius ◽  
A D Stuart
Keyword(s):  
South Africa ◽  
Social Construction ◽  
Full Text ◽  
Aids Epidemic ◽  
The Social ◽  
The World ◽  
Hiv Aids

An in-depth look is taken at the specific discourses surrounding the debilitating HIV/AIDS epidemic sweeping South Africa and the world. Opsomming Hierdie artikel poog om ‘n indiepte ondersoek te loods na die spesifieke diskoerse rondom die MIV/VIGS epidemie in Suid-Afrika en die wêreld. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

scholarly journals Risk of Sexually Transmitted Infections and HIV in Adolescence

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Alba Cortés Alfaro
Keyword(s):  
Sexually Transmitted Infections ◽  
Family Doctor ◽  
Review Article ◽  
Vulnerable Group ◽  
Sexually Transmitted ◽  
The Family ◽  
The World ◽  
The Caribbean ◽  
Good Coverage ◽  
Hiv Aids

Introduction adolescents represent a vulnerable group exposed to sexually transmitted infections including HIV/AIDS. It is a stage in which they are subjected to constant changes in physical, mental and social development and risk factors such as ignorance, early sex, drug addiction, social inequality, gender and myths contribute to this exposure. Objective: To delve into the characteristics of adolescents that put them at risk of acquiring an STI-HIV/AIDS. Methods: A bibliographic review was carried out where the databases included in the LILACS, EBSCO and HINARI services were consulted, and very good coverage was achieved, both in Cuba, Latin America and the Caribbean, and in the rest of the world. Conclusions: This review article on the risks to which adolescents are subjected to acquiring an STI-HIV/AIDS is put in the hands of all personnel involved in working with adolescents. For the family doctor in particular for being a staff closely linked to the community, allowing them to be in better conditions to detect these behaviors thus contributing to exercise and undertake prevention actions that will allow us to achieve the objectives of our Ministry of Public Health in relation to with this indicator.

scholarly journals Global and National Trends of HIV/AIDS

2018 ◽  
Vol 18 (17) ◽  
pp. 151-158
Author(s):  
Hikmat Bahadur Raya
Keyword(s):  
Regression Analysis ◽  
Health Problem ◽  
Quantitative Research ◽  
Secondary Data ◽  
The World ◽  
Entire World ◽  
National Trends ◽  
Positive Results ◽  
Initial Coverage ◽  
Hiv Aids

HIV/AIDS is one of the worst pandemics, the world has ever known and the entire world has been combating with it. Objective of the study is to analyze the global and national trend of HIV/AIDS regarding the indices PLHIV, New infections and AIDS-related death and coverage of ART. This is a quantitative research completely based on the secondary data. The data is analyzed by simple statistical representations. Regression analysis is used to analyze the trends and to make some predictions. The number of PLHIV is increased by 19.9 percent from 1997 to 2015 and by 69.6 percent from 2000 to 2015 in Nepal. In this same duration, the new HIV infection is reduced by 63.8 percent and 82.6 percent, AIDS related death by 52.2 percent and 411.1 percent respectively in the global and Nepal. The initial coverage of ART in both regions was negligible and by the end of 2015 it reached to 46.4 percent and 30.6 percent in the global and Nepal respectively. Nepal along with the global achieves some positive results in the combating of this health problem. By analyzing the trends, it is not worth to say that we are not far from the achievement of SDGs.  

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