Association of Components of Metabolic Syndrome with Depression and Anxiety in Patients Undergoing Weight Reduction Surgery~!2009-09-21~!2009-12-23~!2010-08-27~!

AbstractMetabolic syndrome (MetS) is a condition characterized by a constellation of reversible major risk factors for cardiovascular disease (CVD) and type 2 diabetes (T2DM). While it has been widely demonstrated that weight reduction by 5–10% decreases CVD and T2DM risk factors, including atherogenic dyslipidemia, on the other hand, its effects on comprehensive serum cytokine profile and endotoxemia are less investigated. Furthermore, the impact of weight loss on these parameters was studied especially in subjects with morbid obesity, often after bariatric surgery; while the studies on the effects of a physiological weight reduction with a balanced hypocaloric diet in overweight and moderately obese subjects showed contradictory results.The aim of this pilot study was to investigate in overweight and obese men with MetS the effects of caloric restriction on the MetS-associated risk factors, chemical composition of lipoproteins and serum concentration of a wide spectrum of inflammation markers. In addition, the second purpose of this work was to study the possible correlation between lipoprotein chemical composition and these inflammation markers.Eighteen adult Caucasian males (25 kg/m2 < BMI < 35 kg/m2) with MetS losing at least 5% of their initial weight after six months of a Mediterranean-style balanced hypo-caloric diet were included in the study. Lipoproteins were isolated from plasma by ultracentrifugation in a discontinuous KBr gradient. Lipoprotein concentrations of proteins, cholesterol, phospholipids, and triacylglycerols were determined by colorimetric assays. Peripheral cytokine levels (IL-2, IL-6, IL-7, IL-8, IL-10, IL-12, IL-17, GM-CSF, MCP-1, MIP-1b, IL1-b, IL-4, IL-5, IL-13, G-CSF, INF-g, TNF-a) were determined by Bioplex multiplex immunoassay. Endotoxemia was measured by Limulus Amebocyte lysate assay. The effects of weight-loss were analysed by Wilcoxon's test, the correlations between covariates by Spearman's test (significance: p-value ≤ 0.05).After weight loss, we observed an improvement of MetS-associated risk factors and changes in lipoproteins composition. In particular, together with a reduction of triglyceridemia, we detected a massive transfer of triacylglycerols from HDLs toward LDLs. Furthermore, a significant decrease of IL-6 (0.9 ± 0.7 vs 0.5 ± 0.6), TNF-α (0.7 ± 0.3 vs 0.3 ± 0.18), IL-8 (1.6 ± 0.7 vs 1.3 ± 0.3) and MIP-1β (19.2 ± 1.5 vs 18.5 ± 1.5) was observed. Finally, peripheral levels of TNF-α and IL-8 were directly correlated with all lipid species of VLDL, whereas the concentration of MIP-1β and endotoxin with HDL lipids.Weight loss improved cardio-metabolic risk factors and decreased inflammatory state by reduction of cytokine levels. The relationships between lipoprotein composition and serum inflammation markers deserve to be deepened by studying broader populations.

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Effects of Weight Reduction Therapy on Obstructive Sleep Apnea Syndrome and Arterial Stiffness in Patients with Obesity and Metabolic Syndrome

Journal of Atherosclerosis and Thrombosis ◽

10.5551/jat.17632 ◽

2013 ◽

Vol 20 (11) ◽

pp. 807-820 ◽

Cited By ~ 22

Author(s):

Azusa Iguchi ◽

Hajime Yamakage ◽

Mayu Tochiya ◽

Kazuya Muranaka ◽

Yousuke Sasaki ◽

...

Keyword(s):

Metabolic Syndrome ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Arterial Stiffness ◽

Obstructive Sleep Apnea Syndrome ◽

Weight Reduction ◽

Sleep Apnea Syndrome ◽

Obstructive Sleep ◽

Apnea Syndrome

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Effects of a 3-Week In-Hospital Body Weight Reduction Program on Cardiovascular Risk Factors, Muscle Performance, and Fatigue: A Retrospective Study in a Population of Obese Adults with or without Metabolic Syndrome

Nutrients ◽

10.3390/nu12051495 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1495 ◽

Cited By ~ 1

Author(s):

Antonello E. Rigamonti ◽

Sabrina Cicolini ◽

Diana Caroli ◽

Alessandra De Col ◽

Massimo Scacchi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Body Weight ◽

Weight Reduction ◽

Hdl Cholesterol ◽

Muscle Performance ◽

Weight Reduction Program ◽

Body Weight Reduction ◽

Reduction Program ◽

Obese Subjects

Background. In clinical practice, there is the diffuse conviction that obese subjects with metabolic syndrome may be more difficult to treat. Objectives and Methods. The aim of the present study was that to investigate the effectiveness of a 3-week in-hospital body weight reduction program (BWRP) in a large population of obese subjects with and without metabolic syndrome (n = 1922; 222 men and 1700 women, age range 18–83 yr). Outcomes such as body mass index (BMI), total (TOT) and HDL cholesterol, systolic and diastolic blood pressures (SBP and DBP, respectively), coronary heart disease (CHD) score, fatigue severity score (FSS), and stair climbing test (SCT) time were evaluated before and after the intervention (Δ). A sex-, BMI-, and age-related stratification of the obese population with or without metabolic syndrome was applied. Results. When compared to obese subjects without metabolic syndrome, at the basal conditions, obese subjects had a poorer cardiometabolic profile, as demonstrated by higher triglycerides, TOT-cholesterol, DBP, SBP, and CHD score, and a more compromised muscle performance (evaluated by SCT), associated with more perception of fatigue (measured by FSS). Nevertheless, obese subjects with metabolic syndrome obtained more benefits from BWRP than those without metabolic syndrome for some outcomes (i.e., ΔTOT-cholesterol, ΔSBP, and ΔCHD score). Despite these differences, the BWRP-induced weight loss was similar between the two groups (i.e., ΔBMI) as well as the gain of muscle performance (i.e., ΔSCT) and the reduction of fatigue (i.e., ΔFSS). Interestingly, the potentially deleterious fall in HDL-cholesterol levels after BWRP was less evident in obese subjects with metabolic syndrome than those without metabolic syndrome. When pooling all data, the ΔCHD score was associated with age, sex, and metabolic syndrome. The remaining outcomes, such as ΔBMI, ΔFSS, and ΔSCT time, were associated with sex and age but not with metabolic syndrome. Finally, ΔBMI was positively correlated with ΔCHD score, ΔFSS, and ΔSCT time in both obese subjects without metabolic syndrome and obese subjects with metabolic syndrome. Conclusions. When comparing obese subjects undergoing a BWRP, metabolic syndrome is not a negative predictive factor affecting the effectiveness of this intervention in terms of weight loss, muscle performance, and psychological well-being.

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Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study

Acta Endocrinologica ◽

10.1530/eje-07-0598 ◽

2008 ◽

Vol 158 (3) ◽

pp. 333-341 ◽

Cited By ~ 19

Author(s):

T Lappalainen ◽

M Kolehmainen ◽

U Schwab ◽

L Pulkkinen ◽

D E Laaksonen ◽

...

Keyword(s):

Gene Expression ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

Weight Reduction ◽

Serum Amyloid A ◽

Normal Weight ◽

Serum Amyloid ◽

Serum Concentrations ◽

Amyloid A ◽

Obese Subjects

ObjectiveSerum amyloid A (SAA) is a novel link between increased adipose tissue mass and low-grade inflammation in obesity. Little is known about the factors regulating its serum concentration and mRNA levels. We investigated the association between SAA and leptin in obese and normal weight subjects and analyzed the effect of weight reduction on serum SAA concentration and gene expression in adipose tissue of the obese subjects.MethodsSeventy-five obese subjects (60±7 years, body mass index (BMI) 32.9±2.8 kg/m2, mean±s.d.) with impaired fasting plasma glucose or impaired glucose tolerance and other features of metabolic syndrome, and 11 normal weight control subjects (48±9 years, BMI 23.7±1.9 kg/m2) were studied at the baseline. Twenty-eight obese subjects underwent a 12-week intensive weight reduction program followed by 5 months of weight maintenance. Blood samples and abdominal s.c. adipose tissue biopsies were taken at the baseline and after the follow-up. Gene expression was studied using real-time quantitative PCR.ResultsThe gene expressions in women and serum concentrations of leptin and SAA were interrelated independently of body fat mass in the obese subjects (r=0.54, P=0.001; r=0.24, P=0.039 respectively). In multiple linear regression analyses, leptin mRNA explained 38% of the variance in SAA mRNA (P=0.002) in the obese women. Weight loss of at least 5% increased SAA mRNA expression by 48 and 36% in men and women, but serum SAA concentrations did not change.ConclusionsThe association between SAA and leptin suggests an interaction between these two adipokines, which may have implications in inflammatory processes related to obesity and the metabolic syndrome.

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Erratum to: APJDM 2, 93-96 (2008)Body Weight Reduction Program for Metabolic Syndrome

Asian Pacific Journal of Disease Management ◽

10.7223/apjdm.3.32e ◽

2009 ◽

Vol 3 (1) ◽

pp. 32E-32E

Author(s):

Mio Takimoto ◽

Miwa Kibushi ◽

Yumi Okoshi ◽

Tohru Nakagawa ◽

Masataka Irokawa ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Weight Reduction ◽

Weight Reduction Program ◽

Body Weight Reduction ◽

Reduction Program

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Sleep apnoea and nutrition

Arbor Clinical Nutrition Updates ◽

10.1017/s1446545000000373 ◽

2009 ◽

Vol 302 ◽

pp. 1-3

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Clinical Trials ◽

Weight Reduction ◽

High Fat Diet ◽

Sleep Apnoea ◽

High Fat ◽

Nutritional Treatment ◽

Nutritional Influences

In a nutshellPotential nutritional influences on sleep apnoea include: overweight, oxidative stress, inflammation, metabolic syndrome and high fat diet.However, so far weight reduction is the only nutritional treatment stemming from this list that is well supported by clinical trials.

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