Biological Evaluation of Synthesized Naringenin Derivatives as Antimicrobial Agents
Abstract: Flavonoids are among the most abundant plant secondary metabolites and have been shown to have natural abilities as microbial deterrents and anti-infection agents in plants. Naringenin as one of the flavonoids and its derivatives have been reported to exhibit antimicrobial activity. The aim of the study was to evaluate synthesized novel naringenin derivatives (ND-1 to ND-12) substituted at 3-position with bulky substituent by using the grinding technique (Claisen-Schmidt reaction) as antimicrobial agents. Synthesized naringenin derivatives were evaluated for in-vitro antimicrobial activity by "Agar disc diffusion method". Novel naringenin derivatives showed mild to moderate antimicrobial activity with respect to standard drugs against two gram-positive, two gram-negative bacteria and two fungal strains. The substitution of naringenin derivatives at position 3 with substituted phenyl rings showed variation in activity as chloro, nitro and hydroxyl-substituted phenyl ring showed potent activity while methoxy substituted phenyl ring impede the activity. In conclusion, on the basis of the above findings, the substituted naringenin scaffolds may be selected as a skeleton for the development of flavonoid structurally-related compounds having antimicrobial activity