Functional Nanomaterials and Their Potential Applications in Antibacterial Therapy

2019 ◽  
Vol 7 (2) ◽  
pp. 129-146 ◽  
Author(s):  
Le Hong ◽  
Shu-Han Luo ◽  
Chen-Hao Yu ◽  
Yu Xie ◽  
Meng-Ying Xia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Lower Side ◽  
Functional Nanomaterials ◽  
Graphene Oxides ◽  
The Past ◽  
Potential Applications ◽  
Carbon Based Nanomaterials ◽  
Direct Use

In the past decades, nanomaterials have shown great potential in biomedical fields, especially in drug delivery, imaging and targeted therapy. Recently, the development of novel functional nanomaterials for antibacterial application has attracted much attention. Compared to the traditional direct use of antibiotics, antibacterial nanomaterials either as drug delivery systems or active agents have a higher efficacy and lower side effects. Herein, we will focus on the antibacterial applications of four commonly used nanomaterials, including metal-based nanomaterials, polymeric nanoparticles, graphene oxides or carbon-based nanomaterials and nanogels.

scholarly journals Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Fakhara Sabir ◽  
Muhammad Imran Asad ◽  
Maimoona Qindeel ◽  
Iqra Afzal ◽  
Muhammad Junaid Dar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Chemical Reactivity ◽  
Daily Basis ◽  
Delivery Systems ◽  
The Past ◽  
Future Challenges ◽  
Pros And Cons

Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone of research with speedy developments taking place on a daily basis. An incredible amount of focus is placed on the fabrication of NGs with novel polymers to achieve better control over the drug release. This review article covers a number of aspects of NGs including their types, associated pros and cons, and methods of preparation along with technical and economical superiority and therapeutic efficacy over each other. The last part of review summarizes the applications of NGs in the drug delivery and treatment of various diseases including brain disease, cardiovascular diseases, oxidative stress, diabetes, cancer therapy, tissue engineering, gene therapy, inflammatory disorders, pain management, ophthalmic and autoimmune diseases, and their future challenges. NGs appear to be an outstanding nominee for drug delivery systems, and further study is required to explore their interactions at the cellular and molecular levels.

The application progress of peptides in drug delivery systems in the past decade

2021 ◽  
Vol 66 ◽  
pp. 102880
Author(s):  
Bing Yang ◽  
Tian-tian Wang ◽  
Yu-shun Yang ◽  
Hai-liang Zhu ◽  
Jian-hua Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past

scholarly journals Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo
Keyword(s):  
Drug Delivery ◽  
Sialic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

Functionalization of polyethetherketone for application in dentistry and orthopedics

2017 ◽  
Vol 18 (1-2) ◽  
Author(s):  
Rico Harting ◽  
Marius Barth ◽  
Thomas Bührke ◽  
Regina Sophia Pfefferle ◽  
Svea Petersen
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
High Performance ◽  
Drug Delivery Systems ◽  
Metal Implant ◽  
High Performance Polymer ◽  
Potential Applications ◽  
Physical And Chemical ◽  
Very High ◽  
Huge Challenge

AbstractSince late 1990s, polyetheretherketone (PEEK) has presented a promising polymeric alternative to metal implant components, particularly in orthopedic and traumatic applications. However, PEEK is biologically inert, which has constrained its potential applications. In this manner, enhancing the bioactivity of PEEK is a huge challenge that must be comprehended to completely understand the potential advantages. Up to now, two noteworthy methodologies are discussed to enhance the bioactivity of PEEK, including bulk and surface modification. Although the latter is extremely challenging due to the very high physical and chemical stability of the high performance polymer, there are some stated modification reactions in the literature, which will be collocated with in the literature-reported PEEK composites in the present article. We will furthermore add information on polymer-based drug delivery systems and the biofunctionalization of polymers in general and discuss their applicability for PEEK, as we estimate that these strategies will gain greater attention in the future. At the end of the article, our own research on the development of a PEEK-associated biodegradable drug-delivery system with potential application in dentistry or orthopedics will be highlighted.

scholarly journals Direct Quantification of Drug Loading Content in Polymeric Nanoparticles by Infrared Spectroscopy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 912
Author(s):  
Guzmán Carissimi ◽  
Mercedes G. Montalbán ◽  
Gloria Víllora ◽  
Andreas Barth
Keyword(s):  
Drug Delivery ◽  
Infrared Spectroscopy ◽  
Drug Delivery Systems ◽  
Limit Of Detection ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Delivery Systems ◽  
Relative Mass ◽  
Simple Method ◽  
Recovery Method

Nanotechnology has enabled the development of novel therapeutic strategies such as targeted nanodrug delivery systems, control and stimulus-responsive release mechanisms, and the production of theranostic agents. As a prerequisite for the use of nanoparticles as drug delivery systems, the amount of loaded drug must be precisely quantified, a task for which two approaches are currently used. However, both approaches suffer from the inefficiencies of drug extraction and of the solid-liquid separation process, as well as from dilution errors. This work describes a new, reliable, and simple method for direct drug quantification in polymeric nanoparticles using attenuated total reflection Fourier transform infrared spectroscopy, which can be adapted for a wide variety of drug delivery systems. Silk fibroin nanoparticles and naringenin were used as model polymeric nanoparticle carrier and drug, respectively. The specificity, linearity, detection limit, precision, and accuracy of the spectroscopic approach were determined in order to validate the method. A good linear relation was observed within 0.00 to 7.89% of naringenin relative mass with an R2 of 0.973. The accuracy was determined by the spike and recovery method. The results showed an average 104% recovery. The limit of detection and limit of quantification of the drug loading content were determined to be 0.3 and 1.0%, respectively. The method’s robustness is demonstrated by the notable similarities between the calibrations carried out using two different equipment setups at two different institutions.

scholarly journals Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1232
Author(s):  
Mohammadmahdi Mobaraki ◽  
Madjid Soltani ◽  
Samaneh Zare Harofte ◽  
Elham L. Zoudani ◽  
Roshanak Daliri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Sense Organs ◽  
Drug Bioavailability ◽  
Controllable Release ◽  
The World ◽  
Pros And Cons ◽  
Different Parts

During recent decades, researchers all around the world have focused on the characteristic pros and cons of the different drug delivery systems for cornea tissue change for sense organs. The delivery of various drugs for cornea tissue is one of the most attractive and challenging activities for researchers in biomaterials, pharmacology, and ophthalmology. This method is so important for cornea wound healing because of the controllable release rate and enhancement in drug bioavailability. It should be noted that the delivery of various kinds of drugs into the different parts of the eye, especially the cornea, is so difficult because of the unique anatomy and various barriers in the eye. Nanoparticles are investigated to improve drug delivery systems for corneal disease. Biodegradable nanocarriers for repeated corneal drug delivery is one of the most attractive and challenging methods for corneal drug delivery because they have shown acceptable ability for this purpose. On the other hand, by using these kinds of nanoparticles, a drug could reside in various part of the cornea for longer. In this review, we summarized all approaches for corneal drug delivery with emphasis on the biodegradable nanoparticles, such as liposomes, dendrimers, polymeric nanoparticles, niosomes, microemulsions, nanosuspensions, and hydrogels. Moreover, we discuss the anatomy of the cornea at first and gene therapy at the end.

Functional peptide-based drug delivery systems

2020 ◽  
Vol 8 (31) ◽  
pp. 6517-6529 ◽  
Author(s):  
Zheng Lian ◽  
Tianjiao Ji
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past ◽  
Functional Peptides ◽  
Functional Peptide ◽  
Smart Drug ◽  
Smart Drug Delivery

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.

scholarly journals The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

2015 ◽  
Vol 2015 ◽  
pp. 1-27 ◽  
Author(s):  
Karolina Werengowska-Ciećwierz ◽  
Marek Wiśniewski ◽  
Artur P. Terzyk ◽  
Sylwester Furmaniak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Physical Adsorption ◽  
Drug Carrier ◽  
Anticancer Therapy ◽  
Modern Drug ◽  
Polycyclic Groups ◽  
Novel Drug ◽  
Small Elements

Nanomedicine is, generally, the application of nanotechnology to medicine. The term nanomedicine includes monitoring, construction of novel drug delivery systems, and any possible future applications of nanotechnology and nanovaccinology. In this review, the most important ligand-nanocarrier and drug-nanocarrier bioconjugations are described. The detailed characterizations of covalently formed bonds between targeted ligand and nanocarrier, including amide, thioether, disulfide, acetyl-hydrazone and polycyclic groups, are described. Also, the coupling of small elements and heteroatoms in the form of R-X-R the “click chemistry” groups is shown. Physical adsorption and chemical bonding of drug to nanocarrier surface involving drug on the internal or external surfaces of nanocarriers are described throughout possibility of the formation of the above-mentioned functionalities. Moreover, the most popular nanostructures (liposomes, micelles, polymeric nanoparticles, dendrimers, carbon nanotubes, and nanohorns) are characterized as nanocarriers. Building of modern drug carrier is a new method which could be effectively applied in targeted anticancer therapy.

Chitosan Polyelectrolyte Complexes for Use in Tissue Engineering and Drug Delivery

2007 ◽  
Vol 539-543 ◽  
pp. 577-582
Author(s):  
Silvia Bubeníková ◽  
Igor Lacík ◽  
Dušan Bakoš ◽  
Lucia Vodná
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Reaction Time ◽  
Drug Delivery Systems ◽  
Chondroitin Sulphate ◽  
Delivery Systems ◽  
Medical Field ◽  
Polyelectrolyte Complexes ◽  
Potential Applications ◽  
Cross Linker

The paper presents the first part of the work focused on preparation of biodegradable chitosan microcapsules with tailored properties for potential applications in medical field as drug temporary carriers. In this paper, we aimed to prepare chitosan and chondroitin sulphate microcapsules using TPP as the second cross-linker and investigate the formation of the capsule membrane and its permeability in dependence on conditions of polyionic complexation. As a model, TPP was used to assess an influence of concentration and reaction time on the microcapsule formation. The method of inverse SEC was used for pores size and permeability limit of capsules assessment. For chitosan/CHS/TPP capsules, the distribution of pores size in the membrane is rather broad, which can be suitable for applications in tissue engineering and drug delivery systems.

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