scholarly journals The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

2015 ◽  
Vol 2015 ◽  
pp. 1-27 ◽  
Author(s):  
Karolina Werengowska-Ciećwierz ◽  
Marek Wiśniewski ◽  
Artur P. Terzyk ◽  
Sylwester Furmaniak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Physical Adsorption ◽  
Drug Carrier ◽  
Anticancer Therapy ◽  
Modern Drug ◽  
Polycyclic Groups ◽  
Novel Drug ◽  
Small Elements

Nanomedicine is, generally, the application of nanotechnology to medicine. The term nanomedicine includes monitoring, construction of novel drug delivery systems, and any possible future applications of nanotechnology and nanovaccinology. In this review, the most important ligand-nanocarrier and drug-nanocarrier bioconjugations are described. The detailed characterizations of covalently formed bonds between targeted ligand and nanocarrier, including amide, thioether, disulfide, acetyl-hydrazone and polycyclic groups, are described. Also, the coupling of small elements and heteroatoms in the form of R-X-R the “click chemistry” groups is shown. Physical adsorption and chemical bonding of drug to nanocarrier surface involving drug on the internal or external surfaces of nanocarriers are described throughout possibility of the formation of the above-mentioned functionalities. Moreover, the most popular nanostructures (liposomes, micelles, polymeric nanoparticles, dendrimers, carbon nanotubes, and nanohorns) are characterized as nanocarriers. Building of modern drug carrier is a new method which could be effectively applied in targeted anticancer therapy.

Effect of NDDS on Polyherbal Formulation

2021 ◽  
pp. 106-148
Author(s):  
Sandeep Onkar Waghulde ◽  
Nilofar A. Khan ◽  
Nilesh Gorde
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Plant Materials ◽  
Ancient Times ◽  
Reduced Toxicity ◽  
Novel Drug ◽  
Herbal Formulations

In India, in ancient times, people used plant materials to make drug polyherbal formulations. Herbal drugs have enormous therapeutic potential which can be explored through various beneficial drug delivery systems and novel drug delivery systems. Great advancement has been made in the uses of plant therapeutics on the development of novel herbal formulations like polymeric nanoparticles, nanocapsules, liposomes, phytosomes, nanoemulsions, microsphere, transferosomes, and ethosomes. These formulations have reported having various advantages over the traditional formulations such as improved solubility and bioavailability, reduced toxicity, controlled drug delivery, protections of plant actives from degradation. Also, having the drug targeting properties with improved selectivity, drug delivery, and effectiveness with dose reduction not only increases the safety but also patient compliance.

NANO-CARRIER BASED DRUG DELIVERY SYSTEMS CONTAINING BIOACTIVE FROM CARICA PAPAYA FOR ANTI-DIABETIC ACTIVITY

2021 ◽  
Vol 11 (6) ◽  
pp. 9-15
Author(s):  
Rima Ramesh Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Carica Papaya ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Patient Comfort ◽  
Synthetic Drugs ◽  
Therapeutic Benefits ◽  
Alternative Drug ◽  
Novel Drug

Significant progress has been achieved in the creation of novel drug delivery systems based on herbal bioactive in recent years. Herbal formulations for novel drug delivery systems are more efficient and have more benefits than other alternatives. Papaya (Carica papaya Linn) is very popular for its nutritious as well as therapeutic benefits all over the world. Carica papaya is a tropical and subtropical fruit that is used as a vegetable and in herbal medicine to treat a variety of ailments. The rising prevalence of diabetes, along with the harsh side effects of some synthetic drugs, has prompted an increase in the search for natural alternatives. Liposomes, phytosomes, ethosomes microspheres, nano-capsules, transferosomes, polymeric nanoparticles, nano-emulsions, and nano-emulsions have all been developed using bioactive and plant extracts. The primary motivation for the advancement of alternative drug delivery is to improve drug delivery quality and safety while also providing greater patient comfort.

scholarly journals Impact of Modern Technology on the Development of Natural-based Products

2020 ◽  
Vol 5 (4) ◽  
pp. 133-142
Author(s):  
Siti Fariza Arifin ◽  
◽  
AbdulKareem AlShami ◽  
Sharifah Shakirah Syed Omar ◽  
Azri Abd Jalil ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Modern Technology ◽  
Active Compounds ◽  
Success Stories ◽  
Therapeutic Outcomes ◽  
Modern Drug ◽  
Herbal Formulations

Advanced drug delivery systems such as liposomes, niosomes, ethosomes and phytosomes significantly influence the quality of synthetic drug formulations. However, the trend is now shifting towards natural-based moieties, most probably because of their promising therapeutic responses, and considerably lower incidence of side effects and toxicity issues. The effectiveness of herbal plant formulations in nano-sized particles in the delivery of active compounds is increased since nanoparticles offer a larger surface area and promote longer contact time with the surfaces of the targeted sites. Thus, nanoparticles allow the sustained release of small amounts of active compounds and the optimization of the dosing frequency of the drug. The implementation of nanotechnology in the development of natural-based products is able to enhance the delivery of plant extracts and active phytochemicals to the targeted sites. In fact, maximum therapeutic outcomes can be achieved since the herbal formulations are more stable compared to traditional preparations. The development of herbal formulations in modern drug delivery systems will be further discussed in this review. The possible improvement of phytosomes is highlighted in order to give future insights into improvising phytosomes as a targeted drug carrier system. A compilation of evidence-based studies involving the nanotechnology of herbal formulations is summarized accordingly. The use of modern technology in herbal drug delivery systems has been growing in past decades and needs to be further explored by scientists. Hence, at the end of this review, a brief summary is given of a few success stories regarding modern nano formulations that have been commercialized by leading herbal companies and which can be considered as great achievements in this field. Thus, this review is aimed at exploring the use of nanotechnology in drug delivery systems and discusses their contribution to the design of modern herbal formulations.

scholarly journals Recent development in novel drug delivery systems for delivery of herbal drugs: An updates

2021 ◽  
Vol 8 (2) ◽  
pp. 008-018
Author(s):  
Prajakta N. Dongare ◽  
Anuja S. Motule ◽  
Mahesh R. Dubey ◽  
Manisha P. More ◽  
Prerna A. Patinge ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Herbal Medicines ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Herbal Drugs ◽  
Active Components ◽  
Novel Drug ◽  
Herbal Formulations

In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs. Such systems are polymeric nanoparticles, nanocapsules, phytosomes, animations, microsphere, etc. The present article highlights the current condition of the development of novel herbal formulations and summarizes their type of active components, biological activity, and applications of novel formulations.

Amoxicilin and Clavulanic Acid Intercaled Nanostructures for Dentistry Uses

2019 ◽  
Vol 56 (2) ◽  
pp. 396-398
Author(s):  
Georgeta Zegan ◽  
Daniela Anistoroaei ◽  
Elena Mihaela Carausu ◽  
Eduard Radu Cernei ◽  
loredana Golovcencu
Keyword(s):  
Drug Delivery ◽  
Clavulanic Acid ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Intracellular Transport ◽  
Oral Treatment ◽  
Chitosan Nanoparticles ◽  
Well Being ◽  
Cell Penetrating ◽  
Novel Drug

Amoxicillin and clavulanic acid are two of the most commonly prescribed antibacterial worldwide for treating oral infectious diseases. Oral health is of big importance for well-being and general health. A few novel drug delivery systems were designed for oral treatment and prophylaxis of different diseases in the oral cavity. This work focused on the latest drug delivery development of the most common oral pathologies, namely, periodontitis, oral mucosal infections, dental caries and oral cancer. Herein we reveal the synthesis, characterization and application of chitosan nanoparticles for intracellular transport of the weakly cell-penetrating amoxicillin and clavulanic acid in order to improve their efficacy on bacterial infections.

Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery

2019 ◽  
Vol 26 (14) ◽  
pp. 2502-2513 ◽  
Author(s):  
Md. Iqbal Hassan Khan ◽  
Xingye An ◽  
Lei Dai ◽  
Hailong Li ◽  
Avik Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Release Mechanism ◽  
Innovative Drug ◽  
Pharmaceutical Excipients ◽  
Weight Variation

The development of innovative drug delivery systems, versatile to different drug characteristics with better effectiveness and safety, has always been in high demand. Chitosan, an aminopolysaccharide, derived from natural chitin biomass, has received much attention as one of the emerging pharmaceutical excipients and drug delivery entities. Chitosan and its derivatives can be used for direct compression tablets, as disintegrant for controlled release or for improving dissolution. Chitosan has been reported for use in drug delivery system to produce drugs with enhanced muco-adhesiveness, permeation, absorption and bioavailability. Due to filmogenic and ionic properties of chitosan and its derivative(s), drug release mechanism using microsphere technology in hydrogel formulation is particularly relevant to pharmaceutical product development. This review highlights the suitability and future of chitosan in drug delivery with special attention to drug loading and release from chitosan based hydrogels. Extensive studies on the favorable non-toxicity, biocompatibility, biodegradability, solubility and molecular weight variation have made this polymer an attractive candidate for developing novel drug delivery systems including various advanced therapeutic applications such as gene delivery, DNA based drugs, organ specific drug carrier, cancer drug carrier, etc.

Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

2020 ◽  
Vol 26 ◽  
Author(s):  
Ritu Mishra ◽  
Swati Gupta
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Autoimmune Disease ◽  
Drug Delivery Systems ◽  
Clinical Manifestations ◽  
Adaptive Immune Response ◽  
Delivery Systems ◽  
Current Therapy ◽  
Genetic And Environmental Factors ◽  
Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

Provesicles as Novel Drug Delivery Systems

2015 ◽  
Vol 16 (4) ◽  
pp. 344-364 ◽  
Author(s):  
Zerrin Bayindir ◽  
Nilufer Yuksel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Novel Drug
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