The application progress of peptides in drug delivery systems in the past decade

2021 ◽  
Vol 66 ◽  
pp. 102880
Author(s):  
Bing Yang ◽  
Tian-tian Wang ◽  
Yu-shun Yang ◽  
Hai-liang Zhu ◽  
Jian-hua Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past

scholarly journals Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo
Keyword(s):  
Drug Delivery ◽  
Sialic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

Functional peptide-based drug delivery systems

2020 ◽  
Vol 8 (31) ◽  
pp. 6517-6529 ◽  
Author(s):  
Zheng Lian ◽  
Tianjiao Ji
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past ◽  
Functional Peptides ◽  
Functional Peptide ◽  
Smart Drug ◽  
Smart Drug Delivery

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.

scholarly journals UNDERSTANDING NOVEL POLYMER AND LIPID BASED CARRIER SYSTEMS IN CLINICIAN PERSPECTIVE

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Kallem Sharat Venkat Reddy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Dosage ◽  
Delivery Systems ◽  
Review Article ◽  
Point Of View ◽  
Smart Polymers ◽  
The Past ◽  
Novel Drug ◽  
Carrier Systems

From the past two decades, technological advancements in science and chemistry made possible many new drug delivery systems that have the potential to completely change the course of routine therapeutic ways.  Lipid and polymer-based drug delivery systems are considered to be the pillars of many drug dosage forms, irrespective of their route of administration. With increasing knowledge on their chemistry, lipids and polymers are being modified and used as potential novel drug delivery systems with smart polymers and lipid nanotechnology paving the way for efficient drug delivery into the patient. This review article covers the swing of these drug delivery systems in the current market and interpreting all this from a health care professional’s point of view. Keywords: Gene delivery, Lipid based drug delivery, Polymer based drug delivery, Target specific drugs, Solid lipid nanoparticles

scholarly journals A mini-review of Nanocarriers in drug delivery systems Nanocarriers in drug delivery systems

2021 ◽  
Author(s):  
Mahsa Mazdaei ◽  
Kofi Asare-Addo
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Cancer Chemotherapy ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Therapeutic Gene ◽  
Solid Lipid ◽  
The Past

The application of nanotechnology indrug delivery systems (DDS) has been researched widely and seen an advancementover the past three decades. Since the 1970s, nanoparticles were primarilyutilised in vaccine deliveries and cancer chemotherapy. In more recent years,they have been found to hold promises for broader applications such as inproteins and therapeutic gene delivery systems. To date, there have been only ahandful of nanocarrier-loaded drugs commercialised into the pharmaceuticalmarket. More research is thus needed to facilitate a breakthrough of theseproducts into the current market. This mini-review mainly focuses on four typesof commonly utilised organic nanocarriers including micelles, compactpolymerics, solid-lipid nanoparticles and liposomal vesicles and discusses theprogress and some challenges associated with these nanoparticles (NP). 

scholarly journals Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Rongwei Cui ◽  
Qiang Wu ◽  
Jing Wang ◽  
Xiaoming Zheng ◽  
Rongying Ou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Immunotherapy ◽  
Drug Delivery Systems ◽  
Malignant Tumors ◽  
Delivery Systems ◽  
The Past ◽  
Therapeutic Benefits ◽  
Localized Drug Delivery ◽  
Smart Drug ◽  
Smart Drug Delivery

Immunotherapy has emerged as a promising strategy for cancer treatment, in which durable immune responses were generated in patients with malignant tumors. In the past decade, biomaterials have played vital roles as smart drug delivery systems for cancer immunotherapy to achieve both enhanced therapeutic benefits and reduced side effects. Hydrogels as one of the most biocompatible and versatile biomaterials have been widely applied in localized drug delivery systems due to their unique properties, such as loadable, implantable, injectable, degradable and stimulus responsible. Herein, we have briefly summarized the recent advances on hydrogel-by-design delivery systems including the design of hydrogels and their applications for delivering of immunomodulatory molecules (e.g., cytokine, adjuvant, checkpoint inhibitor, antigen), immune cells and environmental regulatory substances in cancer immunotherapy. We have also discussed the challenges and future perspectives of hydrogels in the development of cancer immunotherapy for precision medicine at the end.

A REVIEW ON THE SECOND-GENERATION LIPID CARRIERS: NLC’S

2021 ◽  
Vol 12 (4) ◽  
pp. 176-182
Author(s):  
A N Jyothsna Sree
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Loading Capacity ◽  
The Past ◽  
Key Aspects

Over the past few years, nanostructured lipid carriers became an emerging drug delivery system as lipid drug delivery systems are more focused. Within them, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have more advantages over other lipid carriers. This article is a cumulation of structure, types, composition, formulation methodologies, drug release from NLCs, various applications of NLCs. The key aspects for promising drug delivery systems are biocompatibility, drug loading capacity, ease of preparation, non-toxicity, and stability

scholarly journals Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Fakhara Sabir ◽  
Muhammad Imran Asad ◽  
Maimoona Qindeel ◽  
Iqra Afzal ◽  
Muhammad Junaid Dar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Chemical Reactivity ◽  
Daily Basis ◽  
Delivery Systems ◽  
The Past ◽  
Future Challenges ◽  
Pros And Cons

Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone of research with speedy developments taking place on a daily basis. An incredible amount of focus is placed on the fabrication of NGs with novel polymers to achieve better control over the drug release. This review article covers a number of aspects of NGs including their types, associated pros and cons, and methods of preparation along with technical and economical superiority and therapeutic efficacy over each other. The last part of review summarizes the applications of NGs in the drug delivery and treatment of various diseases including brain disease, cardiovascular diseases, oxidative stress, diabetes, cancer therapy, tissue engineering, gene therapy, inflammatory disorders, pain management, ophthalmic and autoimmune diseases, and their future challenges. NGs appear to be an outstanding nominee for drug delivery systems, and further study is required to explore their interactions at the cellular and molecular levels.

scholarly journals A Brief Review on Advantages of Nano-based Drug Delivery Systems

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Zahra Hami
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Medical Literature ◽  
Delivery Systems ◽  
The Past ◽  
Current Review ◽  
As Solubility ◽  
Targeted Drug Delivery Systems

Context: During the past two decades, the development of drug delivery systems based on nanomaterials has yielded nanocarriers for smart application in nanomedicine to treat diseases. Evidence Acquisition: The current review presents a summary of some advances in the development and application of nano-delivery systems for improving the efficacy of conventional drugs and reducing their adverse effects through the production of smart delivery carriers with targeting moieties and controlled release strategies used in therapy. The searches were conducted in ScienceDirect, Scopus, Google Scholar, and PubMed databases for relevant studies. Results: As reviewed in the present paper, the investigated targeted drug delivery systems have proven to be more effective than free drugs by enhancing efficacy and reducing the systemic toxicity of therapy. In addition, many studies have shown remarkable advantages of nanoscale drug delivery carriers regarding the possibility to improve properties such as solubility, stability, absorption, diffusivity, bioavailability, targeting, and controlled release of drugs. Conclusions: Despite many advantages of nanoscale drug delivery systems reported in the medical literature, deeper research about the composition, synthesis, characteristics, and clinical applications in this area is needed.

scholarly journals Niosome-loaded antifungal drugs as an effective nanocarrier system: A mini review

2019 ◽  
Author(s):  
Mahmoud Osanloo ◽  
Sara Assadpour ◽  
Ahmad Mehravaran ◽  
Mahdi Abastabar ◽  
Javad Akhtari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Antibacterial Agents ◽  
Penetration Rate ◽  
Delivery Systems ◽  
Antifungal Drugs ◽  
The Body ◽  
Therapeutic Effects ◽  
The Past ◽  
System A

Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate vesicles simplifies the transports of drugs into and across the skin.Niosome nanoparticles are among these drug delivery systems, which have numerous applications in drug delivery and targeting. Niosomes are frequently used for loading drugs serving different purposes (e.g., anticancer, antiviral, and antibacterial agents). In recent years, there has been much research on the use of niosomal systems for the delivery of fungal drugs. A review of the literature investigating the advantages of niosomes in antifungal drug delivery can elucidate the efficiency and superiority of this nanocarrier over other nanocarriers.

scholarly journals Clinical implications of novel polymer and lipid based drug delivery systems

2020 ◽  
Vol 2 (3) ◽  
pp. 60-65
Author(s):  
Kallem Sharat Venkat Reddy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Clinical Implications ◽  
Clinical Settings ◽  
The Past ◽  
Long Time ◽  
Pros And Cons ◽  
Novel Drug

The use of lipids in drug delivery is not a new trend, some of the lipid dosage forms have been in use for a long time such as suppositories, creams, and emulsions. However, there has been much advancement in the designs of lipid carriers over the past decade. In the same way from the past two decades, new approaches in biodegradable and bio-reducible polymers have paved a way for many recent drug delivery systems. Applications of these novel drug delivery formulations have been promising clinically. However, each system has its pros and cons in various factors depending upon their use and intended route of administration. This review focuses on upbringing the challenges in the use of novel lipid and polymer drug delivery systems in clinical settings and few insights on how to overcome them.

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