Rubus ulmifolius: Traditional, Current and Future Pharmaceutical Uses

2018 ◽  
Vol 4 (3) ◽  
pp. 192-203
Author(s):  
Doriana Triggiani ◽  
Rosella Franconi
Keyword(s):  
Rubus Ulmifolius ◽  
Pharmaceutical Uses

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

2020 ◽  
Vol 16 ◽  
Author(s):  
Vitor F. Ferreira ◽  
Alcione S. de Carvalho ◽  
Patricia G. Ferreira ◽  
Carolina G. S. Lima ◽  
Fernando de C. da Silva
Keyword(s):  
Drug Combination ◽  
Medicinal Chemistry ◽  
Pharmaceutical Market ◽  
Important Class ◽  
Therapeutic Applications ◽  
New Applications ◽  
Pharmaceutical Uses

Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases. Objective: The aim of this review was to provide an overview on the quinones that have become drugs for several therapeutic applications. Method: We have comprehensively and critically discussed all the information available in the literature about quinonebased drugs. Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses. Conclusion: The number of studies related to quinone drugs for different pharmaceutical uses shows that the interest in new applications still increasing in recent years.

scholarly journals Jojoba Oil: An Updated Comprehensive Review on Chemistry, Pharmaceutical Uses, and Toxicity

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1711
Author(s):  
Heba A. Gad ◽  
Autumn Roberts ◽  
Samirah H. Hamzi ◽  
Haidy A. Gad ◽  
Ilham Touiss ◽  
...  
Keyword(s):  
Industrial Applications ◽  
Literature Survey ◽  
Jojoba Oil ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Liver Functions ◽  
History Of ◽  
History Of Use ◽  
Pharmaceutical Uses ◽  
Obesity And Cancer

Jojoba is a widely used medicinal plant that is cultivated worldwide. Its seeds and oil have a long history of use in folklore to treat various ailments, such as skin and scalp disorders, superficial wounds, sore throat, obesity, and cancer; for improvement of liver functions, enhancement of immunity, and promotion of hair growth. Extensive studies on Jojoba oil showed a wide range of pharmacological applications, including antioxidant, anti-acne and antipsoriasis, anti-inflammatory, antifungal, antipyretic, analgesic, antimicrobial, and anti-hyperglycemia activities. In addition, Jojoba oil is widely used in the pharmaceutical industry, especially in cosmetics for topical, transdermal, and parenteral preparations. Jojoba oil also holds value in the industry as an anti-rodent, insecticides, lubricant, surfactant, and a source for the production of bioenergy. Jojoba oil is considered among the top-ranked oils due to its wax, which constitutes about 98% (mainly wax esters, few free fatty acids, alcohols, and hydrocarbons). In addition, sterols and vitamins with few triglyceride esters, flavonoids, phenolic and cyanogenic compounds are also present. The present review represents an updated literature survey about the chemical composition of jojoba oil, its physical properties, pharmacological activities, pharmaceutical and industrial applications, and toxicity.

scholarly journals Antioxidant, Antihypertensive and Antimicrobial Properties of Phenolic Compounds Obtained from Native Plants by Different Extraction Methods

2021 ◽  
Vol 18 (5) ◽  
pp. 2475
Author(s):  
Francisco Ramiro Boy ◽  
Rocío Casquete ◽  
Ana Martínez ◽  
María de Guía Córdoba ◽  
Santiago Ruíz-Moyano ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Phenolic Compounds ◽  
Native Plants ◽  
Antimicrobial Properties ◽  
Extraction Methods ◽  
Ultra Sound ◽  
Antihypertensive Activity ◽  
Ultrasound Extraction ◽  
Rubus Ulmifolius ◽  
Cistus Salviifolius

This study aims to evaluate the efficacy of two methods (agitation and ultra-sound) for extracting phenolic compounds from 15 native plants. Plant species collected in the Dehesa of Extremadura were used. The antioxidant, antihypertensive and antimicrobial activity of the phenolic extracts was investigated. Significantly different results were obtained when comparing the two extraction methods, with the highest concentrations of phenolic compounds found for ultrasound extraction. In addition, the extracts obtained for Cistus albidus, Cistus salviifolius, Rubus ulmifolius and Quercus ilex showed the highest concentrations of phenolic compounds. The antioxidant activity was higher in the extracts of Cistus and Q. ilex obtained by ultrasound, as was the antihypertensive activity. Antimicrobial activity was also higher in the extracts obtained by ultrasound from C. salviifolius and Q. ilex plants against bacteria and from Cistus ladanifer against yeasts. Therefore, it can be concluded that, with the ultrasound extraction of phenolic compounds from C. ladanifer, C. albidus and Q. ilex plants, it is possible to obtain extracts with important functional properties, so they could be studied for their use in food with the aim of obtaining healthy and safe products, favouring the sustainability of the environment of the Dehesa Extremeña.

scholarly journals Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Christopher Nguyen ◽  
Ali Mehaidli ◽  
Kiruthika Baskaran ◽  
Sahibjot Grewal ◽  
Alaina Pupulin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Root Extract ◽  
Natural Health Products ◽  
Anticancer Efficacy ◽  
Adjuvant Therapies ◽  
Anticancer Effects ◽  
Health Products ◽  
Xenograft Models ◽  
Pharmaceutical Uses

Many conventional chemotherapies have indicated side effects due to a lack of treatment specificity and are thus not suitable for long-term usage. Natural health products are well-tolerated and safe for consumption, and some have pharmaceutical uses particularly for their anticancer effects. We have previously reported the anticancer efficacy of dandelion (Taraxacum officinale) root and lemongrass (Cymbopogon citratus) extracts. However, their efficacy on prostate cancer and their interactions with standard chemotherapeutics have not been studied to determine if they will be suitable for adjuvant therapies. If successful, these extracts could potentially be used in conjunction with chemotherapeutics to minimize the risk of drug-related toxicity and enhance the efficacy of the treatment. We have demonstrated that both dandelion root extract (DRE) and lemongrass extract (LGE) exhibit selective anticancer activity. Importantly, DRE and LGE addition to the chemotherapeutics taxol and mitoxantrone was determined to enhance the induction of apoptosis when compared to individual chemotherapy treatment alone. Further, DRE and LGE were able to significantly reduce the tumour burden in prostate cancer xenograft models when administered orally, while also being well-tolerated. Thus, the implementation of these well-tolerated extracts in adjuvant therapies could be a selective and efficacious approach to prostate cancer treatment.

scholarly journals Development and validation of a gas chromatography method for the determination of β-caryophyllene in clove extract and its application

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Hee Park ◽  
Chul Jin Kim ◽  
Jin Young Lee ◽  
In Seon Kim ◽  
Sung-Kyu Kim
Keyword(s):  
Active Constituent ◽  
Chromatography Method ◽  
Ich Guidelines ◽  
Specificity Test ◽  
Detection Response ◽  
Standard Solution ◽  
Clove Extract ◽  
Pharmaceutical Uses ◽  
Development And Validation

AbstractThe purpose of this study is to check the effectiveness of the analysis method that separates and quantifies β-caryophyllene among clove extracts and validate according to current ICH guidelines. The β-caryophyllene was active constituent of clove buds. The developed method gave a good detection response. In the specificity test, the standard solution was detected at about 17.32 min, and the test solution was detected at 17.32 min. The linearity of β-caryophyllen was confirmed, and at this time, the correlation coefficient (R2) of the calibration curve showed a high linearity of 0.999 or more in the concentration range. The levels of LOD and LOQ were 1.28 ug/mL and 3.89 ug/mL, respectively. The accuracy was confirmed to be 101.6–102.2% and RSD 0.95 ~ 1.31%. As a result of checking the repeatability and inter-tester reproducibility to confirm the precision, the RSD was found to be 1.34 ~ 2.69%. This validated GC method was successfully applied to a soft capsule containing clove extract and other materials for clinical trials. Therefore, this method can be used as an analytical tool for quality control of various samples, including clove extracts and their products of food and pharmaceutical uses.

Pharmaceutical Uses of Cyclodextrin Derivatives

2017 ◽  
pp. 789-806 ◽  
Author(s):  
Kaneto Uekama ◽  
Fumitoshi Hirayama ◽  
Tetsumi Irie
Keyword(s):  
Cyclodextrin Derivatives ◽  
Pharmaceutical Uses

scholarly journals Spent Coffee Ground Oil as a Potential Alternative for Vegetable Oil Production: Evidence from Oil Content, Lipid Profiling, and Physicochemical Characterization

2021 ◽  
Vol 12 (5) ◽  
pp. 6308-6320
Keyword(s):  
Vegetable Oil ◽  
Vegetable Oils ◽  
Physicochemical Characterization ◽  
Oil Production ◽  
Good Alternative ◽  
Sterol Composition ◽  
Lipid Profiling ◽  
Spent Coffee Ground ◽  
Potential Alternative ◽  
Pharmaceutical Uses

In this work, routinely measured physicochemical indices and lipid profiling of oil extracted from spent coffee grounds (SCG) were evaluated to assess the suitability of SCG as a new candidate for oil production. The obtained results reveal that the oil yield was 18.55±1.5 g/100g. Physicochemical indices were comparable to those of widely consumed vegetable oils in the range set in several studies. The main fatty acids of SCG oil were linoleic acid 43.20±2.19 g/100g, palmitic acid 31.78±2.02 g/100g, and oleic acid 12.68±1.15 g/100g dry basis. For sterol composition, β-sitosterol was the most abundant sterol (44.70±0.01%), followed by stigmasterol (27.57±0.01%) and campesterol (12.16±0.01%). In conclusion, this composition is typical for many other vegetable oils. Therefore, this oil may be considered a good alternative for vegetable oil production for new multi-purpose products such as cosmetic and industrial pharmaceutical uses.

scholarly journals Competitividad y rentabilidad de la producción de frutillas en Jalisco

2020 ◽  
Vol 11 (8) ◽  
pp. 1815-1826
Author(s):  
Edgar Ricardo Lagunes-Fortiz ◽  
Erika Lagunes Fortiz ◽  
Alma Alicia Gómez-Gómez ◽  
Juan Antonio Leos-Rodríguez ◽  
José Miguel Omaña-Silvestre
Keyword(s):  
Rubus Idaeus ◽  
Rubus Ulmifolius

Durante 2017, Jalisco fue el segundo estado con mayor aportación al PIB agrícola nacional (SIAP, 2020). El cultivo de berries es una importante actividad socioeconómica de este estado, los cuales incluyen el arándano (Vaccinium spp.), frambuesa (Rubus idaeus) y zarzamora (Rubus ulmifolius). Jalisco es el principal productor de frambuesa, el segundo de zarzamora, y el cuarto de fresa (Fragaria spp.) a nivel nacional (FIRA, 2016). Sin embargo, se percibe que a diferencia de los cultivos de fresa y zarzamora, la superficie cultivada de frambuesa incrementó en los últimos años, dicho incremento no puede ser explicado por cambios en el precio o rendimiento sino por otros factores. El objetivo del estudio fue determinar si hubo distorsiones en los mercados que pudieron haber influido en la elección de los productores de Jalisco por algún tipo de berry en particular. Se partió de la hipótesis, que de los berries, la frambuesa tuvo una mayor ventaja competitiva o comparativa. Para medir el grado de distorsión del mercado se aplicó la metodología de la matriz de análisis de políticas. Los resultados indican que los tres tipos de berries fueron rentables; sin embargo, algunas distorsiones económicas beneficiaron a la frambuesa y zarzamora, e impactaron negativamente al cultivo de fresa, además existió un gran subsidio a las ganancias del cultivo de frambuesa. Se concluye que distorsiones creadas por el mercado y el gobierno influyeron en la elección del tipo de berry a sembrar por los productores, favoreciendo la producción de frambuesa.

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