scholarly journals Jojoba Oil: An Updated Comprehensive Review on Chemistry, Pharmaceutical Uses, and Toxicity

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1711
Author(s):  
Heba A. Gad ◽  
Autumn Roberts ◽  
Samirah H. Hamzi ◽  
Haidy A. Gad ◽  
Ilham Touiss ◽  
...  

Jojoba is a widely used medicinal plant that is cultivated worldwide. Its seeds and oil have a long history of use in folklore to treat various ailments, such as skin and scalp disorders, superficial wounds, sore throat, obesity, and cancer; for improvement of liver functions, enhancement of immunity, and promotion of hair growth. Extensive studies on Jojoba oil showed a wide range of pharmacological applications, including antioxidant, anti-acne and antipsoriasis, anti-inflammatory, antifungal, antipyretic, analgesic, antimicrobial, and anti-hyperglycemia activities. In addition, Jojoba oil is widely used in the pharmaceutical industry, especially in cosmetics for topical, transdermal, and parenteral preparations. Jojoba oil also holds value in the industry as an anti-rodent, insecticides, lubricant, surfactant, and a source for the production of bioenergy. Jojoba oil is considered among the top-ranked oils due to its wax, which constitutes about 98% (mainly wax esters, few free fatty acids, alcohols, and hydrocarbons). In addition, sterols and vitamins with few triglyceride esters, flavonoids, phenolic and cyanogenic compounds are also present. The present review represents an updated literature survey about the chemical composition of jojoba oil, its physical properties, pharmacological activities, pharmaceutical and industrial applications, and toxicity.

2005 ◽  
Vol 77 (9) ◽  
pp. iv ◽  
Author(s):  
Kenneth Kustin ◽  
Tamas Kiss

The following 10 papers are selections from the 4th International Symposium on Chemistry and Biological Chemistry of Vanadium held 3-5 September 2004 in Szeged, Hungary. This conference attracted over 110 participants from 25 countries and 4 continents. Plenary and invited lectures as well as posters discussed the inorganic chemistry of vanadium, vanadium chemistry in catalysis and organic synthesis, and biological aspects of vanadium chemistry. A new feature was introduced: the presentation of the Vanadis Award.The purpose of the Vanadis Award is to recognize an outstanding contributor to the advancement of vanadium science. The award will be presented at each International Vanadium Symposium prior to a lecture to be given by the recipient. It is awarded on the basis of contributions to a discipline or combination of disciplines of vanadium science, and is presented to an investigator who has produced innovative research with impact on the direction of the field. The nominee is selected on the basis of the following criteria: (1) Innovative research: A history of development or expansion of techniques and procedures and discovery of new chemical, biochemical, biological, technological, or pharmaceutical systems; (2) Development of new applications in one or more of the following areas: chemistry, biochemistry, biology, pharmaceutical science, materials science, and nanotechnology; (3) Wide-ranging influence of the nominee's work on the research of others in one or more disciplines; (4) History of highquality and -impact publications; and (5) Service of the nominee to progress, application, and exploration of vanadium in science. The recipient of the first Vanadis Award is Prof. Debbie C. Crans of Colorado State University, whose award address is the first contribution to be presented herein.The additional contributions begin with papers covering various aspects of the inorganic chemistry of vanadium. These papers are followed by descriptions of recent results in the use of vanadium compounds to further organic synthesis, and on the catalytic behavior of interesting vanadium complexes. The final selection includes papers dealing with the role of vanadium in haloperoxidases, or as insulin-mimetic compounds, which may be orally administered replacements of insulin injections.A tremendous increase in studies of aqueous vanadium chemistry over the past decade has been driven by the need to comprehend the diverse biological effects of vanadium. Examples of the rich array of data and concepts needed to explain the biological role of vanadium are given by models of the vanadium-containing haloperoxidase enzyme activity. However, this selection of papers from the 4th International Vanadium Symposium indicates that basic inorganic studies and a wide range of applications of vanadium chemistry to fundamental chemical problems of synthesis, reactivity, and catalysis are not lacking. Indeed, we look forward to the 5th International Vanadium Symposium to be held in San Francisco, CA USA in the fall of 2006, where additional fundamental studies linked to the need to better understand vanadium nutritional essentiality, vanadium toxicity, vanadium therapy, and vanadium catalysis, including "green chemical" industrial applications will be presented.Kenneth Kustin and Tamas KissConference Editors


2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
María Inés Isla ◽  
María Alejandra Moreno ◽  
Gabriela Nuño ◽  
Fabiola Rodriguez ◽  
Antonella Carabajal ◽  
...  

Zuccagnia punctata Cav. (Fabaceae, Caesalpiniaceae) is a plant with a long history of use in Argentine traditional medicines; it belongs to a monotypic genus, and is an endemic species of Argentina. This review provides a comprehensive overview of the traditional uses, phytochemistry, pharmacological activity and toxicology of Z. punctata. A wide range of traditional uses are cited in the literature such as antibacterial, antifungal, anti-inflammatory, and antitumor, among others. Pharmacological studies to date have demonstrated significant activities that support the traditional uses of this plant. No human clinical trials had been completed up to the time of this review and no toxic effect had been detected in animals. Compounds from different chemical groups have been isolated such as phenolic compounds and essential oils. Plant extracts and phytochemicals isolated exhibit a broad range of activities, anti-inflammatory, antibacterial, antifungal, antigenotoxic, antioxidant, antiulcer, and nematicidal. The main bioactive phytochemicals in the aerial parts (leaf, stem and flower) were identified as 2′, 4′-dihydroxy-3′-methoxychalcone and 2′, 4′-dihydroxychalcone and were proposed as chemical markers. Consequently, standardized dry extracts of aerial parts of Z. puntacta could be used in herbal medicinal products. Also, they could be included in phytotherapeutic preparations such as capsules, creams, and gels, and for microencapsulation.


2019 ◽  
Vol 16 (5) ◽  
pp. 463-480 ◽  
Author(s):  
Manpreet Kaur ◽  
Naveen Chandra Talniya ◽  
Seema Sahrawat ◽  
Arvind Kumar ◽  
Elena E. Stashenko

Medicinal properties of papaya (Carica papaya Linn.) fruit and other parts are wellknown in the traditional system of medicine. Papaya plant originated in Central America and now grown in tropical areas of worldwide, most particularly in Africa and Asia. Studies validate that, papaya has several pharmacological activities, such as antioxidant, antiulcer, antibacterial, woundhealing, anti-inflammatory and anti-sickling, just to name a few. The present review article provides the explicit and updated information on botanical aspects, ethnomedicinal uses, phytochemistry and pharmacological activities of C. papaya plant in order to explore their therapeutic potential. This review conducted a systematic search on C. papaya through electronic database search (Google Scholar, PubMed, SciFinder, Scopus, Science Direct, and Web of Science) and a library search for articles published in peer-reviewed journals, until January of 2018. Constituents of papaya plant belongs to different chemical classes that include alkaloids, flavonoids, terpenoids, saponins, steroids, tannin, vitamins, quinones, minerals and others. Experimental evidence confirmed that these classes of compounds cure the microbial infections, diabetes, inflammatory, cytotoxic and liver disorders. Conclusively, the present review aimed to summarize the information of ethnomedicinal uses, phytochemistry and pharmacological activities to prevent and treat the wide range of diseases and disorders. The future research draws the attention of the researcher for intensive investigations relating to phytochemicals, pharmacological activities and industrial applications.


Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1454
Author(s):  
Young-Kyung Jung ◽  
Dongyun Shin

Imperata cylindrica is a medicinal plant native to southwestern Asia and the tropical and subtropical zones. To date, 72 chemical constituents have been isolated and identified from I. cylindrica Among these compounds, saponins, flavonoids, phenols, and glycosides are the major constituents. Investigations of pharmacological activities of I. cylindrica revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including immunomodulatory, antibacterial, antitumor, anti-inflammatory, and liver protection activities both in vivo and in vitro. The purpose of this review is to provide an overview of I. cylindrica studies until 2019. This article also intends to review advances in the botanical, phytochemical, and pharmacological studies and industrial applications of I. cylindrica, which will provide a useful bibliography for further investigations and applications of I. cylindrica in medicines and foods.


2019 ◽  
Vol 9 (1-s) ◽  
pp. 505-509 ◽  
Author(s):  
Shaheen Sulthana ◽  
P. Pandian

In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Indole, Benzothiazole and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Indole, Benzothiazole and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. Hence, their extensive structural modification has result in different analogues of Indole and Benzothiazole derivatives depicting wide range of biological and pharmacological activities such as antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer. This review article literature survey summarizes the synthesis and pharmacological activities of Indole, Benzothiazole and its derivatives. Keywords: Indole, Benzothiazole, antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer


2020 ◽  
Vol 10 ◽  
Author(s):  
Waill A. Elkhateeb ◽  
Ghoson M. Daba ◽  
Donia Sheir ◽  
The-Duy Nguyen ◽  
Kalani K. Hapuarachchi ◽  
...  

Background: Lichens play an important role in many ecosystems and exist as a symbiotic association between fungi and algae or cyanobacteria. This symbiosis results in production of unique secondary metabolites known as lichen substances, which arise within the thalli and are typically in crystal form on the surface of the fungal hyphae. Recently, lichens and their secondary metabolites have been receiving increased attention due to their nutritional value and pharmaceutical potential. Objectives: This review aims to cast a light on the importance and variety of common lichen substances (secondary metabolites), which are investigated along with their historical and contemporary applications, use in environmental research and discussion of the commercialisation of lichens-based products. Methods: The literature, including research and reviews articles, was analysed and the information was compiled to provide a complete review of Lichens. A desk-based study to elucidate the role of lichens in commercial products was also undertaken. Results: Analysis of metabolites, mostly secondary metabolites, have yielded a wide range of interesting compounds with biological activities from antimicrobial to anticancer. 31 of these compounds are discussed in detail. Further, the nutritional value of lichens is identified alongside a role in environmental monitoring and a number of commercialised lichen-based products are located. Conclusions: Lichens are found on every continent and have a history of use as food, medicine, dyes and livestock feed. The pharmaceutical potential of lichens is high and several companies are now attempting to commercialise these unique attributes.


2021 ◽  
Vol 11 ◽  
pp. 204512532110248
Author(s):  
Rae F. Bell ◽  
Vânia M. Moreira ◽  
Eija A. Kalso ◽  
Jari Yli-Kauhaluoma

Liquorice has a long history of use in traditional Chinese, Ayurvedic and herbal medicine. The liquorice plant contains numerous bioactive compounds, including triterpenes, flavonoids and secondary metabolites, with glycyrrhizin being the main active compound. Liquorice constituents have been found to have anti-inflammatory, antioxidant, antiviral, anticancer, hepatoprotective and neuroprotective properties. In addition, they appear to have antidepressant actions and effects on morphine tolerance. Glycyrrhizin, its metabolite glycyrrhetic (glycyrrhetinic) acid and other liquorice-derived compounds such as isoflavonoids and trans-chalcones, exert potent anti-inflammatory effects via a wide range of mechanisms including high mobility group box 1 protein (HMGB1) inhibition, gap junction blockade and α2A-adrenoceptor antagonism. These properties, together with an increasing body of preclinical studies and a long history of use in herbal medicine, suggest that liquorice constituents may be useful for pain management. Glycyrrhizin is used widely in the confectionary, food and tobacco industries, but has documented adverse effects that may limit clinical use. Whether liquorice plant-derived compounds represent a novel class of analgesics is yet to be established. Having a host of bioactive compounds with a broad range of mechanisms of effect, liquorice is a plant that, in the future, may give rise to new therapies for pain.


Author(s):  
Huda Jasim Altameme ◽  
Imad Hadi Hameed ◽  
Lena Fadhil Hamza

Anethumgraveolens, belong to the family Umbelliferae, is indigenous to southern Europe. It is an annual herb growing in the Mediterranean region, central and southern Asia.Now it is cultivated widely throughout the world. It is used traditionally as a popular aromatic herb and spice that has a very long history of use going back to more than 5,000 years. It was used as a remedy for indigestion and flatulence and as milk secretion stimulant. The essential oil and different extracts of Anethumgraveolensseeds exerted antimicrobial activity against wide range of microorganisms. The essential oils and acetone extracts shown antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, Listeria monocytogenes, Escherichia coli, Yersinia enterocolitica, Salmonella choleraesuis, S. typhimurium, Shigellaflexneri, Salmonella typhii, Pseudomonas aeruginosa, and Mycobacterium. Anethumgraveolens seed extracts exerted moderate activity against Helicobacter pylori.


2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Bikash Adhikari ◽  
Babita Aryal ◽  
Bibek Raj Bhattarai

With the emergence of epidemics, pandemics, and infectious diseases, several research activities have been carried out on natural products to tackle them. As there are structural diversities in natural products, researchers are focused on exploring them for treatment and/or management of various infections and/or diseases. Acacia catechu (L.f.) Willd. belonging to the order Fabales and family Fabaceae shows a wide range of pharmacological functions in the management of diseases in humankind. This review was carried out to gather and provide information about the chemical constituents and pharmacological activities of A. catechu through the literature survey of scientific articles. On preliminary assessments, A. catechu is demonstrated as a significant wellspring of bioactive compounds with a wide range of biological and pharmaceutical applications such as antidiabetic, antioxidant, antimicrobial, anticancer, antidiarrheal, anti-inflammatory, antiviral, hepatoprotective, immunomodulatory, and so on. Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. Further research on diverse bioactive compounds from the plant is required to develop them as a successful potent drug.


2021 ◽  
Author(s):  
Traynard Veronique ◽  
Yuen Muk Wing ◽  
Drapeau Christian

Sea Buckthorn (Hippophae rhamnoides) has a long history of use as food and medicine in Tibet and Northern Asia, where the plant has been associated with a wide range of health benefits. Sea buckthorn (SB) berry, seed and leaf have been reported to contain more than 190 bioactive compounds, including polyphenols (epicatechin, epigallocatechin, gallic acid, proanthocyanidins, chloregenic acid) and flavonoids (quercetin, isorhamnetin, kampferol glycosides, lutoelin, myricetin). SB represents a good source of phenolic compounds and flavonoids acting in synergy with PUFA such as omegas 3, 6, 7 and 9, vitamins (vitamin C), and organic acids. SB exerts antioxidant, anti-inflammatory, cytoprotective, anti-cancer, hepatoprotective properties, associated with improvement in various metabolic markers such as glycemic control and lipid profile. SB polyphenol fraction also demonstrated significant cardioprotective, antihypertensive and neuroprotective actions. SB acts as a natural stem cell mobilizer associated with significant regenerative properties. As a consequence, SB polyphenol consumption stimulates pancreatic regeneration in animal model of insulin-dependent diabetes. In conclusion, SB polyphenols exert a wide range of health benefits in metabolic health including obesity, diabetes and hypertension, as well as liver, kidney and brain health, positioning sea buckthorn berry extract as an interesting and valuable dietary supplement for natural complementary therapy and for antiaging.


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