Medicinal importance, pharmacological activities and analytical aspects of canadine in the medicine: An important phytochemical of Hydrastis canadensis

2021 ◽  
Vol 01 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Natural Products ◽  
Data Analysis ◽  
Human Health ◽  
Scientific Information ◽  
Modern Medicine ◽  
Scientific Data ◽  
Pharmacological Activities ◽  
Hydrastis Canadensis ◽  
Biological Importance ◽  
Human Disorders

Background: Natural products and their derived phytochemicals have been used in the medicine and gaining importance in the modern medicine due to their therapeutic potential and health beneficial effect on human disorders. Plenty of herbal drug based products are available in the market and playing an important role in the human health care system due to their health beneficial properties in human being. In the modern age we can find many herbal based products in the market mainly prepared from the natural products and used for the prevention and treatment of various human disorders. Benzylisoquinoline alkaloids are the important class of alkaloidal compounds and the better example are morphine, codeine, sanguinarine, berberine and canadine which are mainly known for their medicinal value in the medicine. Methods: Hydrastis canadensis is the important medicinal plant found to contain a significant amount of canadine, hydrastine and berberine. In the present investigation, numerous scientific databases such as Google, Pubmed, Science direct etc. have been searched to collect the important scientific information of canadine and analyzed to know the health beneficial aspect of canadine in the medicine. All the collected scientific information data’s were analyzed and have been categorized into mainly pharmacological and analytical aspects. Results: From the analysis of the collected scientific information, it was found that Hydrastis canadensis contain significant amount of canadine with many more phytochemical including canadaline, hydrastidine, isohydrastidine etc. Pharmacological activity data analysis revealed the biological importance of Hydrastis canadensis in the medicine for their traditional uses against gastritis, colitis, duodenal ulcers, loss of appetite, liver disease, bile secretion disorder, snake bites and vaginitis in the medicine. However, scientific data analysis of canadine revealed their effectiveness for their acetylcholinesterase inhibitory activity, anti-cancer, anti-microbial, anti-allergic activity and anti-oxidant activity. Different modern analytical tools have been used in the modern medicine for the isolation and quantification of canadine in the Hydrastis canadensis. Conclusion: Present investigation revealed the medicinal importance and pharmacological activities of a canadine in the medicine for the treatment of numerous human health complications. These scientific data will be helpful to the scientist to know the biological importance of canadine in the medicine against various forms of human complications.

Therapeutic benefit and Biological Importance of Ginkgetin in the Medicine: Medicinal importance, pharmacological activities and analytical aspects

2021 ◽  
Vol 17 ◽  
Author(s):  
Kanika Patel ◽  
Dinesh Kumar Patel
Keyword(s):  
Scientific Information ◽  
Analytical Techniques ◽  
Therapeutic Benefit ◽  
Modern Medicine ◽  
Google Scholar ◽  
Pharmacological Activities ◽  
Scientific Databases ◽  
Biological Importance ◽  
Human Disorders ◽  
Anti Oxidant

Aim: Plants derived bioactive compounds play an important role in the traditional and modern medicine and some of the best examples are morphine, papaverine, vinblastine, vincristine and ephedrine. Flavonoids are naturally occurred phenolic compounds found to be present in the different medicinal plants and responsible for their attractive shades in the nature. Flavonoidal compounds have been well known in the medicine for their anti-oxidant, anti-inflammatory, antihyperlipidemia and anti-apoptotic activities. Methods: In order to know the therapeutic benefit of ginkgetin in the medicine, here in the present investigation different scientific databases have been searched to collect the important scientific information of ginkgetin with respect to the medicinal importance and pharmacological activities. Different scientific databases such as Google, PubMed, Science Direct, Scopus and Google Scholar have been searched to collect the important scientific information of the ginkgetin in the present work. All the collected scientific information’s have been analyzed for the medicinal importance, pharmacological activities and analytical aspects of ginkgetin. Results: Literature databases analysis using various scientific databases such as Google, PubMed, Science Direct, Scopus and Google Scholar revealed that ginkgetin is biflavonoids found to be present in the Ginkgo biloba leaves and have been used in the traditional and allopathic medicine. Databases analysis signified that ginkgetin have effectiveness against inflammatory disorders, lipid peroxidation, prostate cancer, DNA damage, renal cell carcinoma, osteosarcoma and small cell lung cancer. Different analytical techniques for the quantification of ginkgetin have been also included in the present investigation. Conclusion: Present study revealed the biological importance and therapeutic benefit of ginkgetin in the medicine which could be used for the development of effective medicine against human disorders and associated complications.

Medicinal importance of flavonoids “eupatorin” in the health sectors: Therapeutic benefit and pharmacological activities through scientific data analysis

2021 ◽  
Vol 01 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Data Analysis ◽  
Scientific Information ◽  
Health Benefit ◽  
Developed Countries ◽  
Scientific Data ◽  
Isolation And Identification ◽  
Pharmacological Activities ◽  
Important Place ◽  
Traditional Medicines ◽  
Human Disorders

Background: Herbal medicines have been used in the health sector for the treatment of human disorders from the ancient time to till the modern age. Plant based herbal products have an important place in the medicine due to their health beneficial potential and pharmacological activities. Traditional medicines have been used in developing country such as India to the developed countries such as the USA and Europe. Traditional medicines have been used in the health sectors for the treatment of numerous types of human disorders. Phytoconstituents play an important role in the growth, reproduction and development of the human being. Plant products have been used for the treatment of skin disorders, wounds, and various forms of inflammatory diseases. Flavonoids are a colorful component of fruits, seeds, vegetables, nuts and plants. Flavonoids have been used for the treatment of human disorders due to their vast pharmacological activities. Methods: Scientific information of eupatorin has been collected from different literature sources and analyzed in order to know the health benefit of eupatorin in the medicine. All the scientific information presented here is collected from various databases such as Google, Pubmed, and Science direct etc. Pharmacological activity data of eupatorin have been collected from various literature databases and analyzed here to know the health beneficial potential of eupatorin in the medicine. However important analytical tools for the separation, isolation and identification of eupatorin have been also discussed in the present paper. Results: Eupatorin (39,5-dihydroxy-49,6,7-trimethoxyflavone) is a flavone class flavonoidal compound found to be present in the Orthosiphon stamineus, Salvia mirzayanii, Lantana montevidensis, Lantana montevidensis and Tanacetum vulgare. Eupatorin have been used against bronchitis, stomach disorders and various forms of cancer. Eupatorin have a potential role in various cancerous disorders such as human uterus carcinoma, human gastric adenocarcinoma, breast carcinoma, melanoma and colon carcinoma. Pharmacological data analysis revealed the effectiveness of eupatorin in human cancer and various types of inflammatory disorders. However, effectiveness of eupatorin against microorganism and enzymes were also presented in the present work with their herbicidal and vasorelaxation potential in the medicine. Eupatorin has a valuable role in the development of adjuvant chemotherapeutic agent. Conclusion: Present review will be beneficial to the researcher to understand the physiological importance of eupatorin in the medicine for the development of newer and effective medicine.

Health benefits of avicularin in the medicine against cancerous disorders and other complications: Biological importance, therapeutic benefit and analytical aspects of the medicine

2021 ◽  
Vol 17 ◽  
Author(s):  
Kanika Patel ◽  
Dinesh Kumar Patel
Keyword(s):  
Data Analysis ◽  
Scientific Data ◽  
Lespedeza Cuneata ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Biological Importance ◽  
Anti Cancer ◽  
Scientific Data Analysis ◽  
Different Types ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals have been used in medicine for the preparation of different types of pharmaceutical products. Pure phytochemicals including flavonoids, alkaloids and terpenoids have been used in medicine for the treatment of different types of human disorders including cancerous disorders. Flavonoids have been well known in medicine for their anti-viral, anti-bacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-aging and cardioprotective potential. Avicularin, also called quercetin-3-α-l-arabino furanoside, is a pure flavonoid, a class of phytochemicals, found to be present in Lindera erythrocarpa and Lespedeza cuneata. Avicularin has been well known in medicine for its anti-cancer properties. Methods: In the present work, scientific data of avicularin have been collected from different databases such as Google, PubMed, Science Direct, Google Scholar and Scopus and summarized with reference to medicinal importance, pharmacological activities and analytical aspects of avicularin. The present review summarized the health beneficial properties of avicularin in medicine through data analysis of various scientific research works. Further analytical progress in medicine for the qualitative and quantitative analysis of avicularin in medicine has been also discussed in the present work. Results: Scientific data analysis of different literature work revealed the biological importance of flavonoid class of phytochemical ‘avicularin’ in medicine. Scientific data analysis revealed that avicularin was found to be present in the Lindera erythrocarpa, Lespedeza cuneata, Rhododendron schlipenbachii and Psidium guajava. Avicularin has been well known in medicine for its anti-inflammatory, anti-allergic, anti-oxidant, anti-tumor and hepatoprotective activities. Avicularin protects cardiomyocytes and hepatocytes against oxidative stress-induced apoptosis and induces cytotoxicity in cancer lines and tumor tissues. Avicularin has positive influence on human hepatocellular carcinoma and inhibits intracellular lipid accumulation. The role of avicularin in rheumatoid arthritis has been also established with its underlying molecular mechanisms in the scientific work. Recent interest in avicularin has focused on pharmacological investigations for its anti-cancer activity in the medicine. Conclusion: The present work signified the biological importance of avicularin in medicine through its medicinal uses, pharmacological activities and analytical aspects in the biological system.

Biological importance, therapeutic benefit and analytical aspects of bioactive flavonoid pectolinarin in the nature

2021 ◽  
Vol 14 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Biological Activities ◽  
Scientific Information ◽  
Antidepressant Activity ◽  
Therapeutic Benefit ◽  
Experimental Models ◽  
Scientific Data ◽  
Pharmacological Activities ◽  
Traditional System ◽  
Biological Importance ◽  
Biological Potential

Backgrounds: Plants and their derived products have been used in the traditional system of medicine for the treatment of various forms of human disorders since very ancient time. In the traditional system of medicine and modern allopathic medicine, numerous phytoconstituents have been used for the preparation of various types of formulation. Flavonoidal class phytochemicals are the main active phytoconstituents of plants, fruit, vegetables and beverages. Flavonoidal class phytochemicals are more referred as “nutraceuticals” due to their important pharmacological activities in the mammalian body. Methods: In order to understand the health beneficial effects of flavonoidal class chemical, present work summarized the health beneficial aspects of pectolinarin. Present work summarized the medicinal importance, pharmacological activities and analytical aspects of pectolinarin with various experimental models and advance analytical methods. However, all the collected scientific information’s have been analyzed in the present work for their health beneficial potential. Results: From the analysis of all the collected scientific information in the present work it was found that pectolinarin is an important phytochemical found to be present in the numerous medicinal plants but especially found in Cirsium japonicum which is an important medicinal herb of Korea, China and Japan. Pharmacological activities data analysis signified the health beneficial potential of pectolinarin for their anti-rheumatoid arthritis, analgesic, anti-inflammatory, hepatoprotective, anti-diabetic, anti-tumor, anti-dengue, antiviral, neuroprotective and antidepressant activity. However effectiveness of pectolinarin in central nervous system, bone, liver and cancerous disorders have been also reported in the literature. Analysis of present scientific information revealed the health beneficial potential of pectolinarin in the modern medicine due to their numerous pharmacological activities in different part of biological systems. Due to their biological importance in food and human health, a better understanding of their biological activities indicates their potentials as therapeutic agents. Conclusion: Scientific data of the present work signified the biological potential and therapeutic benefit of pectolinarin.

Therapeutic Potential of Poncirin Against Numerous Human Health Complications: Medicinal Uses and Therapeutic Benefit of an Active Principle of Citrus Species

2021 ◽  
Vol 21 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Gastric Cancer ◽  
Medicinal Plants ◽  
Human Health ◽  
Modern Medicine ◽  
Poncirus Trifoliata ◽  
Human Gastric Cancer ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Biological Importance ◽  
Health Complications

: Medicinal plants have been used in the indigenous system of medicine for the treatment of numerous human health complications. Medicinal plants were used for the separation and isolation of pure phytochemical and some of the best examples are tubocurarine, aspirin, morphine, digoxin, atropine, quinine and reserpine. Phytoconstituents are pure plant derived natural chemical found to be present in the medicinal plants and examples are flavonoids, alkaloids and phenolic compounds etc. In the modern medicine there is global growth of herbal medicines due to their nutrition, physical effectiveness and pharmacological activities. Plants have been used in the traditional medicines and modern drug discoveries program. In order to investigate the biological potential of poncirin in modern medicine, here different scientific data have been analyzed in the present investigation through various literature sources. Detailed pharmacological activities of poncirin were also investigated in the present investigation to reveal the medicinal properties of poncirin in the medicine and other allied health sectors. Analytical techniques used for the isolation of poncirin from various medicinal plants have been also presented in this study. Poncirin is a flavanone glycoside found to be present in the Poncirus trifoliata and Citrus reticulate having bitter taste. Biological importance of poncirin for their anti-inflammatory activity through inhibition of PGE2 and IL-6 production has been investigated in the scientific field. Biological importance of poncirin against bacterial, viral infections, gastric disease and human gastric cancer has been investigated in the medicine. Pharmacological data analysis revealed the biological application of poncirin against bone loss, inflammation, colitis, human gastric cancer, gastritis, liver injury and alzheimer's disease. From the analysis of the presented scientific information of poncirin it was found that poncirin have significant biological activities and health benefit in the modern health sectors for the treatment of human health complications and could be used as a drug in the future.

Potential benefits of Tricetin in medicine for the treatment of cancers and other health-related disorders: Medicinal importance and therapeutic benefit

2021 ◽  
Vol 12 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Data Analysis ◽  
Medicinal Plants ◽  
Analytical Data ◽  
Research Work ◽  
Scientific Data ◽  
Breast Adenocarcinoma ◽  
Pharmacological Activities ◽  
Biological Importance ◽  
Biological Potential ◽  
Scientific Data Analysis

Background: Medicinal plants have been used in medicine for the treatment of numerous diseases due to their medicinal properties and pharmacological activities. Popularity of herbal based drugs in the health sector has been increasing due to patient compliance and cost effectiveness. Herbal drugs derived from plant and animal source have been used in the Ayurvedic, Homeopathic, and Naturopathic system of medicine. Medicinal plants have been used as fuel, clothing, shelter and food material in worldwide since very early age. Phytoconstituents are pure plant chemicals found in different parts of the plant material. Flavonoids are important class of phytochemical found in medicinal plants and their derived products. Methods: In order to know the biological importance of tricetin, in the present investigation scientific data of tricetin in respect to their medicinal importance and pharmacological activities were collected and analyzed. Literature database such as Google, PubMed, Science Direct and Scopus has been searched using term tricetin and flavonoid. All the scientific information has been collected from these databases to know the biological importance of tricetin. Analytical data of tricetin have been also collected and analyzed in the present work to know the isolation, separation and identification procedure of trice Results: Scientific data analysis of different research work revealed the presence of tricetin in Triticum dicoccum, Lathyrus pratensis, Eucalyptus globules, Thuja occidentalis and Metasequoia glyptostroboides. Scientific data analysis signified biological importance of tricetin against different form of cancerous disorders, human osteosarcoma, glioblastoma multiforme, human breast adenocarcinoma, human non‑small cell lung cancer and liver cancer. Scientific data analysis also signified biological potential of tricetin against inflammation, neurodegenerative diseases, atherosclerosis, diabetes and respiratory syncytial virus infection. Scientific data analysis revealed the biological importance of tricetin against multidrug resistance and free radicals. Conclusions: Scientific data analysis revealed biological importance and pharmacological activities of tricetin against various form of human disorders including cancer, inflammation, neurodegeneration, atherosclerosis and diabetes.

Biological Importance, Therapeutic Benefit, and Medicinal Importance of Flavonoids, Cirsiliol for the Development of Remedies Against Human Disorders

2021 ◽  
Vol 17 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Data Analysis ◽  
Analytical Data ◽  
Antioxidant Properties ◽  
Scientific Research ◽  
Therapeutic Benefit ◽  
Daily Routine ◽  
Human Beings ◽  
Biological Importance ◽  
Biological Potential ◽  
Human Disorders

Background: Phytochemicals are pure chemical compounds found to be present in different plants part such as leaves, fruit, flower, seeds and the whole plant. These pure plant-based chemicals are having power to treat all disorders of the human beings and other higher animal species on earth. Flavonoidal compounds are responsible for the attractive color and important biological properties of plant material. Flavonoids are having a potential role in the treatment of numerous health complications of human beings. Antioxidant properties are one of the best pharmacological properties of all classes of flavonoidal compounds. A significant amount of these flavonoidal compounds are needed in our daily routine diet. Methods: Cirsiliol also called 5,3′,4′-trihydroxy-6,7-dimethoxyflavone is a flavonoidal class chemical found to be present in different plants including Salvia guaranitica. Various literature databases have been searched to know the biological potential of the cirsiliol in medicine. Different scientific research data of cirsiliol have been collected from various literature sources and analyzed in the present work. Detail pharmacological activities of cirsiliol in medicine have been evaluated in the present work through literature data analysis of various scientific research works. However analytical data has also been collected and analyzed in the present work through different literature sources. Results: From the collected data, it was found that cirsiliol is present in the plants such as Artemisia campestris, Artemisia scoparia, Centaurea jacea, Centaurea phyllocephala, Crossostephium chinense, Dracocephalum tanguticum, Eupatorium lindleyanum, Hyptis pectinata, and Iris germanica. Pharmacological data analysis revealed the biological importance of cirsiliol against cancer, inflammatory diseases, obesity-related insulin resistance, and respiratory disorders. However, the biological potential on ileum, benzodiazepine receptor, arachidonate 5-lipoxygenase, and xanthine oxidase has also been well summarized in the present investigation. High-performance liquid chromatography, bioactivity-guided isolation techniques, UPLC-ESI-MS/MS, LC-MS and HPLC, and other forms of chromatographic techniques have been applicable for the analysis of cirsiliol in the various plants material. Conclusion: The present investigation revealed the biological importance and therapeutic benefit of cirsiliol in medicine for the development of better remedies against human disorders.

scholarly journals Neonicotinoid pesticides and the perspectives of their use with respect to the toxicological properties (literature review)

2020 ◽  
Vol 88 (1) ◽  
pp. 91-103
Author(s):  
O.V. Fedchenko ◽  
P.G. Zhminko ◽  
O.P. Vasetska ◽  
T.V. Yurchenko ◽  
O.S. Zubko ◽  
...  
Keyword(s):  
Human Health ◽  
Current Literature ◽  
Plant Protection ◽  
Scientific Information ◽  
Daily Intake ◽  
Scientific Data ◽  
Problem Analysis ◽  
The European Union ◽  
Neonicotinoid Pesticides ◽  
Acute And Chronic Exposure

The purpose of the Research. Analysis and generalization of current literature data on the toxicological properties of neon-icotinoid pesticides and the justification of their prospects for further use in view of human health hazards. Methods and Materials of the Research. Analytical methods were used in the work: collection of scientific information on the problem, analysis of the abstract database and scientific generalization of the obtained results. Results and Conclusions. On the basis of the analytical review of the current literature, data on the toxicological properties of neonicoti-noid pesticides are summarized and the prospects for their further use are substantiated. Information on toxicity results of pesticide active substances from neonicotinoid classifications has been systematized according to acute, short-term, long-term experiments and longterm animal effects studies, the values of the acceptable daily intake (ADI) of neonicotinoids, which are established in Ukraine and in the countries of the European Union, Australia, Canada, are given. The consequences of human exposure to acute and chronic exposure to neonicotinoid pesticides have been considered. Based on the analysis of scientific data on the toxicological significance of neonicoti-noid pesticides for experimental animals and human health, it has been established that thiacloprid and acetamiprid have the most dangerous toxicological profile. Given the revealed endocrine disruptive properties of thiacloprid, it is a candidate for reassessment by the national regulatory authorities of the rules of application and possible replacement by safer alternative plant protection products. Acetamiprid is also of great concern because it is able to have a toxic effect on fetal development. Therefore, when assessing the potential danger of acetamiprid for humans and determining the prospects for future use in agriculture, it is necessary to consider its neurotoxic effect on posterity. Key Words: neonicotinoids, toxicological properties, danger, poisoning, human health.

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