An Epidemiological Study on the Prevalence of Atrial Fibrillation in the Chinese Population of Mainland China

Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes.

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Adaptation and psychometric testing of the hoarding rating scale (HRS): a self-administered screening scale for epidemiological study in Chinese population

BMC Psychiatry ◽

10.1186/s12888-020-02539-7 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Tai Wa Liu ◽

Simon Ching Lam ◽

Man Hon Chung ◽

Ken Hok Man Ho

Keyword(s):

Epidemiological Study ◽

Chinese Population ◽

Rating Scale ◽

Psychometric Testing ◽

Screening Scale

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Survey Research in the Study of Contemporary China: Learning from Local Samples

The China Quarterly ◽

10.1017/s0305741000043149 ◽

1994 ◽

Vol 139 ◽

pp. 741-765 ◽

Cited By ~ 45

Author(s):

Melanie Manion

Keyword(s):

Survey Research ◽

Chinese Population ◽

Mainland China ◽

Chinese Society ◽

Contemporary China

A widely publicized 1983 Chinese survey found 43 per cent of all “specialized households” in a Shanxi county were households of cadres or former cadres. In what sense, if any, is this finding significant? More, generally, what can be concluded about Chinese society, politics and the economy based on findings from survey research conducted there? This article sets out what can (and what cannot) be inferred from the unrepresentative samples of the Chinese population that are the basis for most survey research conducted in mainland China.

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Prevalence and Risk of Atrial Fibrillation in China: A National Cross-Sectional Epidemiological Study

SSRN Electronic Journal ◽

10.2139/ssrn.3978649 ◽

2021 ◽

Author(s):

Shaobo Shi ◽

Yanhong Tang ◽

Qingyan Zhao ◽

Hong Yan ◽

Bin Yu ◽

...

Keyword(s):

Atrial Fibrillation ◽

Epidemiological Study ◽

Cross Sectional

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Association between modifiable lifestyle and the prevalence of atrial fibrillation in a Chinese population: Based on the cardiovascular health score

Clinical Cardiology ◽

10.1002/clc.22771 ◽

2017 ◽

Vol 40 (11) ◽

pp. 1061-1067 ◽

Cited By ~ 8

Author(s):

Yiheng Yang ◽

Xu Han ◽

Yue Chen ◽

Lianjun Gao ◽

Xiaomeng Yin ◽

...

Keyword(s):

Atrial Fibrillation ◽

Chinese Population ◽

Cardiovascular Health ◽

Population Based ◽

Health Score

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The Relationship between Helicobacter pylori Infection and Different Types of Atrial Fibrillation in a Chinese Population

Internal Medicine Open Access ◽

10.4172/2165-8048.1000151 ◽

2014 ◽

Vol 04 (03) ◽

Author(s):

Dezhao Wang Qing Tang

Keyword(s):

Atrial Fibrillation ◽

Helicobacter Pylori ◽

Chinese Population ◽

Helicobacter Pylori Infection ◽

Different Types ◽

The Relationship

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The role of genetics in Parkinson’s disease: a large cohort study in Chinese mainland population

Brain ◽

10.1093/brain/awaa167 ◽

2020 ◽

Vol 143 (7) ◽

pp. 2220-2234 ◽

Cited By ~ 7

Author(s):

Yuwen Zhao ◽

Lixia Qin ◽

Hongxu Pan ◽

Zhenhua Liu ◽

Li Jiang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Chinese Population ◽

Autosomal Recessive ◽

Age At Onset ◽

Mainland China ◽

Mainland Chinese ◽

Pathogenic Variants ◽

Disease Associated Genes ◽

Mainland Chinese Population

Abstract This study aimed to determine the mutational spectrum of familial Parkinson’s disease and sporadic early-onset Parkinson’s disease (sEOPD) in a mainland Chinese population and the clinical features of mutation carriers. We performed multiplex ligation-dependent probe amplification assays and whole-exome sequencing for 1676 unrelated patients with Parkinson’s disease in a mainland Chinese population, including 192 probands from families with autosomal-recessive Parkinson’s disease, 242 probands from families with autosomal-dominant Parkinson’s disease, and 1242 sEOPD patients (age at onset ≤ 50). According to standards and guidelines from the American College of Medical Genetics and Genomics, pathogenic/likely pathogenic variants in 23 known Parkinson’s disease-associated genes occurred more frequently in the autosomal-recessive Parkinson’s disease cohort (65 of 192, 33.85%) than in the autosomal-dominant Parkinson’s disease cohort (10 of 242, 4.13%) and the sEOPD cohort (57 of 1242, 4.59%), which leads to an overall molecular diagnostic yield of 7.88% (132 of 1676). We found that PRKN was the most frequently mutated gene (n = 83, 4.95%) and present the first evidence of an SNCA duplication and LRRK2 p.N1437D variant in mainland China. In addition, several novel pathogenic/likely pathogenic variants including LRRK2 (p.V1447M and p.Y1645S), ATP13A2 (p.R735X and p.A819D), FBXO7 (p.G67E), LRP10 (c.322dupC/p.G109Rfs*51) and TMEM230 (c.429delT/p.P144Qfs*2) were identified in our cohort. Furthermore, the age at onset of the 132 probands with genetic diagnoses (median, 31.5 years) was about 14.5 years earlier than that of patients without molecular diagnoses (i.e. non-carriers, median 46.0 years). Specifically, the age at onset of Parkinson’s disease patients with pathogenic/likely pathogenic variants in ATP13A2, PLA2G6, PRKN, or PINK1 was significantly lower than that of non-carriers, while the age at onset of carriers with other gene pathogenic/likely pathogenic variants was similar to that of non-carriers. The clinical spectrum of Parkinson’s disease-associated gene carriers in this mainland Chinese population was similar to that of other populations. We also detected 61 probands with GBA possibly pathogenic variants (3.64%) and 59 probands with GBA p.L444P (3.52%). These results shed insight into the genetic spectrum and clinical manifestations of Parkinson’s disease in mainland China and expand the existing repertoire of pathogenic or likely pathogenic variants involved in known Parkinson’s disease-associated genes. Our data highlight the importance of genetic testing in Parkinson’s disease patients with age at onset < 40 years, especially in those from families with a recessive inheritance pattern, who may benefit from early diagnosis and treatment.

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