(Preprint)

2018 ◽  
Author(s):  
Dr Malathi Dayalan ◽  
Dr Sudeshna Sharma ◽  
Dr Shweta Poovani ◽  
Dr Saher Altaf
Keyword(s):  
Myofascial Pain ◽  
Mouth Opening ◽  
Masticatory Muscles ◽  
Matched Pair ◽  
Masticatory Muscle ◽  
Muscle Disorders ◽  
Occlusal Contact ◽  
Group I ◽  
Group Ii

BACKGROUND Masticatory system is a complex functional unit, primarily engaged in chewing, swallowing and breathing functions, and some parts are involved in taste recognition and determination of food consistency. Sophisticated functional performances of speech and emotional expressions are specifically human qualities. Irregularities in occlusion appears to be the precipitating factor in the pathogenesis of myofascial pain dysfunction syndrome. Tek- Scan III records the bite length, number, distribution, timing, duration and the relative force of each tooth contact. It also records the sequence of occlusal contacts in terms of time and the associated force with each occlusal contact. The aim of this study was to treat masticatory muscle disorders with occlusal equilibration, and compare the efficacy of treatment outcomes between selective grinding and stabilization splints using Tek-Scan III. OBJECTIVE Objective of this study was to compare the efficacy of occlusal equilibration achieved through selective griding and stabilization splints using Tek-Scan III. METHODS In this in vivo study, 40 patients with masticatory muscle disorders were selected based on the inclusion and exclusion criteria. The occlusal discrepancies were analyzed using Tek-Scan III. The selected 40 subjects were then randomly divided into 2 groups based on the treatment they recieved; Group I – Selective grinding group (20) and Group II – Stabilization splint group (20). Comparison of pre-treatment and post treatment results were evaluated in terms of pain, mouth opening, left and right side force percentage as recorded through Tek-Scan III and reduction of disclusion time. Statistical analysis was carried out with Kolmogorov Smirnov test, Wilcoxon matched pair test and Mann-Whitney U test. RESULTS Wilcoxon matched pairs test demonstrated that there was statistically significant results ( p = 0.0007) in both the groups for reduction of disclusion time, elimination of pain and improved mouth opening. Patients in Group I showed better results as compared to Group II in terms of disclusion time, pain and mouth opening. CONCLUSIONS Occlusal equilibration brought about by reducing the disclusion time using the Tek- Scan III reduced the symptoms of pain in masticatory muscles. Patients in group I (Selective grinding) however showed better results when compared to patients in group II (Stabilization splints).

Effects of Rest and Exercise on Cardiac Blood Volume Determinations

1997 ◽  
Vol 36 (08) ◽  
pp. 259-264
Author(s):  
N. Topuzović
Keyword(s):  
Radionuclide Ventriculography ◽  
Left Ventricular ◽  
Peak Exercise ◽  
Volume Determination ◽  
Group I ◽  
Lv Volumes ◽  
Group Ii ◽  
Lv Volume

Summary Aim: The purpose of this study was to investigate the changes in blood activity during rest, exercise and recovery, and to assess its influence on left ventricular (LV) volume determination using the count-based method requiring blood sampling. Methods: Forty-four patients underwent rest-stress radionuclide ventriculography; Tc-99m-human serum albumin was used in 13 patients (Group I), red blood cells was labeled using Tc-99m in 17 patients (Group II) in vivo, and in 14 patients (Group III) by modified in vivo/in vitro method. LV volumes were determined by a count-based method using corrected count rate in blood samples obtained during rest, peak exercise and after recovery. Results: In group I at stress, the blood activity decreased by 12.6 ± 5.4%, p <0.05, as compared to the rest level, and increased by 25.1 ± 6.4%, p <0.001, and 12.8 ± 4.5%, p <0.05, above the resting level in group II and III, respectively. This had profound effects on LV volume determinations if only one rest blood aliquot was used: during exercise, the LV volumes significantly decreased by 22.1 ± 9.6%, p <0.05, in group I, whereas in groups II and III it was significantly overestimated by 32.1 ± 10.3%, p <0.001, and 10.7 ± 6.4%, p <0.05, respectively. The changes in blood activity between stress and recovery were not significantly different for any of the groups. Conclusion: The use of only a single blood sample as volume aliquot at rest in rest-stress studies leads to erroneous estimation of cardiac volumes due to significant changes in blood radioactivity during exercise and recovery.

A P-Selectin/CD62P Monoclonal Antibody (LYP-20), in Tandem with Flow Cytometry, Detects in vivo Activated Circulating Rat Platelets in Severe Vascular Trauma

1994 ◽  
Vol 72 (05) ◽  
pp. 745-749 ◽  
Author(s):  
Elza Chignier ◽  
Maud Parise ◽  
Lilian McGregor ◽  
Caroline Delabre ◽  
Sylvie Faucompret ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Flow Cytometry ◽  
Platelet Activation ◽  
Peripheral Blood ◽  
Vascular Trauma ◽  
Activated Platelets ◽  
Group I ◽  
Group Ii ◽  
Rat Platelets

SummaryP-selectin, also known as CD62P, GMP140 or PADGEM, is present in platelet a-granules and endothelial cell Weibel-Palade bodies and is very rapidly expressed on the surface of these cells on activation. In this study, an anti P-selectin monoclonal antibody (LYP20) was used, in tandem with flow cytometry, to identify activated platelets at the site of induced vascular trauma or in peripheral blood. Moreover, electron microscopy was performed to characterize sites of vascular trauma and quantify the number of adhering platelets. The same induced vascular trauma was observed to result into animals responding in 2 different ways (Group I, Group II) following the degree of platelet activation. Five rats, out of 14 with induced vascular trauma, had more than half of their circulating platelets expressing P-selectin when drawn at the site of the trauma (67.4% ± 3.44) or in peripheral blood (78.5% ± 2.5) (Group I). In the remaining 9 animals a much smaller proportion of circulating platelets expressed P-selectin when assayed from trauma sites (18% ± 3.34) or in peripheral blood (18.0% ± 4.30) (Group II). Enhanced P-selectin expression by circulating platelets in Group I, compared to Group II, appears to be linked to the degree of activated platelets adhering at sites of trauma (171 ± 15 × 103 platelets versus 48 ± 31 × 103 platelets per mm2). In the 5 control animals, that were not operated on, platelets expressing P-selectin when drawn at the site of a mock trauma (7.0% ± 1.84) or in the peripheral blood (11.2% ± 3.30) showed little activation. In addition, no platelet adhesion was seen on the vascular bed of these animals. Results from this study show that analysis of P-selectin (CD62P) expression, in circulating platelets, is a valuable and rapid marker of platelet activation following severe vascular trauma induced in rats. However, activated platelets were not detected to the same extent in the peripheral blood of all animals having undergone vascular trauma. It is conceivable that platelets, depending on the degree of activation, may be actively sequestered in organs and prevented from circulating. Alternatively, P-selectin may be rapidly endocytosed, or not expressed, by activated circulating platelets depending on the type of agonists implicated in vivo activation.

scholarly journals Mandibular movements in children with and without signs and symptoms of temporomandibular disorders

2004 ◽  
Vol 12 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Leonardo Rigoldi Bonjardim ◽  
Maria Beatriz Duarte Gavião ◽  
Luciano José Pereira ◽  
Paula Midori Castelo
Keyword(s):  
Clinical Signs ◽  
Mouth Opening ◽  
Signs And Symptoms ◽  
Lateral Movement ◽  
Mandibular Movement ◽  
Group I ◽  
Group Ii ◽  
The Right ◽  
Mandibular Movements ◽  
Digital Caliper

This research aimed to evaluate mandibular movements in children with and without signs and symptoms of temporomandibular dysfunction. The sample taken consisted of 99 children aged 3 to 5 years distributed in two groups: I - Absence of signs and/or symptoms of TMD (25 girls/40 boys); II - Presence of signs and symptoms of TMD (16 girls/18 boys). The symptoms were evaluated through an anamnesis questionnaire answered by the child's parents/caretakers. The clinical signs were evaluated through intra- and extraoral examination. Maximum mouth opening and left/right lateral movements were measured using a digital caliper. The maximum protrusive movement was measured using a millimeter ruler. The means and standard deviations for maximum mouth opening in Group I and Group II were 40.82mm±4.18 and 40.46mm±6.66, respectively. The values found for the left lateral movement were 6.96mm±1.66 for Group I and 6.74mm±1.55 for Group II, while for the right lateral movement they were 6.46mm±1.53 and 6.74mm±1.77. The maximum protrusion movements were 5.67mm±1.76 and 6.12mm±1.92, in Groups I and II, respectively. The mandibular movement ranges neither differed statistically between groups nor between genders. FAPESP Process 96/0714-6.

scholarly journals Temporomandibular joint dysfunction in Parkinson's Disease: an integrative literature review

Revista CEFAC ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. 702-711 ◽  
Author(s):  
Taysa Vannoska de Almeida Silva ◽  
Maria das Graças Wanderley de Sales Coriolano ◽  
Carla Cabral dos Santos Accioly Lins
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Temporomandibular Joint ◽  
Myofascial Pain ◽  
Mouth Opening ◽  
Signs And Symptoms ◽  
Masticatory Muscles ◽  
Therapeutic Interventions ◽  
Temporomandibular Joint Dysfunction ◽  
Language Restriction

ABSTRACT Temporomandibular joint dysfunction is a set of disorders involving the masticatory muscles, temporomandibular joint and associated structures. It is known that the progression of motor symptoms in Parkinson's disease is an indication that these people are more prone to the development of this dysfunction. Thus, this study aims to investigate the signs and symptoms of temporomandibular dysfunction in people with Parkinson's disease. The search was performed in the databases: MEDLINE/ PubMed, LILACs, CINAHL, SCOPUS, Web of Science and PEDro, without timing or language restriction. Specific descriptors were used for each database and keywords, evaluated by the instruments: Critical Appraisal Skill Program and Agency for Health care and Research and Quality. A total of 4,209 articles were found but only 5 were included. After critical analysis of the methodology of the articles, one did not reach the minimum score required by the evaluation instruments, thus, it was excluded. The selected articles addressed, as signs and symptoms of temporomandibular joint dysfunction, the following: myofascial pain, bruxism, limitation of mouth opening, dislocation of the articular disc and asymmetry in the distribution of occlusal contacts. Further studies are needed in order to determine the relationship between cause and effect of the analyzed variables, so as to contribute to more specific and effective therapeutic interventions.

scholarly journals Assessing the effectiveness of botulinum toxin injections into masticatory muscles in the treatment of temporomandibular disorders

2018 ◽  
Vol 24 (3) ◽  
pp. 107-111 ◽  
Author(s):  
Alexis Kahn ◽  
Helios Bertin ◽  
Pierre Corre ◽  
Morgan Praud ◽  
Arnaud Paré ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Temporomandibular Disorders ◽  
Myofascial Pain ◽  
Mouth Opening ◽  
Masticatory Muscles ◽  
University Hospital ◽  
Duration Of Action ◽  
Beneficial Effects ◽  
Duration Of Effect ◽  
The Mean

Introduction: Temporomandibular disorders (TMD) are a common and invalidating disease sometimes difficult to treat. Current international recommendations favour reversible and non-invasive treatments, including the injection of botulinum toxin (BTX) into masticatory muscles. There is no strong evidence of its effectiveness. Objective: The main goal of this study was to assess the effectiveness of BTX six months following injection, in terms of pain, mouth opening, improvement of symptoms and duration of effect. Materials and methods: A retrospective study carried out at Nantes University Hospital between 2014 and 2016. Results: Thirty-four patients were included. The mean age was 37 years (17–76) and seventy six percents were female. Eighty percent of patients reported a significant improvement, notably in cases of arthralgia, which decreased in 8/18 (44%) patients (p < 0.05). The mean duration of measured efficacy was 4.2 months. Discussion: Significant improvement in cases of arthralgia and a tendency for improvement in cases of myalgia, with a mean duration of action of 4.2 months. Although BTX injection do not guarantee complete resolution of myofascial pain, it have been shown to have beneficial effects on some symptoms have been shown. Conclusion: Botulinum toxin should be considered as an alternative treatment when other conservative methods fail to yield satisfactory results. A thorough multicentre assessment is necessary in the future to scientifically validate its use.

Correlation of blood rheology with vascular resistance in critically ill patients

1975 ◽  
Vol 39 (6) ◽  
pp. 1008-1011 ◽  
Author(s):  
P. M. Scholz ◽  
J. H. Karis ◽  
F. E. Gump ◽  
J. M. Kinney ◽  
S. Chien
Keyword(s):  
Critically Ill ◽  
Blood Viscosity ◽  
Critically Ill Patients ◽  
Peripheral Resistance ◽  
Plasma Viscosity ◽  
Low Flow ◽  
Red Cell Deformability ◽  
Group I ◽  
Group Ii

Blood rheologic measurements together with peripheral resistance determinations in vivo were made in 27 critically ill patients. Eighteen of these patients (group I) suffered from violent trauma or operative injury and the other 9 (group II) were patients with generalized sepsis. As a result of fluid therapy all patients underwent hemodilution, resulting in a decrease in blood viscosity. This drop in blood viscosity was counteracted to some extent by an increased plasma viscosity due to elevated fibrinogen levels and a decreased red cell deformability associated with massive transfusions of stored blood. The correlation of vivo hemodynamics with blood rheological data made it possible to separate the relative roles of vascular dimensions and blood viscosity in affecting the total peripheral resistance. This approach permitted us to distinguish varying degrees of vasoconstriction in nonseptic patients in low flow states (group I) and varying degrees of vasodilation in septic patients (group II). This type of analysis serves to elucidate the pathophysiology of hemodynamic alterations in disease and provides a rational basis for devising an effective therapeutic program.

scholarly journals Differential Abilities of Capsulated and Noncapsulated Staphylococcus aureus Isolates from Diverse agr Groups To Invade Mammary Epithelial Cells

2006 ◽  
Vol 75 (2) ◽  
pp. 886-891 ◽  
Author(s):  
Fernanda R. Buzzola ◽  
Lucía P. Alvarez ◽  
Lorena P. N. Tuchscherr ◽  
María S. Barbagelata ◽  
Santiago M. Lattar ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mammary Gland ◽  
Epithelial Cells ◽  
Pcr Amplification ◽  
Variable Region ◽  
Polymorphism Analysis ◽  
Accessory Gene ◽  
Group I ◽  
Group Ii

ABSTRACT Staphylococcus aureus is the bacterium most frequently isolated from milk of bovines with mastitis. Four allelic groups, which interfere with the regulatory activities among the different groups, have been identified in the accessory gene regulator (agr) system. The aim of this study was to ascertain the prevalence of the different agr groups in capsulated and noncapsulated S. aureus bacteria isolated from mastitic bovines in Argentina and whether a given agr group was associated with MAC-T cell invasion and in vivo persistence. Eighty-eight percent of the bovine S. aureus strains were classified in agr group I. The remainder belonged in agr groups II, III, and IV (2, 8, and 2%, respectively). By restriction fragment length polymorphism analysis after PCR amplification of the agr locus variable region, six agr restriction types were identified. All agr group I strains presented a unique allele (A/1), whereas strains from groups II, III, and IV exhibited more diversity. Bovine S. aureus strains defined as being in agr group I (capsulated or noncapsulated) showed significantly increased abilities to be internalized within MAC-T cells, compared with isolates from agr groups II, III, and IV. agr group II or IV S. aureus strains were cleared more efficiently than agr group I strains from the murine mammary gland. The results suggest that agr group I S. aureus strains are more efficiently internalized within epithelial cells and can persist in higher numbers in mammary gland tissue than S. aureus strains classified in agr group II, III, or IV.

scholarly journals THE STATE OF CHILDREN MASTICATORY MUSCLES WITH DENTITION DEFECTS IN THE FRONTAL AREA AND NARROWING OF DENTAL ARCHES IN THE TRANSVERSE PLANE

10.23856/4336 ◽  
2021 ◽  
Vol 43 (6) ◽  
pp. 279-286
Author(s):  
Svitlana Savonik
Keyword(s):  
Orthodontic Treatment ◽  
Masticatory Muscles ◽  
The State ◽  
Frontal Area ◽  
Orthodontic Appliance ◽  
Dynamic Changes ◽  
Group I ◽  
Group Ii ◽  
Removable Appliances ◽  
Better Than

Orthopedic and orthodontic treatment of 49 patients aged 6 to 17 years with dentition defects in the frontal area was examined and performed to conduct and determine the state of the masticatory muscles in children with dentition defects. Patients were divided into two groups depending on the period of formation of the dento-maxillaire system and each of the groups was divided into two subgroups depending on the method of treatment and the mechanism of fixation of the orthodontic appliance in the oral cavity. When comparing the indicators between groups I A and I B, we can state that there were more qualitative and dynamic changes in electromyographic indicators in children of group I B than group I A. When comparing the data received after orthopedic and orthodontic treatment of children in group II, we can state that quantitative and qualitative indicators of electromyography for group II B were better than those of children in group II A. In children who were treated with removable appliances, these indicators improved, but remained at a worse level than in those treated with non-removable appliances.

scholarly journals Determination of Maxillary Incisal Edge Position using Canine Visibility as a Guide – An In vivo Study

2021 ◽  
pp. 165-171
Author(s):  
Ankita Piplani ◽  
G. Ganadhipathi ◽  
M. C. Suresh Sajjan
Keyword(s):  
Age Groups ◽  
Adhesive Tape ◽  
Central Incisor ◽  
Upper Lip ◽  
Maxillary Central Incisor ◽  
Group Iii ◽  
Incisal Edge ◽  
Group I ◽  
Group Ii

Purpose:  To evaluate the reliability of the visibility of the central incisor & the canine for the cervico incisal positioning of anterior maxillary teeth related to age & sex while the upper lip was in repose in dentate patients & the development of rehabilitation recommendations for edentulous individuals with regard to the location of the maxillary incisal edge Methodology: 308 subjects [152 Males & 156 Females] belonging to the age of 30 to 59 years were selected using a simple stratified random technique. There were three age and sex groups: Group I was 30 to 39 years old, Group II was 40 to 49 years old, and Group III was 50 to 59 years old. The vertical distances (in mm) between the lower border of the upper lip and the right maxillary central incisal edge and canine tip were measured and recorded using adhesive tape marked with millimetres. A single examiner recorded all the measurements and the values were tabulated and subjected to statistical analysis. Results: Men in Groups I and II had maxillary central incisor exposure ranging from +6 to -1mm, whereas males in Group III had exposure ranging from +5 to -2mm. There was an exposure range of +6 to -2 mm in females in Group I, +7 to -2 mm in Group II, and +5 to -2 mm in Group III for the central incisors. While the canine exposure in Group I and II and Group III ranged from +2 to -4mm in females, the exposure ranged from +3 to -3mm in men of all ages. In all groups, females had statistically significant (P0.05) more central incisor and canine exposure than men. Conclusions: The canine visibility was less variable in all the age groups and in both males and females in comparison to the central incisor. When restoring edentulous individuals, the average canine exposure dimension can be employed for cervico-incisal location of the anterior maxillary teeth.

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