An Outperforming Artificial Intelligence Model to Identify Referable Blepharoptosis for General Practitioners (Preprint)

2021 ◽  
Author(s):  
Ju-Yi Hung ◽  
Ke-Wei Chen ◽  
Chandrashan Perera ◽  
Hsu-Kuang Chiu ◽  
Cherng-Ru Hsu ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
General Practitioners ◽  
Binary Classification ◽  
Area Under The Curve ◽  
Eyelid Margin ◽  
Accurate Identification ◽  
Upper Eyelid ◽  
Physician Group ◽  
Activation Mapping ◽  
Visual Geometry

BACKGROUND Accurate identification and prompt referral for blepharoptosis can be challenging for general practitioners. An artificial intelligence-aided diagnostic tool could underpin decision-making. OBJECTIVE To develop an AI model which accurately identifies referable blepharoptosis automatically and to compare the AI model’s performance to a group of non-ophthalmic physicians. METHODS Retrospective 1,000 single-eye images from tertiary oculoplastic clinics were labeled by three oculoplastic surgeons with ptosis, including true and pseudoptosis, versus healthy eyelid. The VGG (Visual Geometry Group)-16 model was trained for binary classification. The same dataset was used in testing three non-ophthalmic physicians. The Gradient-weighted Class Activation Mapping (Grad-CAM) was applied to visualize the AI model RESULTS The VGG16-based AI model achieved a sensitivity of 92% and a specificity of 88%, compared with the non-ophthalmic physician group, who achieved a mean sensitivity of 72% [Range: 68% - 76%] and a mean specificity of 82.67% [Range: 72% - 88%]. The area under the curve (AUC) of the AI model was 0.987. The Grad-CAM results for ptosis predictions highlighted the area between the upper eyelid margin and central corneal light reflex. CONCLUSIONS The AI model shows better performance than the non-ophthalmic physician group in identifying referable blepharoptosis, including true and pseudoptosis, correctly. Therefore, artificial intelligence-aided tools have the potential to assist in the diagnosis and referral of blepharoptosis for general practitioners.

scholarly journals Anomaly Identification during Polymerase Chain Reaction for Detecting SARS-CoV-2 Using Artificial Intelligence Trained from Simulated Data

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 20
Author(s):  
Reynaldo Villarreal-González ◽  
Antonio J. Acosta-Hoyos ◽  
Jaime A. Garzon-Ochoa ◽  
Nataly J. Galán-Freyle ◽  
Paola Amar-Sepúlveda ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Real Time ◽  
Binary Classification ◽  
Simulated Data ◽  
Classification Model ◽  
Rt Pcr ◽  
Simon Bolivar ◽  
Polymerase Chain ◽  
Available Information

Real-time reverse transcription (RT) PCR is the gold standard for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), owing to its sensitivity and specificity, thereby meeting the demand for the rising number of cases. The scarcity of trained molecular biologists for analyzing PCR results makes data verification a challenge. Artificial intelligence (AI) was designed to ease verification, by detecting atypical profiles in PCR curves caused by contamination or artifacts. Four classes of simulated real-time RT-PCR curves were generated, namely, positive, early, no, and abnormal amplifications. Machine learning (ML) models were generated and tested using small amounts of data from each class. The best model was used for classifying the big data obtained by the Virology Laboratory of Simon Bolivar University from real-time RT-PCR curves for SARS-CoV-2, and the model was retrained and implemented in a software that correlated patient data with test and AI diagnoses. The best strategy for AI included a binary classification model, which was generated from simulated data, where data analyzed by the first model were classified as either positive or negative and abnormal. To differentiate between negative and abnormal, the data were reevaluated using the second model. In the first model, the data required preanalysis through a combination of prepossessing. The early amplification class was eliminated from the models because the numbers of cases in big data was negligible. ML models can be created from simulated data using minimum available information. During analysis, changes or variations can be incorporated by generating simulated data, avoiding the incorporation of large amounts of experimental data encompassing all possible changes. For diagnosing SARS-CoV-2, this type of AI is critical for optimizing PCR tests because it enables rapid diagnosis and reduces false positives. Our method can also be used for other types of molecular analyses.

scholarly journals DNN-m6A: A Cross-Species Method for Identifying RNA N6-Methyladenosine Sites Based on Deep Neural Network with Multi-Information Fusion

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 354
Author(s):  
Lu Zhang ◽  
Xinyi Qin ◽  
Min Liu ◽  
Ziwei Xu ◽  
Guangzhong Liu
Keyword(s):  
Neural Network ◽  
Deep Neural Network ◽  
Area Under The Curve ◽  
Nucleotide Composition ◽  
Computational Method ◽  
Feature Subset ◽  
Accurate Identification ◽  
Genome Wide ◽  
Dinucleotide Composition ◽  
Optimal Feature Subset

As a prevalent existing post-transcriptional modification of RNA, N6-methyladenosine (m6A) plays a crucial role in various biological processes. To better radically reveal its regulatory mechanism and provide new insights for drug design, the accurate identification of m6A sites in genome-wide is vital. As the traditional experimental methods are time-consuming and cost-prohibitive, it is necessary to design a more efficient computational method to detect the m6A sites. In this study, we propose a novel cross-species computational method DNN-m6A based on the deep neural network (DNN) to identify m6A sites in multiple tissues of human, mouse and rat. Firstly, binary encoding (BE), tri-nucleotide composition (TNC), enhanced nucleic acid composition (ENAC), K-spaced nucleotide pair frequencies (KSNPFs), nucleotide chemical property (NCP), pseudo dinucleotide composition (PseDNC), position-specific nucleotide propensity (PSNP) and position-specific dinucleotide propensity (PSDP) are employed to extract RNA sequence features which are subsequently fused to construct the initial feature vector set. Secondly, we use elastic net to eliminate redundant features while building the optimal feature subset. Finally, the hyper-parameters of DNN are tuned with Bayesian hyper-parameter optimization based on the selected feature subset. The five-fold cross-validation test on training datasets show that the proposed DNN-m6A method outperformed the state-of-the-art method for predicting m6A sites, with an accuracy (ACC) of 73.58%–83.38% and an area under the curve (AUC) of 81.39%–91.04%. Furthermore, the independent datasets achieved an ACC of 72.95%–83.04% and an AUC of 80.79%–91.09%, which shows an excellent generalization ability of our proposed method.

scholarly journals Double Rectangle Fascia Lata Frontalis Sling: A Rationale Approach for Ptosis

2021 ◽  
Vol 54 (01) ◽  
pp. 058-062
Author(s):  
Pawan Agarwal ◽  
Dhananjaya Sharma ◽  
Vikesh Agrawal ◽  
Swati Tiwari ◽  
Rajeev Kukrele
Keyword(s):  
Retrospective Study ◽  
Surgical Outcomes ◽  
Functional Outcomes ◽  
Fascia Lata ◽  
Modified Technique ◽  
Eyelid Margin ◽  
Upper Eyelid ◽  
Light Reflex ◽  
Straight Line

AbstractBackground The purpose of this study was to evaluate the functional outcomes of a modified technique of double rectangle pattern for correction of severe ptosis.Methods This is a retrospective study over a period of 8 years including patients who underwent correction of ptosis by double rectangle using autologous fascia lata sling. Surgical outcomes were assessed postoperatively by distance from the corneal light reflex to the upper eyelid margin (MRD1) and levator function.Results Twenty-six eyelids were operated in 20 patients. There were 9 males and 11 females, with age ranging from 4 to 35 years. Preoperatively, all patients had poor MRD1 and poor levator function. Postoperative MRD1 was good in 13 patients (17 eyelids), fair in 5 (7eyelids), and poor in 2 patients (2 eyelids). Postoperative levator function was excellent in 12 patients (15 eyelids), good in 6 (9 eyelids), and fair in 2 patients (2 eyelids). At a mean follow-up of 12 months, adequate correction was achieved in 24 eyelids, and 2 eyelids had undercorrection.Conclusion Frontalis sling with a double rectangle is simple and more efficient, as it provides a straight line of pull to the eyelid for correction of severe ptosis.

Automated Large Artery Occlusion Detection in Stroke: A Single-Center Validation Study of an Artificial Intelligence Algorithm

2021 ◽  
pp. 1-6
Author(s):  
Gabriel Rodrigues ◽  
Clara M. Barreira ◽  
Mehdi Bouslama ◽  
Diogo C. Haussen ◽  
Alhamza Al-Bayati ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Secondary Analysis ◽  
Large Artery ◽  
Single Center ◽  
Characteristic Analysis ◽  
Cohen’S Kappa ◽  
Accurate Identification ◽  
Vessel Occlusion ◽  
Test Characteristic ◽  
Cohen's Kappa

<b><i>Introduction:</i></b> Expediting notification of lesions in acute ischemic stroke (AIS) is critical. Limited availability of experts to assess such lesions and delays in large vessel occlusion (LVO) recognition can negatively affect outcomes. Artificial intelligence (AI) may aid LVO recognition and treatment. This study aims to evaluate the performance of an AI-based algorithm for LVO detection in AIS. <b><i>Methods:</i></b> Retrospective analysis of a database of AIS patients admitted in a single center between 2014 and 2019. Vascular neurologists graded computed tomography angiographies (CTAs) for presence and site of LVO. Studies were analyzed by the Viz-LVO Algorithm® version 1.4 – neural network programmed to detect occlusions from the internal carotid artery terminus (ICA-T) to the Sylvian fissure. Comparisons between human versus AI-based readings were done by test characteristic analysis and Cohen’s kappa. Primary analysis included ICA-T and/or middle cerebral artery (MCA)-M1 LVOs versus non-LVOs/more distal occlusions. Secondary analysis included MCA-M2 occlusions. <b><i>Results:</i></b> 610 CTAs were analyzed. The AI algorithm rejected 2.5% of the CTAs due to poor quality, which were excluded from the analysis. Viz-LVO identified ICA-T and MCA-M1 LVOs with a sensitivity of 87.6%, specificity of 88.5%, and accuracy of 87.9% (AUC 0.88, 95% CI: 0.85–0.92, <i>p</i> &#x3c; 0.001). Cohen’s kappa was 0.74. In the secondary analysis, the algorithm yielded a sensitivity of 80.3%, specificity of 88.5%, and accuracy of 82.7%. The mean run time of the algorithm was 2.78 ± 0.5 min. <b><i>Conclusion:</i></b> Automated AI reading allows for fast and accurate identification of LVO strokes with timely notification to emergency teams, enabling quick decision-making for reperfusion therapies or transfer to specialized centers if needed.

Social media users and cybersecurity awareness: predicting self-disclosure using a hybrid artificial intelligence approach

Kybernetes ◽  
2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Naurin Farooq Khan ◽  
Naveed Ikram ◽  
Hajra Murtaza ◽  
Muhammad Aslam Asadi
Keyword(s):  
Artificial Intelligence ◽  
Social Networking Sites ◽  
Hybrid Approach ◽  
Area Under The Curve ◽  
Protective Behavior ◽  
Self Disclosure ◽  
Content Type ◽  
Privacy Risks ◽  
Intelligence Approach ◽  
Artificial Intelligence Approach

PurposeThis study aims to investigate the cybersecurity awareness manifested as protective behavior to explain self-disclosure in social networking sites. The disclosure of information about oneself is associated with benefits as well as privacy risks. The individuals self-disclose to gain social capital and display protective behaviors to evade privacy risks by careful cost-benefit calculation of disclosing information.Design/methodology/approachThis study explores the role of cyber protection behavior in predicting self-disclosure along with demographics (age and gender) and digital divide (frequency of Internet access) variables by conducting a face-to-face survey. Data were collected from 284 participants. The model is validated by using multiple hierarchal regression along with the artificial intelligence approach.FindingsThe results revealed that cyber protection behavior significantly explains the variance in self-disclosure behavior. The complementary use of five machine learning (ML) algorithms further validated the model. The ML algorithms predicted self-disclosure with an area under the curve of 0.74 and an F1 measure of 0.70.Practical implicationsThe findings suggest that costs associated with self-disclosure can be mitigated by educating the individuals to heighten their cybersecurity awareness through cybersecurity training programs.Originality/valueThis study uses a hybrid approach to assess the influence of cyber protection behavior on self-disclosure using expectant valence theory (EVT).

scholarly journals Application of artificial intelligence in a real-world research for predicting the risk of liver metastasis in T1 colorectal cancer

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Tenghui Han ◽  
Jun Zhu ◽  
Xiaoping Chen ◽  
Rujie Chen ◽  
Yu Jiang ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Predictive Model ◽  
Area Under The Curve ◽  
Predictive Ability ◽  
Subsequent Treatment ◽  
Training Dataset ◽  
Discriminative Ability ◽  
Fundamental Parameters

Abstract Background Liver is the most common metastatic site of colorectal cancer (CRC) and liver metastasis (LM) determines subsequent treatment as well as prognosis of patients, especially in T1 patients. T1 CRC patients with LM are recommended to adopt surgery and systematic treatments rather than endoscopic therapy alone. Nevertheless, there is still no effective model to predict the risk of LM in T1 CRC patients. Hence, we aim to construct an accurate predictive model and an easy-to-use tool clinically. Methods We integrated two independent CRC cohorts from Surveillance Epidemiology and End Results database (SEER, training dataset) and Xijing hospital (testing dataset). Artificial intelligence (AI) and machine learning (ML) methods were adopted to establish the predictive model. Results A total of 16,785 and 326 T1 CRC patients from SEER database and Xijing hospital were incorporated respectively into the study. Every single ML model demonstrated great predictive capability, with an area under the curve (AUC) close to 0.95 and a stacking bagging model displaying the best performance (AUC = 0.9631). Expectedly, the stacking model exhibited a favorable discriminative ability and precisely screened out all eight LM cases from 326 T1 patients in the outer validation cohort. In the subgroup analysis, the stacking model also demonstrated a splendid predictive ability for patients with tumor size ranging from one to50mm (AUC = 0.956). Conclusion We successfully established an innovative and convenient AI model for predicting LM in T1 CRC patients, which was further verified in the external dataset. Ultimately, we designed a novel and easy-to-use decision tree, which only incorporated four fundamental parameters and could be successfully applied in clinical practice.

High-dimensional Unbalanced Binary Classification by Genetic Programming with Multi-criterion Fitness Evaluation and Selection

2021 ◽  
pp. 1-26
Author(s):  
Wenbin Pei ◽  
Bing Xue ◽  
Lin Shang ◽  
Mengjie Zhang
Keyword(s):  
Genetic Programming ◽  
Fitness Function ◽  
Binary Classification ◽  
Class Imbalance ◽  
Area Under The Curve ◽  
High Dimensional ◽  
Genetic Operators ◽  
Minority Class ◽  
Fitness Evaluation ◽  
Unbalanced Classification

Abstract High-dimensional unbalanced classification is challenging because of the joint effects of high dimensionality and class imbalance. Genetic programming (GP) has the potential benefits for use in high-dimensional classification due to its built-in capability to select informative features. However, once data is not evenly distributed, GP tends to develop biased classifiers which achieve a high accuracy on the majority class but a low accuracy on the minority class. Unfortunately, the minority class is often at least as important as the majority class. It is of importance to investigate how GP can be effectively utilized for high-dimensional unbalanced classification. In this paper, to address the performance bias issue of GP, a new two-criterion fitness function is developed, which considers two criteria, i.e. the approximation of area under the curve (AUC) and the classification clarity (i.e. how well a program can separate two classes). The obtained values on the two criteria are combined in pairs, instead of summing them together. Furthermore, this paper designs a three-criterion tournament selection to effectively identify and select good programs to be used by genetic operators for generating better offspring during the evolutionary learning process. The experimental results show that the proposed method achieves better classification performance than other compared methods.

Universal architecture of corneal segmental tomography biomarkers for artificial intelligence-driven diagnosis of early keratoconus

2021 ◽  
pp. bjophthalmol-2021-319309
Author(s):  
Gairik Kundu ◽  
Rohit Shetty ◽  
Pooja Khamar ◽  
Ritika Mullick ◽  
Sneha Gupta ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Refractive Surgery ◽  
Three Dimensional ◽  
Area Under The Curve ◽  
Preoperative Imaging ◽  
Imaging Data ◽  
Wavefront Aberrations ◽  
Healthy Eyes ◽  
Fellow Eyes

AimsTo develop a comprehensive three-dimensional analyses of segmental tomography (placido and optical coherence tomography) using artificial intelligence (AI).MethodsPreoperative imaging data (MS-39, CSO, Italy) of refractive surgery patients with stable outcomes and diagnosed with asymmetric or bilateral keratoconus (KC) were used. The curvature, wavefront aberrations and thickness distributions were analysed with Zernike polynomials (ZP) and a random forest (RF) AI model. For training and cross-validation, there were groups of healthy (n=527), very asymmetric ectasia (VAE; n=144) and KC (n=454). The VAE eyes were the fellow eyes of KC patients but no further manual segregation of these eyes into subclinical or forme-fruste was performed.ResultsThe AI achieved an excellent area under the curve (0.994), accuracy (95.6%), recall (98.5%) and precision (92.7%) for the healthy eyes. For the KC eyes, the same were 0.997, 99.1%, 98.7% and 99.1%, respectively. For the VAE eyes, the same were 0.976, 95.5%, 71.5% and 91.2%, respectively. Interestingly, the AI reclassified 36 (subclinical) of the VAE eyes as healthy though these eyes were distinct from healthy eyes. Most of the remaining VAE (n=104; forme fruste) eyes retained their classification, and were distinct from both KC and healthy eyes. Further, the posterior surface features were not among the highest ranked variables by the AI model.ConclusionsA universal architecture of combining segmental tomography with ZP and AI was developed. It achieved an excellent classification of healthy and KC eyes. The AI efficiently classified the VAE eyes as ‘subclinical’ and ‘forme-fruste’.

scholarly journals Multiresolution Application of Artificial Intelligence in Digital Pathology for Prediction of Positive Lymph Nodes From Primary Tumors in Bladder Cancer

2020 ◽  
pp. 367-382 ◽  
Author(s):  
Stephanie A. Harmon ◽  
Thomas H. Sanford ◽  
G. Thomas Brown ◽  
Chris Yang ◽  
Sherif Mehralivand ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Digital Pathology ◽  
Area Under The Curve ◽  
The Cancer Genome Atlas ◽  
Clinicopathologic Features ◽  
Combined Model ◽  
Primary Tumors ◽  
Logistic Regression Models ◽  
Spatially Resolved ◽  
Digital Evaluation

PURPOSE To develop an artificial intelligence (AI)–based model for identifying patients with lymph node (LN) metastasis based on digital evaluation of primary tumors and train the model using cystectomy specimens available from The Cancer Genome Atlas (TCGA) Project; patients from our institution were included for validation of the leave-out test cohort. METHODS In all, 307 patients were identified for inclusion in the study (TCGA, n = 294; in-house, n = 13). Deep learning models were trained from image patches at 2.5×, 5×, 10×, and 20× magnifications, and spatially resolved prediction maps were combined with microenvironment (lymphocyte infiltration) features to derive a final patient-level AI score (probability of LN metastasis). Training and validation included 219 patients (training, n = 146; validation, n = 73); 89 patients (TCGA, n = 75; in-house, n = 13) were reserved as an independent testing set. Multivariable logistic regression models for predicting LN status based on clinicopathologic features alone and a combined model with AI score were fit to training and validation sets. RESULTS Several patients were determined to have positive LN metastasis in TCGA (n = 105; 35.7%) and in-house (n = 3; 23.1%) cohorts. A clinicopathologic model that considered using factors such as age, T stage, and lymphovascular invasion demonstrated an area under the curve (AUC) of 0.755 (95% CI, 0.680 to 0.831) in the training and validation cohorts compared with the cross validation of the AI score (likelihood of positive LNs), which achieved an AUC of 0.866 (95% CI, 0.812 to 0.920; P = .021). Performance in the test cohort was similar, with a clinicopathologic model AUC of 0.678 (95% CI, 0.554 to 0.802) and an AI score of 0.784 (95% CI, 0.702 to 0.896; P = .21). In addition, the AI score remained significant after adjusting for clinicopathologic variables ( P = 1.08 × 10−9), and the combined model significantly outperformed clinicopathologic features alone in the test cohort with an AUC of 0.807 (95% CI, 0.702 to 0.912; P = .047). CONCLUSION Patients who are at higher risk of having positive LNs during cystectomy can be identified on primary tumor samples using novel AI-based methodologies applied to digital hematoxylin and eosin–stained slides.

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