scholarly journals Deterioration of heart rhythm during short-term hydroxychloroquine therapy for COVID-19: report of two cases

2021 ◽  
Vol 7 (1) ◽  
pp. 54-62
Author(s):  
Anggoro Budi Hartopo ◽  
Brilliant Winona Jhundy ◽  
Afik Maulana Rachman ◽  
Vita Yanti Anggraeni ◽  
Erika Maharani ◽  
...  
Keyword(s):  
Case Report ◽  
Risk Stratification ◽  
Cardiac Toxicity ◽  
Heart Rhythm ◽  
Adult Patients ◽  
Morbidity And Mortality ◽  
Cardiac Conduction ◽  
Significant Morbidity ◽  
Short Term ◽  
Rapid Spread

The rapid spread of the coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality globally. Hydroxychloroquine is one of the medications for eradicating COVID-19. Despite concerns due to its potential cardiac toxicity, hydroxychloroquine is widely used in treating mild and moderate COVID-19 pneumonia. In this case report, we report two cases of Indonesian adult patients with suspected COVID-19 pneumonia who received hydroxychloroquine as part of the medications and experienced deterioration of cardiac conduction which required stopping the drug prematurely. This case report highlights the need for risk stratification, electrocardiogram monitor and QTc evaluation before and during hydroxychloroquine therapy.

Acute gastrointestinal bleeding

2021 ◽  
pp. 175573802110469
Author(s):  
Victoria Evans ◽  
Helen King
Keyword(s):  
Risk Stratification ◽  
Gastrointestinal Bleeding ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Acute Gastrointestinal Bleeding ◽  
Surgical Emergency

Acute gastrointestinal bleeding is a common medical and/or surgical emergency that can be caused by a range of diverse pathologies. Gastrointestinal Bleeding can be divided into upper and lower in nature, presenting in sometimes subtly different fashions, but with differing requirements for investigation and management. Prompt identification, risk stratification and treatment are required in order to minimise the ongoing significant morbidity and mortality rates associated with severe presentations of gastrointestinal bleeding.

Erdheim—Chester Disease

2003 ◽  
Vol 7 (2) ◽  
pp. 129-132
Author(s):  
Susan E. Lenahan ◽  
Klaus F. Helm ◽  
Kenneth D. Hopper
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Erdheim Chester Disease ◽  
Pathologic Findings ◽  
Erdheim Chester ◽  
Chester Disease

Background: Erdheim–Chester disease is a rare non-Langerhans' cell histiocytosis. Objective: This case report is presented to familiarize clinicians with Erdheim–Chester disease and its differential diagnosis. Results and Conclusion: Erdheim–Chester disease presents with unique clinical and pathologic findings. Its xanthoma-like lesions can cause significant morbidity and mortality.

scholarly journals COVID-19: Knowns, Unknowns, and Questions

mSphere ◽  
2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Stuart Weston ◽  
Matthew B. Frieman
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Hubei Province ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Current State ◽  
Recent Emergence ◽  
Rapid Spread ◽  
The World ◽  
Current Outbreak ◽  
Answering Questions

ABSTRACT The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.

scholarly journals A rare case of necrotizing fasciitis of eyelid in a young immunocompetent lady- case report and review of literature

2021 ◽  
Vol 7 (11) ◽  
pp. 1834
Author(s):  
Nithya Venkataramani ◽  
Sonali Muralidhar ◽  
Ravi Sachidananda
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Early Identification ◽  
Rare Case ◽  
Rare Condition ◽  
Necrotising Fasciitis ◽  
Aggressive Treatment ◽  
Review Of Literature ◽  
Significant Morbidity ◽  
Rapid Spread

<p class="abstract">Necrotising fasciitis of the periorbital region is a rare condition where there is destruction of the periorbital soft tissue with potential of rapid spread causing significant morbidity and mortality. It is generally seen in immuno suppressed individuals following trivial trauma. Here we present a case of periorbital necrotising fasciitis in a young immonocompetent lady with emphasis on early identification and aggressive treatment to prevent loss of vision and mortality.</p>

scholarly journals Rare Strain ofVibrio choleraeSepticemia in a Patient with Multiple Myeloma

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Deepu Daniel ◽  
Sunil Kumar
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Vibrio Cholerae ◽  
Multiorgan Failure ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Vibrio Cholera ◽  
Case Presentation ◽  
Immunosuppressed Patients

Introduction. Non-O1/non-O139 is a rare strain ofVibrio cholerathat has been documented to cause significant morbidity and mortality in the immunosuppressed population.Case Presentation. A patient with multiple myeloma develops non-O1/non-O139Vibrio cholerasepticemia, leading to multiorgan failure and ultimately death.Discussion. An exceedingly rare strain ofVibrio cholera, non-O1/non-O139, may be an important factor of morbidity and mortality in certain immunosuppressed populations, such as patients with multiple myeloma and malignancies.Conclusion. Bacteremia involving generally noninvasive microbes, such as non-O1/non-O139Vibrio cholerae, can have significant deleterious effects in the immunosuppressed patients as shown by this case report. Physicians need to be more diligent when treating these patients.

scholarly journals Pediatric Stroke: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Daniel S. Tsze ◽  
Jonathan H. Valente
Keyword(s):  
Risk Factors ◽  
Clinical Presentation ◽  
Management Strategies ◽  
Morbidity And Mortality ◽  
Pediatric Stroke ◽  
Significant Morbidity ◽  
Short Term ◽  
Delay In Diagnosis

Stroke is relatively rare in children, but can lead to significant morbidity and mortality. Understanding that children with strokes present differently than adults and often present with unique risk factors will optimize outcomes in children. Despite an increased incidence of pediatric stroke, there is often a delay in diagnosis, and cases may still remain under- or misdiagnosed. Clinical presentation will vary based on the child's age, and children will have risk factors for stroke that are less common than in adults. Management strategies in children are extrapolated primarily from adult studies, but with different considerations regarding short-term anticoagulation and guarded recommendations regarding thrombolytics. Although most recommendations for management are extrapolated from adult populations, they still remain useful, in conjunction with pediatric-specific considerations.

scholarly journals Burns from foul play? No – previously unsuspected epilepsy

2013 ◽  
Vol 21 (2) ◽  
pp. 105-107
Author(s):  
Peter W. Kaplan
Keyword(s):  
Case Report ◽  
Young Woman ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Clonic Seizures ◽  
Forensic Implications ◽  
New Onset

SUMMARY Introduction. Injuries such as burns may occur from unwitnessed and unsuspected new onset epilepsy with forensic implications. Case report. A young woman was found with >25% 2nd and 3rd degree body burns after an unwitnessed morning event in a shower. Discussion. The onset of tonic-clonic seizures and limb jerks in adolescence with a typical EEG recording of 3–4/second spike/polyspike-and-waves are diagnostic of Juvenile Myoclonic Epilepsy (JME). Worldwide there is a significant morbidity and mortality in epilepsy from burns. The treatment of JME and of burns was discussed.

scholarly journals Possible pitfalls in the workup of ectopic ACTH secretion illustrated by four rare cases

2019 ◽  
Vol 12 (11) ◽  
pp. e231067
Author(s):  
Jorianne Boers ◽  
P Christine Oldenburg-Ligtenberg ◽  
Aline ME Stades ◽  
Mark JC van Treijen
Keyword(s):  
Case Report ◽  
Adrenocorticotropic Hormone ◽  
Progressive Disease ◽  
Diagnostic Workup ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Acth Secretion ◽  
Ectopic Acth ◽  
Ectopic Acth Secretion ◽  
Ectopic Adrenocorticotropic Hormone

In this case report, we highlight four different cases of ectopic adrenocorticotropic hormone (ACTH) secretion with different pitfalls in the diagnostic workup. Ectopic ACTH secretion (EAS) is an uncommon cause of Cushing’s syndrome that accompanies a variety of tumours. It is associated with significant morbidity and mortality. This underlines the importance of early and adequate diagnosis. We will review the causes of EAS and their presentation to increase awareness of this rare and progressive disease.

Age deciles contribute to risk stratification of short-term pancreatectomy morbidity and mortality

2013 ◽  
Vol 217 (3) ◽  
pp. S60
Author(s):  
Nadia M. Obeid ◽  
Ilan S. Rubinfeld ◽  
David S. Kwon ◽  
Nathan H. Schmoekel ◽  
Ryan Kather ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Morbidity And Mortality ◽  
Short Term

scholarly journals A Patient with Dermatomyositis Developing Steroid Induced Myopathy: A Case Report

2016 ◽  
Vol 24 (2) ◽  
pp. 156-159
Author(s):  
Taslima Akter ◽  
Md Enamul Karim ◽  
Partha Pratim Das ◽  
Sarmistha Biswas ◽  
AKM Humayon Kabir ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Steroid Therapy ◽  
Immunosuppressive Drug ◽  
Morbidity And Mortality ◽  
Effective Management ◽  
Significant Morbidity ◽  
Medical College ◽  
Uncommon Disease ◽  
Atypical Presentations

Dermatomyositis is not a very uncommon disease affecting skin and muscles. Some varieties have atypical presentations and early diagnosis is pivotal to the effective management as it has significant morbidity and mortality including malignancy. Corticosteroids and other immunosuppressive is the mainstay of treatment; however, it should also be aimed to reduce the complications of steroid therapy as there is a possibility of steroid induced myopathy where withdrawal of steroid with introduction of other immunosuppressive drug is promptly warranted. Here, we presented a 60 year old lady with dermatomyositis who developed steroid induced myopathy.J Dhaka Medical College, Vol. 24, No.2, October, 2015, Page 156-159

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