EFFECTS OF PSYCHOTROPICS ON NEUTROPHIL-LYMPHOCYTE RATIO IN PSYCHIATRIC PATIENTS

Objective: The objective of this study was to investigate whether psychotropic has any effect on neutrophils and lymphocyte ratio (NLR) in psychiatric patients. Methods: In this hospital-based prospective quasi-randomized follow-up study, we analyzed every 10 patients with newly diagnosed with depression, schizophrenia, and bipolar disorder for complete blood count before and after treatment with the selected psychotropic. Results: There was a significant increase in NLR of patients with depression after treatment with psychotropic (p=0.001), also in schizophrenia, there was a slight increase in NLR of patients after treatment with psychotropic (p=0.005), but in bipolar disorder, there was a significant decrease in NLR of patients after treatment with psychotropic (p=0.002). Conclusion: The present study confirmed that psychotropics have a statistically significant effect on the increase in NLR in patients with depression, a slight increase in patients with schizophrenia, and a decrease in patients with bipolar disorder. Further studies are needed for a better understanding of the mechanism of psychotropic drug effect on NLR.

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Prediction of Troponin elevation in Non- ST Acute Coronary Syndrome Patients presenting to The Emergency Department Using Neutrophil-lymphocyte ratio

QJM ◽

10.1093/qjmed/hcab090.035 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Sarah Mohamed Mahmoud ◽

Bassam Sobhy ◽

Ramy Raymond

Keyword(s):

Emergency Department ◽

Acute Coronary Syndrome ◽

Complete Blood Count ◽

P Value ◽

Troponin Elevation ◽

Positive Group ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Coronary Syndrome

Abstract Background The neutrophil–lymphocyte ratio (NLR) is considered an independent predictor of mortality and myocardial infarction (MI) in stable coronary artery disease (SCAD). Also NLR have prognostic value in patients with acute coronary syndromes (ACSs). However the diagnostic power of NLR in patients suspected of ACS is still under study Objective is to determine the ability of neutrophil-lymphocyte ratio to predict troponin elevation in patients presenting to emergency department with acute coronary syndrome Material and Methods From June 2018 to March 2019, 100 patients were enrolled who presented to the ER with NST-ACS. Patients were divided into 2 groups based upon the troponin positivity in the 12- to 24-hour follow-up. Baseline Complete blood count with calculation of NLR is done Results The study population was divided into 2 groups: troponin- negative group (n = 50) and troponin-positive group (n = 50). Mean age was 55.8 ± 11.3. 77% of the patients were male. No significance difference in the level of hemoglobin, WBCs and platelets between the 2 groups. The neutrophil count was significantly higher in the troponin-positive group (p < 0.001). The median admission. NLR was significantly higher in the troponin-positive group (2 vs. 3.9, P < 0.001). A cutoff point of 3.4 for NLR measured on admission had 84% sensitivity and 84% specificity in predicting follow-up troponin positivity. A highly significant correlation was found between NLR and level of troponin change (p value <0.01) Conclusion NLR can be used as a diagnostic tool in the differentiation of patients with acute coronary syndrome. NLR is a non-expensive, simple and available parameter that can be used in diagnosis of NSTEMI.

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Weighted blankets for insomnia in affective disorder and ADHD – a clinical follow up study

10.31234/osf.io/wjsr2 ◽

2018 ◽

Author(s):

Bodil Ekholm ◽

Mats Adler

Keyword(s):

Affective Disorder ◽

Rating Scale ◽

Psychiatric Patients ◽

Sleep Onset ◽

Clinical Routine ◽

Positive Effects ◽

Follow Up Study ◽

Before And After ◽

One Year

Introduction: Weighted blankets are used for the treatment of insomnia in patients with affective disorders and ADHD, despite the lack of scientific support. This study aimed to evaluate the clinical use of weighted blankets for insomnia in patients with affective disorder and ADHD. Methods: 199 psychiatric patients with affective and ADHD diagnoses and co-occurring insomnia were included consecutively and treated with weighted blankets as a part of a clinical routine. They were evaluated before and after four weeks use of the blanket concerning time to sleep onset and ten sleep-related symptoms, using a self-rating scale, and after one year by a telephone interview.Results: The use of weighted blankets reduced the median time to fall asleep from 70 to 30 minutes (p<0.001) and led to a significant improvement of ten other sleep-related symptoms at the follow up after four weeks. After one year the positive effects on sleep were still maintained.Conclusions: The favourable results the results of this open clinical study should be interpreted with caution. Studies with a controlled design are warranted.

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Neutrophil‐lymphocyte ratio as a predictor of kidney function decline among individuals with diabetes and prediabetes: A 3‐year follow‐up study

Journal of Diabetes ◽

10.1111/1753-0407.12903 ◽

2019 ◽

Vol 11 (6) ◽

pp. 427-430

Author(s):

Jia Li ◽

Tong Li ◽

Haibin Wang ◽

Wenhua Yan ◽

Yiming Mu

Keyword(s):

Kidney Function ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Follow Up Study ◽

Kidney Function Decline

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A 2-year follow-up study of discharged psychiatric patients with bipolar disorder

Psychiatry Research ◽

10.1016/j.psychres.2014.04.029 ◽

2014 ◽

Vol 218 (1-2) ◽

pp. 75-78 ◽

Cited By ~ 8

Author(s):

Chunyang Li ◽

Chao Chen ◽

Bin Qiu ◽

Guang Yang

Keyword(s):

Bipolar Disorder ◽

Psychiatric Patients ◽

Follow Up Study

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Neurological Evaluation of Patients with Newly Diagnosed Coeliac Disease Presenting to Gastroenterologists: A 7-Year Follow-Up Study

Nutrients ◽

10.3390/nu13061846 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1846

Author(s):

Marios Hadjivassiliou ◽

Iain D. Croall ◽

Richard A. Grünewald ◽

Nick Trott ◽

David S. Sanders ◽

...

Keyword(s):

Coeliac Disease ◽

Brain Imaging ◽

Cerebellar Atrophy ◽

Neurological Dysfunction ◽

Close Monitoring ◽

Newly Diagnosed ◽

Positive Serology ◽

Original Cohort ◽

Follow Up Study

We have previously shown that 67% of patients with newly diagnosed coeliac disease (CD) presenting to gastroenterologists have evidence of neurological dysfunction. This manifested with headache and loss of co-ordination. Furthermore 60% of these patients had abnormal brain imaging. In this follow-up study, we re-examined and re-scanned 30 patients from the original cohort of 100, seven years later. There was significant reduction in the prevalence of headaches (47% to 20%) but an increase in the prevalence of incoordination (27% to 47%). Although those patients with coordination problems at baseline reported improvement on the gluten free diet (GFD), there were 7 patients reporting incoordination not present at baseline. All 7 patients had positive serology for one or more gluten-sensitivity related antibodies at follow-up. In total, 50% of the whole follow-up cohort were positive for one or more gluten-related antibodies. A comparison between the baseline and follow-up brain imaging showed a greater rate of cerebellar grey matter atrophy in the antibody positive group compared to the antibody negative group. Patients with CD who do not adhere to a strict GFD and are serological positive are at risk of developing ataxia, and have a significantly higher rate of cerebellar atrophy when compared to patients with negative serology. This highlights the importance of regular review and close monitoring.

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Impact of COVID-19 on child malnutrition, obesity in women and household food insecurity in underserved urban settlements in Sri Lanka: a prospective follow up study

Public Health Nutrition ◽

10.1017/s1368980021001841 ◽

2021 ◽

pp. 1-24

Author(s):

Renuka Jayatissa ◽

Himali Herath ◽

Amila Gayan Perera ◽

Thulasika Thejani Dayaratne ◽

Nawmali Dhanuska De Alwis ◽

...

Keyword(s):

Sri Lanka ◽

Food Insecurity ◽

Child Malnutrition ◽

Nutrition Status ◽

Household Food Insecurity ◽

Follow Up Study ◽

Household Food ◽

Before And After ◽

Urban Settlements

Abstract Objectives: To determine changes and factors associated with child malnutrition, obesity in women and household food insecurity before and after the first wave of COVID-19 pandemic. Design: A prospective follow up study. Setting: In 2019, the baseline Urban Health and Nutrition Study (UHNS-2019) was conducted in 603 households, which were selected randomly from 30 clusters to represent underserved urban settlements in Colombo. In the present study, 35% of households from the UHNS-2019 cohort were randomly selected for repeat interviews, one year after the baseline study and 6 months after COVID-19 pandemic in Sri Lanka. Height/length and weight of children and women were re-measured, household food insecurity was reassessed, and associated factors were gathered through interviewer administered questionnaires. Differences in measurements at baseline and follow-up studies were compared. Participants: A total of 207 households, comprising 127 women and 109 children were included. Results: The current prevalence of children with wasting and overweight was higher in the follow-up study than at baseline UHNS-2019 (18.3%vs13.7%;p=0.26 and 8.3%vs3.7%;p=0.12 respectively). There was a decrease in prevalence of child stunting (14.7%vs11.9%;p=0.37). A change was not observed in overall obesity in women, which was around 30.7%. Repeated lockdown was associated with a significant reduction in food security from 57% in UHNS-2019 to 30% in the current study (p<0.001). Conclusions: There was an increase in wasting and overweight among children while women had a persistent high prevalence of obesity. This population needs suitable interventions to improve nutrition status of children and women to minimise susceptibility to COVID-19.

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Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort

Journal of Perinatal Medicine ◽

10.1515/jpm-2020-0403 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Esin Merve Erol Koç ◽

Rahime Bedir Fındık ◽

Hatice Akkaya ◽

Işılay Karadağ ◽

Eda Özden Tokalıoğlu ◽

...

Keyword(s):

Complete Blood Count ◽

Perinatal Outcomes ◽

Control Group ◽

Strong Positive Correlation ◽

Monocyte Count ◽

Distribution Width ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Significant Difference ◽

Adverse Perinatal Outcomes

AbstractObjectivesTo evaluate the relationship between Coronavirus Disease 2019 (COVID-19) in pregnancy and adverse perinatal outcomes. The secondary aim is to analyze the diagnostic value of hematologic parameters in COVID-19 complicated pregnancies.MethodsThe current study is conducted in a high volume tertiary obstetrics center burdened by COVID-19 pandemics, in Turkey. In this cohort study, perinatal outcomes and complete blood count indices performed at the time of admission of 39 pregnancies (Study group) complicated by COVID-19 were compared with 69 uncomplicated pregnancies (Control group).ResultsThere was no significant difference between the obstetric and neonatal outcomes of pregnancies with COVID-19 compared to data of healthy pregnancies, except the increased C-section rate (p=0.026). Monocyte count, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) were significantly increased (p<0.0001, p=0.009, p=0.043, p<0.0001, respectively) whereas the MPV and plateletcrit were significantly decreased (p=0.001, p=0.008) in pregnants with COVID-19. ROC analysis revealed that the optimal cut-off value for MLR was 0.354 which indicated 96.7% specificity and 59.5% sensitivity in diagnosis of pregnant women with COVID-19. A strong positive correlation was found between the MLR and the presence of cough symptom (r=41.4, p=<0.0001).ConclusionsThe study revealed that, pregnancies complicated by COVID-19 is not related with adverse perinatal outcomes. MLR may serve as a supportive diagnostic parameter together with the Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in assessment of COVID-19 in pregnant cohort.

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ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867417720517 ◽

2017 ◽

Vol 52 (7) ◽

pp. 680-689

Author(s):

Sheng-Yu Lee ◽

Tzu-Yun Wang ◽

Shiou-Lan Chen ◽

Yun-Hsuan Chang ◽

Po-See Chen ◽

...

Keyword(s):

Bipolar Disorder ◽

Cognitive Function ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β1 ◽

C Reactive Protein ◽

Reactive Protein ◽

Follow Up Study ◽

Cytokine Levels

Objectives: We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder. Methods: Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor α, C-reactive protein, interleukin 6 and transforming growth factor β1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined. Results: A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -β1. Conclusion: The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.

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