scholarly journals EFFECT OF AQUEOUS EXTRACT OF CITRULLUS LANATUS PULP ON SCOPOLAMINE INDUCED COGNITIVE DYSFUNCTION IN SWISS ALBINO MICE

2021 ◽  
pp. 56-60
Author(s):  
DIVYA N
Keyword(s):  
Protective Effect ◽  
Cognitive Dysfunction ◽  
Aqueous Extract ◽  
Medical Condition ◽  
Citrullus Lanatus ◽  
Experimental Models ◽  
Swiss Albino Mice ◽  
Group I ◽  
Lycopene Content ◽  
Albino Mice

Objective: Amnesia is a medical condition involving the loss of memory. The memory loss is attributed to a number of illnesses or factors including Alzheimer’s disease (AD) and dementia, amnesia is often caused by head injury, brain trauma, or brain surgery. The incidence of amnesia affects only a small percent of the world’s population, the relevant study is becoming increasingly important with the rising numbers of people with AD. Alzheimer’s is predicted to strike 34 million people globally by 2025 and 14 million within the U.S. alone over subsequent 40 years. Methods: The study the possible protective effect of aqueous extract of Citrullus lanatus pulp (ACL) using scopolamine-induced amnesia in Swiss Albino mice. The mice were divided randomly into six groups each of five mice (n=5). Groups IV, V, and VI received mice feed and ACL 25%, 50%, and 100% instead of water for 21 days. Mice of Groups I, II, and III were treated with mice feed and water ad libitum. The animals were subjected to a single dose of scopolamine (1 mg/kg b.wt. ip) except in Group I on the 21st day 60 min after respective drug administration and observed for the effects in brain activity for the learning and memory. The behavioral parameters such as passive avoidance, Morris water maze, Y-Maze, and elevated plus maze were used as a tool for cognitive dysfunction study. Results: The ACL significantly reversed the scopolamine induced amnesia in mice. This is evident as C. lanatus is rich in lycopene content. The experimental models demonstrated that all the concentration of ACL treated mice showed remarkable results in restoring the effect of amnesia induced by scopolamine. Conclusion: To concise, these results suggest that ACL may exhibit protective effect on the brain to reverse the scopolamine induced amnesia. Further, it can be explored extracting the lycopene content of watermelon.

scholarly journals Effect of aqueous Extract of Terminalia bellirica fruit pulp on Alcohol affected learning in swiss albino mice

2021 ◽  
Vol 6 (2) ◽  
pp. 76-78
Author(s):  
Sowmya ◽  
Manohar VR ◽  
Mohandas Rai ◽  
H N Gopalakrishna ◽  
Chandrashekar R
Keyword(s):  
Aqueous Extract ◽  
Protective Action ◽  
Negative Control ◽  
Control Group ◽  
Acute Administration ◽  
Aqueous Extracts ◽  
Swiss Albino Mice ◽  
Alcohol Administration ◽  
Group I ◽  
Albino Mice

To evaluate the effect of Aqueous extract of Terminalia belliricafruit pulp (AETB) on learning by Hebb William maze model in mice with acute alcohol consumption.Swiss albino mice (n=48) of either sex weighing 20-30g will be divided into eight groups of six mice each. Drugs were given orally after 12 hours of fasting. Group I mice received 10ml/kg of Normal Saline, Group II mice received Piracetam 200mg/kg, Group III received AETB 36mg/kg, Group IV received ethanol 1.5g/kg orally, Group V received ethanol(1.5g/kg )+ piracetam (200mg/kg), Group VI mice received ethanol(1.5g/kg) +AETB(9mg/kg), Group VII mice received ethanol(1.5g/kg) +AETB (18mg/kg), Group VIII mice received ethanol(1.5g/kg) +AETB(36mg/kg). Time taken by the animal to reach the reward chamber from the start chamber (TRC) in Hebb-William maze was used as a parameterto evaluate the learning.Acute alcohol administration showed increase in TRC. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp showed a decrease in TRC when compared to the control group. The TRC values for the groups that were administered AETB along with acute alcohol administration showed decrease in TRC values compared to the negative control.Current study showed acute alcohol administration caused impairment of thelearning ability in mice. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp (AETB)caused enhancement of learning. Pre-treatment with AETB before acute alcohol administration indicated protective action of AETB on alcohol affected learning in mice.

scholarly journals EVALUATION OF ANTIDEPRESSANT ACTIVITY OF TAPENTADOL IN SWISS ALBINO MICE

2017 ◽  
Vol 10 (8) ◽  
pp. 103
Author(s):  
Pradeep Be ◽  
Narendranath S ◽  
Shruthi Ks ◽  
Shashikala Gh ◽  
Krishnagouda Patil ◽  
...  
Keyword(s):  
Animal Studies ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Experimental Models ◽  
Control Group ◽  
Swiss Albino Mice ◽  
Group I ◽  
Antidepressant Efficacy ◽  
Albino Mice ◽  
Post Hoc

Objective: The aim of this study is to evaluate the antidepressant activity of tapentadol using forced swimming test (FST) and tail suspension test (TST) experimental models.Methods: A total of 36 Swiss albino mice (18 for each experimental model) were divided into 3 groups of 6 animals each. In both the experimental models, Group I received normal saline – 10 ml/kg (Control group), Groups II and III given tapentadol 20 mg/kg and tapentadol 40 mg/kg, respectively, for 7 days, intraperitoneally. On day 7, the drugs were given 40 minutes before conducting the experiment. The duration of immobility was noted and compared among all the 3 groups. The observations were analyzed using analysis of variance and Tukey’s post-hoc test.Results: The duration of immobility was significantly decreased in both the experimental models. Tapentadol groups when compared to control group showed statistically significant values, and better results were obtained with tapentadol 20 mg/kg groups in both the models. The mean duration of Immobility was 34.67 seconds in FST model and 101.00 seconds in TST model when treated with tapentadol 20 mg/kg compared to 102.33 seconds in FST control and 141 seconds in TST control groups. FST model demonstrates greater antidepressant efficacy of tapentadol (p<0.00) than with TST model (p<0.04).Conclusion: Tapentadol showed significant antidepressant activity at the dose of 20 mg/kg. The results should be further confirmed by animal studies with different experimental models for the evaluation of depression and by human clinical studies, and if found effective, tapentadol can be preferred for patients with chronic pain, such as cancer pain.

scholarly journals NEUROPHARMACOLOGICAL STUDY OF PHYLLANTHUS NIRURI IN SWISS ALBINO MICE

2021 ◽  
pp. 157-160
Author(s):  
NAGARAJ P ◽  
SARAVANAN P ◽  
MANI R
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
In Vivo Studies ◽  
Phyllanthus Niruri ◽  
Swiss Albino Mice ◽  
Behavioral Profile ◽  
Group I ◽  
Autonomic Changes ◽  
Albino Mice ◽  
Cns Stimulant

Objective: The objective of this study is to evaluate the neurological, behavioral, and autonomic changes of Phyllanthus niruri in Swiss albino mice using Irwin’s method. Methods: A total of 24 mice was divided into four groups of six each (3-male, 3-female in each group). Aqueous extract of P. niruri was prepared. Based on body weight aqueous extract was given to the mice by orally through gavage tube (Group I – 300 mg/kg, Group II – 600 mg/kg, Group III – 900 mg/kg, and Group IV – 1200 mg/kg). Neuropharmacological profile is studied for each mice using Irwin’s observational test, the mice were observed for 4 h after oral administration for various behavioral, neurological, and autonomic changes at 0, 1, 2, 3, 4 h. Results: P. niruri showed negligible actions at 300 mg/kg and 600 mg/kg body weight. At 900 mg/kg and 1200 mg/kg P. niruri showed certain behavioral and neuronal changes. P. niruri increased alertness, stereotypy, restlessness, irritability/aggressiveness in behavioral profile indicating that the drug is a CNS stimulant. Furthermore, it showed mild tremors in neurological profile indicating CNS excitation. Conclusion: Aqueous extract of P. niruri at 900 mg/kg and 1200 mg/kg showed changes in behavioral profile, neurological profile, showing it as CNS stimulant properties. Since it is an observational study further research should be done to explore CNS stimulant properties in various in vivo studies.

scholarly journals Analgesic activity of aqueous extract of Amorphophallus paeoniifolius in Swiss albino mice

2019 ◽  
Vol 8 (6) ◽  
pp. 1327
Author(s):  
Hemalatha A. ◽  
Sathiya Vinotha A. T.
Keyword(s):  
Aqueous Extract ◽  
Analgesic Activity ◽  
Group Iv ◽  
Alcoholic Extract ◽  
Swiss Albino Mice ◽  
Group I ◽  
Cox Inhibitor ◽  
Albino Mice ◽  
Group Ii ◽  
Animal House

Background: Pain is defined as an unpleasant feeling caused by intense or damaging stimuli. Amorphophallus paeoniifolius known as “Elephant foot yam” is a highly potential tropical tuber crop of Araceae family. The tubers are used as antihaemorrhoidal, haemostatic, expectorant, appetizer, anthelmintic, aphrodisiac and rejuvenating agent. Diclofenac, a COX inhibitor is used as analgesic widely. Analgesic activity of alcoholic extract of Amorphophallus paeoniifolius has been proved in previous animal studies.Methods: Swiss Albino mice of either sex (20-30g) were procured from the central animal house of KFMS&R, Coimbatore. Animals were maintained under controlled temperature and light conditions with food and water ad libitum. Mice were kept in the department to get acclimatized. 24 mice were divided into 4 groups (n=6). Drugs were given orally after 12 hours of fasting. Group I was the control received normal saline, Group II received standard-diclofenac (25mg/kg). Group III and Group IV received aqueous extract of Amorphophallus paeoniifolius 200mg/kg and 400mg/kg respectively.Results: The latency period of Group IV (aqueous extract of Amorphophallus paeoniifolius 400mg/kg) was significant (p<0.01) compared to Group I (controls) and Group II (standard) was significant (p<0.001) when compared to Group IV (aqueous extract of Amorphophallus paeoniifolius 400mg/kg) by hot plate method. In acetic acid induced writhing when compared to control, the percentage inhibition of aqueous extract of Amorphophallus paeoniifolius was 43.65% at 200mg/kg, 46.09% at 400mg/kg and that of the standard was 54.39%.Conclusions: It was concluded that aqueous extract of Amorphophallus paeoniifolius has analgesic activity due to peripheral and central inhibition of prostaglandins synthesis. The extract may have phytoconstituents which inhibit COX enzyme peripherally or act on central opioid receptors(µreceptors) for producing analgesia. It can be used as an add-on drug there by reducing side effects by conventional analgesics.

PROTECTIVE EFFECT OF ROSEMARY (ROSMARINUS OFFICINALIS L.) EXTRACT OVER THE GENOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN SWISS ALBINO MICE

2016 ◽  
Vol 72 (9) ◽  
Author(s):  
Dr. Ayman Salah El-Seedy ◽  
Hany George Shalaby ◽  
Mohamed Ahmed El-Sehrigy ◽  
Madiha Mohiy El-Dein Ghoneim
Keyword(s):  
Protective Effect ◽  
Rosmarinus Officinalis ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Rosmarinus Officinalis L

scholarly journals Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

2014 ◽  
Vol 4 (5) ◽  
pp. 398-400 ◽  
Author(s):  
Annie George ◽  
Sasikala Chinnappan ◽  
Yogendra Choudhary ◽  
Praveen Bommu ◽  
Murthy Sridhar
Keyword(s):  
Aqueous Extract ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Carbon Clearance ◽  
Polygonum Minus ◽  
Albino Mice

Protective effect of geraniin against carbon tetrachloride induced acute hepatotoxicity in Swiss albino mice

2017 ◽  
Vol 487 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Hoda Aayadi ◽  
Smriti P.K. Mittal ◽  
Anjali Deshpande ◽  
Makarand Gore ◽  
Saroj S. Ghaskadbi
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Swiss Albino Mice ◽  
Albino Mice

Protective Effect of Metformin on Cardiac and Hepatic Toxicity Induced by Adriamycin in Swiss Albino Mice

2008 ◽  
Vol 3 (2) ◽  
pp. 99-108 ◽  
Author(s):  
A.M. Aleisa ◽  
S.S. Al-Rejaie ◽  
S.A. Bakheet ◽  
A.M. Al-Bekairi ◽  
O.A. Al-Shabana ◽  
...  
Keyword(s):  
Protective Effect ◽  
Hepatic Toxicity ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals The Effect of Piracetam on Valproic Acid Induced Congenital Malformations in Swiss Albino Mice

2019 ◽  
Vol 21 (3) ◽  
pp. 204-209
Author(s):  
Shamsher Shrestha ◽  
M. Singh ◽  
S.P. Mishra
Keyword(s):  
Valproic Acid ◽  
Brain Injuries ◽  
Treated Group ◽  
Aging Brain ◽  
Teratogenic Effects ◽  
Swiss Albino Mice ◽  
Group Iii ◽  
Group I ◽  
Albino Mice ◽  
Higher Doses

Valproic acid (VPA) is an antiepileptic drug which is widely used in humans and is a well known teratogenic agent when used during pregnancy. Piracetam is a nootropic or cognitive enhancer drug used to treat cognitive impairment in aging, brain injuries as well as dementia. In the present study, these two drugs VPA and Piracetam were administered orally to Swiss albino mice in the doses of400 mg/kg and 800 mg/kg body weight respectively from gestational day (GD) 6-11 in order to see the protective effect of Piracetam against VPA induced teratogenesis. The fetuses were collected on GD 18 after uterotomy and observed for gross malformations if any. In VPA treated group the malformations observed were exencephaly, cranioschisis, limb and tail defects, haemorrhage, resorptions and retardation. No such anomalies were observed in control and Piracetam treated groups. However,in VPA+ Piracetam treated group some resorptions and growth retardation were noted. This group showed highly significant (p < 0.001) protection against the teratogenic effects of VPA treated group though the developmental parameters were significantly reduced (p < 0.001) in comparison to those of group I (control) and group III (receiving piracetam). These findings suggest that Piracetam, if given in higher doses might protect the development in utero against the teratogenic effects of VPA.

Sign in / Sign up

Export Citation Format

Share Document