scholarly journals A COMPLETE AND UPDATED REVIEW ON VARIOUS TYPES OF DRUG DELIVERY SYSTEMS

2020 ◽  
pp. 1-16
Author(s):  
RAJEEV GARG ◽  
SHARANPREET KAUR ◽  
RITIKA ◽  
SHEHNAZ KHATOON ◽  
NAINA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Research Area ◽  
Dosage Forms ◽  
Delivery Systems ◽  
The World ◽  
Different Types

The World of medicine has gained considerable interest in the research area all over the World. Scientists constantly work on the three parameters ‘Quality, Safety, Efficacy’ of a pharmaceutical ingredient. Refine these parameters; they are continually developing different dosage forms. These unique types of dosage forms help to provide improved bioavailability and efficacy of a pharmaceutical ingredient. The role of dosage form is to improve the availability of the medicine to treat the symptoms and disease. This article focus on the different types of dosage forms, their advantages and some important facts related to that dosage forms.

Development of Innovative Orally Fast Disintegrating Film Dosage Forms: A Review

2012 ◽  
Vol 5 (2) ◽  
pp. 1666-1674 ◽  
Author(s):  
Bibhu Prasad Panda ◽  
N.S Dey ◽  
M.E.B. Rao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Geriatric Patients ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Design And Development ◽  
Innovative Drug ◽  
Potential Benefits ◽  
Pharmaceutical Industries

Over the past few decades, there has been an increased interest for innovative drug delivery systems to improve safety, efficacy and patient compliance, thereby increasing the product patent life cycle. The discovery and development of new chemical entities is not only an expensive but also time consuming affair. Hence the pharmaceutical industries are focusing on the design and development of innovative drug delivery systems for existing drugs. One such delivery system is the fast disintegrating oral film, which has gained popularity among pediatric and geriatric patients. This fast disintegrating film with many potential benefits of a fast disintegrating tablet but devoid of friability and risk of choking is more acceptable to pediatric and geriatric patients. Formulation of fast disintegrating film can be achieved by various techniques, but common methods of preparation include spraying and casting. These film forming techniques use hydrophilic film former in combination with suitable excipients, which allow the film to disintegrate or dissolve quickly in the mouth within a few seconds without the administration of water. In view of the advantages of the fast disintegrating films over the fast disintegrating tablets and other dosage forms, it has the potential for commercial exploitation. The oral film dosage form not only has certain advantages of other fast disintegrating systems but also satisfies the unmet needs of the market. The present review emphasizes on the potential benefits, design and development of robust, stable, and innovative orally fast- disintegrating films and their future scenarios on a global market as a pharmaceutical dosage form.  

scholarly journals Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 357
Author(s):  
Shery Jacob ◽  
Anroop B. Nair ◽  
Jigar Shah ◽  
Nagaraja Sreeharsha ◽  
Sumeet Gupta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Dressing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Advantages And Disadvantages ◽  
Different Types ◽  
Dressing Materials ◽  
Wound Dressing Materials

The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, and controllable degradability. Functionalization strategies to overcome the deficiencies of conventional hydrogels and expand the role of advanced hydrogels such as DNA hydrogels are extensively discussed in this review. Different types of cross-linking techniques, materials utilized, procedures, advantages, and disadvantages covering hydrogels are tabulated. The application of hydrogels, particularly in buccal, oral, vaginal, and transdermal drug delivery systems, are described. The review also focuses on composite hydrogels with enhanced properties that are being developed to meet the diverse demand of wound dressing materials. The unique advantages of hydrogel nanoparticles in targeted and intracellular delivery of various therapeutic agents are explained. Furthermore, different types of hydrogel-based materials utilized for tissue engineering applications and fabrication of contact lens are discussed. The article also provides an overview of selected examples of commercial products launched particularly in the area of oral and ocular drug delivery systems and wound dressing materials. Hydrogels can be prepared with a wide variety of properties, achieving biostable, bioresorbable, and biodegradable polymer matrices, whose mechanical properties and degree of swelling are tailored with a specific application. These unique features give them a promising future in the fields of drug delivery systems and applied biomedicine.

scholarly journals Mucoadhesive Drug Delivery Systems: A Review of Recent Developments

2021 ◽  
Vol 2 (1) ◽  
pp. 50-64
Author(s):  
Sharaf Alawdi ◽  
Ajay B. Solanki
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Epithelial Surface ◽  
Factors Affecting ◽  
Therapeutic Outcomes ◽  
Mucus Membrane ◽  
Recent Developments

Purpose: The aim of this article is to present a review of mucoadhesion drug delivery systems. The review covers the mucoadhesive concepts, polymers used, theories and mechanisms of mucoadhesion, and factors affecting the mucoadhesive dosage forms. Study Design: An extensive review was carried out on mucoadhesion formulations, applications, mechanisms, theories, and polymers used in these dosage forms. Results: Mucoadhesive drug delivery system can interact with the mucus membrane, which covers the mucin molecules and mucosal epithelial surface. This interaction leads to an increment of the dosage form residence time at the site of absorption and hence increasing the bioavailability, efficacy of drugs, and improving therapeutic outcomes. Polymers are used to provide muco-adhesion of the dosage form, enhancing drug release pattern, solubility and dissolution of inadequately soluble drugs. Conclusion: Mucoadhesive drug delivery systems were found to be the best alternative approaches for the traditional dosage forms to enhance bioavailability of poorly soluble drugs and to avoid GIT degradation and first pass metabolism of some drugs.

scholarly journals A Mini Review on Mucoadhesion

2020 ◽  
Vol 11 (3) ◽  
pp. 3521-3527
Author(s):  
Gnanasekaran John Selvaraj ◽  
Arul Balasubramanian ◽  
Kothai Ramalingam
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Drug Dosage ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Application Site ◽  
Epithelial Surface ◽  
Drug Dosage Form

The concept of mucoadhesion was started in early 1980’s with the aim of controlled delivery of drugs. Mucoadhesion is simply defined as the adhesion between two materials, in which one is the mucosal surface and the another one is the mucoadhesive dosage form. In the recent decades, mucoadhesive drug delivery system draw the attention in the gastroretentive delivery system. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time. Mucoadhesive dosage forms are designed to increase the retention of the drug/dosage form at the application site, to provide a controlled release of drug for increased curative consequence. The medications which have local action or those which have maximum absorption in gastrointestinal tract require increased duration of stay in GIT. Mucoadhesive drug delivery systems were prepared by using either natural or synthetic polymers, which is interacting with the mucous layer and used to prevail over the physiological barriers for extended drug delivery. The mucoadhesive ability of a dosage form is depending upon variety of factors, such as the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various theories of mucoadhesion, properties of mucoadhesive materials, methods to study the mucoadhesion, and finally various mucoadhesive dosage forms.

Emerging Role of Colloidal Drug Delivery Systems (CDDS) in NSAID Topical Administration

2013 ◽  
Vol 20 (14) ◽  
pp. 1847-1857 ◽  
Author(s):  
Carmelo Puglia ◽  
Giorgia Tirendi ◽  
Francesco Bonina
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Topical Administration ◽  
Delivery Systems

Role of novel drug delivery systems in coronavirus disease-2019 (covid-19): time to act now

2020 ◽  
Vol 17 ◽  
Author(s):  
Neeraj Mittal ◽  
Varun Garg ◽  
Sanjay Kumar Bhadada ◽  
O. P. Katare
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
World Health ◽  
Ongoing Research ◽  
Standard Drug ◽  
Corona Virus ◽  
Novel Drug

: The corona virus disease 2019 (COVID-19) has found its roots from Wuhan (China). COVID-19 is caused by a novel corona virus SARS-CoV2, previously named as 2019-nCoV. COVID-19 has spread across the globe and declared as pandemic by World health organization (WHO) on 11th March, 2020. Currently, there is no standard drug or vaccine available for the treatment, so repurposing of existing drugs is the only solution. Novel drug delivery systems (NDDS) will be boon for the repurposing of drugs. The role of various NDDS in repurposing of existing drugs for treatment of various viral diseases and their relevance in COVID-19 has discussed in this paper. It focuses on the currently ongoing research in the implementation of NDDS in COVID-19. Moreover it describes the role of NDDS in vaccine development for COVID-19. This paper also emphasizes how NDDS will help to develop the improved delivery systems (dosage forms) of existing therapeutic agents and also explore the new insights to find out the void spaces for a potential targeted delivery. So in these tough times, NDDS and nanotechnology can be a safeguard to humanity.

An Overview of Excipients Classification and Their Use in Pharmaceuticals

2020 ◽  
Vol 16 ◽  
Author(s):  
Cansel Kose Ozkan ◽  
Ozgur Esim ◽  
Ayhan Savaser ◽  
Yalcin Ozkan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Dosage Forms ◽  
Design Development ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Product Identification ◽  
Direct Administration ◽  
Active Substances

: The content and the application of pharmaceutical dosage forms must meet several basic requirements to ensure and maintain efficiency, safety and quality. A large number of active substances have limited ability to direct administration. Excipients are generally used to overcome the limitation of direct administration of these active substances. However, the function, behavior and composition of the excipients need to be well known in the design, development and production of pharmaceutical dosage forms. In this review, excipients used to assist in any pharmaceutical dosage form production processes of drugs, to preserve, promote or increase stability, bioavailability and patient compliance, to assist in product identification / separation, or to enhance overall safety and effectiveness of the drug delivery system during storage or use are explained. Moreover, the use of these excipients in drug delivery systems are identified. Excipient toxicity, which is an issue discussed in the light of current studies, also discussed in this review.

Recent advances in polymer shell-oily core nanocapsules for drug delivery applications

Nanomedicine ◽  
2021 ◽  
Author(s):  
Ahmed S AbdElhamid ◽  
Dina G Zayed ◽  
Lamia Heikal ◽  
Sherine N Khattab ◽  
Omar Y Mady ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Early Stage ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Polymeric Membranes ◽  
Polymer Shell ◽  
Recent Advances ◽  
Target Sites ◽  
Different Types

Polymeric nanocapsules are vesicular drug delivery systems composed of an inner oily reservoir surrounded by polymeric membranes. Nanocapsules have various advantages over other nanovesicular systems such as providing controlled drug release properties. We discuss the recent advances in polymeric shell-oily core nanocapsules, illustrating the different types of polymers used and their implementation. Nanocapsules can be utilized for many purposes, especially encapsulation of highly lipophilic drugs. They have been shown to have variable applications, especially in cancer therapy, due to the ability of the polymeric shell to direct the loaded drugs to their target sites, as well as their high internalization efficacy. Those productive applications guaranteed their high potential as drug delivery systems. However, their clinical development is still in an early stage.

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