scholarly journals UJI KLINIS TERBUKA EFEK TERAPI STATIN (SIMVASTATIN) TERHADAP KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) PADA PENDERITA DIABETES TIPE 2

2012 ◽  
Vol 6 (1) ◽  
Author(s):  
Isbandiyah .
Keyword(s):  
High Sensitivity ◽  
Diabetes Type 2 ◽  
Drop Out ◽  
Test Design ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Post Test ◽  
Hs Crp ◽  
Dm Type 2

Latar Belakang. Diabetes mellitus (DM) mempunyai resiko kematian karena penyakit kardiovaskular dua sampai enam kali dibanding pasien tanpa DM. diketahui bahwa inflamasi berperan dalam pathogenesis aterosklerosis. hs-CRP merupakan salah satu marker inflamasi yang paling kuat dibanding marker inflamasi lain. HMG-CoA reduktase inhibitor atau statin mempunyai efek biologi yang luas disamping sebagai terapi menurunkan kadar kolesterol, juga dapat menurunkan kadar C-reaktive protein (CRP), hal ini dikenal sebagai efek pleotropik statin. Subyek. Pasien diabetes type 2, di poliklinik Endrokinologi Penyakit Dalam RSSA Malang. Tujuan. Tujuan dari penelitian ini adalah untuk menilai efek terapi statin terhadap kadar hs-CRP. Bahan dan Cara. Penelitian ini merupakan suatu uji klinis pre-post test design. Pasien DM type 2 dengan kadar LDL kolesterol > 100 mg/dl diberikan terapi statin, dengan target terapi statin < 100 mg/dl. Setelah satu bulan terapi statin 5 mg per hari, pasien yang tidak mencapai target diberikan statin 10 mg per hari selama satu bulan, selanjutnya sampai dosis statin 20 mg. pemeriksaan hs-CRP dilakukan dengan metode chemiluminesen dan LDL kolesterol dihitung dengan menggunakan formula Friedewald. Pemeriksaan laboratorium dikerjakan sebelum dan setelah terapi statin. Analisa statistik menggunakan T-test dan uji korelasi, dikatakan bermakna jika p < 0,05. Hasil. Dari 79 pasien penelitian, 5 pasien drop out. Terapi statin 5 mg per hari dapat menurunkan rerata kadar hs-CRP, kolesterol LDL, kolesterol total, non-HDL, dan TG secara bermakna masing-masing 26,8%, 27,31%, 14,12%, 23,83%, dan 11,82% (p< 0,05). Pada terapi statin 10 mg didapatkan penurunan bermakna kadar kolesterol LDL, non-HDL dan kolesterol total, masing-masing 9,71%, 15,49%, 23,51% (p< 0,05). Dengan terapi statin 20 mg tidak ada hasil yang bermakna secara statistik. Pasien yang mencapai target terapi LDL < 100 mg/dl dengan terapi statin 5 mg sebanyak 41 pasien (56,16%), pada terapi statin 10 mg sebanyak 27 pasien (84,37%), dan pada statin 20 mg sebanyak 2 pasien (66,66%). Tidak didapatkan korelasi antara LDL kolesterol dengan hs-CRP. Kesimpulan. Statin 5 mg dapat menurunkan kadar hs-CRP, LDL kolesterol, kolesterol total, non-HDL, trigliserida serta peningkatan HDL kolesterol secara bermakna, jika dibanding statin 10 mg dan 20 mg. tidak ada korelasi antara LDL kolesterol dengan hs-CRP.  Kata kunci: HMG-CoA reduktase, DM type 2, hs-CRP, LDL kolesterol

scholarly journals Serum High-Sensitivity C-Reactive Protein and Endogenous Sex Hormones in Diabetic Men

2016 ◽  
Vol 10 (1) ◽  
pp. 48-52
Author(s):  
Shakir F.T. Al-Aaraji
Keyword(s):  
Sex Hormones ◽  
Serum Testosterone ◽  
Total Testosterone ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Hs Crp ◽  
Dm Type 2 ◽  
Endogenous Sex Hormones

The objective of this cross sectional study was to assess the effect of diabetes mellitus (DM) type 2  in men on endogenous sex hormones: estradiol (E2) and  total testosterone (TT); pituitary gland hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH)  as well as high sensitive C-Reactive protein (hs-CRP) in men. This study comprised a total of (80) subjects out of which (40) were normal and (40) were diabetic males. The results obtained indicated a significant increasing (p≤ 0.05) of serum hs-CRP and E2 in men with DM type 2 comparison to non-diabetics, while a significant reduction (p≤ 0.05) of  serum testosterone in men with DM type 2 comparison to non-diabetics, and non-significant reduction of serum LH, FSH in men with DM type 2 comparison to non-diabetics were observed. The data from this study show the role of endogenous sex hormones and hs-CRP in diabetes risk. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention

scholarly journals Evaluation of Serum High Sensitivity C-reactive Protein (hs-CRP) In Type-2 Diabetic Patient

1970 ◽  
Vol 11 (1) ◽  
pp. 20-23
Author(s):  
AKM Fazlul Haque ◽  
ARM Saifuddin Ekram ◽  
Quazi Tarikul Islam ◽  
Md Sarwar Jahan ◽  
Md Zahirul Haque
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Patient ◽  
Healthy Subjects ◽  
High Sensitivity ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Type 2 Diabetic

Type-2 diabetes may remain in subclinical form for years before diagnosis. This quiescence of type-2 diabetes is a great concern for health care providers. The earliest change of the type-2 diabetes is the insulin resistance, which is associated with the increased macrovascular risk due to induction of chronic inflammation in the vessels of the body which leads to atherosclerotic change in the vessels. High sensitivity CRP (hs-CRP) is the measure of C-reactive protein with greater accuracy and the lower limit of its assay is .01 mg/L which is more than 100 times as sensitive as the usual CRP measurement (lower limit 5 mg/L). The median level of hs-CRP from blood samples of apparent healthy subjects is 0.8 mg/L. For this, physician uses the hs-CRP parameter as a marker of chronic inflammation in apparently normal healthy individuals, specially for the assessment of atherosclerosis, which is a chronic inflammatory procedure from the very beginning, in type-2 diabetic, obese and hypertensive patients. This vascular atherosclerosis assessment help them to calculate the cardiovascular as well as cerebrovascular risk of those patients. To help the type-2 diabetic patients from the very begining in respect of the prognostic view of the macrovascular risk, estimations of serum hs-CRP in the early stage of these patient may be a enthusiastic one. This descriptive study was carried out by choosing 70 diabetic patient who had no other comorbidity or any complications of diabetes and 35 healthy subjects who were neither diabetic nor had any diseases. Both the groups were non-smoker and non-alcoholic and non-hypertensive, hs-CRP level was measured in both the groups along with the HbA1c%. The mean hs-CRP in diabetic group was 1.13 mg/L and in normal healthy subjects was 0.39 mg/L. This higher level of mean hs-CRP (1.13 mg/L) in diabetic patients is statisticaly significant (P<0.01) compared with that of the normal healthy subjects mean hs-CRP (0.39 mg/L). This mean level of hs-CRP in normal healthy subjects was below the lower level of cardiovascular risk (1 mg/L). Keywords: High sensitivity CRP, C-reactive protein, diabetes DOI:10.3329/jom.v11i1.4263 J Medicine 2010: 11: 20-23

scholarly journals High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and/or high blood pressure

2007 ◽  
Vol 51 (6) ◽  
pp. 956-960 ◽  
Author(s):  
Luciana M. Lima ◽  
Maria das Graças Carvalho ◽  
Anna L. Soares ◽  
Adriano de P. Sabino ◽  
Ana P. Fernandes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
High Sensitivity ◽  
Normal Subjects ◽  
C Reactive Protein ◽  
Hypertensive Patients ◽  
Reactive Protein ◽  
Hs Crp

Type 2 diabetes mellitus (DM2) and high blood pressure (HBP) may contribute to the development of cardiovascular disease, and inflammation may be an important factor in these diseases. In the present study, plasma levels of high-sensitivity C-reactive protein (hs-CRP) were measured in subjects with DM2 and/or HBP and compared to those of normal subjects. Eighty-nine subjects were analyzed for hs-CRP, including 13 normotensive patients with DM2, 17 patients with HBP, 34 hypertensive patients with DM2 (DM2+HBP) and 25 normal subjects. The plasma hs-CRP levels were significantly lower in the controls than in the HBP+DM2 group (p < 0.05). DM2 associated with HBP was also correlated with increased plasma hs-CRP levels (n = 89, r = 0.25, p = 0.0162). Only hypertensive patients with DM2 had higher levels of hs-CRP, a circulating inflammatory marker, than normal subjects. This finding suggests that patients with two associated diseases have a more active inflammatory state.

Positive Association Between Serum Levels of High-Sensitivity C-Reactive Protein and Depression/Anxiety in Female, but Not Male, Patients With Type 2 Diabetes Mellitus

2019 ◽  
Vol 22 (2) ◽  
pp. 178-187 ◽  
Author(s):  
Qian-Qian Yang ◽  
Di Shao ◽  
Jie Li ◽  
Chun-Ling Yang ◽  
Min-Hua Fan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Positive Association ◽  
High Sensitivity ◽  
Depression And Anxiety ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Symptoms Of Depression ◽  
Hs Crp

Purpose: Patients with Type 2 diabetes (T2D) have increased risk of depression and anxiety. Evidence suggests that a heightened inflammatory state may contribute to this association. Females experience more depression and higher inflammation levels than males. This study compared associations of serum high-sensitivity C-reactive protein (hs-CRP) levels with symptoms of depression and anxiety between men and women with Type 2 diabetes mellitus (T2DM). Method: Cross-sectional data including demographic and disease characteristics, symptoms of depression and anxiety, clinical data, and laboratory values were collected from 392 patients with T2DM recruited from a general hospital in Shandong Province, China. We evaluated associations between serum hs-CRP level and symptoms of depression and anxiety in males and females separately using multiple linear regressions and χ2 tests for trend. Results: Sex moderated the association between serum hs-CRP level and symptoms of depression ( B = .112 [ SE = 0.049]; p = .022) and anxiety ( B = .137 [ SE = 0.053]; p = .011). Among females, hs-CRP level was positively associated with depression ( B = .034, 95% confidence interval [CI] = [.006, .061]; p = .016, false discovery rate [FDR]-adjusted p = .020) and anxiety ( B = .041, 95% CI [.011, .071], p = .007, FDR-adjusted p = .007). Positive trends indicated a higher prevalence of clinically significant symptoms of depression and anxiety in higher serum hs-CRP categories in females. No associations were found in males. Conclusion: Findings demonstrate that associations between serum hs-CRP level and symptoms of depression and anxiety in patients with T2D are sex-specific, with only females demonstrating a significant positive association.

scholarly journals Pengaruh Pemberian Sari Ubi Ungu (Ipomea batatas L.) Terhadap KadarHigh Sensitivity C-Reactive Protein(hs-CRP) Pada Tikus Sprague Dawley Dengan Pakan Tinggi Lemak

2018 ◽  
Vol 7 (4) ◽  
pp. 155
Author(s):  
Irene Nucifera Puspitadewi ◽  
Ani Margawati ◽  
Hartanti Sandi Wijayanti
Keyword(s):  
High Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Sprague Dawley ◽  
C Reactive Protein ◽  
Control Group Design ◽  
Reactive Protein ◽  
Ipomea Batatas ◽  
Post Test ◽  
Hs Crp

Latar Belakang: Komposisi makanan tinggi lemak dapat menjadi faktor terjadinya obesitasyang menyebabkan oksidasi lemak. Oksidasi lemak dapat menyebabkan inflamasi yang dikarakterisasikan dengan tingginya kadar High Sensitivity C-Reactive Protein (hs-CRP). Ubi ungu kaya akan antioksidan terutama antosianin yang mungkin dapat menurunkan kadar hs-CRP. Penelitian ini bertujuan untuk mengetahui pengaruh sari ubi ungu terhadap kadar hs-CRP tikus sprague dawley dengan pakan tinggi lemak.Metode: Jenis penelitian ini adalah true experimental dengan  pre-post test control group design. 24 tikus sprague dawley jantan dibagi menjadi 4 kelompok yaitu kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2. Perlakuan 1 dan 2 diberikan sari ubi ungu dengan dosis 2 gram/200grBB dan 3 gram/200grBB berturut-turut selama 6 hari. Sebelum dan sesudah perlakuan, kadar hs-CRP dianalisis dengan menggunakan metode ELISA (Enzyme Linked Immunosorbent Assay).Hasil: Selisih kadar  hs-CRP pada keolompok kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2 adalah 0.4±0.20, -0.07±4.70, -4.3±0.79 dan -8.1±0.45. Terdapat perbedaan signifikan kadar  hs-CRP antar kelompok sesudah intervensi (p=<0.001). Pada kelompok perlakuan 2 terdapat penurunan yang paling tinggi (persen delta 33,33% dengan nilai p=<0.001).Simpulan: Sari ubi ungu dapat menurunkan kadar  High Sensitivity C-Reactive Protein (hs-CRP) secara signifikan.

scholarly journals Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jinling Zhang ◽  
Zhehao Lv ◽  
Deli Zhao ◽  
Lili Liu ◽  
Yong Wan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Sensitivity ◽  
Coronary Plaque ◽  
C Reactive Protein ◽  
Coronary Cta ◽  
Reactive Protein ◽  
Improve Risk Stratification ◽  
Luminal Narrowing ◽  
Hs Crp

Little is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2). This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptomatic DM2 patients and 107 non-DM2 patients using a 256-slice CT. The extent and types of plaque as well as luminal narrowing were evaluated. Patients with DM2 were more likely to have significant stenosis (>50%) with calcified plaques in at least one coronary segment (p<0.01); the prevalence rates of diffuse calcified plaques in the DM2 and non-DM2 groups were 31.6% and 4.7%, respectively (p<0.01). Plasma hs-CRP levels in DM2 with calcified plaques were higher compared with values obtained for the non-DM2 group (p<0.01). In conclusion, combination of coronary CTA and hs-CRP might improve risk stratification in symptomatic DM2 patients.

scholarly journals STUDY OF SERUM ADIPONECTIN AND HIGH SENSITIVITY C-REACTIVE PROTEIN IN DIABETIC PATIENTS

2018 ◽  
Vol 11 (7) ◽  
pp. 163
Author(s):  
Shailza Shreshtha ◽  
Preeti Sharma ◽  
Pradeep Kumar ◽  
Rachna Sharma ◽  
Shivani Gupta ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Sugar ◽  
High Sensitivity ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Increased Risk ◽  
Hs Crp

Objectives: Adiponectin, a major cytokine from adipose tissue, and high sensitivity C-reactive protein (hs-CRP), well-established markers of inflammation are known to be associated with increased risk of cardiovascular disorders (CVD). Therefore the objective of our study was to evaluate the levels of these parameters and determine their correlation with glycemia to assess the cardiovascular risks in the patients with Type 2 diabetes mellitus.Methods: This study was conducted in the Department of Biochemistry, Santosh Medical College, Ghaziabad, with 25 Type 2 diabetic patients and 25 age and sex-matched controls. Ethical clearance from the institution and informed consent from the patients were taken before the study. Adiponectin was analyzed by enzyme-linked immunoadsorbent assay, and blood sugar and CRP were estimated by the kit based method.Results: Fasting blood sugar (FBS, 158.2±37.2) and hs-CRP (3.97±1.54) were significantly high, adiponectin was significantly low in the patients with diabetes compared to controls (80.52±9.72, 1.27±0.75, and 10.78±1.69, respectively, p<0.05). Adiponectin showed a negative correlation with FBS (r=−0.427) and hs-CRP (r=−0.336), but the correlation was significant only in case of FBS (p<0.05). hs-CRP positively correlated with FBS (r=0.568) and was statistically significant.Conclusion: The results of our study further support the role of adiponectin and hs-CRP as a predictive biomarker of CVD risks in the patients suffering from Type 2 diabetes.

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