scholarly journals Pengaruh Pemberian Sari Ubi Ungu (Ipomea batatas L.) Terhadap KadarHigh Sensitivity C-Reactive Protein(hs-CRP) Pada Tikus Sprague Dawley Dengan Pakan Tinggi Lemak

2018 ◽  
Vol 7 (4) ◽  
pp. 155
Author(s):  
Irene Nucifera Puspitadewi ◽  
Ani Margawati ◽  
Hartanti Sandi Wijayanti
Keyword(s):  
High Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Sprague Dawley ◽  
C Reactive Protein ◽  
Control Group Design ◽  
Reactive Protein ◽  
Ipomea Batatas ◽  
Post Test ◽  
Hs Crp

Latar Belakang: Komposisi makanan tinggi lemak dapat menjadi faktor terjadinya obesitasyang menyebabkan oksidasi lemak. Oksidasi lemak dapat menyebabkan inflamasi yang dikarakterisasikan dengan tingginya kadar High Sensitivity C-Reactive Protein (hs-CRP). Ubi ungu kaya akan antioksidan terutama antosianin yang mungkin dapat menurunkan kadar hs-CRP. Penelitian ini bertujuan untuk mengetahui pengaruh sari ubi ungu terhadap kadar hs-CRP tikus sprague dawley dengan pakan tinggi lemak.Metode: Jenis penelitian ini adalah true experimental dengan  pre-post test control group design. 24 tikus sprague dawley jantan dibagi menjadi 4 kelompok yaitu kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2. Perlakuan 1 dan 2 diberikan sari ubi ungu dengan dosis 2 gram/200grBB dan 3 gram/200grBB berturut-turut selama 6 hari. Sebelum dan sesudah perlakuan, kadar hs-CRP dianalisis dengan menggunakan metode ELISA (Enzyme Linked Immunosorbent Assay).Hasil: Selisih kadar  hs-CRP pada keolompok kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2 adalah 0.4±0.20, -0.07±4.70, -4.3±0.79 dan -8.1±0.45. Terdapat perbedaan signifikan kadar  hs-CRP antar kelompok sesudah intervensi (p=<0.001). Pada kelompok perlakuan 2 terdapat penurunan yang paling tinggi (persen delta 33,33% dengan nilai p=<0.001).Simpulan: Sari ubi ungu dapat menurunkan kadar  High Sensitivity C-Reactive Protein (hs-CRP) secara signifikan.

scholarly journals MODULASI SEL PUNCA MESENKIMAL DALAM MENURUNKAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SEBAGAI TERAPI NEFRITIS LUPUS

Biomedika ◽  
2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Indah Putri Maharani ◽  
Zainal Arifin Adnan ◽  
Arief Nurudhin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Systemic Lupus ◽  
Control Group Design ◽  
Group Design ◽  
Reactive Protein ◽  
Post Test

Systemic Lupus Erythematosus merupakan penyakit inflamasi autoimun kronis dengan gambaran klinis luas dan perjalanan penyakit beragam. Pemberian pristan intraperitoneal dapat menginduksi lupus pada mencit. Secretome sel punca mesenkimal bekerja secara parakrin memberikan efek antinflamasi dan imunomodulasi antara lain mensupresi sel T dan sel B autoreaktif. High Sensitivity C-Reactive Protein (hsCRP) terkait dengan patogenesis SLE dan selaras dengan aktifitas penyakit.Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap kadar hsCRP pada mencit model lupus dengan induksi pristan. Desain penelitian adalah eksperimental dengan randomisasi, post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok perlakuan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok terapi (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Sesudah perlakuan dinilai kadar hsCRP secara ELISA. Analisis statistik menggunakan SPSS 22 for windows dengan uji Kruskal-Wallis dilanjutkan Mann-Whitney U test. P bermakna jika p<0,05. Hasil penelitian menunjukkan bahwa rata-rata kadar hsCRP pada ketiga kelompok yaitu kontrol 440.68(110.08-564.29) ng/ mL; perlakuan (pristan) 2964.26(601.13-3926.10) ng/mL; terapi pristan+secretome) 506.93(207.62-1473.46) ng/mL, dengan kemaknaan p=0.008. Terdapat perbedaan bermakna kadar hsCRP antara kelompok pristan vs pristan+secretome (2457.33 ng/mL; p=0.047). Secretome sel punca mesenkimal mampu menurunkan kadar hsCRP pada mencit model lupus dengan induksi pristan.Kata Kunci: High Sensitivity C-Reactive Protein, Nefritis lupus, Secretome

scholarly journals PENGARUH PEMBERIAN IKAN TERI (Engraulis encrasicolus) TERHADAP KADAR C-REACTIVE PROTEIN (CRP) TIKUS SPRAGUE DAWLEY USIA SATU BULAN

2014 ◽  
Vol 3 (4) ◽  
pp. 966-971
Author(s):  
Nadia Savitri ◽  
Niken Puruhita
Keyword(s):  
Control Group ◽  
Omega 3 ◽  
Sprague Dawley ◽  
C Reactive Protein ◽  
Control Group Design ◽  
Engraulis Encrasicolus ◽  
Group Design ◽  
Reactive Protein ◽  
Post Test

Latar Belakang: C-reactive protein (CRP), adalah marker inflamasi yang merupakan prediktor kuat kejadian penyakit kardiovaskuler (PKV). Peningkatan kadar CRP berkaitan dengan peningkatan risiko PKV. Asam lemak omega-3 diketahui memiliki sifat-sifat anti inflamasi sehingga asam lemak omega-3 dipercaya memiliki efek protektif terhadap PKV. CRP juga berkaitan dengan indeks omega-3 sebagai prediktor asupan omega-3. Kadar indeks omega-3 yang rendah diketahui meningkatkan risiko PKV. Ikan teri (Engraulis encrasicolus) mengandung asam lemak omega-3 yang tinggi yang dimungkinkan dapat menurunkan kadar CRP. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ikan teri kadar CRP tikus.Metode: Penelitian eksperimental murni dengan post test only with control group design yang diterapkan pada 14 tikus Sprague dawley usia 1 bulan yang dikelompokkan menggunakan sistem acak sederhana menjadi 1 kelompok kontrol dan 1 kelompok intervensi. Subjek diberikan pakan modifikasi dengan penambahan ikan teri sebanyak 1.5 gr per 10 gr pakan selama 19 hari. Sampel darah diambil dari plexus retro orbitalis dan pengukuran kadar CRP dari serum ditentukan menggunakan metode CRP kuantitatif. Data dianalisis dengan analisa data deskriptif. Hasil: Kadar CRP pada kedua kelompok, kontrol dan perlakuan adalah sama yaitu dalam batas < 5 mg/L yang termasuk dalam kategori normal. Kesimpulan: Data yang diperoleh pada penelitian ini tidak dapat digunakan untuk menjelaskan mekanisme protektif PKV dari diet tinggi asam lemak omega-3 yang berasal dari ikan teri terhadap kadar CRP tikus sehat

scholarly journals Analysis of the links between endothelium-dependent vasodilation indicators and the levels of high-sensitivity C-reactive protein and fractalkine/CX3CL1 in patients with acute coronary syndrome

2020 ◽  
Vol 11 (2) ◽  
pp. 102-110
Author(s):  
E. A. Polunina ◽  
K. Yu. Kuzmichev ◽  
L. P. Voronina ◽  
O. S. Polunina ◽  
I. V. Sevostyanova
Keyword(s):  
Acute Coronary Syndrome ◽  
High Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
Pharmacological Test ◽  
Acute Mi ◽  
Hs Crp

Objective: to study and analyze the links between endothelium-dependent vasodilation (EDV) indicators and the levels of fractalkine (FN/CX3CL1) and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS).Materials and methods: among the examined individuals with ACS, 63 patients had acute myocardial infarction (MI); 41 patients had unstable angina (UA), represented by first – time angina in 15 people and 26 people had progressive angina. Control group included 20 healthy control individuals. Pharmacological test with 5% acetylcholine (AcH) was used to assess the functional state of the vascular endothelium. Enzyme-linked immunosorbent assay was used to determine the levels of FN/CX3CL1 and hs-CRP.Results: all the examined patients with ACS showed statistically significant changes in EDV indicators compared to the control group, as well as an increase in the level of FN/CX3CL1 and hs-CRP. The most pronounced changes of the values of EDV indicators and the levels of FN/CX3CL1 and hs-CRP, from the examined patients, were detected among patients with acute MI. Th e presence of correlations between the studied indicators was revealed. Th e strength of the identified links was greater among patients with acute MI, compared to patients with UA. Th e strength of the links found in patients with both UA and acute MI was greater between EDV indicators and FN/CX3CL1 levels, than between EDV indicators and hs-CRP levels.Conclusions:all the examined patients with ACS had the EDV disorders associated with the severity of systemic infl ammation. In the group of patients with acute MI, the severity of EDV disorders was greater than in patients with UA, which was apparently due to the infl uence of the resorption-necrotic syndrome, which potentiates increased systemic infl ammation and damage to the endothelium of microvessels with EDV disorders, which was confirmed by the results of correlation analysis. A positive link was found between the levels of FN/CX3CL1 hs-CRP.

scholarly journals High Sensitivity C-Reactive Protein sebagai Parameter Diagnostik dan Prediktor Luaran Sepsis pada Anak yang Menderita Systemic Inflammatory Response Syndrome

Sari Pediatri ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. 278
Author(s):  
Sofni Sarmen ◽  
Mayetti Mayetti ◽  
Hafni Bachtiar
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Immunosorbent Assay ◽  
High Sensitivity ◽  
Systemic Inflammatory Response ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Elisa Data

Latar belakang. Sepsis merupakan salah satu penyebab morbiditas dan mortalitas pada anak. Diagnosissepsis ditegakkan berdasarkan gejala Systemic Inflammatory Response Syndrome (SIRS) dan penemuan bakteripada kultur darah. Kultur bakteri darah memiliki sensitifitas yang rendah dan membutuhkan waktu yanglama sehingga sering menyebabkan terjadinya overdiagnosis dan overtreatment. C-reactive protein adalahreaktan fase akut yang kadarnya meningkat pada keadaan infeksi. High sensitivity C-reactive protein (hs-CRP) adalah metode yang lebih sensitif untuk mengukur kadar CRP dalam jumlah kecil.Tujuan. Mengetahui peran hs-CRP sebagai parameter diagnostik dan prediktor luaran sepsis pada anakyang menderita SIRS.Metode. Penelitian uji diagnostik dengan desain potong lintang terhadap 85 anak dengan gejala SIRS berusia1 bulan sampai dengan 15 tahun dan dirawat di bangsal anak RS.Dr.M.Djamil Padang sejak Juni sampaiNovember 2012. Pemeriksaan hs-CRP dilakukan dengan metode enzyme-linked immunosorbent assay (ELISA).Data dianalisis dengan SPSS serta dilakukan uji diagnostik. Baku emas sepsis adalah biakan darah.Hasil. Cut off point hs-CRP untuk menentukan sepsis adalah 15,55 ng/ml, (sensitivitas 90,9% dan spesivisitas53,8%). Kadar rata-rata hs-CRP meningkat sesuai dengan beratnya penyakit.Kesimpulan. High sensitivity C-reactive protein dapat dijadikan sebagai parameter diagnostik sepsis padapasien SIRS dengan cut off point 15,55 ng/ml, serta dapat dipakai sebagai prediktor luaran sepsis.

scholarly journals PENGARUH KONSELING MODIFIKASI GAYA HIDUP TERHADAP PENURUNAN ASUPAN NATRIUM, TEKANAN DARAH, DAN KADAR C-REACTIVE PROTEIN (CRP) PADA REMAJA OBESITAS DENGAN SINDROM METABOLIK

2015 ◽  
Vol 4 (3) ◽  
pp. 300-307
Author(s):  
Addina Rizky F ◽  
Muhammad Sulchan
Keyword(s):  
T Test ◽  
Control Group ◽  
C Reactive Protein ◽  
Control Group Design ◽  
Group Design ◽  
Reactive Protein ◽  
Post Test ◽  
Test Control

Latar Belakang: Sindrom metabolik merupakan prediktor dari penyakit kardiovaskular. Modifikasi gaya hidup merupakan salah satu upaya yang dapat dilakukan dalam penanganan sindrom metabolik. Penelitian ini bertujuan menganalisis pengaruh konseling modifikasi gaya hidup tehadap penurunan asupan natrium, tekanan darah, dan kadar CRP pada remaja obesitas dengan sindrom metabolik.Metode: Desain penelitian ini adalah non randomized pre-post test control group design yang melibatkan 27 remaja di SMA 2 Semarang. Intervensi yang diberikan berupa konseling modifikasi gaya hidup untuk memperbaiki kualitas diet dan aktifitas fisik selama 2 bulan. Tekanan darah diukur menggunakan sphygmomanometer sedangkan kadar CRP diukur menggunakan teknik aglutinasi. Pada analisis statistik digunakan uji independent-t-test, Mann Whitney, dan  Wilcoxon.Hasil: Konseling modifikasi gaya hidup dapat meningkatkan kualitas diet dan aktivitas fisik serta menurunkan asupan natrium, tekanan darah sistolik, dan kadar CRP. Pada kelompok konseling intensif, variabel yang meliputi kualitas diet, asupan natrium, dan kadar CRP memiliki perbedaan yang signifikan (p<0,05) antara sebelum dan sesudah penelitian. Pada kelompok konseling intensif, kualitas diet (1,09) lebih baik daripada kelompok konseling tidak intensif (0,81), penurunan asupan natrium (989) lebih baik daripada kelompok konseling tidak intensif (935), sedangkan penurunan kadar CRP (2,91) lebih tinggi dibandingkan dengan konseling tidak intensif (1,21).Simpulan: Konseling modifikasi gaya hidup berpengaruh terhadap peningkatan kualitas diet dan aktifitas fisik serta penurunan asupan natrium, tekanan darah sistolik, dan kadar CRP. Dibandingkan dengan kelompok konseling tidak intensif, pada kelompok konseling intensif terjadi peningkatan kualitas diet, penurunan asupan natrium dan kadar CRP tetapi tidak terjadi peningkatan aktifitas fisik dan penurunan tekanan darah.

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

scholarly journals UJI KLINIS TERBUKA EFEK TERAPI STATIN (SIMVASTATIN) TERHADAP KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) PADA PENDERITA DIABETES TIPE 2

2012 ◽  
Vol 6 (1) ◽  
Author(s):  
Isbandiyah .
Keyword(s):  
High Sensitivity ◽  
Diabetes Type 2 ◽  
Drop Out ◽  
Test Design ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Post Test ◽  
Hs Crp ◽  
Dm Type 2

Latar Belakang. Diabetes mellitus (DM) mempunyai resiko kematian karena penyakit kardiovaskular dua sampai enam kali dibanding pasien tanpa DM. diketahui bahwa inflamasi berperan dalam pathogenesis aterosklerosis. hs-CRP merupakan salah satu marker inflamasi yang paling kuat dibanding marker inflamasi lain. HMG-CoA reduktase inhibitor atau statin mempunyai efek biologi yang luas disamping sebagai terapi menurunkan kadar kolesterol, juga dapat menurunkan kadar C-reaktive protein (CRP), hal ini dikenal sebagai efek pleotropik statin. Subyek. Pasien diabetes type 2, di poliklinik Endrokinologi Penyakit Dalam RSSA Malang. Tujuan. Tujuan dari penelitian ini adalah untuk menilai efek terapi statin terhadap kadar hs-CRP. Bahan dan Cara. Penelitian ini merupakan suatu uji klinis pre-post test design. Pasien DM type 2 dengan kadar LDL kolesterol > 100 mg/dl diberikan terapi statin, dengan target terapi statin < 100 mg/dl. Setelah satu bulan terapi statin 5 mg per hari, pasien yang tidak mencapai target diberikan statin 10 mg per hari selama satu bulan, selanjutnya sampai dosis statin 20 mg. pemeriksaan hs-CRP dilakukan dengan metode chemiluminesen dan LDL kolesterol dihitung dengan menggunakan formula Friedewald. Pemeriksaan laboratorium dikerjakan sebelum dan setelah terapi statin. Analisa statistik menggunakan T-test dan uji korelasi, dikatakan bermakna jika p < 0,05. Hasil. Dari 79 pasien penelitian, 5 pasien drop out. Terapi statin 5 mg per hari dapat menurunkan rerata kadar hs-CRP, kolesterol LDL, kolesterol total, non-HDL, dan TG secara bermakna masing-masing 26,8%, 27,31%, 14,12%, 23,83%, dan 11,82% (p< 0,05). Pada terapi statin 10 mg didapatkan penurunan bermakna kadar kolesterol LDL, non-HDL dan kolesterol total, masing-masing 9,71%, 15,49%, 23,51% (p< 0,05). Dengan terapi statin 20 mg tidak ada hasil yang bermakna secara statistik. Pasien yang mencapai target terapi LDL < 100 mg/dl dengan terapi statin 5 mg sebanyak 41 pasien (56,16%), pada terapi statin 10 mg sebanyak 27 pasien (84,37%), dan pada statin 20 mg sebanyak 2 pasien (66,66%). Tidak didapatkan korelasi antara LDL kolesterol dengan hs-CRP. Kesimpulan. Statin 5 mg dapat menurunkan kadar hs-CRP, LDL kolesterol, kolesterol total, non-HDL, trigliserida serta peningkatan HDL kolesterol secara bermakna, jika dibanding statin 10 mg dan 20 mg. tidak ada korelasi antara LDL kolesterol dengan hs-CRP.  Kata kunci: HMG-CoA reduktase, DM type 2, hs-CRP, LDL kolesterol

Correlation Between High Sensitivity C-Reactive Protein Level and Executive Function Disorders in Elderly Patients

2020 ◽  
Vol 17 (7) ◽  
pp. 3113-3116
Author(s):  
Dyah Anetta Afri Rukmi ◽  
Joseph Eko Wahono Rahardjo
Keyword(s):  
Executive Function ◽  
Elderly Patients ◽  
Complete Blood Count ◽  
High Sensitivity ◽  
High Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high-sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the frontal-subcortical circuit. To determine the correlation between high serum concentration of hs-CRP and executive function disorder in elderly patients. Thirty six elderly patients was examined by using a case control study. The subjects were enrolled from the out-patient at Neurology Department Dr. Soetomo General Hospital, Surabaya, Indonesia. The time period was 4 months (April to July 2015). Executive function was measured with the Trail Making Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis. Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%) subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0, 538-58, 860). These data suggested that high levels of hs-CRP was not associated with executive function in elderly patients.

scholarly journals Evaluating the role of high-sensitivity C-reactive protein in asthmatic Iraqi patients and its correlation with parameters of patients’ clinical characteristics and pulmonary function tests

2016 ◽  
Vol 7 (3) ◽  
pp. 47-53
Author(s):  
Muhammed Saleh Najdat ◽  
Ahmed M Lutfi
Keyword(s):  
Pulmonary Function ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Pulmonary Function Tests ◽  
High Sensitivity ◽  
Control Group ◽  
Inhaled Corticosteroid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Aims and Objectives: To evaluate the relevance of high-sensitivity assays for C-reactive protein (hs-CRP), as a sensitive marker of inflammation in asthmatic Iraqi patients. Additionally, correlations of serum levels of hs-CRP with patients’ clinical characteristics and pulmonary function tests (PFTs) will be studied in a cross-sectional design.Materials and Methods: A random sample of 58 individuals were divided into a healthy (control) group (n = 12) and two groups of adult patients with chronic stable asthma; (n = 22) patients had been receiving inhaled corticosteroids (inhaled corticosteroid-positive, or ICS+VE, group) for the past 2–3 months, and (n = 24) steroid-naive patients (inhaled corticosteroid-negative, or ICS-VE, group). The selected individuals were subjected to hs-CRP measurement and PFTs.Results: The forced expiratory volume in one second (FEV1)/forced vital capacity (FVC), was measured in all subjects. In the ICS+VE and the ICS-VE groups, there was a significant correlation between the level of hs-CRP and FEV1/FVC with r: ?0.891 and a p-value of < 0.0005 for both groups. In the ICS-VE group, 78.5% had significant clinical symptoms, whereas only 22.7% of the ICS+VE group had significant clinical symptoms. This difference (for the prevalence of clinical symptoms) was significant with a chi-square value of 19.59, degree of freedom (df) = 1, and p < 0.0005.Conclusion: In the ICS-VE group, the level of hs-CRP was significantly higher than in both the ICS+VE group and the control group. The values of the PFTs were significantly lower in the ICS-VE group. The prevalence of clinical features was significantly higher in the ICS-VE group.Asian Journal of Medical Sciences Vol. 7(3) 2016 47-53

scholarly journals To study the association of high sensitivity C-reactive protein with metabolic syndrome

2018 ◽  
Vol 6 (2) ◽  
pp. 572 ◽  
Author(s):  
Vinod Saini ◽  
Abhishek Gupta ◽  
Mayank Arora ◽  
S. K. Virmani
Keyword(s):  
Metabolic Syndrome ◽  
High Sensitivity ◽  
Case Control ◽  
High Density ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Care Hospital ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Background: Metabolic Syndrome is a constellation of dyslipidemia (elevated triglycerides, low high-density lipoproteins (HDL)), elevation of arterial blood pressure (BP), dysregulated glucose homeostasis, and increased abdominal obesity.Methods: We studied the association of high sensitivity C-reactive protein with metabolic syndrome by case-control method in our tertiary care hospital in West U.P.Results: The mean age of cases and controls was 52.6 ± 7.7 and 51.4±7.0 years, respectively. There were 25 (50%) male and 25 (50%) female in case groups, and 27 (54%) males and 23 (46%) females in control group. Our analysis revelaed that there was a significant association between hs-CRP and the central obesity when compared in case-control group (3.57 vs 0.96 mg/L) (p value <0.001). There was no significant association between hs-CRP and high triglycerides, hypertension, diabetes, and reduced high density lipoprotein cholesterol.Conclusions: Raised hsCRP level can be considered as a surrogate marker of chronic inflammation in patients with metabolic syndrome.

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