scholarly journals Treatment of high blood pressure in diabetic patients and risk of undernutrition in a population in extreme Western Algeria

2021 ◽  
Vol 11 (1) ◽  
pp. 8-12
Author(s):  
Hamza Nadjib Merad-boudia ◽  
Majda Dali-Sahi ◽  
Youcef Kachekouche ◽  
Nouria Dennoun-Medjati ◽  
Takwa Salmi ◽  
...  
Keyword(s):  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
University Hospital ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Diabetic Patients ◽  
Angiotensin Ii Receptor ◽  
Diabetic Hypertensive Patient ◽  
Relevant Variables ◽  
Status Assessment ◽  
Receptor Blockers

Introduction: Assessing the risk of undernutrition in hypertensive diabetics is essential. It makes it possible to detect undernutrition for better care. The objective of our study is to describe the factors influencing this undernutrition. Methods: A descriptive study was conducted on a sample of 366 diabetics with hypertension and 326 with normo-glycemic hypertension aged 50 years and over. Patients were enrolled at the University Hospital in Tlemcen from January to June 2018. The data collection was carried out using a questionnaire: The MNA (The Mini Nutritional Assessment). Results: The study made it possible to establish the profile of subjects at high risk of undernutrition. In our sample, age was not correlated with risk of malnutrition in diabetic hypertensives and normo-glycemic hypertensives respectively (p = 0.304 and p = 0.444). The linear regression model uses gender as an age-independent factor that affects the risk of undernutrition (p = 0.001). BMI was one of the most relevant variables for predicting the occurrence of undernutrition (p = 0.000). Thus, diabetic hypertensive patients in our study who were treated with an Angiotensin II receptor blockers , an angiotensin converting enzyme inhibition or an ARB/diuretic combination were more at risk of undernutrition (p = 0.009, p = 0.026 and p = 0.013). Conclusion: Particular attention should be paid to diabetic hypertensive subject.  The treatment of hypertension in diabetics aggravates this malnutrition. Thus, a nutritional status assessment should be established in any diabetic hypertensive patient allowing appropriate therapeutic management to avoid all complications associated with undernutrition.

scholarly journals Quality of life, symptoms and dietary habits in oncology outpatients with malnutrition: A cross-sectional study

2021 ◽  
Vol 38 (2) ◽  
Author(s):  
Mira Sonneborn-Papakostopoulos ◽  
Clara Dubois ◽  
Viktoria Mathies ◽  
Mara Heß ◽  
Nicole Erickson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
At Risk ◽  
Side Effects ◽  
Dietary Habits ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
University Hospital ◽  
Cross Sectional ◽  
European Organization

AbstractCancer-related malnutrition has a high prevalence, reduces survival and increases side effects. The aim of this study was to assess oncology outpatients and risk of malnutrition. Reported symptoms and quality of life (QoL) in patients found to be at risk of malnutrition or malnourished were compared to patients without malnutrition. Using a standardized questionnaire, the European Organization for Research and Treatment of Cancer Questionnaire for Quality of Life and the Mini Nutritional Assessment (MNA), patients in an outpatient cancer clinic undergoing chemotherapy treatment at a German University Hospital were assessed for nutrition, risk of malnutrition and quality of life. Based on the MNA, 39 (45.9%) patients were categorized as malnourished or at risk for malnutrition. Loss of appetite (n = 37.6%, p < 0.001) and altered taste sensation (n = 30,3%, p < 0.001) were the symptoms most frequently associated with reduced food intake. Patients with risk of malnutrition scored lower on the global health status (n = 48.15%, p = 0.001). Side effects of cancer treatments lead to a higher risk of malnutrition and as a consequence lower QoL. These side effects should be addressed more efficiently in cancer care.

scholarly journals Update on RAAS Modulation for the Treatment of Diabetic Cardiovascular Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Stella Bernardi ◽  
Andrea Michelli ◽  
Giulia Zuolo ◽  
Riccardo Candido ◽  
Bruno Fabris
Keyword(s):  
Cardiovascular Disease ◽  
Diabetic Patients ◽  
Paradigm Shifts ◽  
Angiotensin Ii Receptor ◽  
First Line ◽  
Chronic Complications ◽  
First Line Therapy ◽  
Patients With Diabetes ◽  
Receptor Blockers ◽  
Diabetic Population

Since the advent of insulin, the improvements in diabetes detection and the therapies to treat hyperglycemia have reduced the mortality of acute metabolic emergencies, such that today chronic complications are the major cause of morbidity and mortality among diabetic patients. More than half of the mortality that is seen in the diabetic population can be ascribed to cardiovascular disease (CVD), which includes not only myocardial infarction due to premature atherosclerosis but also diabetic cardiomyopathy. The importance of renin-angiotensin-aldosterone system (RAAS) antagonism in the prevention of diabetic CVD has demonstrated the key role that the RAAS plays in diabetic CVD onset and development. Today, ACE inhibitors and angiotensin II receptor blockers represent the first line therapy for primary and secondary CVD prevention in patients with diabetes. Recent research has uncovered new dimensions of the RAAS and, therefore, new potential therapeutic targets against diabetic CVD. Here we describe the timeline of paradigm shifts in RAAS understanding, how diabetes modifies the RAAS, and what new parts of the RAAS pathway could be targeted in order to achieve RAAS modulation against diabetic CVD.

Functional Dependence and Nutritional Status among Leprosy Survivors in Sungai Buloh, Malaysia

2016 ◽  
Vol 1 (1) ◽  
pp. 29
Author(s):  
Mohamad-Rodi Isa ◽  
Siti-Munira Yasin ◽  
Mohammad-Idris Zamhuri
Keyword(s):  
Nutritional Status ◽  
Nutritional Assessment ◽  
Functional Dependence ◽  
Mini Nutritional Assessment ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
The Social ◽  
Degree Of Disability ◽  
Status Assessment ◽  
Nutritional Score

Introduction: Leprosy is a chronic granulomatous disease which also known as Hansen’s disease caused by Mycobacterium leprae. The social rights and health requirements should not be neglected among the remaining survivors. Although nutritional status and leprosy invasion has been studied in the past, there is still an unclear relationship between these two. The aim of this study was to assess the relationship between nutritional status and disability among the leprosy survivors. Methods: A community based, cross-sectional study using convenience sampling was conducted at Sungai Buloh, Selangor area from June 2014 to July 2014. The degree of disability was assessed using Barthel’s Index and the nutritional status assessment was assessed using Mini Nutritional Assessment. The data was analysed using SPSS version 20. Results: A total of 73 patients were involved in the study (60.3% were male and 89.0% were Chinese). The prevalence of disability was 56.2% (95% CI: 44.5 – 67.8) with walking up-stair was the highest item that need help (50.7%). There were 9.6% malnourished and 49.3% were at risk of malnutrition. There was a negative strong correlation between Nutritional score and the Barthel’s index score (Spearman rho, ρ = -0.714, p < 0.001). Conclusions: Measures must be taken to improve their nutritional status in order to increase their ability to be more independent particularly those who are very old. The degree of disability increases with malnutrition.

scholarly journals The Graz Malnutrition Screening (GMS): a new hospital screening tool for malnutrition

2015 ◽  
Vol 115 (4) ◽  
pp. 650-657 ◽  
Author(s):  
Regina E. Roller ◽  
Doris Eglseer ◽  
Anna Eisenberger ◽  
Gerhard H. Wirnsberger
Keyword(s):  
Predictive Value ◽  
Nutritional Assessment ◽  
Short Form ◽  
Hospital Setting ◽  
Mini Nutritional Assessment ◽  
University Hospital ◽  
Nutritional Risk ◽  
Risk Screening ◽  
Hospitalised Patients ◽  
Blinded Manner

AbstractDespite the significant impact of malnutrition in hospitalised patients, it is often not identified by clinical staff in daily practice. To improve nutritional support in hospitals, standardised routine nutritional screening is essential. The Graz Malnutrition Screening (GMS) tool was developed for the purpose of malnutrition risk screening in a large hospital setting involving different departments. It was the aim of the present study to validate the GMS against Nutritional Risk Screening (NRS) and Mini Nutritional Assessment-short form (MNA-sf) in a randomised blinded manner. A total of 404 randomly selected patients admitted to the internal, surgical and orthopaedic wards of the University Hospital Graz were screened in a blinded manner by different raters. Concurrent validity was determined by comparing the GMS with the NRS and in older patients (70+ years) with the MNA-sf additionally. According to GMS, 31·9 or 28·5 % of the admitted patients were categorised as at ‘risk of malnutrition’ (depending on the rater). According to the reference standard of NRS, 24·5 % of the patients suffered from malnutrition. Pearson’srvalues of 0·78 compared with the NRS and 0·84 compared with the MNA showed strong positive correlations. Results of accuracy (0·85), sensitivity (0·94), specificity (0·77), positive predictive value (0·76) and negative predictive value (0·95) of GMS were also very high. Cohen’sκfor internal consistency of the GMS was 0·82. GMS proves to be a valid and reliable instrument for the detection of malnutrition in adult patients in acute-care hospitals.

Breast cancer, placing drug interactions in the spotlight: Is polypharmacy the cause of everything?

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24027-e24027
Author(s):  
José Alberto Domínguez-Alonso ◽  
David Conde-Estévez ◽  
Maria Pi-Figueras ◽  
Sonia Servitja ◽  
Ana Digón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Median Number ◽  
University Hospital ◽  
Breast Cancer Patients ◽  
Baseline Characteristics ◽  
Demographical Data

e24027 Background: Breast cancer is the most prevalent and lethal cancer among women. Forty one percent of cases occur in people ≥ 65 years. Decision on cancer treatment is particularly challenging among this group of age given its comorbidities and polypharmacy (PP). The main objectives are the analysis of potential drug-drug interactions (PDDI) in elderly breast cancer patients between daily medications and oncospecific therapy and their probable associations with age, BMI, Mini Nutritional Assessment (MNA), frailty and PP and the adverse effects during oncospecific treatment. Methods: A cohort of 77 patients ≥ 70 years with breast cancer underwent a Comprehensive Geriatric Assessment (CGA) by a Geriatrist at a university hospital. Baseline characteristics of the patients, demographical data, cancer stage, and oncospecific and daily treatments, as well as the complications and derived adverse effects were retrospectively collected using electronic medical records. Moreover, frailty categorization, daily medication number, comorbidities, Lawton and Barthel Index, malnutrition, MNA, BMI were prospectively collected using CGA report. PDDI between daily and oncospecific treatments were analyzed. Results: The median age of patients was 85 years (range 72-95). The median number of daily medications at CGA was 6 drugs (range 0-22) and most of the patients had PP at CGA and during oncospecific treatment (73% and 91%, respectively). Out of 719 PDDI, 530 (74%) were moderate ( r2= 0.72) and the median number of drugs during oncospecific treatment ( r2= 0.73) was 9 (range 3-26). Overall, by using Kruskal Wallis, 59 patients (77%) had any adverse effects statistically associated with frailty categorization and MNA ( p < 0.05). Furthermore, there was a tendency with oncospecific treatment, BMI and age ( p = 0.098, 0.089 and 0.062, respectively). The distribution of major, moderate and minor as well as total PDDI was statistically associated with PP at CGA and during oncospecific treatment ( p < 0.05). Conclusions: CGA should be applied in oncology elderly patients not only to assess clinical outcomes and categorize them in each frailty group but also to analyze PDDI by using specific web databases, thereby improving PP, PDDI and economic costs.

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