scholarly journals Design, Development and Evaluation of Silk Based Film Forming Spray for Wound Healing

2021 ◽  
Vol 11 (3-S) ◽  
pp. 15-18
Author(s):  
Vipul Wayal ◽  
K. Nagasree ◽  
B. A. Vishwanath
Keyword(s):  
Wound Healing ◽  
Centella Asiatica ◽  
Silk Protein ◽  
Spray Angle ◽  
Design Development ◽  
Drying Time ◽  
Film Forming ◽  
Site Of Action ◽  
Ph Range ◽  
Dry Film

The objective of the present study is to formulate and evaluate Silk based film forming spray for wound healing. On the wound surface the solution solidifies into a film which can deliver the active moiety on site of action. The spray solution was prepared by simple mixing of active extract of Centella Asiatica, Silk Protein and various film forming polymers. Silk protein form scaffold for active fibroblast movement and Asiaticosides from Centella Asiatica extract improve and fasten collagen synthesis. A clear yellowish solution was obtained. The formulations (F1-F8) had a pH range between 5.5–6.5, which was close to the pH of skin. The viscosity of formulation in range of 25–50 cps, completely dry film formed within 5 min in open environment. The Effects of polymers, plasticizers and solvents on spreadability. Surface tension and Spray angle were studied. The high content of ethanol in the formulation fastens the drying time. The results indicated that formulation (F8) showed good spreadability and less drying time. Keywords: Film forming spray, Wound healing, Silk protein, Asiaticoside, Scaffold

scholarly journals Film-Forming Systems for the Delivery of DNDI-0690 to Treat Cutaneous Leishmaniasis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 516
Author(s):  
Katrien Van Bocxlaer ◽  
Kerri-Nicola McArthur ◽  
Andy Harris ◽  
Mo Alavijeh ◽  
Stéphanie Braillard ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cutaneous Leishmaniasis ◽  
Mouse Skin ◽  
Parasite Load ◽  
Leishmania Species ◽  
Lesion Size ◽  
Drying Time ◽  
Sustained Drug Delivery ◽  
Film Forming ◽  
The Impact

In cutaneous leishmaniasis (CL), parasites reside in the dermis, creating an opportunity for local drug administration potentially reducing adverse effects and improving treatment adherence compared to current therapies. Polymeric film-forming systems (FFSs) are directly applied to the skin and form a thin film as the solvent evaporates. In contrast to conventional topical dosage forms, FFSs strongly adhere to the skin, favouring sustained drug delivery to the affected site, reducing the need for frequent applications, and enhancing patient compliance. This study reports the first investigation of the use of film-forming systems for the delivery of DNDI-0690, a nitroimidazole compound with potent activity against CL-causing Leishmania species. A total of seven polymers with or without plasticiser were evaluated for drying time, stickiness, film-flexibility, and cosmetic attributes; three FFSs yielded a positive evaluation for all test parameters. The impact of each of these FFSs on the permeation of the model skin permeant hydrocortisone (hydrocortisone, 1% (w/v) across the Strat-M membrane was evaluated, and the formulations resulting in the highest and lowest permeation flux (Klucel LF with triethyl citrate and Eudragit RS with dibutyl sebacate, respectively) were selected as the FFS vehicle for DNDI-0690. The release and skin distribution of the drug upon application to Leishmania-infected and uninfected BALB/c mouse skin were examined using Franz diffusion cells followed by an evaluation of the efficacy of both DNDI-0690 FFSs (1% (w/v)) in an experimental CL model. Whereas the Eudragit film resulted in a higher permeation of DNDI-0690, the Klucel film was able to deposit four times more drug into the skin, where the parasite resides. Of the FFSs formulations, only the Eudragit system resulted in a reduced parasite load, but not reduced lesion size, when compared to the vehicle only control. Whereas drug delivery into the skin was successfully modulated using different FFS systems, the FFS systems selected were not effective for the topical application of DNDI-0690. The convenience and aesthetic of FFS systems alongside their ability to modulate drug delivery to and into the skin merit further investigation using other promising antileishmanial drugs.

Preparation and Property Study of Core-Shell Ambient-Temperature Crosslinkable Polyacrylate Binder

2013 ◽  
Vol 469 ◽  
pp. 3-6 ◽  
Author(s):  
Mu Li ◽  
Xiao Song Lin ◽  
Xiao Yu Li ◽  
Hai Qiao Wang
Keyword(s):  
Ambient Temperature ◽  
Butyl Acrylate ◽  
Core Shell ◽  
Drying Time ◽  
Acrylic Polymer ◽  
Force Microscopy ◽  
Atomic Force ◽  
Transmission Electron ◽  
Film Forming ◽  
Water Based

As the binder of waterborne inks, the capability of acrylic polymer has great influences on the quality of inks. In this contribution, structured latex particles with a poly (stryrene-butyl acrylate-methacrylate) core and a poly (butyl acrylate-methyl methacrylate-methacrylic acid-diacetone acrylamide (DAAM)) shell, which can be used as binders of water-based ink, were prepared by emulsion polymerization. The emulsion can cure in the course of film forming at ambient temperature through the reaction between DAAM and the adipic acid dihydrazide (ADH). Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), transmission electron microscopy (TEM), atomic force microscopy (AFM) were used to characterize the structures and study the properties of the latices. The drying time of the crosslinking latices was investigated. In addition, influences of DAAM monomer dosage and the mole ratio of DAAM to ADH on the mechanical properties of self-crosslinkable core-shell latices were also discussed. It was found that the core-shell crosslinkable particles with a low glass transition temperature (Tg) core and a high Tg shell have better film properties and would be more applicable to binders of water-based ink for plastic film, in comparison with those particles with a high Tg core and a low Tg shell.

scholarly journals Surgery and Medicinal Plants: A review of important indigenous medicinal plants of Iran for burn wound healing

2019 ◽  
Vol 6 (2) ◽  
pp. 264-269
Author(s):  
Masoud Sharifian ◽  
Afshin Hasanvand ◽  
Gholam Basati ◽  
Saber Abbaszadeh
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Herbal Remedy ◽  
Medical Science ◽  
Aloe Vera ◽  
Centella Asiatica ◽  
Recovery Process ◽  
Herbal Remedies ◽  
Burn Wound ◽  
Burn Wounds

Surgical Science is one of the branches of medical science that deals with surgical and medicinal interventions, which can cure surgical wounds, cuts, burns and so on. The accelerated recovery process has always been a concern for surgeons and physicians. Standard local antibiotic drugs such as silver nitrate, mafenide acetate, sulfadiazine silver and AgNO3 are also used to treat wounds which are associated with some complications. Considering the fact that no effective herbal remedy has been introduced for wound healing, the purpose of this review is to investigate and identify indigenous Iranian herbs used for wound healing after surgery, especially burn wounds. In this systematic review paper, published articles in the period 1952 to 2017 with keywords of surgery, wound healing, burns, herbs, etc. from databases such as SID, MEDLIB, ProQuest, Magiran, Europe PubMed Central and Google Scholar. Abstract and title of all articles were studied and non-relevant articles were deleted and remaining articles were used for review. Based on the results of the study, Malva sylvestris, Camellia sinensis, Aloe vera, Cydonia oblonga, Scrophularia striata, Centella asiatica, Arnebia euchroma, Calendula officinalis and Hypericum perforatum are the most important herbal remedies for burn restoration. The following is an explanation of the most important herbal remedies for native burn wounds in Iran.

Burn and Wound Healing Using Radiation Sterilized Human Amniotic Membrane and Centella asiatica Derived Gel: a Review

2019 ◽  
Vol 6 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Md. Liakat Hossain ◽  
Md. Arifur Rahman ◽  
Ayesha Siddika ◽  
M. H. Adnan ◽  
Hafizur Rahman ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Centella Asiatica ◽  
Human Amniotic Membrane

Effects of topical applications of porcine acellular urinary bladder matrix and Centella asiatica extract on oral wound healing in a rat model

2018 ◽  
Vol 23 (5) ◽  
pp. 2083-2095 ◽  
Author(s):  
Fabio Camacho-Alonso ◽  
M. R. Torralba-Ruiz ◽  
N. García-Carrillo ◽  
J. Lacal-Luján ◽  
F. Martínez-Díaz ◽  
...  
Keyword(s):  
Wound Healing ◽  
Urinary Bladder ◽  
Rat Model ◽  
Centella Asiatica ◽  
Urinary Bladder Matrix ◽  
Oral Wound Healing ◽  
Topical Applications

scholarly journals Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Afnan Sh. Ahmed ◽  
Muhammad Taher ◽  
Uttam Kumar Mandal ◽  
Juliana Md Jaffri ◽  
Deny Susanti ◽  
...  
Keyword(s):  
Wound Healing ◽  
Centella Asiatica ◽  
Pharmacological Properties

Wound healing efficacy of a chitosan-based film-forming gel containing tyrothricin in various rat wound models

2014 ◽  
Vol 38 (2) ◽  
pp. 229-238 ◽  
Author(s):  
Ju-Young Kim ◽  
Joon-Ho Jun ◽  
Sang-Joon Kim ◽  
Kyu-Mok Hwang ◽  
Sung Rak Choi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Film Forming

Effect of Centella asiatica L (Umbelliferae) on Normal and Dexamethasone-Suppressed Wound Healing in Wistar Albino Rats

2006 ◽  
Vol 5 (3) ◽  
pp. 137-143 ◽  
Author(s):  
B. Somashekar Shetty ◽  
S. L. Udupa ◽  
A. L. Udupa ◽  
S. N. Somayaji
Keyword(s):  
Wound Healing ◽  
Centella Asiatica ◽  
Albino Rats ◽  
Wistar Albino Rats

Inhibition of Lysophosphatidate Signaling by Lidocaine and Bupivacaine 

1997 ◽  
Vol 86 (5) ◽  
pp. 1112-1119 ◽  
Author(s):  
Gregor W. Nietgen ◽  
Carrie K. Chan ◽  
Marcel E. Durieux
Keyword(s):  
Wound Healing ◽  
Local Anesthetics ◽  
Xenopus Oocytes ◽  
Inhibitory Concentration ◽  
Angiotensin Ii Receptor ◽  
Activated Platelets ◽  
Surgical Wounds ◽  
Smooth Muscle Proliferation ◽  
Site Of Action ◽  
G Protein Coupled

Background Lidocaine and bupivacaine impair wound healing, but the mechanism of this side effect has not been determined. The phospholipid messenger lysophosphatidate is released from activated platelets and induces fibroblast and smooth muscle proliferation. Because it may play a role in wound healing, the authors studied the effects of local anesthetics on lysophosphatidate signaling in Xenopus oocytes. Methods Defolliculated Xenopus oocytes expressing endogenous G protein-coupled lysophosphatidate receptors were voltage clamped and studied in the presence or absence of lidocaine or bupivacaine. Lysophosphatidate-induced Ca(2+)-activated Cl- currents (IC1(Ca)) were measured. To determine the site of action of the local anesthetics on the signaling pathway, the authors studied 1) the effects of local anesthetics on signaling induced by intracellular injection of the second messenger inositoltrisphosphate, and 2) the effects of local anesthetics on functioning of recombinantly expressed angiotensin II receptor signaling through the same pathways as the lysophosphatidate receptor. Results Lysophosphatidate signaling was inhibited in the presence of local anesthetics. The half maximal inhibitory concentration (IC50S) for lidocaine and bupivacaine were 29.6 mM and 4.7 mM, respectively. Neither responses induced by inositoltrisphosphate injection nor angiotensin signaling were influenced by local anesthetics. Conclusions Lysophosphatidate signaling is inhibited by the extracellular application of lidocaine or bupivacaine. In contrast, inositoltrisphosphate or angiotensin signaling was not affected by local anesthetics. Therefore local anesthetics have a specific, extracellular effect on lysophosphatidate receptor functioning. As the local anesthetic concentrations used were similar to those observed after injection around surgical wounds, LP inhibition may play a role in the observed detrimental effects of local anesthetics on wound healing.

scholarly journals Preparation, Characterization, and Wound Healing Activity of Papaya Leaves Extract on Spray Gel

2020 ◽  
Vol 25 (2) ◽  
pp. 103
Author(s):  
Dina Permata Wijaya ◽  
Herlina Herlina ◽  
Najma Annuria Fitri ◽  
Mardiyanto Mardiyanto ◽  
Mustikasanti Mustikasanti ◽  
...  
Keyword(s):  
Wound Healing ◽  
Positive Control ◽  
Negative Control ◽  
Gellan Gum ◽  
Gelling Agent ◽  
Carbopol 940 ◽  
Ph Range ◽  
Wound Healing Activity

Papaya leaves have been using for wound healing that contains flavonoids, saponins, phenolics, chymopapain, and papain enzymes. The aim of this research were preparation, characterization, and wound healing activity of papaya leaves extract on spray gel. Spray gel was formulated with variation of gelling agent such as carbopol 940, HPMC, gellan gum, and hydroxyethylcellulose. The spray gel were characterizated by organoleptic, pH, stickiness test, viscosity, homogeneity, weight, and wound healing activity in rats. The results showed were all of formula spray gel have brown and homogeneous, pH between 5,947-6,347 within pH range of skin, stickiness test between 1,92-8,12 s, viscosity between 880-1740 cPs. Papaya leaves extract on spray gel has wound healing activity in rats faster than extract and positive control that is 16 days. The wound healing of papaya leaves extract on spray gel exhibited significantly different (p<0,05) than negative control.

Sign in / Sign up

Export Citation Format

Share Document