scholarly journals FORMULATION AND EVALUATION OF SUMATRIPTAN IMMEDIATE RELEASE TABLETS

2018 ◽  
Vol 8 (5) ◽  
pp. 241-247
Author(s):  
P Munija ◽  
G Srikanth
Keyword(s):  
Performance Testing ◽  
Immediate Release ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Sumatriptan Succinate ◽  
Orodispersible Tablet ◽  
Drastic Effect ◽  
Mouth Feel

The rationale of this investigation is to design an immediate release oral dosage of Sumatriptan succinate by using microcrystalline cellulose as filler, camphor and menthol as subliming agents by direct compression method .The basic objective of this dissertation is to develop an orodispersible tablet of sumatriptan succinate used in anti-migraine with an aim of reduces the lag time and providing faster onset of action to relief the acute migraine effect immediately. Disintegrates and disperses in oral cavity within 30 seconds without the need of drinking water. Has pleasant mouth feel and there is no after taste or grittiness. Successfully discriminates the ability of three superdisintegrants to promote drug dissolution and proposes a model formulation for disintegrants performance testing and quality control purposes. The formulation F6 containing 8% of CCS and 10% of menthol showed disintegration time of 18seconds after drying. Menthol as subliming agent was found to be most effective of all other subliming agents as it had showed drastic effect on the drug release. Keywords: Sumatriptan succinate, sublimation, menthol, anti-migraine

scholarly journals Impact of Tablet Shape on Drug Dissolution Rate Through Immediate Released Tablets

2020 ◽  
Vol 10 (4) ◽  
pp. 656-661
Author(s):  
Fatima Molavi ◽  
Hamed Hamishehkar ◽  
Ali Nokhodchi
Keyword(s):  
Dissolution Rate ◽  
Release Kinetics ◽  
Immediate Release ◽  
Drug Dissolution ◽  
Dissolution Time ◽  
Sufficient Information ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Dissolution Efficiency

Purpose : The aim of this study was to evaluate the influence of the geometric shape on the dissolution rate of the domperidone, a drug model for immediate release dosage form. In this regard, a lack of sufficient information about the effective dissolution rate of the drugs regarding their shapes has made this issue an interesting subject for researchers. Methods: For this purpose, three tablet shapes, namely flat and biconvex both in a round and oblong shapes, with different four sizes were modelled for the preparation of domperidone tablet. In vitro dissolution test was accomplished using a USP dissolution apparatus II. The drug dissolution rate was assessed by calculating various dissolution parameters; e.g., dissolution efficiency (DE), mean dissolution rate (MDR), mean dissolution time (MDT), and difference and similarity factors (f1 and f2 ). Results: Regarding the disintegration time, the larger tablets showed a faster disintegration time. When the size of the tablets was smaller, the amount of released drug was significantly decreased. In addition, #9 tablets with a flat or biconvex geometry had obvious effects on the DE values. Generally, biconvex tablets had higher DE percentage than the flat tablets. Conclusion: Noticeable differences in dissolution parameters by considering the different geometric shapes play an important role in the drug release kinetics which makes a significant effect on quick onset of action in oral administration.

scholarly journals Development of Tropisetron Hydrochloride Orodispersible Tablet using Natural Superdisintigrants

2021 ◽  
pp. 191-210
Author(s):  
Rupalben K. Jani ◽  
Gohil Krupa ◽  
Aanal Gandhi ◽  
Vijay Upadhye ◽  
Roshani Pragnesh Amin
Keyword(s):  
Drug Candidate ◽  
Antiemetic Drug ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Cassia Tora ◽  
Weight Variation ◽  
Orodispersible Tablet ◽  
Value Loss ◽  
Time Required

The foremost objective of this research was to compare and evaluate natural super disintegrants with synthetic super disintegrants for the preparation of the orodispersible tablet. Tropisetron hydrochloride is widely used as an antiemetic drug, which is a potential drug candidate for developing an orodispersible tablet for quick onset of action. Various formulations were prepared using different concentrations (5%, 7.5%, and 10%) by direct compression method of natural super disintegrants (Banana power and Cassia tora powder) and synthetic super disintegrants (Croscarmellose sodium, Crospovidone, and Sodium starch glycolate). The compatibility studies between the drug and excipients were carried out using FTIR spectroscopy before tablet formulation. The pre-compression parameters were evaluated for additive properties. Standardization of banana powder was done by various parameters like extractive value, ash value, loss on drying, TLC identification test, etc. Post-compression parameters like hardness, weight variation, friability, thickness, the time required for disintegration, wetting time, the release of drug in-vitro, and in-vitro dispersion time of the tablets were evaluated. The disintegration time and in-vitro drug release of optimized formulation (F2) were found to be 4.66±1.15 secs and 99.25±0.15%. The optimized formulation (F2) was subjected to stability studies (40 C& 75 % RH) for one month. The results were shown that natural super disintegrants require less disintegration time as compared to synthetic super disintegrants. Hence present study reveals that the orodispersible tablets prepared using Banana powder and Cassia tora powder is super disintegrants that shown better appearance and rapid disintegration time.

scholarly journals Formulation, Evaluation and Optimization of Orodispersible Tablets of Naproxen sodium by using Superdisintegrant

2019 ◽  
Vol 9 (4-s) ◽  
pp. 462-468
Author(s):  
Mohd. Razi Ansari ◽  
Sumer Singh ◽  
M.A. Quazi ◽  
Yaasir Ahmed Ansari ◽  
Jameel Abbas
Keyword(s):  
Patient Compliance ◽  
Naproxen Sodium ◽  
Rapid Onset ◽  
Angle Of Repose ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Weight Variation

Among the different type of route of administration oral route for drug administration is most common route in which Orodispersible tablet is preferred for the patient which are unconscious, week or for immediate control. The tablet gets dispersed in mouth cavity without water, present study deals with formulation of Naproxen sodium mouth dissolving tablets using super disintegrants. Naproxen sodium is analgesic and NSAID, used for the treatment of pain and inflammation caused by different condition such as osteoarthritis, rheumatoid arthritis and menstrual cramps. However gastric discomfort caused by naproxen sodium result in poor patient compliance associated with it conventional doses form but now days Naproxen sodium MDTs produces rapid onset of action and minimise gastric discomfort associated with it. Thus improves patient compliance, enhance bioavailability and reduces the dose of drug. MDTs are formulated by direct compression method using super disintegrants in different proportion. The powder blend is subjected to pre-compression evaluation parameters like bulk density, true density, and tapped density and angle of repose. Formulations are evaluated for weight variation, hardness, wetting time, water absorption time, disintegration time. And in vitro dissolution studies and all formulations complies Pharmacopoeias standards. The tablets are evaluated and result compared for all five formulation the most efficacious super disintegrants for MTDs of Naproxen sodium as suggested by the dispersion time, disintegration time and drug dissolution profiles. Keywords: - MDT, Naproxen Sodium, crosscarmellose Sodium, Sodium starch glycolate, Cross-povidone.

scholarly journals Formulation and Evaluation of Effects of Superdisintegrants on Immediate Release Tablet of Linagliptin, a DDP-4 Inhibitor

2021 ◽  
Vol 24 (2) ◽  
pp. 168-179
Author(s):  
Tanoy Saha ◽  
Md Mahbubul Alam ◽  
Dilshad Noor Lira ◽  
Abu Shara Shamsur Rouf
Keyword(s):  
Drug Release ◽  
Immediate Release ◽  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Angle Of Repose ◽  
Drug Dissolution ◽  
Disintegration Time ◽  
Weight Variation ◽  
Tablet Dosage ◽  
Release Tablet

The study aimed to develop and evaluate an immediate-release tablet dosage form of Linagliptin. Different concentrations (ranges 5-10%) of super-disintegrants, Croscarmellose sodium (CCS), and Sodium starch glycolate (SSG) were used to prepare nine tablet dosage forms (F1 to F9) through the direct compression method. The compatibility of the formulations was evaluated by FTIR to reveal any possible drug-excipient interactions and it was proved to be compatible with all formulations. Precompression (bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose) and post-compression parameters (weight variation, hardness, thickness, and friability) were analyzed for all tablets and the results were found satisfactory as well as within limits as per USP guidelines. All the formulated batches (F1 to F9) exhibited disintegration of tablets within 2 minutes, where formulation F9 represented the lowest disintegration time (51±3 sec) which was also found significantly better than the marketed product (310±5 sec). In terms of drug dissolution, 90% of drug release was observed for all nine formulations within 45 minutes and formulation F9 (5% CCS and 5% SSG) illustrated the rapid and highest dissolution rate compared to the marketed one’s, 100% drug release at 20 minutes and 91.77 % drug release at 30 minutes successively. The respective data sets of drug release were mathematically fitted to several kinetic models and for all formulations, drug release pattern obeyed first-order kinetics amongst those, formulation F2 (r2= 0.98), F4 (r2= 0.99), F5 (r2= 0.98), and F9 (r2= 0.97) were found to be best fitted in this kinetic norm. Based on disintegration time and dissolution data comparison to a brand leader market product, F9 was experienced as the best formulation. Furthermore, it was observed that if SSG and CCS were combined, then these two parameters were more improved compared to their separate uses. Thus, incorporation of the optimum amount of super-disintegrants in a formulation showed rapid swelling, faster disintegration as well as ease of dissolution of tablet dosage forms. Bangladesh Pharmaceutical Journal 24(2): 168-179, 2021

scholarly journals Formulation and Optimization of Orodispersible Tablet of Loratadine Using Box Behnken Design

2019 ◽  
Vol 9 (4-A) ◽  
pp. 86-94
Author(s):  
Aliasgar Kundawala ◽  
Pratik Patel ◽  
Khushbu Chauhan ◽  
Anjali Desai ◽  
Dhwani Kapadia
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Angle Of Repose ◽  
Drug Dissolution ◽  
Taste Masking ◽  
Disintegration Time ◽  
Box Behnken Design ◽  
Orodispersible Tablets ◽  
Orodispersible Tablet ◽  
Wetting Time

In present study Orodispersible tablets (ORDT) of Loratadine were prepared and optimized. Solid dispersion of Loratadine- β cyclodextrin complex were prepared and used in preparation of Orodispersible tablets. Various super-disintegrating agent like Cross carmellose sodium, Cross povidone and Kyron T-314 were employed for faster disintegrating effect. The 24 factorial and Box-Behnken design were utilized to optimize the tablet formulation. The Orodispersible tablet of Loratadine was optimized by Box Behnken Design, where concentrations Kyron T-314, CRP and Pearlitol SD200 were employed and its effect on Disintegration time (DT), Wetting time (WT) and % drug release at 20 min (Q20) was evaluated. Precompression parameters like angle of repose, bulk density, % compressibility, Hausner’s ratio was studies. The different batches of Orodispersable tablets were prepared and evaluated for disintegration time, friability, wetting time and drug release studies. Different batches prepared showed disintegration time in the range of 23 ± 2.52 to 59 ± 2.64, wetting time in between 27± 0.57 to 66.3 ± 3.4, drug release (Q 20) in between 86.1 ± 0.6 to 96.7 ± 0.4 in 20 min., friability less than 1 % and hardness 3.4 to 4.2 Kg/cm2. The optimized formula when compared with marketed product it showed faster disintegration time and rapid drug dissolution in phosphate buffer 6.8. The solid dispersion of Loratadine not only helped improve in solubility but may also help in taste masking. Keywords: Orodispersible tablets, Loratadine, β cyclodextrin Solid dispersion

scholarly journals Formulation and Evaluation of Rapimelt Tablet of Anti-Vertigo Drug (Lorazepam)

2020 ◽  
Vol 13 (4) ◽  
pp. 341-349
Author(s):  
B. M. Kadu ◽  
S. Bhasme ◽  
R. D. Bawankar ◽  
D. R. Mundhada
Keyword(s):  
Rapid Onset ◽  
Dissolution Time ◽  
Direct Compression ◽  
Compression Method ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Ft Ir ◽  
Wetting Time ◽  
Mouth Feel

A. Rapimelt tablet of Lorazepam was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants with aim to get rapid onset of action, improve bioavailability and to give pleasant taste and better mouth feel. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and invitro dissolution time and were found to be within limits as per Indian Pharmacopoeia. FT-IR spectra of physical mixture of Lorazepam with Indion 414showedretention of basic peaks of Lorazepam. The developed formulation of Lorazepam batch F5 (10% Indion 414) showed good palatability and dispersed within 30 seconds as compared to Crosscarmellose Sodium batches F1-F3 and Sodium starch glycolate batches F6-F9.

scholarly journals Formulation and Quality Control of Orally Disintegrating Tablets (ODTs): Recent Advances and Perspectives

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Mohammadali Poursharifi Ghourichay ◽  
Seyed Hossein Kiaie ◽  
Ali Nokhodchi ◽  
Yousef Javadzadeh
Keyword(s):  
Quality Control ◽  
Immediate Release ◽  
Rapid Onset ◽  
Review Article ◽  
Oral Dosage ◽  
Onset Of Action ◽  
Current Review ◽  
Orally Disintegrating Tablets ◽  
Release Property ◽  
Preparation Techniques

Orally disintegrating tablets (ODTs) rapidly disintegrate or dissolve in the oral cavity without using water. Demand for ODTs has increased, and the field has overgrown in the pharmaceutical industry and academia. It is reported that ODTs have several advantages over other conventional tablets. Since some of them are absorbed from the mouth, pharynx, and esophagus as the saliva passes down into the stomach, in such cases, the bioavailability of the drug improves meaningfully. Furthermore, the immediate release property of ODTs makes them a popular oral dosage form in patients with swallowing challenges, children, and for cases with a need for rapid onset of action. The current review article explains the features of active ingredients and excipients used in the formulation of ODTs, discusses multiple ODT formulation and preparation techniques with their merits and demerits, and also, offers remedies for problems associated with ODTs. Moreover, quality control steps and required considerations are presented.

Vitamin C Fast Action Tablets by Doctor's Formulas' Food Supplements: Evaluation of Matrix Properties

2019 ◽  
Vol 11 (11) ◽  
pp. 1111-1114
Author(s):  
Marilena Vlachou ◽  
Angeliki Siamidi ◽  
Natassa Pippa ◽  
Nikolaos Fikioris
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Corn Starch ◽  
Radical Scavenging ◽  
Immediate Release ◽  
Magnesium Stearate ◽  
Food Supplements ◽  
Dissolution Profile ◽  
Onset Of Action ◽  
Disintegration Time

Vitamin C (ascorbic acid) is a diet dependent vitamin that promotes antioxidation though free radical scavenging and electron donation, has anti-inflammatory properties, supports growth of healthy immune cells and enhances bioavailability of iron in hemoglobin. Vitamin C as a food supplement is commercially available in many forms like immediate/extended release, effervescent and chewable tablets. Its absorption from a solid dosage form after oral administration depends on the release of the active ingredient from the product under physiological conditions and the permeability across the gastrointestinal tract. Generally, immediate release formulations provide rapid drug absorption and consequently a quick onset of the therapeutic effect. The aim of this study was to examine whether the physicochemical properties of the excipients, present in the solid pharmaceutical formulation under study, promote a synergistic interaction with the stereoelectronic features of ascorbic acid, so that the latter is released into the gastric-like dissolution environment in 30 minutes, thus ensuring fast onset of action. Vitamin C fast action tablets by Doctor's Formulas' Food Supplements were evaluated regarding their tablets' properties. Uniformity of tablets regarding their weight, thickness, friability, hardness, disintegration and dissolution was achieved. The careful choice of the appropriate type and quantity of excipients (calcium phosphate, corn starch, silicon dioxide, maltodextrin and magnesium stearate) in the tablet formulation, along with the application of the suitable compression force, ensures right handling/packaging and safe transportation. Moreover the disintegration time as well as the dissolution profile matched the requirements needed for immediate release formulations.

scholarly journals AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS

2018 ◽  
Vol 6 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Pravin Kumar Sharma ◽  
Pankaj Kumar Sharma ◽  
Gajanan N Darwhekar ◽  
Birendra Shrivastava
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Solid Dosage Forms ◽  
Onset Of Action ◽  
Cold Sore ◽  
Solid Dosage ◽  
Oral Films ◽  
Oral Dosage Forms

Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.

Formulation Development and Characterization on the Impact of Superdisintegrants on Oral Dispersible Tablets of Didanosine

1970 ◽  
Vol 9 (2) ◽  
pp. 3181-3188
Author(s):  
Suryakanta Swain ◽  
Muddana Eswara Bhanoji Rao ◽  
Chinam Niranjan Patra ◽  
Sitty Manohar Babu
Keyword(s):  
Dissolution Rate ◽  
Immediate Release ◽  
Conventional Technique ◽  
Formulation Development ◽  
Disintegration Time ◽  
Ich Guidelines ◽  
Dispersible Tablet ◽  
Mouth Feel ◽  
The Impact

The present study was undertaken to develop and evaluate an oro-dispersible tablet of didanosine by direct compression using cross carmellose sodium, crosspovidone and sodium starch glycolate (5-20%) as a superdisintegrants, Avicel 102 (15-30%) was used as diluents along with directly compressible mannitol  (20%) to enhance mouth feel, faster disintegration and dissolution rate of the drug. Absorption of the drug can be impacted by oral fast dissolving dosage form; this may have implication for medications to treat human immunodeficiency virus (HIV) infection and those having difficulty in swallowing tablets or capsules resulting in improved patient compliance. The prepared tablets were evaluated for impact of superdisintegrants on the disintegration behavior of the tablet in the oral cavity and also evaluated for post compression parameters and         in vitro drug release characteristics. The tablets demonstrated a hardness of 3 to 6 kg/cm2, friability of 0.48 to 1 %, disintegration time of 5 to 14 sec and drug content was found to be 98 to 100 %. Based on evaluation parameters the formulation (F6) containing 20 % of crosspovidone and 15% of MCC Avicel 102 showed promising performance against all other formulations with hardness of 5 ± 0.13 kg/cm2 and faster disintegration within 5 s and better dissolution rate. An appropriate combination of excipients made it possible to obtain orally disintegrating immediate release tablets of didanosine using simple and conventional technique. The formulations were subjected to stability studies as per ICH guidelines and were found to be stable after a 3 months study.

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