scholarly journals RELATIONSHIP BETWEEN CORONAVIRUS AND MUCORMYCOSIS DISEASE

2021 ◽  
Vol 10 (5) ◽  
pp. 3601-3605
Author(s):  
Pallavi Londhe
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Paranasal Sinuses ◽  
Uncontrolled Diabetes ◽  
Uncommon Disease ◽  
General Wellbeing

As the human-to-human communicated infection, Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has been a crisis worldwide general wellbeing event. Mucormycosis is a genuine, irregular however cosmopolitan, uncommon artful contagious contamination brought about by a gathering of molds called mucormycetes. These molds live throughout all the climate. It most normally influences the sinuses or the lungs in the wake of breathing in parasitic spores from the air. Mucormycosis is an uncommon disease, which when recognized early can be controlled. The connection among Coronavirus and mucormycosis of the paranasal sinuses should be given genuine thought. Uncontrolled diabetes and over-ardent utilization of steroids are two primary variables irritating the ailment, and both of these should be appropriately checked.

scholarly journals Mucormycosis involving paranasal sinuses in a post-COVID-19 patient with an uncontrolled diabetes-A rare presentation in an ongoing pandemic

2021 ◽  
Vol 6 (2) ◽  
pp. 137-140
Author(s):  
Sankalp Yadav ◽  
Novelesh Bachchan ◽  
Gautam Rawal ◽  
Pallawi Rai
Keyword(s):  
Mortality Rate ◽  
Fungal Infection ◽  
Opportunistic Infection ◽  
Paranasal Sinuses ◽  
Ethmoid Sinus ◽  
Rare Presentation ◽  
Uncontrolled Diabetes ◽  
Life Threatening ◽  
Second Wave ◽  
Indian Male

Mucormycosis (MCR) involving paranasal sinuses is a rare life-threatening opportunistic infection in immunocompromised individuals. In humans, MCR is considered as one of the most rapidly progressive lethal forms of fungal infection with a high mortality rate of 70–100%. During the second wave of COVID-19 in India, the cases of MCR have increased rapidly. We herein report a case of a 70-year-old Indian male with an uncontrolled diabetes diagnosed as maxillary and ethmoid sinus MCR.

scholarly journals The double trouble: COVID-19 associated mucormycosis a focused review and future perspectives

2021 ◽  
Vol 16 ◽  
pp. 4
Author(s):  
Arun Kumar Agnihotri ◽  
Monika Vij ◽  
Okezie I. Aruoma ◽  
Vipul D Yagnik ◽  
Theeshan Bahorun ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Paranasal Sinuses ◽  
Fungal Infections ◽  
Fungal Spores ◽  
Diabetic Patients ◽  
Corticosteroid Administration ◽  
Uncontrolled Diabetes ◽  
The Family ◽  
Need To Evaluate ◽  
The Many

Mucormycosis, a deadly fungal infection, has affected thousands of COVID-19 patients in India. Mucormycosis, formerly known as zygomycosis, is caused by the many fungi that belong to the family “Mucorales.” These molds are commonly found in soil, air, and damp walls and frequently colonize oral mucosa, nose, paranasal sinuses, and throat. The pathophysiological consequences of diabetes combined with the acute inflammatory surge in COVID-19 and steroid treatment weakens person’s immunity and renders susceptibility to fungal infections. Patients treated for severe COVID-19 have damaged lungs and suppressed immune system, an environment that supports fungal infection. Fungal spores can grow in airways or sinuses, and invade bodies’ tissues, explaining why the nasal cavity and paranasal sinuses are the most common site of mucormycosis infection, the consequential spread to the eyes can cause blindness, or causing headaches or seizures if the infection spreads to the brain. Poorly controlled diabetes often results in acidosis in tissues a suitable environment for Mucorales fungi to grow, exacerbating the risk for mucormycosis. This becomes clinically important, especially in India that has an increased prevalence of undiagnosed and uncontrolled diabetes. Given that a significant increase in the cases of mucormycosis in the diabetic patients treated for COVID-19 is strongly associated with corticosteroid administration, there is a need to evaluate use of dietary nutraceuticals with immune boosting potentials that modulate metabolic abnormalities in the management of COVID-19 associated mucormycosis.

scholarly journals A Lung Transcriptomic Analysis for Exploring Host Response in COVID-19

2020 ◽  
Vol 14 (suppl 1) ◽  
pp. 1077-1081
Author(s):  
Aditya Saxena ◽  
Uma Chaudhary ◽  
Alok Bharadwaj ◽  
Nitin Wahi ◽  
Jitender Reddy Kalli ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Host Response ◽  
Drug Targets ◽  
Significant Risk ◽  
Human Coronavirus ◽  
Gene Signatures ◽  
Key Genes ◽  
Significant Expression ◽  
Novel Coronavirus ◽  
General Wellbeing

Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) rose without precedent for Wuhan, China, in December 2019. It is a kind of exceptionally pathogenic human coronavirus (HCoV) which causes zoonotic sicknesses and represents a significant risk to general wellbeing. Recognizing the hidden biology and pathogenesis of this novel coronavirus is extremely critical to comprehend as well as boosting the treatment of this deadly pandemic. The point of this study is to recognize key genes which show significant expression in the SARS-CoV-2 infected lungs as compared to healthy ones. Our analysis uncovered 149 gene-signatures that show substantial up-regulation in COVID-19 lungs. Out of these, top ten dysregulated genes STAP1, CASP5, FDCSP, CARD17, ST20, AKR1B10, CLC, KCNJ2-AS1, RNASE2 and FLG are found to be significant based on various crucial statistical factors and may end up being acceptable helpful drug targets.

scholarly journals Sphenoid Sinus Cholesteatoma—Complications and Skull Base Osteomyelitis: Case Report and Review of Literature

2019 ◽  
Vol 12 ◽  
pp. 117954761983518 ◽  
Author(s):  
Dichapong Kanjanawasee ◽  
Pattraporn Chaowanapanja ◽  
Somboon Keelawat ◽  
Kornkiat Snidvongs
Keyword(s):  
Skull Base ◽  
Paranasal Sinuses ◽  
Sphenoid Sinus ◽  
Purulent Discharge ◽  
Mastoid Cavity ◽  
Inferior Wall ◽  
Case Presentation ◽  
Uncommon Disease ◽  
Extensive Debridement

Introduction: Cholesteatoma of the paranasal sinuses is uncommon. Its clinical characteristics are an expanding growth of the affected paranasal sinuses consisting of keratinizing squamous epithelium with bony wall destruction. Among involved paranasal sinuses, sphenoid sinus cholesteatoma is the least common. Case presentation: An 82-year-old female diabetic patient presented with subacute onset of fever after experiencing chronic progressive headaches for more than 20 years. Nasal endoscopy found purulent discharge from left sphenoethmoidal recess. Computed tomography (CT) scan of the paranasal sinus showed soft tissue lesions that totally filled the left sphenoid sinus with posterior and inferior wall destruction. There was no evidence of connection to the left mastoid cavity. Management and outcome: Left sphenoidotomy was performed. Histopathology revealed cholesteatoma. Two months after surgery, she became worse and CT showed extensive skull base destruction. The patient underwent bilateral sphenoidectomy and craniotomy with surgical debridement of osteomyelitis of the skull base. She received long-term intravenous ertapenam and sitafloxacin for treating drug-resistant Klebsiella infection. The osteomyelitis could not be controlled, and she died. Discussion: Progressive headache can be caused by an uncommon disease such as sphenoid sinus cholesteatoma, which is a surgical condition. Complicating osteomyelitis of the skull base requires extensive debridement surgery and should be anticipated.

scholarly journals Syncephalastrum racemosum as aRare Agent of Rhino-orbital Mucormycosis:A Case Report and Review

2021 ◽  
Author(s):  
Neelam Gulati ◽  
Poonam Gupta ◽  
Charu Nayyar ◽  
BL Sherwal ◽  
Sunil Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Case Report ◽  
Paranasal Sinuses ◽  
Human Disease ◽  
Rare Case ◽  
Syncephalastrum Racemosum ◽  
The Third ◽  
Uncontrolled Diabetes ◽  
The Common

Fungal infection of the paranasal sinuses is an increasingly recognised entity both in immunocompetent and immunocompromised individuals. Aspergillus species are the most common aetiologic agents of this disease. Zygomycete agents are the common culprits in the immunocompromised group. The most common agent causing human disease is Rhizopus species followed by Rhizomucorspp. The important risk factors are uncontrolled diabetes mellitus and immunsupression. Here, a rare case of pansinusitis with Syncephalastrum racemosum was reported in a 13-year-old male child with aplastic anaemia. Syncephalastrum racemosum has been debated for its role in human diseases and very few reports are documented. To the best of our knowledge this was the third report of rhino-orbital infection caused by this fungus. Syncephalastrum racemosum should be considered as one of the aetiologic agents of rhino-orbital infections especially in the immunocompromised group.

Normal Radiographic Anatomy of the Paranasal Sinuses

1973 ◽  
Vol 6 (2) ◽  
pp. 429-457 ◽  
Author(s):  
Eiji Yanagisawa ◽  
Howard W. Smith
Keyword(s):  
Paranasal Sinuses

Social and Temporal Comparisons as Moderators of Psychological Resources Associations With Wellbeing

2016 ◽  
Vol 37 (2) ◽  
pp. 96-104 ◽  
Author(s):  
Hasida Ben-Zur
Keyword(s):  
Life Satisfaction ◽  
Positive Affect ◽  
Subjective Wellbeing ◽  
Social Comparisons ◽  
Self Esteem ◽  
Psychological Resources ◽  
Low Levels ◽  
Age Range ◽  
General Wellbeing

Abstract. The current study investigated the associations of psychological resources, social comparisons, and temporal comparisons with general wellbeing. The sample included 142 community participants (47.9% men; age range 23–83 years), who compared themselves with others, and with their younger selves, on eight dimensions (e.g., physical health, resilience). They also completed questionnaires assessing psychological resources of mastery and self-esteem, and three components of subjective wellbeing: life satisfaction and negative and positive affect. The main results showed that high levels of psychological resources contributed to wellbeing, with self-enhancing social and temporal comparisons moderating the effects of resources on certain wellbeing components. Specifically, under low levels of mastery or self-esteem self-enhancing social or temporal comparisons were related to either higher life satisfaction or positive affect. The results highlight the role of resources and comparisons in promoting people’s wellbeing, and suggest that self-enhancing comparisons function as cognitive coping mechanisms when psychological resources are low.

Perceptions about Severe Acute Respiratory Syndrome Experience Scales

2006 ◽  
Author(s):  
Robert G. Maunder ◽  
William J. Lancee ◽  
Kenneth E. Balderson ◽  
Jocelyn P. Bennett ◽  
Bjug Borgundvaag ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome
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