APPLICATION OF LUTEIN-ZEAXANTHIN OF EGG YOLK BASED HYDROGEL EYE MASK AS A PREVENTIVE EFFORT AGAINST COMPUTER VISION SYNDROME (CVS)

Aims and objectives: Computer Vision Syndrome(CVS) is a collection of symptoms related to eye disorders due to the use of computer-based digital devices. So substantial protection is needed against damage caused by exposure to blue light by digital devices. Lutein and zeaxanthin are carotenoids that contain antioxidants so that they can overcome inflammation, have a calming effect and can maintain eye health. The purpose of this research is to produce a topical preparation in the form of a hydrogel eye mask from egg yolk which is useful for overcoming Computer Vision Syndrome(CVS). Methods: This study formulated three formulas with the active ingredients of egg yolk extract 400µg, 600µg and 800µg using 8.75 g of sodium alginate base and 3.75 g of xanthan gum. Evaluation of the preparations included organoleptic tests, weight and size, pH, swellability, shrinkage, homogeneity, viscosity, spreadability, adhesion and stability tests. Results: of the evaluation of the preparations hydrogel eye mask in the three formulas showed good physical characteristics and stability. The results of the evaluation that have been carried out show that the organoleptic test has no changes in color, odor and shape. Test the appropriate weight and size under the eye area. The pH test of the three formulas before storage was 7.3±0.15, 7.1±0.05, 7.1±0.17 and after storage 7.5±0.1, 7.4±0.1, 7.2±0.2. The expansion and shrinkage test showed an increase in weight every hour and a decrease in weight every 10 minutes. The homogeneity test showed the three formulas were homogeneous. The viscosity test is in a good range. The dispersion test of the three formulas before storage was 5.13±0.2, 5.07±0.15 and 5.18±0.28 cm and after storage was 5.05±0.13, 5.20±0.32, and 5.11±0.22 cm. The adhesion of each formula before storage was 4.23±0.51, 3.27±0.84, 3.28±0.62 seconds and after storage 3.24±0.38, 3.26±0.15, 2.96±0.77 seconds. Conclusion: The three formulas produced have good pharmaceutical characteristics and stability so that they can be used to treat Computer Vision Syndrome (CVS). Peer Review History: Received: 5 September 2021; Revised: 8 October; Accepted: 25 October, Available online: 15 November 2021 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indones UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Mohammad Bayan, Faculty of Pharmacy, Philadelphia University, P.O. Box: 1 Philadelphia University 19392 Jordan, [email protected] Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, [email protected] Similar Articles: IN-VITRO ANTIBACTERIAL ACTIVITY OF LACTOBACILLI METABOLITES LOADED HYDROGEL FORMULATIONS AGAINST PSEUDOMONAS AERUGINOSA

Download Full-text

Computer Vision Syndrome: Implications for the Occupational Health Nurse

Workplace Health & Safety ◽

10.1177/2165079917731790 ◽

2017 ◽

Vol 66 (2) ◽

pp. 56-60 ◽

Cited By ~ 2

Author(s):

Ann Regina Lurati

Keyword(s):

Computer Vision ◽

Occupational Health ◽

Leisure Time ◽

Related Condition ◽

Digital Devices ◽

Computer Vision Syndrome ◽

Health Nurse ◽

Health Related ◽

Occupational Health Nurse

Computers and other digital devices are commonly used both in the workplace and during leisure time. Computer vision syndrome (CVS) is a new health-related condition that negatively affects workers. This article reviews the pathology of and interventions for CVS with implications for the occupational health nurse.

Download Full-text

ENHANCEMENT OF WOUND HEALING BY TOPICAL APPLICATION OF EPIDERMAL GROWTH FACTOR IN ANIMAL MODEL

Universal Journal of Pharmaceutical Research ◽

10.22270/ujpr.v5i1.357 ◽

2020 ◽

Author(s):

George Zhu ◽

Xu HL ◽

Zhou XP ◽

Zhi QW

Keyword(s):

Wound Healing ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Peer Review ◽

Healing Time ◽

Epidermal Growth ◽

Review Reports ◽

E Mail

Objective: Wound healing is a complex process of biological events involving re-epithelialization and granulation that are mainly mediated by several endogenously released growth factors such as epidermal growth factor. This work was undertaken to study the effects of various doses of locally applied recombinant human epidermal growth factor (rhEGF) on wound healing in rats. Methods: Recombinant human EGF consists of 53 amino acids. In vitro, rhEGF promoted it’s obvious cell growth and proliferation when added to cultured 3T3 cells using MTT assay. In the test groups, in vivo, wound sites were given daily with a solution containing 2, 5, 10, 50ug of EGF spray and 40ug of EGF ointment, respectively. We presented evidence that a significant decreased healing time in wound was observed in all rhEGF groups when compared with the control, and reach to its maximal efficacy at 10ug/ml of rhEGF spray. Results: The rate of wound closure was over 50 per cent at initial 3 days of treatment. Treatment with rhEGF significantly decreased the length of time to over 50 per cent healing by approximately 4-5 days, and that to 70 per cent and 90 per cent healing by approximately 3-4 days and 3 days, respectively. A stimulatory, dose-dependent effect of EGF on wound healing was observed with increased hEGF concentration. In toxicological group, higher doses of 100ug/ml of rhEGF spray was applied by local dorsal incision in rats. Moreover, a dose of single 200ug, single 300ug or 300ug within 24 hours of subcutaneous and intramuscular rhEGF injection was given respectively. There were no significant adverse side effects.Conclusion: Current study recommended a proposal of clinical drug doses in wound at 2µg, 5 µg and 10 µg /ml of rhEGF spray, and 10 µg and even higher 40 µg rhEGF/g of ointment. The results indicated that prepared rhEGF by our genetic engineering is safe, and is emerging in clinical effective use in assisting wound healing time. Peer Review History: Received 8 January 2020; Revised 12 February; Accepted 2 March, Available online 15 March 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Name: Asmaa Ahmed Mohamed Ahmed Khalifa Affiliation: Pharos University, Alexandria, Egypt E-mail: [email protected] Name: Dr. Sabah Hussien El-Ghaiesh Affiliation: Tanta University, Egypt E-mail: [email protected] Comments of reviewer(s): Similar Articles: POTENTIAL OF SNAKEHEAD FISH (OPHIOCEPHALUS STRIATUS) IN ACCELERATING WOUND HEALING

Download Full-text

Computer vision syndrome in children & it's management: an Ayurvedic approach

National Journal of Research in Ayurved Science ◽

10.52482/ayurlog.v8i05.702 ◽

2020 ◽

Vol 8 (05) ◽

Author(s):

Sulbha Kalme

Keyword(s):

Computer Vision ◽

Screen Time ◽

Working Adults ◽

Digital Devices ◽

Computer Vision Syndrome

Technology has become such an integral part of our life, most of us spend many hours staring at screens today. The digital devices in the form of computers, laptops, i-pads & smartphones etc. are included in day to day lives of everyone. So now a days working adults are not the only ones who are dealing with computer vision syndrome (CVS),even children are affected because of this. Today millions of children use computers & smartphones daily. Too much screen time may cause vision problems for kids.CVS also called digital eye strain. CVS comes under Netrarogas in Ayurveda. Acharya Sushruta & Vagbhata have described about netrarogas in detail in Uttartantra as compared to other Acharyas. So an attempt has made to understand the wisdom of our Acharyas through Ayurvedic classics interpreted by them long ago.

Download Full-text

Knowledge, Attitudes and Practices of Computer Vision Syndrome among Medical Students in Goa

Epidemiology International ◽

10.24321/2455.7048.202102 ◽

2021 ◽

Vol 06 (01) ◽

pp. 9-14

Author(s):

Tanvi Poy Raiturcar ◽

Keyword(s):

Computer Vision ◽

Medical Students ◽

Public Awareness ◽

Descriptive Study ◽

Educational Institutions ◽

Cross Sectional ◽

Attitudes And Practices ◽

Digital Devices ◽

Computer Vision Syndrome ◽

Knowledge Attitudes And Practices

Introduction: There has been a tremendous increase in the use of computers and other screens by young adults in educational institutions for education, communication, and recreation. This can lead to computer vision syndrome. Computer vision syndrome includes a variety of symptoms faced by individuals who use computers for long hours every day. Most early symptoms are not recognized and the condition goes undiagnosed. Creating public awareness about the healthy use of computers is the need of the hour. Aim: To study knowledge, attitudes and practices of computer vision syndrome among medical students in Goa. Methods: Settings and Design: Cross-sectional descriptive study. Study Duration: 1 month (June 2020) Statistical Analysis Tools Used: Simple percentages and proportions. Result: It is seen that among participants who use digital devices for more than 6 hours, 39 (92.9%) were symptomatic. 62 (57.4%) participants experienced worsening of symptoms due to lockdown. Conclusion: The present study revealed that more than three-fourths of the students complained of one or more symptoms of computer vision syndrome while working on the devices.

Download Full-text

COVID-19: CURRENT PHARMACOLOGICAL THERAPEUTIC APPROACHES

Universal Journal of Pharmaceutical Research ◽

10.22270/ujpr.v5i6.514 ◽

2021 ◽

Author(s):

Mai ES. Ghoneim ◽

Asmaa A. Khalifa ◽

Bassma M. Ali

Keyword(s):

Peer Review ◽

Treatment Strategies ◽

Medical Sciences ◽

Initial Stage ◽

Unique System ◽

The World ◽

Repurposed Drugs ◽

Review Reports

By the end of 2019, SARS-CoV-2, a new virus from Coronaviruses family, has been detected in China and was responsible for COVID-19 disease. This disease has been suddenly and vigorously disseminated among individuals all over the world. Based on genetic vicinity, this novel virus is similar to SARS-CoV and MERS-CoV; it can spread from an unknown animal host to individuals. Till now, there is no specific therapy or vaccine for the treatment of COVID-19 patients. However, published clinical data and in vitro studies may offer treatment strategies of some effective antiviral and repurposed drugs, including remdesivir, favipiravir, lopinavir/ritonavir, corticosteroids, etc. This narrative review describes current pharmacological proposed treatments for COVID-19 patients and available experimental and clinical studies for these drugs. Eventually, these data may help to explain the most preferable way to treat COVID-19 and lessen symptoms and complications accompanied with it. Peer Review History: Received 6 November 2020; Revised 25 Decembe; Accepted 4 January, Available online 15 January 2021 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Comments of reviewer(s): Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, [email protected] Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, [email protected] Dr. Nuray Arı, Ankara University, Turkiye, [email protected] Similar Articles: USE OF COLCHICINE TO COUNTERACT THE STRONG HYPERINFLAMMATORY STATE INDUCED BY SARS-COV-2 THE RISKS AND ADVANTAGES OF ANTI-DIABETES THERAPY IN THE POSITIVE COVID-19 PATIENT EUCALYPTUS ESSENTIAL OIL; AN OFF-LABEL USE TO PROTECT THE WORLD FROM COVID-19 PANDEMIC: REVIEW-BASED HYPOTHESES SUDANESE EXPERIENCE OF HERBAL FORMULAS USED DURING COVID-19 INFECTION TRADITIONAL TO RECENT APPROACHES IN HERBAL MEDICINE THERAPY OF COVID-19

Download Full-text

Relationship between Computer Vision Syndrome and A Collection of Musculoskeletal Pain among Frequent Computer Users

Strengthening Hospital Competitiveness to Improve Patient Satisfaction and Better Health Outcomes ◽

10.26911/the6thicph.05.24 ◽

2019 ◽

Author(s):

Hari Peni Julianti ◽

◽

Trilaksana Nugroho ◽

Dea Amarilisa Adespin ◽

Arwinda Nugraheni ◽

...

Keyword(s):

Computer Vision ◽

Musculoskeletal Pain ◽

Computer Users ◽

Computer Vision Syndrome

Download Full-text

Study on Knowledge and Prevalence of Computer Vision Syndrome among Computer Operators in Nobel Medical College Teaching Hospital, Biratnagar, Nepal

Journal of Nobel Medical College ◽

10.3126/jonmc.v9i2.33386 ◽

2020 ◽

Vol 9 (2) ◽

pp. 45-49

Author(s):

Pramod Sharma Gautam ◽

Uday Chandra Prakash ◽

Subreena Dangol

Keyword(s):

Computer Vision ◽

Teaching Hospital ◽

Human Life ◽

College Teaching ◽

Extended Period ◽

Visual Display ◽

Work Place ◽

Medical College ◽

Computer Vision Syndrome ◽

Department Of Ophthalmology

Background: The eye and vision related problems that results from continuous use of computers and other visual display terminals for extended period of time leads to computer vision syndrome. Due to rapid digitalization in human life, the risk of developing it has also increased in many folds. So, with an aim of determining the prevalence and level of awareness of computer vision syndrome among computer users along with their attitude and practices to prevent it, this study was conducted in the office employees who use computer for a considerable period of time. Materials and Methods: A hospital based observational descriptive study was conducted in the out-patient department of Ophthalmology in Nobel Medical College and Teaching Hospital, Biratnagar, where 105 employees working in different work stations of same institution were enrolled. A questionnaire and the clinical findings were used to collect data. Results: About 80% of the employees were using computer for about (8-11) hours per day. Prevalence of computer vision syndrome noted was (92.4%) with low level of knowledge (85.7%) about it. About 45% of them wore glasses for their refractive errors but attitude and practices in work place to prevent the bad effects of using visual display terminals were found to be lacking (53.3%). Burning sensation in the eye, headache, ocular irritation and itching and neck, shoulder or back pain were the common symptoms. Around (60-70)% of the eyes tested positive for dry eye. Conclusion: Lack of awareness of computer vision syndrome and lack of personal protective measures were associated with its high level of prevalence.

Download Full-text

Evaluation of Snake Venom’s PhospholipaseA2 Enzyme Inhibition Activity of Cyphostemma adenocoule

Current Chemical Biology ◽

10.2174/2212796814999200917114914 ◽

2020 ◽

Vol 14 (3) ◽

pp. 196-202

Author(s):

Atul Kaushik ◽

Teamrat S. Tesfai ◽

Daniel K. Barkh ◽

Furtuna K. Ghebremeskel ◽

Habtom G. Zerihun ◽

...

Keyword(s):

Enzyme Inhibition ◽

Snake Venom ◽

Ethanol Extract ◽

Egg Yolk ◽

Chloroform Extract ◽

Inhibition Activity ◽

Traditional Use ◽

Snake Bites ◽

Ethanol Extracts

Background: A snake bite is fundamentally an injury often resulting in puncture wounds meted out by the animal's fangs and occasionally resulting in envenomation. Rate of snake bites around 5,400,000 bites per year leads to over 2,500,000 envenomings and around 125,000 fatal cases annually. Snake venom enzymes are rich in metalloproteinases, phospholipaseA2, proteinases, acetylcholinesterases and hyaluronidases. Objective: Cyphostemma adenocoule is traditionally being used for the treatment of snake bites in Eritrea. The present research was aimed at evaluating the snake venom enzyme inhibition activity of C. adenocoule against puff adder venom and developing a base for the traditional use of the plant against snakebites in Eritrea. Methods: The anti-venom activity of C. adenocoule was assessed in-vitro through phospholipaseA2 enzyme inhibition assay using egg yolk as a cell. The ethanol and chloroform extracts of C. adenocoule showed in vitro anti phospholipase A2 activity, whereas the water extracts of the plant showed no activity. Results: Among the extracts of C. adenocoule, the highest percentage of inhibition was obtained from chloroform extract (95.55% at 100mg/ml). The extract showed prominent activity at different concentrations (34.7% at10mg/ml, 48.8% at 20mg/ml, 54.8% at 40mg/ml, 60.9% at 60mg/ml, 80.5% at 80mg /ml). The ethanol extract also showed certain activity at various concentrations (25.22% at10mg/ml, 14.78% at 20mg/ml, 2.6% at40mg/ml). The activity of the chloroform extracts increases as concentration increases, whereas the activity of the ethanol extracts decreases as concentration increases. The aqueous extract of C. adenocoule did not show any activity at all concentrations. Conclusion: In this study, the chloroform and ethanol extracts of the plant inhibited the enzyme of interest and thus proved the efficacy of anti-snake venom activity of the plant.

Download Full-text