scholarly journals Acute and subacute toxicity of Solanum aethiopicum Linn Gilo (Solanaceae) aqueous leaves extract in Wistar rats

2022 ◽  
Vol 11 (1) ◽  
pp. 01-09
Author(s):  
Tuem SR ◽  
Ndomou M ◽  
Manz KJC ◽  
Nsoga JVF ◽  
Bekwankoa FGS ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Solanum Aethiopicum ◽  
Subacute Toxicity

scholarly journals Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Alian Désiré Afagnigni ◽  
Maximilienne Ascension Nyegue ◽  
Chantal Florentine Ndoye Foe ◽  
Youchahou Njankouo Ndam ◽  
Frédéric Nico Njayou ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Shigella Flexneri ◽  
Female Rats ◽  
Male Rats ◽  
Dependent Manner ◽  
Subacute Toxicity ◽  
Antidiarrheal Activity ◽  
Dose Dependent ◽  
Ethanolic Leaf Extract

The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D. multiflora. Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that D. multiflora leaf extract is efficient against diarrhea caused by S. flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.

scholarly journals Subacute toxicity study in Wistar rats fed with StemEnhanceTM, an extract from Aphanizomenon flos-aquae

2010 ◽  
pp. 125 ◽  
Author(s):  
Dirikolu ◽  
Thushara Chakkath ◽  
Susan Ball-Kell ◽  
Christy Elamma ◽  
Timothy M. Fan ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Toxicity Study ◽  
Subacute Toxicity

scholarly journals Acute and Subacute Toxicological Evaluation of the Aerial Extract ofMonsonia angustifoliaE. Mey. ex. A. Rich in Wistar Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Anthony Jide Afolayan ◽  
Olubunmi Abosede Wintola ◽  
Gerda Fouche
Keyword(s):  
Wistar Rats ◽  
Morphological Changes ◽  
Plasma Concentrations ◽  
Toxicity Testing ◽  
Experimental Period ◽  
Control Group ◽  
Toxicological Evaluation ◽  
Subacute Toxicity ◽  
Significant Difference ◽  
Dose Dependent

The acute and subacute toxicity profile of the aerial extract ofMonsonia angustifoliain Wistar rats was evaluated. The Organization for Economic Cooperation and Development (OECD) 420 guideline was adopted in the acute toxicity testing with a single oral dose of 5000 mg/kg (b.w.). For the 28-day daily oral dosing, the extract was administered at 75, 150, and 300 mg/kg b.w.; 1% ethanol in sterile distilled water was used as control. Clinical toxicity signs were subsequently evaluated. At a single dose of 5000 mg/kg b.w. the extract elicited no treatment-related signs of toxicity in the animals during the 14 days of experimental period. In the subacute toxicity, there was no significant difference in hematological, renal, and liver function indices. However, dose-dependent significant increases were observed on the plasma concentrations of white blood cell and platelet counts of the treated animals compared to the control group. While cage observations revealed no treatment-facilitated signs of toxicity, histopathological examinations of the kidneys and liver also showed no obvious lesions and morphological changes. These results suggest that the extract may be labelled and classified as safe and practically nontoxic within the doses and period of investigation in this study.

scholarly journals Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
C. P. Ekanayake ◽  
M. G. Thammitiyagodage ◽  
S. Padumadasa ◽  
B. Seneviratne ◽  
C. Padumadasa ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Ethyl Acetate ◽  
Wistar Rats ◽  
Cocos Nucifera ◽  
Toxicity Study ◽  
Immature Inflorescence ◽  
Subacute Toxicity ◽  
Toxicity Studies ◽  
Female Wistar Rats

Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.

scholarly journals Toxicopathological Evaluation of Hydroethanol Extract ofDianthus basuticusin Wistar Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Anofi Omotayo Tom Ashafa ◽  
Mutiu Idowu Kazeem
Keyword(s):  
Acute Toxicity ◽  
Oral Administration ◽  
Toxicity Test ◽  
Wistar Rats ◽  
Acute Toxicity Test ◽  
Toxicity Profile ◽  
Subacute Toxicity ◽  
Whole Plant ◽  
Single Oral Administration ◽  
Treatment Of Diabetes

Background. Dianthus basuticusis a commonly used medicinal plant in Basotho traditional medicine for the treatment of diabetes, but there is no report on its safety or toxicity. Therefore, we evaluated the toxicity profile of the hydroethanol whole plant extract ofDianthus basuticusin Wistar rats.Methods.Acute toxicity test was performed with single oral administration of 100–3200 mg/kg body weight ofD. basuticusextract to rats and the animals were observed for 14 days for signs of toxicity. The subacute toxicity experiment was conducted by oral administration of graded doses (200, 400, and 800 mg/kg) ofD. basuticusextract daily for 28 days. Behavioural changes as well as haematological, biochemical, and histological parameters were then evaluated.Results.There was no observable sign of toxicity in the acute toxicity test. There were significant decreases (P<0.05) in the feed and water intake as well as total cholesterol and triglycerides of theD. basuticusextract-treated rats in subacute toxicity study. There were no treatment related differences in the haematological, biochemical, and histopathological evaluations.Conclusions.Administration of hydroethanol extract ofD. basuticusmay be safe at the dosages tested in this study but its continuous usage can cause anorexia.

scholarly journals Physicochemical characteristics, acute and subacute toxicity of cashew nut shell oil in Wistar rats

2020 ◽  
Vol 8 ◽  
pp. e00391
Author(s):  
Goodnews Okereke ◽  
Okezie Emmanuel ◽  
Victor Chibueze Ude ◽  
Celestine Nwabu Ekweogu ◽  
Victor Okezie Ikpeazu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Physicochemical Characteristics ◽  
Subacute Toxicity ◽  
Cashew Nut ◽  
Cashew Nut Shell

scholarly journals Acute and subacute toxicity of Cassia occidentalis L. stem and leaf in Wistar rats

2011 ◽  
Vol 136 (2) ◽  
pp. 341-346 ◽  
Author(s):  
Mirtes G.B. Silva ◽  
Ticiana P. Aragão ◽  
Carlos F.B. Vasconcelos ◽  
Pablo A. Ferreira ◽  
Bruno A. Andrade ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Cassia Occidentalis ◽  
Subacute Toxicity

scholarly journals Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
I. J. Asiedu-Gyekye ◽  
T. G. Borovskaya ◽  
M. E. Poluektova ◽  
А. V. Vychuzhanina ◽  
Y. А. Shchemerovа ◽  
...  
Keyword(s):  
Theobroma Cacao ◽  
Congenital Malformations ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
High Dose ◽  
Dna Comet Assay ◽  
Subacute Toxicity ◽  
Genotoxic Potential ◽  
Survival Index

Unsweetened natural cocoa (UNCP) was evaluated for reproductive toxicity in rats. A preliminary genotoxic potential was evaluated by the DNA comet assay test using C57Bl/6 mice. Both therapeutic dose (TD; 900 mg/kg) and high dose (HD; 9000 mg/kg) of UNCP were used. White Wistar rats were used in two experimental groups. The females received UNCP 15 days before crossing with untreated males. The males received UNCP for 48 days before mating with untreated females. Subacute toxicity was observed during a 14-day oral administration of UNCP. Results show that a high tail DNA% was observed with methyl mesylate administration in all tissues analysed. The lowest tail DNA% value was observed in the liver (1.64 ± 0.26) and kidney (1.63 ± 0.30) during UNCP (TD) administration. UNCP did not induce observable physical congenital malformations on the pubs of treated female and male rats, lacks genotoxic potential, and did not adversely affect pregnancy index, pub weights, and survival index, but UNCP exhibited proimplantation potential ( p > 0.05 ).

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