scholarly journals Study on Relationship Between Age and Coffee Preference: Application to Specialty Coffee Association Brewing Control Chart

Author(s):  
Joy Xue

The Specialty Coffee Association Brewing Control chart has been used for the past 50 years, and is intended to assist the coffee brewer by stating the brew ratio and TDS (total dissolved solids) value needed to brew an “ideal” cup of coffee. Since coffee is a common and popular beverage that is consumed among populations ranging from children to elders, the objective of this study was to find out whether taste preferences in coffee vary based on age and whether these preferences match the current brewing control chart standard. Data collected in this study was based on a taste test with 32 total participants selected randomly. Of these participants, 10 fell into the 10-19 years old age range, 5 in the 20-29 range, 4 in the 30-39 range, 7 in the 40-49 range, and 6 in the 50-59 range. Based on the data from these respondents, no obvious trend between age range and coffee preference was observed; but, this is subject to change with larger sample sizes.Overall taste preferences, however, do generally fit the current standard ideal range on the coffee brewing control chart.

2000 ◽  
Vol 1 (4) ◽  
pp. 205-212 ◽  
Author(s):  
A. Gee ◽  
D. Moffitt ◽  
M. Churn ◽  
R.D. Errington

Background: Radiotherapy skin reactions have been well documented in the past. Until recently, washing of the treated area and the use of perfumed products that contain metals has not been advocated during treatment. The aims of this study were to assess the skin reactions of patients using a non-metallic deodorant and to see whether there were any psychological benefits from being able to use the deodorant.Method: 41 women attending for radiotherapy to either the breast or breast and axilla were recruited into the trial. They were randomised into one of two groups. Complete data was obtained for 36 patients. 20 patients used the deodorant and 16 did not. Any skin reactions noted were recorded on a weekly basis. Patients were also asked to complete a questionnaire relating to feelings and activities and to comment on the deodorant if they had used it.Results: Skin reactions did seem to be slightly worse in the patients using deodorant, and it was only in this group of patients that axillary reactions were noted. However, neither of these results were statistically significant. The use of the deodorant did not have any impact on the psychological well being of the patients, but patients using it had found it pleasant to use and the majority said that they would use it again.Conclusion: Further study is indicated to look at skin reactions using the deodorant with a larger sample of patients.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1053
Author(s):  
Jasmine L. King ◽  
Soumya Rahima Benhabbour

Gliomas are the most common type of brain tumor that occur in adults and children. Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in adults and is universally fatal. The current standard-of-care options for GBM include surgical resection, radiotherapy, and concomitant and/or adjuvant chemotherapy. One of the major challenges that impedes success of chemotherapy is the presence of the blood–brain barrier (BBB). Because of the tightly regulated BBB, immune surveillance in the central nervous system (CNS) is poor, contributing to unregulated glioma cell growth. This review gives a comprehensive overview of the latest advances in treatment of GBM with emphasis on the significant advances in immunotherapy and novel therapeutic delivery strategies to enhance treatment for GBM.


2018 ◽  
Vol 38 (01) ◽  
pp. 050-061 ◽  
Author(s):  
Zachary Reitman ◽  
Frank Winkler ◽  
Andrew Elia

Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. The current standard of care for GBM is maximal resection followed by postoperative radiation with concomitant and adjuvant temozolomide. Despite this multimodality treatment, the median survival for GBM remains marginally better than 1 year. In the past decade, genome-wide analyses have uncovered new molecular features of GBM that have refined its classification and provided new insights into the molecular basis for GBM pathogenesis. Here, we review these molecular features and discuss major clinical trials that have recently defined the field. We describe genetic alterations in isocitrate dehydrogenase, ATRX, the telomerase promoter, and histone H3 variants that promote GBM tumorigenesis and have altered GBM categorization. We also discuss intratumoral genetic heterogeneity as one explanation for therapeutic failures and explain how ultra-long extensions of glioma cells, called tumor microtubes, mediate therapeutic resistance. These findings provide new insights into GBM biology and offer hope for the development of next-generation therapies.


2019 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Muhammad Azeem ◽  
Leonardo Mataruna

Purpose The purpose of this paper is to investigate important determinants of the culture of collective leadership in academic organizations. The present school improvement framework of Dubai School Inspection Board (DSIB) does not include cultural factors such as collective leadership, which is, according to many researchers, a leading factor of the operational efficiency and sustainable growth. The research objective was to identify the set of conditions that extend support to the development of collective leadership culture in the school work environment. In order to achieve research objectives, a sample of 271 employees from 12 underperforming private schools in Dubai was selected to examine the degree of the presence of visible practices promoting the culture of collective leadership. The past literature was explored to identify three manifest variables as determinants of the culture of collective leadership in the organization. The descriptive research design was adopted, and factor loadings on three manifest variables were examined through exploratory factor analysis (EFA) to validate the scale, and later the model hypotheses were tested using the linear regression model. The study has revealed that shared vision, employee’s commitment to achieving the organizational goal, and collaboration are key determinants, whereas staff commitment is the most important determinant of collective leadership. Generalization of the findings is one of the main concerns due to small sample size, which can be improved in future similar studies by running the model on the larger sample size. Indeed, this study is one of the few that provides a quantitative approach to the measurement of collective leadership in schools, and its findings can be a source of guideline for institutions in higher education and non-academic organizations as well. Design/methodology/approach The descriptive research design was adopted to explain the the characteristics of the population with respect to variables used in the model. The underlying variables were explored through the past literature; therefore, EFA was also undertaken to validate the relationship between scale items and manifest independent variables of the hypothesized construct. The testing of hypothesis makes this research “confirmatory” that allows making inference about the parameters of the multiple regression models in this empirical model. Findings The concept of collective leadership is explaining the wider role of leadership function in an organization. It is one of the cultural aspects that can be seen through everyday practices in any educational institution. These practices include shared vision among employees, commitment to achieving the common goal, and collaboration and teamwork. The results show that staff commitment is the most important determinant of collective leadership. The understanding of a cultural aspect of collective leadership is necessary to deal with the problems of nonperforming educational organizations. It is important that school leaders must think beyond the current DSIB model and include elements of collective leadership in their strategic plans. This will enable them to achieve sustainable students and organizational achievements. Employees’ clarity on the objectives, trust and collaboration are prerequisite of such culture. Research limitations/implications Generalization is one of the main concerns in this study. The larger sample size can help overcome this problem. The sample size in the current study was also gathered without stratification of the population. Schools can be classified with respect to gender, ethnicity, curriculum and social status. These factors were controlled in this study but can produce different results if included for the analysis. Data collection can be expanded to the entire country, Middle East and Asian region for further generalized interpretation. This will also open the scope to the cross-cultural analysis on the subject. Moreover, the mediating or moderating role of many other variables needs to be involved in the model for more accurate findings, such as curriculum, economic status of students, employees nationality and qualification, leadership experience and school budgetary volume are considered important factors which may affect school performance. A similar study can be conducted for the entire country covering all states. Practical implications The culture of collective leadership is not a sole cultural factor that creates success for the institution. When an organization achieves maturity in the collective leadership, employees set up goals in their own work in alignment to the overall organizational objectives. These goals will act as challenges, and with the motivated employees will take up these challenges and find new and improved ways to address the problems. This will provoke the creative thinking among employees. They will start realizing the importance of the critical knowledge in the work. Ultimately, when the organization develops a system to identify, store and make use of such knowledge, it will become learning organization, which is ready to meet future challenges. Social implications This study will help organizations in other sector and industry as well, especially in service industry including financial institutions, higher education, etc. This will also provide guidelines to the education ministries across the region and beyond. Originality/value This is a new contribution in the field of HRM or workplace practices. It describes the factors determining the culture of collective leadership that in return creates success for the organization. This paper was never published before.


An inquiry has been completed recently involving comparisons of all the best records of heights of British adolescents and adults. They cover the period from about 1850 to the present day, and far more males than females are represented. The main object of the inquiry was to find out any changes there may have been in the age curve for height during the past hundred years. It is commonly supposed that the general situation regarding this question is known. The best records for British series of children are in good agreement in showing that height standards for particular ages were improving from decade to decade, if not from year to year. The latest generation was repeatedly found to have the highest mean heights for school years of age, and this secular trend was persistent. It has often been supposed that British people generally were becoming taller, so that the age curve for a filial generation would be found to be above that for the parental generation throughout the whole age range from birth to the oldest ages. But this is an inference based on the records for children and it might be incorrect. An alternative possibility is that there was a secular change in the rate of growth but that more rapid growth was associated with the attainment of maturity at a younger age; the faster growing children when mature might be no taller or shorter on the average than their parents were. The question could be examined directly by comparing the records collected at different times relating to the last stage of growth and adult years of life. The evidence has to be treated by making detailed comparisons of data for a considerable number of series and subseries of people. In this brief account of the inquiry it is only possible to indicate the more important general considerations involved and the principal results obtained. The records referred to are for a total of more than two million British men. The material is of a miscellaneous kind. It is due chiefly to various official and other bodies and to independent research workers whose activities were not co-ordinated. The need for a national anthropometric survey has often been advocated in this country, but one has never been established.


2018 ◽  
Vol 6 (1) ◽  
pp. 232596711774864
Author(s):  
Rohit Singh ◽  
Amit Bhalla ◽  
Matthew Ockendon ◽  
Stuart Hay

Background: Motocross is a form of motorcycle racing held on established off-road circuits and has been a recreational and competitive sport across the world for >100 years. In the United Kingdom alone, motocross has grown into a phenomenally ambitious and popular franchise. There are >200 motocross clubs across the country, permitting >900 events annually. Purpose: To assess the current trend of spine-related motocross injuries over the past 5 years. Study Design: Descriptive epidemiology study. Methods: Data were prospectively collected over 5 years (August 2010–August 2015) at our regional trauma and spine unit, regardless of whether the rider was performing the sport competitively or recreationally. Results: During the study period, spine-related injuries were identified for 174 patients (age range, 6-75 years) who were directly referred to our department following recreational or competitive motocross, with most injuries being sustained within the early spring and summer months, representing the start of the motocross season. A significant number of injuries were in males (n = 203, 94%), with the majority of injuries occurring within the 21- to 30-year-old age group. A total of 116 (54%) injuries required operative treatment. The most common spinal injury was thoracolumbar burst fracture (n = 95), followed by chance fractures (n = 26). Conclusion: This data series emphasizes the prevalence and devastation of motocross-related spinal injuries in the United Kingdom and may serve in administering sanctions and guidelines to governing bodies of motocross. The spinal injuries that occur during motocross have significant capital connotations for regional spinal centers. The recent surge in motocross popularity is correlated with the number of injuries, which have increased over the past 5 years by almost 500%.


Author(s):  
George W. Sledge ◽  
Fatima Cardoso ◽  
Eric P. Winer ◽  
Martine J. Piccart

Overview: Metastatic breast cancer (MBC), a usually incurable disease, continues to vex physicians and patients. Recent decades have seen great improvements in the treatment of MBC, based on the availability of novel targeted therapeutics and more standard chemotherapeutic agents. This article describes the goals of therapy for MBC, the progress made against MBC in recent decades, the current standard of care, and the ongoing efforts of basic and translational researchers to transfer the fruits of modern scientific discovery to patients in the clinic.


2015 ◽  
Vol 40 (1) ◽  
pp. 161-174 ◽  
Author(s):  
Kenneth R. Young

The past and present impacts of humans on the biosphere have altered many ecological and evolutionary processes. One of the most dramatic set of examples comes from domestication, which has transformed species, landscapes, and socioeconomic systems over the last 30 millennia. Recent research driven by advances in molecular biology and information sciences, and enriched by whole genome analyses of the main plant and animal domesticates, is now able to elucidate obscure phylogenetic relationships complicated by past hybridization and chromosome rearrangements. These methods also reveal information on the historical events that converted wild species into useful, and in some cases, codependent taxa. A further set of human-domesticate interactions produces the great diversification behind the origin and maintenance of numerous crop landraces, fruit and vegetable variants, and animal breeds. Fashion, taste preferences, and familial dynamics are some of the additional factors involved beyond usefulness that collectively result in human-caused artificial selection. Domestication is an important dimension to consider in understanding the biogeographical implications of the Anthropocene.


2003 ◽  
Vol 42 (4II) ◽  
pp. 569-583 ◽  
Author(s):  
Azeema Faizunnisa ◽  
Minhaj Ul Haque

The world is experiencing the largest cohort of adolescents in its history, and there are about 1 billion youngsters in this age group, most of whom belong to the developing countries. Worldwide, the adolescent age group is gaining prominence for researchers, policy-makers and donors. This issue is more important for Pakistan where about one-third of 150 million Pakistanis are in the age range of 10-24 years [Pakistan Census Organisation (2001)]. In Pakistan, the fertility transition has just begun [Sathar and Casterline (1998)], and we will have the largest cohort of young people in next five years. With a TFR of 4.1 which represents a significant decline in fertility in the past two decades for about two children [Pakistan (2003)], still we have a large population base. Nearly 33 percent of the population is aged 10-24, and ready to enter marriage and childbearing. Adolescents represents as a “bulge” in the population pyramid of Pakistan that will have serious implications at a variety of levels.


Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6239
Author(s):  
Joan Tymon-Rosario ◽  
Naomi N. Adjei ◽  
Dana M. Roque ◽  
Alessandro D. Santin

Taxanes and epothilones are chemotherapeutic agents that ultimately lead to cell death through inhibition of normal microtubular function. This review summarizes the literature demonstrating their current use and potential promise as therapeutic agents in the treatment of epithelial ovarian cancer (EOC), as well as putative mechanisms of resistance. Historically, taxanes have become the standard of care in the front-line and recurrent treatment of epithelial ovarian cancer. In the past few years, epothilones (i.e., ixabepilone) have become of interest as they may retain activity in taxane-treated patients since they harbor several features that may overcome mechanisms of taxane resistance. Clinical data now support the use of ixabepilone in the treatment of platinum-resistant or refractory ovarian cancer. Clinical data strongly support the use of microtubule-interfering drugs alone or in combination in the treatment of epithelial ovarian cancer. Ongoing clinical trials will shed further light into the potential of making these drugs part of current standard practice.


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